Accession
MI0000368
Description
Drosophila melanogaster
dme-mir-283 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Dme-mir-283, a highly conserved host microRNA in Drosophila, is significantly upregulated in response to alphavirus infection and is predicted to target the 3′UTR of the DmDNMT2 gene [PMC8402854]. This upregulation aligns with the observed SINV-responsive expression pattern of dme-mir-283 and its target [PMC8402854]. Despite its response to viral infection, dme-mir-283 shows a lack of correlation with the expression profiles of other miRNAs in its cluster, such as dme-mir-304 and dme-mir-12, as well as with its own star form, dme-mir-283* [PMC3150300]. This suggests a distinct regulatory role for dme-mir-283 that is not shared with closely related miRNAs within its cluster [PMC3150300].
Literature search
9 open access papers mention dme-mir-283
(17 sentences)
(17 sentences)
Sequence
395575
reads,
2309
reads per million, 49 experiments
cucacacgauucucaaagguAAAUAUCAGCUGGUAAUUCUGGgagcuaagccuaaauaugaaacacuCGGAAUUUCAGUUGGUAUCGAcuuuuuugaauu
.......(((((..((((((..(((((((((((.(((((((((......................))))))))))))))))))))..))))))..)))))
.......(((((..((((((..(((((((((((.(((((((((......................))))))))))))))))))))..))))))..)))))
Structure
cucacac uc AA U agcuaagccu
gauuc aaaggu AUAUCAGCUGG AAUUCUGGg a
||||| |||||| ||||||||||| |||||||||
uuaag uuuucA UAUGGUUGACU UUAAGGCuc a
------- uu GC - acaaaguaua
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chrX: 15507956-15508055 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from dme-mir-283
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Database links
Mature dme-miR-283-5p
| Accession | MIMAT0000347 |
| Description | Drosophila melanogaster dme-miR-283-5p mature miRNA |
| Sequence | 21 - AAAUAUCAGCUGGUAAUUCUGG - 42 |
| Evidence |
experimental
Northern [1-2], 454 [3-4], Illumina [4] |
| Database links |
|
| Predicted targets |
|
Mature dme-miR-283-3p
| Accession | MIMAT0020810 |
| Description | Drosophila melanogaster dme-miR-283-3p mature miRNA |
| Sequence | 68 - CGGAAUUUCAGUUGGUAUCGA - 88 |
| Evidence | not_experimental |
| Database links |
|
References
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