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9 publications mentioning chi-mir-1

Open access articles that are associated with the species Capra hircus and mention the gene name mir-1. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 43
The continuously up-regulated expression patterns of miR-1, miR-206, miR-133 and miR-378 were similar to those in pig [14], which is consistent with their critical roles during muscle development. [score:7]
Among all DE known miRNAs, chi-miR-183 sufferedthe largest down-regulation (-8.41) in comparison to E45 vs E105, while chi-miR-1 benefited from the highest up-regulation (6.08) between E45 and B3. [score:7]
For example, 22 continuously down-regulated miRNAs (e. g. miR-196a/b) across all sampled stages were significantly enriched into Profile 0 (Fig 5), whereas the miRNAs showing gradually increasing expression (miR-1/miR-133a-3p/miR-133a-5p) did not cluster significantly. [score:6]
Twenty-six commonly up-regulated miRNAs were present in the comparisons of three prenatal stages and the neonatal stage, including chi-miR-1, chi-miR-378-3p and chi-miR-26a-5p (Fig 4D). [score:4]
In addition to the myomiRs (miR-1, miR-133 and miR-206), other miRNAs, such as miR-542-3p and let-7a, are highly expressed in skeletal muscle throughout the prenatal and neonatal periods, suggesting that other miRNAs also play important roles in regulating pig myogenesis [14]. [score:4]
Moreover, the regulation of the myostatin gene may be connected with the synthesis of miR-1 and miR-206, which directly affects muscularity in Belgian Texel sheep [15]. [score:3]
The most abundant miRNA was chi-miR-1, which was highly expressed throughout the four sampled stages and detected 598,572.64 RPM (5,387,272 raw counts) in eight libraries, encompassing 10.59% of all known miRNAs. [score:3]
In particular, 40 of the highly expressed known miRNAs (average RPM > 1000) were significantly DE among all the pairwise comparisons, which included miR-1, miR-133a-3p and miR-499-5p (S6 Table). [score:3]
This result was consistent with the established roles of miR-1 during skeletal muscle development [3]. [score:2]
2003; 4(5): 1- doi: 10.1186/gb-2003-4-5-p3 35 Chen J-F, Tao Y, Li J, Deng Z, Yan Z, Xiao X, et al microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7. [score:2]
2009; 106(32): 13383– 7. 3 Chen J-F, Man del EM, Thomson JM, Wu Q, Callis TE, Hammond SM, et al The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. [score:1]
These were chi-miR-1, chi-miR-196b, chi-miR-140-3p, chi-miR-199a-5p, chi-miR-27a-3p, chi-miR-143-3p, chi-miR-135a, chi-miR-133a-3p, and chi-miR-24-3p. [score:1]
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[+] score: 29
The result also indicated that, except muscle specific miRNA (for instance, miR-1, miR-206, miR-133 etc), many non-muscle special miRNAs also played important roles in myocyte proliferation or differentiation through target some myogenic transcription factors, this was consist with previous studies that reported non-muscle-specific miRNAs regulate skeletal muscle differentiation [74], [75]. [score:4]
Pax7 was targeted by miRNA-1 [25], miRNA-206 [26] and miRNA-486 [26]. [score:3]
For example, YY1 is targeted by miRNA-1 [20] and miRNA-29a [21]. [score:3]
On the other hand, the experimentally proved target genes for miRNA-1 include YY1, HDAC4, Cx43, Pax3 and Pax7. [score:3]
In addition, the expression level of miR-1 is significant higher (log2 ratio:−2.37) in six month old goat muscle. [score:3]
Pax3 was reported to be targeted by miRNA-1 [11], miRNA-27b [23] and miRNA-206 [24]. [score:3]
MiR-1 or miR-206 promotes myogenic differentiation, while miR-133 over -expression enhances myoblast proliferation, but represses differentiation [10]– [11], [56]. [score:3]
The most abundant miRNAs identified in our study were highly consisted with study on Boer goat, which reported that miR-133, miR-1, miR-378 and miR-206 families were the top 20 miRNAs in 6 month old Boer goat longissimus tissue [53], indicating the importance of these miRNAs on skeletal muscle development and growth. [score:2]
The other miRNA families, such as miRNA-1, miRNA-221 and miRNA-206, had only one member. [score:1]
Moreover, miR-1 and miR-133 have been implicated in skeletal muscle hypertrophy [14]. [score:1]
As six month-old is the important phase of muscle hypertrophy, we suppose that miR-1 may play an important role in caprine skeletal muscle hypertrophy. [score:1]
For instance, miR-1, miR-206, let-7f, let-7a-5p, let-7b, let-7c, let-7g, miR-378 etc, indicating that miRNA was highly conserved between cattle and goat. [score:1]
The muscle specific miR-1, miR-133 and miR-206 are three of the most studied miRNAs up to now. [score:1]
[1 to 20 of 13 sentences]
[+] score: 14
Our results showed that the expression patterns of miR-1, miR-133a, miR-133b, miR-144, miR-206, miR-299, miR-331 and miR-4286 (Additional file 3: Figure S3) were significantly different in the three stages (p < 0.01), indicating that they may participate in the regulation of follicular transition. [score:4]
Of the nine miRNAs were specifically expressed in cashmere goat dorsal skin [18], only four of them were examined in the present study: miR-1, miR-374, miR-455-3p and miR-92b. [score:3]
To verify the Solexa sequencing data, we randomly selected five differentially expressed miRNAs (miR-1, miR-206, miR-122, miR-222, and miR-133), and conducted quantitative RT-PCR. [score:3]
In the whole hair cycle, the abundance of expression of let-7a-5p, let-7f, let-7b, let-7c, let-7g, miR-199a-3p, miR-143, miR-1, and miR-320a reached their highest levels in the present study (Table  2). [score:3]
The abundance of miR-1, miR-206, miR-122, miR-222, and miR-133 were normalised relative to the abundance of U6 small nuclear RNA (snRNA). [score:1]
[1 to 20 of 5 sentences]
[+] score: 13
Other miRNAs from this paper: chi-mir-155
Pre-miRNA-1∼4 were designed to target myostatin mRNA. [score:3]
M: Supercoiled DNA Ladder Marker; NC: pDG-miRNA-NC; m1: pDG-miRNA-1; m3: pDG-miRNA-3. (A, C) Plasmids used to express miRNAs. [score:3]
M: Supercoiled DNA Ladder Marker; NC: pD-miRNA-NC; m1∼4: pD-miRNA-1∼4. [score:1]
In addition, miRNA-1 (m1) and miRNA-3 (m3) showed the highest efficacy, reducing myostatin mRNA by up to ∼38% and myostatin protein by ∼48%, respectively. [score:1]
PC: parental 293FT cells control; NC: pD-miRNA-NC; m1∼4: pD-miRNA-1∼4; scale bar: 100 µm. [score:1]
NC: pD-miRNA-NC; m1∼4: pD-miRNA-1∼4; PC: parental 293FT cells control. [score:1]
M: Supercoiled DNA Ladder Marker; NC: pDG-miRNA-NC; m1: pDG-miRNA-1; m3: pDG-miRNA-3. 10.1371/journal. [score:1]
PC: parental fetal myoblasts control; NC: pDG-miRNA-NC; m1: pDG-miRNA-1; m3: pDG-miRNA-3; TT: transient transfection; ST: stable transfection. [score:1]
M: Supercoiled DNA Ladder Marker; NC: pDG-miRNA-NC; m1: pDG-miRNA-1; m3: pDG-miRNA-3. 10.1371/journal. [score:1]
[1 to 20 of 9 sentences]
[+] score: 11
Our research showed that miR-1 and miR-133 participated in skeletal muscle cell differentiation and maturation processes, in which miR-1 could promote the differentiation of skeletal muscle cells, but miR-133 inhibited differentiation to promote muscle cell proliferation [14]. [score:3]
One study found that miR-1 and miR-206, which are similar and have the same seed sequence, can facilitate bovine skeletal muscle satellite cell myogenic differentiation by restricting the expression of Pax7 and HDAC4 [37]. [score:3]
To date, many muscle-specific miRNAs, miR-1, miR-133, miR-206, miR-27, were found, which have been shown to play critical roles in skeletal muscle development. [score:2]
miR-1 and miR-133 originate from the same miRNA polycistronic region and are co-transcribed, but miR-1 and miR-133 have opposite functions, confirming that miRNAs may play a very important role in regulating the balance of cell proliferation and differentiation. [score:2]
miR-1 and miR-206 promote the differentiation of myoblasts, and miR-133 promotes satellite cell proliferation 13– 15. [score:1]
[1 to 20 of 5 sentences]
[+] score: 7
Clop et al. [12] demonstrated that the GDF8 allele of Texel sheep is characterised by a G → A transition in the 3' UTR that creates a target site for miR-1 and miR-206, which are highly expressed in skeletal muscle; consequently, translational inhibition of the myostatin gene occurs, thereby contributing to muscular hypertrophy in Texel sheep. [score:7]
[1 to 20 of 1 sentences]
[+] score: 6
Other miRNAs from this paper: mmu-mir-1a-1, mmu-mir-127, mmu-mir-134, mmu-mir-136, mmu-mir-154, mmu-mir-181a-2, mmu-mir-143, mmu-mir-196a-1, mmu-mir-196a-2, mmu-mir-21a, rno-mir-329, mmu-mir-329, mmu-mir-1a-2, mmu-mir-181a-1, mmu-mir-181b-1, mmu-mir-181c, mmu-mir-375, mmu-mir-379, mmu-mir-181b-2, rno-mir-21, rno-mir-127, rno-mir-134, rno-mir-136, rno-mir-143, rno-mir-154, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-196a, rno-mir-181a-1, mmu-mir-196b, rno-mir-196b-1, mmu-mir-412, mmu-mir-370, oar-mir-431, oar-mir-127, oar-mir-432, oar-mir-136, mmu-mir-431, mmu-mir-433, rno-mir-431, rno-mir-433, ssc-mir-181b-2, ssc-mir-181c, ssc-mir-136, ssc-mir-196a-2, ssc-mir-21, rno-mir-370, rno-mir-412, rno-mir-1, mmu-mir-485, mmu-mir-541, rno-mir-541, rno-mir-493, rno-mir-379, rno-mir-485, mmu-mir-668, bta-mir-21, bta-mir-181a-2, bta-mir-127, bta-mir-181b-2, bta-mir-181c, mmu-mir-181d, mmu-mir-493, rno-mir-181d, rno-mir-196c, rno-mir-375, mmu-mir-1b, bta-mir-1-2, bta-mir-1-1, bta-mir-134, bta-mir-136, bta-mir-143, bta-mir-154a, bta-mir-181d, bta-mir-196a-2, bta-mir-196a-1, bta-mir-196b, bta-mir-329a, bta-mir-329b, bta-mir-370, bta-mir-375, bta-mir-379, bta-mir-412, bta-mir-431, bta-mir-432, bta-mir-433, bta-mir-485, bta-mir-493, bta-mir-541, bta-mir-181a-1, bta-mir-181b-1, ssc-mir-1, ssc-mir-181a-1, mmu-mir-432, rno-mir-668, ssc-mir-143, ssc-mir-181a-2, ssc-mir-181b-1, ssc-mir-181d, ssc-mir-196b-1, ssc-mir-127, ssc-mir-432, oar-mir-21, oar-mir-181a-1, oar-mir-493, oar-mir-433, oar-mir-370, oar-mir-379, oar-mir-329b, oar-mir-329a, oar-mir-134, oar-mir-668, oar-mir-485, oar-mir-154a, oar-mir-154b, oar-mir-541, oar-mir-412, mmu-mir-21b, mmu-mir-21c, ssc-mir-196a-1, ssc-mir-196b-2, ssc-mir-370, ssc-mir-493, bta-mir-154c, bta-mir-154b, oar-mir-143, oar-mir-181a-2, chi-mir-127, chi-mir-134, chi-mir-136, chi-mir-143, chi-mir-154a, chi-mir-154b, chi-mir-181b, chi-mir-181c, chi-mir-181d, chi-mir-196a, chi-mir-196b, chi-mir-21, chi-mir-329a, chi-mir-329b, chi-mir-379, chi-mir-412, chi-mir-432, chi-mir-433, chi-mir-485, chi-mir-493, rno-mir-196b-2, bta-mir-668, ssc-mir-375
For example, miR-273 and the lys-6 miRNA have been shown to be involved in the development of the nervous system in nematode worm [3]; miR-430 was reported to regulate the brain development of zebrafish [4]; miR-181 controlled the differentiation of mammalian blood cell to B cells [5]; miR-375 regulated mammalian islet cell growth and insulin secretion [6]; miR-143 played a role in adipocyte differentiation [7]; miR-196 was found to be involved in the formation of mammalian limbs [8]; and miR-1 was implicated in cardiac development [9]. [score:6]
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[+] score: 1
The miRNA with biggest difference was bea-miR-1, with a 120.57-fold change, 6 and 463 raw reads in early and late lactation respectively, and four miRNAs (bta-miR-26a, chi-miR-362-3p, efu-miR-193-3p, and chi-miR-29b-3p) also showed higher differences (Fig.   6). [score:1]
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[+] score: 1
Among the top 20 most abundant miRNAs, 12 miRNAs were present in the early lactation, peak lactation and dry period mammary gland samples (Table S7), and six of them, miR-1, miR-29a, miR-140, miR-320, miR-199a-3p and miR-2284x were detected in our library. [score:1]
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