miRBase entry: mmu-mir-138-2

Stem-loop mmu-mir-138-2


Accession
MI0000164
Symbol
MGI: Mir138-2
Description
Mus musculus mmu-mir-138-2 precursor miRNA mir-138
Gene
family?
RF00671; mir-138

Literature search
92 open access papers mention mmu-mir-138-2
(710 sentences)

Sequence

400994 reads, 1112 reads per million, 103 experiments
cAGCUGGUGUUGUGAAUCAGGCCGacgagcagcgcauccucuuacccgGCUAUUUCACGACACCAGGGUug
...(((((((((((((...(((((..(((.((......)))))...)))))..))))))))))))).....

Structure
--cAG             UCA     -ac   c  cg 
     CUGGUGUUGUGAA   GGCCG   gag ag  c
     |||||||||||||   |||||   ||| ||   
     GACCACAGCACUU   UCGgc   uuc uc  a
guUGG             -UA     cca   -  cu 


Annotation confidence Not enough data
Do you think this miRNA is real?
Comments
Mouse miR-138 was cloned from mouse brain tissue in [1]. There are 2 predicted hairpin precursor structures in the mouse genome, each has a closely related human homologue [2]. mir-138-1 (MIR:MI0000722) is found on mouse chromosome 8, and mir-138-2 (MIR:MI0000164, previously named mir-138 here) on chromosome 9. Kim et al. and Obernosterer et al. independently show that the mature product is a 23mer [3,4].

Genome context
chr8: 94324311-94324381 [+]

Database links

Mature mmu-miR-138-5p

Accession MIMAT0000150
Description Mus musculus mmu-miR-138-5p mature miRNA
Sequence 2 - AGCUGGUGUUGUGAAUCAGGCCG - 24
Evidence experimental
cloned [1,5], Illumina [6-7]
Database links
Predicted targets

Mature mmu-miR-138-2-3p

Accession MIMAT0016987
Description Mus musculus mmu-miR-138-2-3p mature miRNA
Sequence 49 - GCUAUUUCACGACACCAGGGU - 69
Evidence experimental
Illumina [7]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739

  3. PubMed ID: 20215419
    MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
    "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
    "Mol Hum Reprod (2010) 16:463-471

  4. PubMed ID: 20413612
    Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
    "Genes Dev (2010) 24:992-1009

  5. PubMed ID: 15634332
    New human and mouse microRNA genes found by homology search
    "Weber MJ"
    "FEBS J (2005) 272:59-73

  6. PubMed ID: 14691248
    Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
    "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
    "Proc Natl Acad Sci U S A (2004) 101:360-365

  7. PubMed ID: 16738409
    Post-transcriptional regulation of microRNA expression
    "Obernosterer G, Leuschner PJ, Alenius M, Martinez J"
    "RNA (2006) 12:1161-1167