Stem-loop mmu-mir-206

Accession

MI0000249

Symbol

MGI: Mir206

Description

Mus musculus mmu-mir-206 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

mmu-mir-206 is a microRNA identified in mice, analogous to hsa-miR-206 in humans, and is involved in the regulation of gene expression [PMC4383946]. It has been observed that the expression of mmu-mir-206, along with other microRNAs such as mmu-miR-1 and mmu-miR-133a, can be positively influenced by IGF1 treatment when combined with MAPK/ERK inhibitor treatment [PMC4325962]. The regulation of mmu-mir-206 appears to be transcriptional as both precursor and mature forms are similarly affected [PMC4325962]. The expression of this microRNA is also sensitive to other factors; for instance, Rb1 markedly inhibits the transcripts of mmu-mir-206 among other microRNAs [PMC9120625]. Additionally, mmu-mir-206 has been associated with transcription factors such as NF-γ after orchiectomy in mice [PMC7074395], and its expression increases progressively during embryonic development [PMC1635289]. In muscle cell differentiation studies involving C2C12 cells, mmu-mir-206 was identified as one of the upregulated microRNAs [PMC3753644], and its locus has been mapped to chromosome 1 in mice [PMC2064500]. The expression levels of this miRNA vary with age in muscle tissue; for instance, it was upregulated during late testing (LT) periods compared to other time points such as short term (ST) or intermediate term (IT) testing periods where different miRNAs were downregulated [PMC3030602]. Experimental manipulation can also alter levels of mmu-mir-206 through transfection with inhibitors or overexpression constructs coupled with GFP [PMC3973319], highlighting its functional significance and potential for targeted research.

Literature search

193 open access papers mention mmu-mir-206
(2338 sentences)

Sequence

563617 reads, 3121 reads per million, 83 experiments

ccaggccACAUGCUUCUUUAUAUCCUCAUAgauaucucagcacuaUGGAAUGUAAGGAAGUGUGUGGuuuugg
(((((((((((((((((((((((.(.(((((...........)))))).)))))))))))))))))).)))))

Structure

     -                  C U     auau 
ccagg ccACAUGCUUCUUUAUAU C CAUAg    c
||||| |||||||||||||||||| | |||||    u
gguuu GGUGUGUGAAGGAAUGUA G GUauc    c
     u                  A -     acga 

Annotation confidence Not enough data

Genome context

chr1: 20679010-20679082 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from mmu-mir-206

Mature mmu-miR-206-5p

• Accession: MIMAT0017004
• Description: Mus musculus mmu-miR-206-5p mature miRNA
• Sequence: 8 - ACAUGCUUCUUUAUAUCCUCAUA - 30
• Evidence: experimental ; Illumina [4]

Mature mmu-miR-206-3p

• Accession: MIMAT0000239
• Description: Mus musculus mmu-miR-206-3p mature miRNA
• Sequence: 46 - UGGAAUGUAAGGAAGUGUGUGG - 67
• Evidence: experimental ; cloned [1-2], Illumina [3-4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12554859
   New microRNAs from mouse and human
   "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
   "RNA (2003) 9:175-179


3. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


4. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009