Stem-loop mmu-mir-341

Accession

MI0000625

Symbol

MGI: Mir341

Description

Mus musculus mmu-mir-341 precursor miRNA mir-341

Gene
family

RF03771; mir-341

Literature search

8 open access papers mention mmu-mir-341
(30 sentences)

Sequence

46350 reads, 157 reads per million, 86 experiments

aaaaugaugaugucaguuggcCGGUCGGCCGAUCGCUCGGUCugucagucagucggUCGGUCGAUCGGUCGGUCGGUcagucggcuuccugucuuc
.....(((((.(((.((((((((((((((((((((.((((.(((.(.....).))))))).)))))))))))))))))))).))).))..)))...

Structure

aaaau   --  u   a                    C    U   u a 
     gau  ga guc guuggcCGGUCGGCCGAUCG UCGG Cug c g
     |||  || ||| |||||||||||||||||||| |||| ||| | u
     cug  cu cgg ugacUGGCUGGCUGGCUAGC GGCU ggc g c
--cuu   uc  u   c                    U    -   u a 

Annotation confidence Not enough data

Comments

Kim et al. cloned 40 new miRNAs from rat E18 primary cortical neurons [1]. This mouse miRNA is predicted based on homology to the verified rat sequence (MIR:MI0000624) - its expression was later verified in mouse [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context

chr12: 109611500-109611595 [+]

Clustered miRNAs

2 other miRNAs are < 10 kb from mmu-mir-341

Mature mmu-miR-341-5p

• Accession: MIMAT0017037
• Description: Mus musculus mmu-miR-341-5p mature miRNA
• Sequence: 22 - CGGUCGGCCGAUCGCUCGGUC - 42
• Evidence: experimental ; Illumina [4]

Mature mmu-miR-341-3p

• Accession: MIMAT0000588
• Description: Mus musculus mmu-miR-341-3p mature miRNA
• Sequence: 57 - UCGGUCGAUCGGUCGGUCGGU - 77
• Evidence: experimental ; cloned [2], Illumina [3-4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


3. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


4. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365