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MIR210 is a microRNA that is associated with neuroinflammation and hypoxia in Parkinson's disease (PD) [PMC7215947]. In a study, changes in the relative expression levels of three microRNAs, including MIR210, were assessed in a pre-motor PD model [PMC7215947]. A hydrogel loaded with the secretory body from the human ADSC line HATMSC2 was found to have high levels of MIR210, indicating its potential in chronic wound treatment [PMC9742286]. Overexpression of MIR210 was observed in advanced hepatocellular carcinoma (HCC) and was associated with higher disease stage, poor overall and disease-free survival, and high incidence of recurrence after chemotherapy [PMC8799276]. Transgenic mouse experiments using doxycycline-inducible transgenic mice showed the use of MIR210 (Tg-210) [PMC8088433]. HIF-1α was found to be required for the induction of MIR210 in activated T cells, suggesting that HIF-1 acts upstream of miR-210 [PMC3996831]. In addition to MIR210, miR21 and miR155 were also studied for their cancer and immune-related functions [PMC6862702].
MIR210 is a hypoxia-associated microRNA that has been implicated in neuroinflammation and various diseases such as Parkinson's disease (PD) and hepatocellular carcinoma (HCC) [PMC7215947] [PMC9742286] [PMC8799276] [PMC8088433] [PMC3996831] [PMC6862702].
accc ca -c gg C CC - C c - c
gg gugc uccaggcgcag cAGCC CUG CAC CGCACA UG g cug
|| |||| ||||||||||| ||||| ||| ||| |||||| || | ||| c
cc cgcg ggguccguguc GUCGG GAC GUG GCGUGU ac c gac
---c ag ac uA C -A U C c a c
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This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences . Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Its expression was later verified in human BC-1 cells .