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4 publications mentioning ccr-mir-21

Open access articles that are associated with the species Cyprinus carpio and mention the gene name mir-21. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 38
The most abundant miRNAs in the present study were miR-430, miR-21, miR-22a, miR-181a, let-7a, miR-199-5p, miR-9-3p, miR-125b, miR-26a, miR-101a, miR-143, and miR-200a, which were not only co-expressed, but also significantly differentially expressed among the five different development stages in Yellow River carp. [score:6]
The predicted target genes of miR-21 included genes in the MAPK, B-cell receptor, TGF-β, and apoptotic pathways, suggesting that it may play crucial roles in ovary development, gonadal differentiation [58], and endocrine regulation [11, 59]. [score:5]
MiR-430-3p and miR-30-5p were the dominantly expressed conserved miRNAs in primordial germ cells, with >100,000 reads (Table  2), while ccr-miR-21 and ccr-let-7a were the dominantly expressed existing carp miRNAs in primordial gonads, with >10,000 reads (Table  3). [score:5]
Let-7a was highly abundant and increased throughout the ovary development period (Fig.   4, profile 19), as did expression of miR-21 (Fig.   4, profile 19). [score:4]
In this study, miR-21 was abundant in all five stages, but was obviously up-regulated in the primordial gonad. [score:4]
Has-miR-21 was also up-regulated by ovarian steroids in mouse granulosa cells and human endometrial stromal cells or glandular epithelial cells [56, 57]. [score:4]
A previous study indicated that miR-21 played a role in preventing apoptosis in periovulatory granulosa cells as they transit to luteal cells [55], while miR-21 expression in cattle was also significantly increased in ovary compared with testis, suggesting that miR-21 may play a regulatory role in female physiology [12]. [score:3]
MiR-122, let-7, miR-192, miR-21, miR-499, miR-146, miR-101, miR-128, miR-26, and miR-124 were highly expressed in adult bighead carp and silver carp [54]. [score:3]
Overall, these results suggest that miR-430, miR-21, let-7, miR-181a, and miR-143 may play important roles in ovary differentiation and development in Yellow River carp. [score:2]
The most abundant miRNAs in primordial gonads were miR-430, miR-21, let-7a, miR-199-5p, miR-9-3p, miR-22a, miR-125b, miR-26a, miR-181a, miR-101a, miR-143, and miR-200a with >10,000 reads each. [score:1]
Existing carp miRNAs were registered in miRBase of common carp, including 145, 139, 143, 143, and 145 existing carp miRNAs (i. e., miRNAs included in C. carpio miRBase) from the five libraries, respectively, of which miR-430, miR-21, let-7a, miR-199-5p, miR-9-3p, miR-22a, miR-125b, miR-26a, miR-181a, miR-101a, miR-143, and miR-200a were the most abundant (Additional file 3). [score:1]
[1 to 20 of 11 sentences]
[+] score: 26
miR-21 is a key determinant in the IL-11/Stat3 anti-apoptotic signaling pathway involved in the preconditioning of skeletal myoblasts [25], miR-26a targets Ezh2 during myogenesis [44], miR-27 regulates behaviors of muscle stem cells by repression of Pax3 expression [45], miR-214 promotes myogenic differentiation by facilitating exit from mitosis via down-regulation of proto-oncogene N-ras [38], and miR-221 and miR-222 modulate differentiation and maturation of skeletal muscle cells by targeting p27 [41]. [score:11]
Of these, miR-1, miR-133a-3p, and miR-206, were found to be specifically expressed in heart, skeletal muscle, gut, eye, and skin (Fig. 4B), whereas miR-21, miR-26a, miR-181a-5p, and miR-222 were detected in all the samples with little expression level change. [score:5]
Of note, half of detected miRNAs (miR-21, miR-26a, miR-27a, and miR-214) were expressed at a higher level in the fertilized oocytes than in embryos after fertilization (Figure S3); this is likely caused by the existence of maternal miRNAs or dicer. [score:3]
The results showed that the expression of miR-1, miR-133a-3p, miR-206, and miR-21 was increased in the skeletal muscles from 30 day post-hatching to 2-year-old (Figure 5). [score:3]
We then selected miR-1, miR-21, miR-23a, miR-24, miR-26a, miR-27a, miR-133a-3p, miR-181a-5p, miR-206, miR-214, and miR-222, which have been reported to play roles in the development of vertebrate skeletal muscle (Table 3). [score:2]
These results suggest that miR-1, miR-133a-3p, miR-21, miR-26, and miR-206 play roles in the growth and functional maintenance of carp skeletal muscles. [score:1]
Other muscle-related miRNAs in vertebrates, including miR-21, miR-214, miR-26, miR-27, miR-221, and miR-222, have also been identified in the common carp. [score:1]
[1 to 20 of 7 sentences]
[+] score: 3
Probes were also designed to target an exogenous spike-in control (a synthetic RNA oligonucleotide based on Arabidopsis thaliana miRNA ath-miR15.6g, miRBase accession MIMAT0001012) and several endogenous positive controls (host miRNA sequences ccr-miR-21, ccr-miR-22a, ccr-let-7a and ccr-et-7b; miRBase accessions MIMAT0026267, MIMAT0026275, MIMAT0026189 and MIMAT0026190 respectively). [score:3]
[1 to 20 of 1 sentences]
[+] score: 1
Among the deposited miRNAs, 13 miRNAs (Ccr-miR-22a, ccr-miR-122, ccr-miR-146a, ccr-miR-192, ccr-miR-148, ccr-miR-100, ccr-miR-21, ccr-miR-126-3p, ccr-miR-143, ccr-miR-26a, ccr-let-7a, ccr-miR-101a, and ccr-miR-199-5p) were the most abundant miRNAs (TPM > 10,000) in both samples (TPM = Readout × 1,000,000/Mapped reads, Table S2). [score:1]
[1 to 20 of 1 sentences]