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20 publications mentioning ssc-mir-378b

Open access articles that are associated with the species Sus scrofa and mention the gene name mir-378b. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 137
Recently, a report showed that MyoD could promote expression of miR-378, which suppressed MyoR, a MyoD inhibitor, by recognizing its 3′ UTR, and differentiation was accelerated because of relief of MyoD inhibition [29]. [score:9]
MicroRNAs may regulate multi-targets simultaneously, which was in accordance with our result that miR-378 could downregulate both BMP2 and MAPK1 by recognizing their 3′UTR. [score:7]
These results suggested that miR-378 directly targeted the BMP2 and MAPK1 3′UTR, and might regulate myogenesis in the manner of acceleration of the differentiation and inhibition of proliferation (Figure 5). [score:7]
To determine the biological function of miR-378 in the regulation of myogenesis, TargetScan, an online program, was used for prediction of potential target mRNAs (http://www. [score:6]
To acquire more knowledge concerning the biological role of miR-378 in skeletal muscle differentiation, regulatory targets were predicted using TargetScan. [score:6]
Although ssc-miR-378 was expressed in almost all the organs, it was much more highly expressed in skeletal muscles and heart than in other organs. [score:5]
Lee et al. proved that miR-378 enhanced cell survival, tumor growth, and angiogenesis by repressing the expression of two tumor suppressors, Sufu and Fus-1 [25]. [score:5]
The qPCR showed that ssc-miR-378 was expressed at low levels at 33dpc and high at 65 and 90 dpc, which was consistent with the pattern of fiber formation during fetal development, suggesting that this kind of miRNA might be involved in muscle fiber formation. [score:4]
The results of luciferase activities suggested that miR-378 could target the wild type 3′UTRs of porcine BMP2 or MAPK1, but not the mutation ones in which the binging sites were deleted. [score:4]
It was possible that miR-378 repressed proliferation of myoblasts by inhibiting this pathway and thus promoted differentiation in an indirect manner. [score:4]
We can also speculate that there still exist numerous targets interacting with miR-378 in the regulation of myogenesis. [score:4]
Dynamic Expression of Ssc-miR-378 During Various Ontogenetic Development. [score:4]
Expression profiles of miR-378 during various development periods. [score:4]
Finally, target genes of miR-378 were predicted, and KEGG pathway analysis suggests that this miRNA is involved in the regulation of the MAPK signaling pathway. [score:4]
Our qPCR results showed that ssc-miR-378 was expressed highly in cardiac and skeletal muscles, and it may exert important physiological effects on muscle development. [score:4]
BMP2 and MAPK1 are Endogenous Target of miR-378. [score:3]
As shown in Figure 3, the expression of ssc-miR-378 was extremely low in 33 dpc, increased in 65 and 90 dpc, reached its maximum level at postnatal day 0, decreased during postnatal individual growth and was maintained at a stable level in the adult stage. [score:3]
To gain further understanding of the biological role of ssc-miR-378 in the process of myogenesis, total RNAs from longissimus muscles of adult pig, fetuses in the 33, 65, 90 days post-coitus (dpc) stages and piglets in the 0, 10, 100, and 180 postnatal days were isolated, and qPCR was performed to identify its expression pattern. [score:3]
The high expression periods of ssc-miR-378 were consistent with that of myofiber formation, suggesting that it might be an important miRNA in promoting muscle fiber formation. [score:3]
Maintenance of a relatively high level of expression of ssc-miR-378 during postnatal days 0 to 10 might be closely related to this tertiary fiber wave. [score:3]
Thus, miR-378 may promote myoblasts differentiation by suppressing BMP2. [score:3]
BMP2 and MAPK1 are potential target of miR-378. [score:3]
The targets of miRNA-378 were predicted, and the predicted targets were analyzed to investigate their involvement in known pathways. [score:3]
Previous research showed that 33, 65 and 90 days’ gestation can be considered as critical time points in prenatal skeletal muscle development [28]; therefore, we selected those three stages to analyze the expression pattern of ssc-miR-378 during fetal periods. [score:3]
We detected the dynamic expression of ssc-miR-378 in prenatal and postnatal skeletal muscle. [score:3]
The results showed that ssc-miR-378 was abundantly expressed in skeletal muscles. [score:3]
Therefore, we concerned about these two genes and verified whether they were the candidate targets of miR-378. [score:3]
Target Prediction of miR-378 and GO Analysis. [score:3]
Presumed regulatory network of miR-378 in myogenesis. [score:2]
MiR-378 can also mediate the differentiation of MC3T3-E1, which is a type of osteoblastic cell, through modulating nephronectin, which will promote osteoblast differentiation and bone nodule formation when overexpressed [26]. [score:2]
To determine the regulation role of miR-378 against BMP2 and MAPK1, luciferase reporter vectors containing wild-type or mutant 3′UTR of BMP2 or MAPK1 (Figure 4B) were constructed and co -transfected with miR-378 mimics or negative control mimics into PIEC and PK15 cell lineages. [score:2]
Therefore, miR-378 probably controls myoblast differentiation by regulation of this pathway. [score:2]
These lines of evidence suggest that miR-378 plays an important role in regulating cellular proliferation and differentiation. [score:2]
In summary, ssc-miR-378 might play an important role in the regulation of myogenesis, especially in fiber formation in both the fetal and newborn periods. [score:2]
We speculated that ssc-miR-378 might be a vital miRNA in skeletal muscles. [score:1]
This finding also confirmed the biological function of miR-378 in myoblast differentiation. [score:1]
An example was ssc-miR-378, which we found at a much higher abundance than their study found. [score:1]
Ssc-miR-206, ssc-miR-1 and ssc-miR-378 had the most reads in our Solexa results. [score:1]
The 3′UTR of BMP2 or MAPK1 containing miR-378 binding site was amplified from porcine genomic DNA by the method of PCR. [score:1]
The same situation, which was mentioned above, existed for ssc-miR-new_28 and ssc-miR-new_75 comparing to ssc-miR-378. [score:1]
The 60 nM miR-378 mimics/negative control duplexes (GenePharma) were co -transfected with 200 ng luciferase reporter containing BMP2/MAPK1 3′UTR using Lipofectamine 2000 reagent (Invitrogen) in 24-well plates. [score:1]
0052123.g005 Figure 5 (A) Predicted miR-378 binding site (highlighted in red) in the 3′UTR of BMP2 or MAPK1 showing species conservation. [score:1]
0052123.g004 Figure 4 (A) Predicted miR-378 binding site (highlighted in red) in the 3′UTR of BMP2 or MAPK1 showing species conservation. [score:1]
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[+] score: 27
Ssc-miR-21, ssc-miR-30d, ssc-miR-181, ssc-miR-199*, and ssc-miR-378 were all expressed at higher levels at the prenatal compared with the neonatal stage, and their distinct expression patterns during muscle development clearly reflected the relationship between miRNA and myogenesis. [score:5]
Our group has reported that miR-378 is a potential myogenic miRNA that regulates skeletal muscle development by targeting BMP2 and MAPK1 [17]. [score:5]
We found that miR-1 was expressed at higher levels on D100 and that miR-378 was expressed at higher levels on E90. [score:5]
These data were consistent with the previously described role of miR-1 in regulating skeletal muscle satellite cell proliferation and differentiation by repressing Pax7 and that of miR-378 in targeting the myogenic repressor MyoR during myoblast differentiation [26, 40]. [score:4]
As presented in Table 2, one class showed 100-fold greater levels of expression at E90 compared to D100, which included ssc-miR-126, ssc-miR-143-3p, ssc-miR-127, ssc-miR-148a, ssc-miR-196b-5p, and ssc-miR-369; another class exhibited expression levels of were slightly lower than 100-fold, which included ssc-miR-542-3p, ssc-miR-99b, ssc-miR-378, ssc-miR-30a-5p, ssc-miR-10b, and ssc-miR-21. [score:4]
Nine differentially expressed miRNAs (ssc-miR-7a, ssc-miR-10b, ssc-miR-21, ssc-miR-30d, ssc-miR-127, ssc-miR-148a, ssc-miR-181, ssc-miR-199*, and ssc-miR-378) were chosen for the validation of the Solexa sequencing data via RT-qPCR. [score:3]
Aside from ssc-miR-206 and ssc-miR-1, ssc-miR-378 was the most abundant at E90, followed by ssc-miR-143-3p, ssc-let-7a, ssc-let-7f, ssc-let-7c, ssc-miR-30d, ssc-miR-30a-5p, ssc-miR-10b, ssc-miR-127, ssc-miR-148a, ssc-miR-126, ssc-miR-7i, and ssc-miR-21. [score:1]
[1 to 20 of 7 sentences]
[+] score: 27
of Host miRNAs In silico target prediction were performed for those most abundant and DE porcine miRNAs presenting differential expression between NIA-3 and Begonia infected groups: miR-92a and miR-92b-3p from the in vitro approach and miR-206, miR-133a, miR-133b and miR-378 from the in vivo approach. [score:5]
In silico target prediction were performed for those most abundant and DE porcine miRNAs presenting differential expression between NIA-3 and Begonia infected groups: miR-92a and miR-92b-3p from the in vitro approach and miR-206, miR-133a, miR-133b and miR-378 from the in vivo approach. [score:5]
Focusing on those more expressed miRNAs in infected groups and DE between them, we observed that miR-206 (FC = 648), miR-133a (FC = 108), miR-133b (FC = 88) and miR-378 (FC = 5) were more expressed in NIA-3 group (Table S4). [score:5]
Focusing on the in vivo approach, there were miRNAs DE between virulent and attenuated strains, particularly more expressed in NIA-3 infected group, like miR-133a (FC = 108), miR-133b (FC = 88), miR-378 (FC = 5) and miR-206 (FC = 648), suggesting that they could work activating those pathways related to the response against the viral infection. [score:3]
Regarding the involvement of host miRNAs in the regulatory network, miR-133a, miR-133b, miR-92a, miR-92b-3p and miR-378 were related to LLT and the regulatory genes EP0, IE180, UL41 and UL48. [score:3]
Significant related pathways to target genes were found for all miRNAs except for miR-378. [score:3]
miR-92a, miR-92b-3p, miR-133b, and miR-378 also interacted with LLT and with the regulatory genes IE180, UL41 and UL48. [score:2]
Thus, miR-92a, miR-92b-3p, miR-133a, miR-133b, miR-378 and miR-206 generated a total of 71 significant interactions with 37 SuHV-1 genes (Figure 2). [score:1]
[1 to 20 of 8 sentences]
[+] score: 17
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-27a, hsa-mir-29a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-199a-1, hsa-mir-208a, hsa-mir-148a, hsa-mir-10a, hsa-mir-181a-2, hsa-mir-181c, hsa-mir-199a-2, hsa-mir-181a-1, hsa-mir-214, hsa-mir-221, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-23b, hsa-mir-27b, hsa-mir-125b-1, hsa-mir-128-1, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-143, hsa-mir-125b-2, hsa-mir-126, hsa-mir-127, hsa-mir-206, hsa-mir-1-1, hsa-mir-128-2, hsa-mir-29c, hsa-mir-26a-2, hsa-mir-378a, hsa-mir-148b, hsa-mir-133b, hsa-mir-424, ssc-mir-125b-2, ssc-mir-148a, ssc-mir-23a, ssc-mir-24-1, ssc-mir-26a, ssc-mir-29b-1, ssc-mir-181c, ssc-mir-214, ssc-mir-27a, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-103-1, ssc-mir-128-1, ssc-mir-29c, hsa-mir-486-1, hsa-mir-499a, hsa-mir-503, hsa-mir-411, hsa-mir-378d-2, hsa-mir-208b, hsa-mir-103b-1, hsa-mir-103b-2, ssc-mir-17, ssc-mir-221, ssc-mir-133a-1, ssc-mir-1, ssc-mir-503, ssc-mir-181a-1, ssc-mir-206, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-378-1, ssc-mir-133b, ssc-mir-29a, ssc-mir-199a-2, ssc-mir-128-2, ssc-mir-499, ssc-mir-143, ssc-mir-10a, ssc-mir-486-1, ssc-mir-103-2, ssc-mir-181a-2, ssc-mir-27b, ssc-mir-24-2, ssc-mir-23b, ssc-mir-148b, ssc-mir-208b, ssc-mir-424, ssc-mir-127, ssc-mir-125b-1, hsa-mir-378b, hsa-mir-378c, ssc-mir-411, ssc-mir-133a-2, ssc-mir-126, ssc-mir-199a-1, ssc-mir-378-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-499b, ssc-let-7a-2, ssc-mir-486-2, hsa-mir-378j, ssc-let-7d, ssc-let-7f-2, ssc-mir-29b-2, hsa-mir-486-2
Interestingly, recently studies have validated that ssc-miR-378 regulated myogenesis by directly targeting the BMP2 or MAPK1 in pig, suggesting that the STEM clustering was reliable for analyzing miRNA expression profiles as well as for predicting of candidate myogenic miRNAs. [score:7]
STEM clustering results suggested that ssc-miR-378 functioned as a new candidate miRNA for porcine myogenesis because of its expression profile similar to ssc-miR-1 and -133a-3p (Figure 5A). [score:3]
Similarly, two other myomiRs, miR-133 [21] and miR-206 [23], were highly expressed and ranked the 4 [th] and 6 [th] respectively, while two other miRNAs (miR-378 [24, 25] and miR-143 [25]) ranked the 2 [nd] and 3 [rd] have been identified to participate in the proliferation and differentiation of muscle cells. [score:3]
Interestingly, the second abundant DE miRNA was miR-378, a new candidate miRNA for myogenesis in pigs by down -regulating porcine BMP2 or MAPK1 [53]. [score:2]
Consequently, 18 candidate miRNAs were selected, including ssc-miR-378, -127, -128, -411, 23b, -27b, -10a, -140*, -9-1/-2, -148a/b, -126, 542-3p, 30a-5p/d/e-5p and miR-103 (Figure 5). [score:1]
In addition to the best-studied myomiRs (miR-1, -206 and miR-133 families), 11 other DE muscle-related miRNAs (miR-378 [24], miR-148a [27], miR-26a [28, 29], miR-27a/b [30, 31], miR-23a [32, 33], miR-125b [34], miR-24 [35], miR-128 [36], miR-199a [37] and miR-424 [38]) with high abundance (average RPM >1,000) and another 14 (miR-181a/b/c/d-5p [26], miR-499-5p [11], miR-503 [38], miR-486 [39], miR-214 [40], miR-29a/b/c [41– 43], miR-221/222 [44] and miR-208 [11] with low abundance (average RPM <1,000) were detected in myogenesis of pig. [score:1]
[1 to 20 of 6 sentences]
[+] score: 11
miRNAs overexpressed in E. coli F18-sensitive individuals include ssc-miR-143 (highest expression), ssc-let-7f, ssc-miR-143, ssc-miR-192, ssc-miR-21, ssc-miR-215, ssc-miR-378, ssc-miR-145, ssc-miR-26a, and ssc-miR-30e. [score:5]
MiRNAs with a mean value >10000 by sequence counting (i. e., expression) included ssc-miR-143, ssc-let-7f, ssc-miR-192, ssc-miR-21, ssc-miR-215 and ssc-miR-378. [score:3]
Analysis of pri-miRNA sequences identified two miR-378 precursors: ssc-miR-378-1 and ssc-miR-378-2. The specific genome locations of the precursor sequences of differentially expressed miRNAs were determined using the Sanger database. [score:3]
[1 to 20 of 3 sentences]
[+] score: 9
Other miRNAs from this paper: ssc-mir-378-1, ssc-mir-4335, ssc-mir-378-2
Gerin et al. found that miR-378 could increase the size of lipid droplets and promote the incorporation of acetate into triacylglycerol by specifically increasing the transcription dependent on C/EBPα and C/EBPβ 59, which is in accordance with our finding that the hypermethylated promoter of miR-378 caused a reduced expression of miR-378 and consequently a decrease in the expression of C/EBPα and C/EBPβ (Fig. 6b). [score:5]
The hypermethylated promoter of miR-378 may decrease the expression of C/EBPα and C/EBPβ in LBF and thus cause higher adipocyte volumes and an enhanced capacity for fat deposition. [score:3]
Furthermore, we also found that the promoter of miR-378 displayed higher methylation levels in LBF than in RBF, which was also confirmed by BSP (Fig. 4b). [score:1]
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[+] score: 9
This result is consistent with a previous report showing that ssc-miR-27a negatively regulates adipocyte differentiation by inhibiting the expression of PPARγ[10] (Additional file 9), and that miR-378 expression is also negatively correlated with cattle backfat thickness [35]. [score:8]
As an example, ssc-miR-27a and ssc-miR-378 were decreased by 3.14-fold and 6.06-fold in the castrated male pigs, respectively. [score:1]
[1 to 20 of 2 sentences]
[+] score: 8
Though Hou et al. found that the expression level of miR-378 increased at 65 and 90 dpc and peaked at postnatal day 0, these results both suggested that miRNA-378 was a new candidate miRNA for myogenesis in pigs (Hou et al., 2012; Qin et al., 2013). [score:3]
In our study, miR-378 showed the highest expression level in the E90 stage. [score:3]
For example, miR-378 promotes myogenesis in pigs through regulation of bone morphogenetic protein 2 (BMP2) and mitogen-activated protein kinase 1 (MAPK1), especially in fiber formation in both the fetal and newborn periods (Hou et al., 2012). [score:2]
[1 to 20 of 3 sentences]
[+] score: 7
Four of the top ten miRNAs, miR-378, -148a, -143, and -27b, were up-regulated (more than 1.5-fold change, P < 0.001) in PMM compared with LDM; however, there have been no reports documenting their possible in vivo/ vitro roles in muscle development. [score:4]
Click here for file KEGG pathways enriched for the predicted protein coding target genes of miR-378, -148a, -143, and -27b. [score:3]
[1 to 20 of 2 sentences]
[+] score: 7
In a comparison between the pig breeds, 49 dpc showed the most significant differences in G1 (up-regulated), in which miR-378, miR-30a, miR-148a, and miR-127 showed drastic changes. [score:4]
Ganesan J miR-378 prevents cardiomyocyte hypertrophy through repression of four factors in the MAP kinase pathwayNaunyn-Schmiedebergs Arch. [score:1]
miR-378 prevents cardiomyocyte hypertrophy through the repression of four components of the MAP kinase pathway [19]. [score:1]
Figure  3 shows that in G1 (up), we clearly found that 49 dpc showed the most significant differences between breeds; in this group, miR-378, miR-148a and miR-127 showed drastic changes. [score:1]
[1 to 20 of 4 sentences]
[+] score: 6
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-20a, hsa-mir-22, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-98, hsa-mir-101-1, hsa-mir-16-2, mmu-let-7g, mmu-let-7i, mmu-mir-1a-1, mmu-mir-15b, mmu-mir-101a, mmu-mir-126a, mmu-mir-130a, mmu-mir-133a-1, mmu-mir-142a, mmu-mir-181a-2, mmu-mir-194-1, hsa-mir-208a, hsa-mir-30c-2, mmu-mir-122, mmu-mir-143, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-181a-1, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-15b, hsa-mir-122, hsa-mir-130a, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-142, hsa-mir-143, hsa-mir-126, hsa-mir-194-1, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-208a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-15a, mmu-mir-16-1, mmu-mir-16-2, mmu-mir-18a, mmu-mir-20a, mmu-mir-22, mmu-mir-26a-1, mmu-mir-26b, mmu-mir-29c, mmu-mir-98, mmu-mir-326, rno-mir-326, rno-let-7d, rno-mir-20a, rno-mir-101b, mmu-mir-101b, hsa-mir-1-1, mmu-mir-1a-2, hsa-mir-181b-2, mmu-mir-17, mmu-mir-19a, mmu-mir-181a-1, mmu-mir-26a-2, mmu-mir-19b-1, mmu-mir-181b-1, mmu-mir-181c, hsa-mir-194-2, mmu-mir-194-2, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-101-2, hsa-mir-26a-2, hsa-mir-378a, mmu-mir-378a, hsa-mir-326, mmu-mir-133a-2, mmu-mir-133b, hsa-mir-133b, mmu-mir-181b-2, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-15b, rno-mir-16, rno-mir-17-1, rno-mir-18a, rno-mir-19b-1, rno-mir-19a, rno-mir-22, rno-mir-26a, rno-mir-26b, rno-mir-29c-1, rno-mir-30c-1, rno-mir-30c-2, rno-mir-98, rno-mir-101a, rno-mir-122, rno-mir-126a, rno-mir-130a, rno-mir-133a, rno-mir-142, rno-mir-143, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-194-1, rno-mir-194-2, rno-mir-208a, rno-mir-181a-1, hsa-mir-423, hsa-mir-18b, hsa-mir-20b, hsa-mir-451a, mmu-mir-451a, rno-mir-451, ssc-mir-122, ssc-mir-15b, ssc-mir-181b-2, ssc-mir-19a, ssc-mir-20a, ssc-mir-26a, ssc-mir-326, ssc-mir-181c, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-18a, ssc-mir-29c, ssc-mir-30c-2, hsa-mir-484, hsa-mir-181d, hsa-mir-499a, rno-mir-1, rno-mir-133b, mmu-mir-484, mmu-mir-20b, rno-mir-20b, rno-mir-378a, rno-mir-499, hsa-mir-378d-2, mmu-mir-423, mmu-mir-499, mmu-mir-181d, mmu-mir-18b, mmu-mir-208b, hsa-mir-208b, rno-mir-17-2, rno-mir-181d, rno-mir-423, rno-mir-484, mmu-mir-1b, ssc-mir-15a, ssc-mir-16-2, ssc-mir-16-1, ssc-mir-17, ssc-mir-130a, ssc-mir-101-1, ssc-mir-101-2, ssc-mir-133a-1, ssc-mir-1, ssc-mir-181a-1, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-378-1, ssc-mir-133b, ssc-mir-499, ssc-mir-143, ssc-mir-423, ssc-mir-181a-2, ssc-mir-181b-1, ssc-mir-181d, ssc-mir-98, ssc-mir-208b, ssc-mir-142, ssc-mir-19b-1, hsa-mir-378b, ssc-mir-22, rno-mir-126b, rno-mir-208b, rno-mir-133c, hsa-mir-378c, ssc-mir-194b, ssc-mir-133a-2, ssc-mir-484, ssc-mir-30c-1, ssc-mir-126, ssc-mir-378-2, ssc-mir-451, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, mmu-mir-378b, mmu-mir-101c, hsa-mir-451b, hsa-mir-499b, ssc-let-7a-2, ssc-mir-18b, hsa-mir-378j, rno-mir-378b, mmu-mir-133c, mmu-let-7j, mmu-mir-378c, mmu-mir-378d, mmu-mir-451b, ssc-let-7d, ssc-let-7f-2, ssc-mir-20b-1, ssc-mir-20b-2, ssc-mir-194a, mmu-let-7k, mmu-mir-126b, mmu-mir-142b, rno-let-7g, rno-mir-15a, rno-mir-29c-2, rno-mir-1b, ssc-mir-26b
miR-101, miR-378 and 143 expression patterns. [score:3]
The expression of miR-378 was highly variable among the tissues tested (Figure 2E). [score:3]
[1 to 20 of 2 sentences]
[+] score: 5
The microRNA expression plasmids miR-26a, miR-654, miR-591, miR-601, miR-608, miR-654, miR-509, miR-378, miR-939, miR-491 and miR-Ctr (the same nucleotides as miR-26a but randomized) were kind gifts of Professor Wenlin Huang from our institute 9. The plasmids and miRNA inhibitors were transfected into cells using Lipofectamine [TM]2000 (Invitrogen) according to the manufacturer’s recommendations. [score:5]
[1 to 20 of 1 sentences]
[+] score: 5
Hou et al. [40] showed that ssc-miR-206, ssc-miR-378, and ssc-miR-1 were expressed at extremely high levels in the longissimus dorsi muscles of Tong Cheng pigs. [score:3]
Two miRNAs, ssc-miR-26a [29, 30] and ssc-miR-378 [31], that ranked 2 [nd] and 3 [rd], respectively, have been reported to be involved in the proliferation and differentiation processes of skeletal muscle. [score:1]
In the present study, we found that ssc-miR-206, ssc-miR-378, and ssc-miR-1 were ranked 1 [st], 3 [rd], and 4 [th] in abundance among the ten libraries, which is consistent with the previous study. [score:1]
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[+] score: 4
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-17, hsa-mir-21, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-27a, hsa-mir-30a, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-107, mmu-let-7g, mmu-let-7i, mmu-mir-27b, mmu-mir-30a, mmu-mir-30b, mmu-mir-125b-2, mmu-mir-9-2, mmu-mir-150, mmu-mir-24-1, mmu-mir-204, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-30e, hsa-mir-204, hsa-mir-210, hsa-mir-221, hsa-mir-222, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-27b, hsa-mir-30b, hsa-mir-125b-1, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125b-2, hsa-mir-150, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-15a, mmu-mir-21a, mmu-mir-24-2, mmu-mir-27a, mmu-mir-103-1, mmu-mir-103-2, mmu-mir-326, mmu-mir-107, mmu-mir-17, mmu-mir-210, mmu-mir-221, mmu-mir-222, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-125b-1, hsa-mir-30c-1, hsa-mir-30e, hsa-mir-378a, mmu-mir-378a, hsa-mir-326, ssc-mir-125b-2, ssc-mir-24-1, ssc-mir-326, ssc-mir-27a, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-103-1, ssc-mir-107, ssc-mir-204, ssc-mir-21, ssc-mir-30c-2, ssc-mir-9-1, ssc-mir-9-2, hsa-mir-378d-2, hsa-mir-103b-1, hsa-mir-103b-2, ssc-mir-15a, ssc-mir-17, ssc-mir-30b, ssc-mir-210, ssc-mir-221, ssc-mir-30a, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-378-1, ssc-mir-30d, ssc-mir-30e, ssc-mir-103-2, ssc-mir-27b, ssc-mir-24-2, ssc-mir-222, ssc-mir-125b-1, hsa-mir-378b, hsa-mir-378c, ssc-mir-30c-1, ssc-mir-378-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, mmu-mir-378b, ssc-let-7a-2, hsa-mir-378j, mmu-mir-21b, mmu-let-7j, mmu-mir-378c, mmu-mir-21c, mmu-mir-378d, mmu-mir-30f, ssc-let-7d, ssc-let-7f-2, ssc-mir-9-3, ssc-mir-150-1, ssc-mir-150-2, mmu-let-7k, mmu-mir-9b-2, mmu-mir-9b-1, mmu-mir-9b-3
We found 13 adipogenesis-promoting miRNAs (let-7、miR-9、miR-15a、miR-17、miR-21、miR-24、miR-30、miR-103、miR-107、miR-125b、miR-204、miR-210、and miR-378) target 860 lncRNA loci. [score:3]
We analyzed the relationship between the 343 identified lncRNAs with the 13 promoting adipogenesis miRNAs (let-7、miR-9、miR-15a、miR-17、miR-21、miR-24、miR-30、miR-103、miR-107、miR-125b、miR-204、miR-210、and miR-378) and five depressing adipogenesis miRNAs (miR-27, miR-150, miR-221, miR-222, and miR-326). [score:1]
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[+] score: 4
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-21, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-99a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-16-2, hsa-mir-192, hsa-mir-148a, hsa-mir-10b, hsa-mir-181a-2, hsa-mir-181a-1, hsa-mir-215, hsa-mir-223, hsa-mir-224, hsa-mir-200b, hsa-mir-15b, hsa-mir-27b, hsa-mir-125b-1, hsa-mir-141, hsa-mir-143, hsa-mir-152, hsa-mir-125b-2, hsa-mir-126, hsa-mir-146a, hsa-mir-184, hsa-mir-200c, hsa-mir-155, hsa-mir-29c, hsa-mir-200a, hsa-mir-99b, hsa-mir-296, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-378a, hsa-mir-342, hsa-mir-148b, hsa-mir-451a, ssc-mir-125b-2, ssc-mir-148a, ssc-mir-15b, ssc-mir-184, ssc-mir-224, ssc-mir-23a, ssc-mir-24-1, ssc-mir-26a, ssc-mir-29b-1, ssc-let-7f-1, ssc-mir-103-1, ssc-mir-21, ssc-mir-29c, hsa-mir-486-1, hsa-mir-499a, hsa-mir-671, hsa-mir-378d-2, bta-mir-26a-2, bta-mir-29a, bta-let-7f-2, bta-mir-103-1, bta-mir-148a, bta-mir-16b, bta-mir-21, bta-mir-499, bta-mir-99a, bta-mir-125b-1, bta-mir-126, bta-mir-181a-2, bta-mir-27b, bta-mir-31, bta-mir-15b, bta-mir-215, bta-mir-30e, bta-mir-148b, bta-mir-192, bta-mir-200a, bta-mir-200c, bta-mir-23a, bta-mir-29b-2, bta-mir-29c, bta-mir-10b, bta-mir-24-2, bta-mir-30a, bta-mir-200b, bta-let-7a-1, bta-mir-342, bta-let-7f-1, bta-let-7a-2, bta-let-7a-3, bta-mir-103-2, bta-mir-125b-2, bta-mir-15a, bta-mir-99b, hsa-mir-664a, ssc-mir-99b, hsa-mir-103b-1, hsa-mir-103b-2, ssc-mir-15a, ssc-mir-16-2, ssc-mir-16-1, bta-mir-141, bta-mir-143, bta-mir-146a, bta-mir-152, bta-mir-155, bta-mir-16a, bta-mir-184, bta-mir-24-1, bta-mir-223, bta-mir-224, bta-mir-26a-1, bta-mir-296, bta-mir-29d, bta-mir-378-1, bta-mir-451, bta-mir-486, bta-mir-671, bta-mir-29e, bta-mir-29b-1, bta-mir-181a-1, ssc-mir-181a-1, ssc-mir-215, ssc-mir-30a, bta-mir-2318, bta-mir-2339, bta-mir-2430, bta-mir-664a, bta-mir-378-2, ssc-let-7a-1, ssc-mir-378-1, ssc-mir-29a, ssc-mir-30e, ssc-mir-499, ssc-mir-143, ssc-mir-10b, ssc-mir-486-1, ssc-mir-152, ssc-mir-103-2, ssc-mir-181a-2, ssc-mir-27b, ssc-mir-24-2, ssc-mir-99a, ssc-mir-148b, ssc-mir-664, ssc-mir-192, ssc-mir-342, ssc-mir-125b-1, oar-mir-21, oar-mir-29a, oar-mir-125b, oar-mir-181a-1, hsa-mir-378b, hsa-mir-378c, ssc-mir-296, ssc-mir-155, ssc-mir-146a, bta-mir-148c, ssc-mir-126, ssc-mir-378-2, ssc-mir-451, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-451b, hsa-mir-499b, ssc-let-7a-2, ssc-mir-486-2, hsa-mir-664b, hsa-mir-378j, ssc-let-7f-2, ssc-mir-29b-2, ssc-mir-31, ssc-mir-671, bta-mir-378b, bta-mir-378c, hsa-mir-486-2, oar-let-7a, oar-let-7f, oar-mir-103, oar-mir-10b, oar-mir-143, oar-mir-148a, oar-mir-152, oar-mir-16b, oar-mir-181a-2, oar-mir-200a, oar-mir-200b, oar-mir-200c, oar-mir-23a, oar-mir-26a, oar-mir-29b-1, oar-mir-30a, oar-mir-99a, bta-mir-664b, chi-let-7a, chi-let-7f, chi-mir-103, chi-mir-10b, chi-mir-125b, chi-mir-126, chi-mir-141, chi-mir-143, chi-mir-146a, chi-mir-148a, chi-mir-148b, chi-mir-155, chi-mir-15a, chi-mir-15b, chi-mir-16a, chi-mir-16b, chi-mir-184, chi-mir-192, chi-mir-200a, chi-mir-200b, chi-mir-200c, chi-mir-215, chi-mir-21, chi-mir-223, chi-mir-224, chi-mir-2318, chi-mir-23a, chi-mir-24, chi-mir-26a, chi-mir-27b, chi-mir-296, chi-mir-29a, chi-mir-29b, chi-mir-29c, chi-mir-30a, chi-mir-30e, chi-mir-342, chi-mir-378, chi-mir-451, chi-mir-499, chi-mir-671, chi-mir-99a, chi-mir-99b, bta-mir-378d, oar-mir-29b-2, ssc-mir-141, ssc-mir-200b, ssc-mir-223, bta-mir-148d
Micro -RNA378 (miR-378) regulates ovarian estradiol production by targeting aromatase. [score:4]
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[+] score: 3
Previous studies have demonstrated that the myomiRs miR-1, miR-133a/b, miR-206, miR-486, miR-26a, miR-27b, miR-378, miR-148a and miR-181 are highly enriched in skeletal muscle and play a key role in skeletal muscle metabolism [28, 29, 30, 31]. [score:1]
The top nine most abundant miRNAs shared between the two groups were ssc-miR-10b, ssc-miR-22-3p, ssc-miR-486, ssc-miR-26a, ssc-miR-27b-3p, ssc-miR-191, ssc-miR-378, ssc-126-5p and ssc-miR-181. [score:1]
In our sequencing libraries, five of these known myomiRs (miR-486, miR-26a, miR-27b, miR-378 and miR-181) were identified with the greatest abundance, accounting for 26% and 29% of the total normalized miRNA reads in the LPS-challenged and saline -treated groups, respectively. [score:1]
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[+] score: 1
Other miRNAs, such as miR-17/92 [20], miR-143 [21], and miR-378 [22], have also been shown to play important roles during adipogenesis. [score:1]
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[+] score: 1
Among them, five miRNAs (miR-365-3p, miR-378, miR-30c-5p, miR-181a, and miR-92a) had two copies in the genome, while P-m0299-5p did not map to any chromosome in the database available (supplemental Table S3). [score:1]
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[+] score: 1
The five most abundant miRNAs represented 47.9% of the total cpm in the dataset including ssc-miR-1, ssc-miR-133a­3p, ssc­miR-378, ssc-miR-206, and ssc-miR-10b. [score:1]
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[+] score: 1
Other miRNAs, such as miR-17/92 [5], miR-143 [6] and miR-378 [7], are also discovered to play important roles in adipogenesis. [score:1]
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