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10 publications mentioning ssc-mir-150-1

Open access articles that are associated with the species Sus scrofa and mention the gene name mir-150-1. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 24
As examples, the liver-specific miR-122 promotes the replication of hepatitis C virus (HCV) [17], [18], while miR-196, miR-199, miR-296, miR-351, miR-431 and miR-448 inhibit HCV genome propagation [19], [20]; miR-32 effectively restricts the accumulation of primate foamy virus type 1 (PFV-1) in human cells [21]; miR-323, miR-491 and miR-654 inhibit the replication of the H1N1 influenza A virus by binding to the viral PB1 gene [22]; miR-28, miR-125b, miR-150, miR-223 and miR-382 target the 3′ end of human immunodeficiency virus (HIV) mRNA, thereby restricting HIV production [23]; miR-199a-3p and miR-210 limit the hepatitis B virus (HBV) surface antigen and polymerase production by degrading and/or inhibiting translation of viral mRNAs encoding these proteins [24]; overexpression of miR-24 and miR-93 suppresses vesicular stomatitis virus (VSV) replication through targeting the viral genes encoding RNA -dependent RNA polymerase (L protein) and phosphoprotein (P protein), respectively [25]; in macrophages, upregulation of miR-155 suppresses VSV replication, while inhibition of miR-155 had the opposite effect. [score:24]
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2
[+] score: 21
Another miRNA identified in human studies as regulated after H1N1 infection is hsa-miR-150-5p which was reported by one study to be up-regulated 11 while it was found to be down-regulated in another study 12. [score:8]
Only four miRNAs (hsa-miR-223-5p, ssc-miR-31, ssc-miR-29a, and ssc-miR-182) were differentially expressed at 24 h pi, whereas 10 miRNAs were differentially expressed at 72 h pi (ssc-miR-29b, hsa-miR-203a-3p, hsa-miR-449a, ssc-miR-21, ssc-miR-29a, hsa-miR-23a-3p, ssc-miR-23b, ssc-miR-30c-5p, ssc-miR-423-5p, and hsa-miR-150-5p). [score:5]
We found that hsa-miR-150-5p was down-regulated in porcine leukocytes 72 h and 14d after H1N2 challenge in pigs (Fig. 1a). [score:4]
one third was quantifiable in porcine leukocytes; however, only five were significantly differentially expressed (one-way ANOVA): hsa-miR-223-5p (p = 3.20E-07), hsa-miR-23a-3p (p = 0.0001), hsa-miR-30c-5p (p = 1.10E-07), hsa-miR-150-5p (p = 0.0002), and hsa-miR-92b-3p (p = 0.0005). [score:3]
However, the highest number of significantly regulated miRNAs compared to before challenge was found at 14d pi, at which time point the infection had completely cleared (ssc-miR-15a, ssc-miR-29b, ssc-miR-29a, hsa-miR-449a, ssc-miR-186, ssc-miR-22-5p, ssc-miR-28-5p, hsa-miR-203a-3p, ssc-miR-146a-5p, hsa-miR-150-5p, ssc-miR-23b, hsa-miR-223-3p, hsa-miR-23a-3p, hsa-miR-16-5p). [score:1]
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3
[+] score: 18
In mature B and T cells, the miR-150 was found to block early B cell development when expressed prematurely, and also found to control B cell differentiation by targeting the transcription factor of c-Myb [21]. [score:6]
0003225.g002 Figure 2 Expression levels of five miRNAs (miR-150, miR-193b, miR-196a, miR-187b and miR-495) were detected by Real time PCR (right) and microarray (left). [score:3]
Expression levels of five miRNAs (miR-150, miR-193b, miR-196a, miR-187b and miR-495) were detected by Real time PCR (right) and microarray (left). [score:3]
The expression levels for miR-150, miR-193b, miR-187b and miR-196a, as determined by RT-PCR, were in concordance with the normalized microarray data (Pearson correlation coefficient >0.9, q value<0.001, Figure 2). [score:3]
Five representative differentially expressed miRNAs (miR-150, miR-193b, miR-196a, miR-187b and miR-495) were chosen for validation by the stem–loop RT–PCR based real-time PCR method [6] using three independent samples (The primer sequences are available in Table S6). [score:2]
These include miR-214, miR-140, miR-150, miR-10, as well as miR-181. [score:1]
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4
[+] score: 15
The overexpression of miR-150 promoted the proliferation and growth of gastric cancer cells by directly regulating the pro-apoptotic gene EGR2 (early growth response 2) and of lung cancer cells by targeting P53 [53], [54]. [score:7]
In our study, other 6 miRNAs (miR-155, miR-150-1, miR-204, miR-132, miR-212 and miR-218-2) were consistently upregulated across two of three weaning times. [score:4]
Only 3 miRNAs (miR-155, miR-150-1 and miR-204) at W1 and W4, and 4 miRNAs (miR-132, miR-146b, miR-212 and miR-218-2) at W4 and W7 were consistently upregulated across two of three time points. [score:4]
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5
[+] score: 11
Schmidt et al. [78] found that miR-146b-5p, miR-150, miR-342-3p and let-7g were downregulated in peripheral blood leukocytes during acute lipopolysaccharide (LPS) induced inflammation, which was similar to our result. [score:4]
The expression of hsa-miR-150, hsa-miR-31, hsa-miR-155, hsa-miR-29a, hsa-miR-29b, hsa-miR-342-5p, and hsa-miR-146b-5p were present in lower abundance, whereas hsa-miR-148a and hsa-miR-886-3p were present in higher abundance in PBMCs from critically ill patients infected with H1N1 influenza virus than that from healthy controls. [score:3]
validation of differentially expressed miRNAs and ROC analysisThe microarray data were validated by performing, qRT-PCR for nine miRNAs, including hsa-miR-146b-5p, hsa-miR-148a, hsa-miR-150, hsa-miR-31, hsa-miR-155, hsa-miR-29a, hsa-miR-29b, hsa-miR-342-5p, and hsa-miR-886-3p. [score:3]
The microarray data were validated by performing, qRT-PCR for nine miRNAs, including hsa-miR-146b-5p, hsa-miR-148a, hsa-miR-150, hsa-miR-31, hsa-miR-155, hsa-miR-29a, hsa-miR-29b, hsa-miR-342-5p, and hsa-miR-886-3p. [score:1]
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6
[+] score: 7
For example, miR-150 targets the Myb gene, which then regulates the formation of pre-B and B1 cells in the mouse immune system [8]. [score:4]
A high level of miR-150 holds Myb expression in check, preventing the pre-maturation of pro-B cells into pre-B cells. [score:3]
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7
[+] score: 6
However, we did not detect differential expression of other previously identified miRNAs (miR-223, miR-150, miR-92a), although miR-10b, miR-20a, miR-30a-5p, miR-34a, miR-17—5p, miR-16, miR-146b, and miR-155-5p expression was significantly different. [score:5]
Many immune-related miRNAs have been identified in innate and adaptive immune systems, including the miR-17—92 cluster, miR-221, miR-10, miR-196b, miR-126, miR-155, miR-150; miR-181a, miR-326, miR-142-3p, miR-424, miR-21, miR-106a, miR-223, miR-146; the let-7 family, miR-9, and miR-34 [6]. [score:1]
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8
[+] score: 6
FTO was predicted by this research as a potential target of ssc-\miR-185, ssc-F3-C29, ssc-miR-101, ssc-miR-152 and ssc-miR-150, which were down-regulated in the castrated male pigs (Additional file 9). [score:6]
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9
[+] score: 4
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-17, hsa-mir-21, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-27a, hsa-mir-30a, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-107, mmu-let-7g, mmu-let-7i, mmu-mir-27b, mmu-mir-30a, mmu-mir-30b, mmu-mir-125b-2, mmu-mir-9-2, mmu-mir-150, mmu-mir-24-1, mmu-mir-204, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-30e, hsa-mir-204, hsa-mir-210, hsa-mir-221, hsa-mir-222, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-27b, hsa-mir-30b, hsa-mir-125b-1, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125b-2, hsa-mir-150, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-15a, mmu-mir-21a, mmu-mir-24-2, mmu-mir-27a, mmu-mir-103-1, mmu-mir-103-2, mmu-mir-326, mmu-mir-107, mmu-mir-17, mmu-mir-210, mmu-mir-221, mmu-mir-222, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-125b-1, hsa-mir-30c-1, hsa-mir-30e, hsa-mir-378a, mmu-mir-378a, hsa-mir-326, ssc-mir-125b-2, ssc-mir-24-1, ssc-mir-326, ssc-mir-27a, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-103-1, ssc-mir-107, ssc-mir-204, ssc-mir-21, ssc-mir-30c-2, ssc-mir-9-1, ssc-mir-9-2, hsa-mir-378d-2, hsa-mir-103b-1, hsa-mir-103b-2, ssc-mir-15a, ssc-mir-17, ssc-mir-30b, ssc-mir-210, ssc-mir-221, ssc-mir-30a, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-378-1, ssc-mir-30d, ssc-mir-30e, ssc-mir-103-2, ssc-mir-27b, ssc-mir-24-2, ssc-mir-222, ssc-mir-125b-1, hsa-mir-378b, hsa-mir-378c, ssc-mir-30c-1, ssc-mir-378-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, mmu-mir-378b, ssc-let-7a-2, hsa-mir-378j, mmu-mir-21b, mmu-let-7j, mmu-mir-378c, mmu-mir-21c, mmu-mir-378d, mmu-mir-30f, ssc-let-7d, ssc-let-7f-2, ssc-mir-9-3, ssc-mir-150-2, mmu-let-7k, ssc-mir-378b, mmu-mir-9b-2, mmu-mir-9b-1, mmu-mir-9b-3
Five depressing-adipogenesis miRNAs (miR-27, miR-150, miR-221, miR-222, and miR-326) target 217 lncRNAs. [score:3]
We analyzed the relationship between the 343 identified lncRNAs with the 13 promoting adipogenesis miRNAs (let-7、miR-9、miR-15a、miR-17、miR-21、miR-24、miR-30、miR-103、miR-107、miR-125b、miR-204、miR-210、and miR-378) and five depressing adipogenesis miRNAs (miR-27, miR-150, miR-221, miR-222, and miR-326). [score:1]
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10
[+] score: 1
Among them, six microRNAs (ssc-miR-128, ssc-miR-186, ssc-miR-4332, ssc-miR-218-3p, ssc-miR-2320-5p and ssc-miR-150) were predicted to bind to the 3′UTR of WUH3 PRRSV genome. [score:1]
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