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12 publications mentioning ssc-mir-7-1

Open access articles that are associated with the species Sus scrofa and mention the gene name mir-7-1. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 16
Of these, 40 miRNAs are minimally expressed (0 < average signals ≤ 100; p ≤ 0.01), 77 miRNAs are modestly expressed 100 < average signals ≤ 1,000; p ≤ 0.01), 85 miRNAs were highly expressed (1,000 < average signals ≤ 10,000), and, in particular, 20 miRNAs were extremely highly expressed in the anterior pituitary (average signals ≥ 10,000; p ≤ 0.01), including ssc-miR-7, Y-90, ssc-miR-26a, ssc-miR-125b, Y-1, ssc-miR-125a, Y-77, ssc-let-7g, ssc-miR-29a, ssc-let-7i, ssc-let-7a, ssc-let-7f, ssc-miR-148a, ssc-miR-21, ssc-miR-335, ssc-miR-30b-5p, ssc-miR-191, ssc-miR-29c, ssc-miR-23b, and ssc-miR-23a (Fig 1C). [score:9]
For example, miR-7 is the most abundant miRNA in both pig breeds, which was consistent with our previous study[18] and studies in mouse[24]; it was reported that miR-375 mediated in POMC regulation by targeting mitogen-activated protein kinase 8[25] and miR-200 mediated in female fertility, regulating LH secretion by targeting ZEB1[26]. [score:7]
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2
[+] score: 15
Among the detected miRNAs, 53 had an expression signal greater than 1, 26 reached a signal greater than 2, and 18 reached a signal greater than 3, each with the miR-7 on the top (16.8), which was significantly higher than the expression in skeletal muscles and adipose tissues (data unpublished). [score:5]
The selection included miR-7, which was ranked at the top for its expression by both methods and miRNAs that had a microarray fold change as low as 0.0047 and a Solexa sequencing frequency count as low as 168. [score:3]
Although those reported data were quite incomplete for miRNA profiles in pituitary; it appeared that miR-7 is the most highly expressed miRNA in the pituitary in all the three species. [score:3]
0024883.g002 Figure 2 The selected miRNAs for the analysis include: miR-99b, miR-204, miR-27a, miR-24, miR-7, miR-145, miR-124, miR-21, miR-125b, miR-30b, miR-128a, miR-122, miR-183, and miR-103. [score:1]
0024883.g003 Figure 3 The selected miRNAs for the analysis include: miR-99b, miR-204, miR-27a, miR-24, miR-7, miR-145, miR-124, miR-21, miR-125b, miR-30b, miR-128a, miR-122, miR-183, and miR-103. [score:1]
The selected miRNAs for the analysis include: miR-99b, miR-204, miR-27a, miR-24, miR-7, miR-145, miR-124, miR-21, miR-125b, miR-30b, miR-128a, miR-122, miR-183, and miR-103. [score:1]
Bak et al. reported 8 miRNAs (mir-7, mir-7b, mir-375, mir-141, mir-200a, mir-200c, mir-25and mir-152) with more than 3-fold enrichment in the pituitary of adult mice in a profile of the miRNAs in the central nervous system [36]; and Farh et al. and Landgraf et al. reported 6 (mir-7, mir-212, mir-26a, mir-191, mir-375 and mir-29) when comparing the miRNAs in normal and tumor pituitary cells [37], [38]. [score:1]
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3
[+] score: 13
For example, ssc-miR-19a targets TNFα, IL-12α, and IL-20; ssc-miR-19b targets TNFα and IL-20; ssc-miR-7 targets IL-1β, IL-2, and TGF-β1; ssc-let-7a targets IFN- delta-1; ssc-miR-30a-5p targets IL-12α and IL-12β; and ssc-miR-24-3p targets IL-1α. [score:13]
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4
[+] score: 11
Both miR-7 and miR-194 could directly target and suppress the expression of insulin-like growth factor 1 receptor (IGF-1R) whereas miR-25 regulates insulin synthesis at its mRNA level [70– 72]. [score:9]
Since insulin and insulin-like growth factor system are crucial for normal glucose homeostasis [73, 74], it is likely that miR-7 and miR-194 could play a role in glucose metabolism via IGF-1R and insulin. [score:1]
MiR-7, miR-194 and miR-25 were identified to correlate with GP activity. [score:1]
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5
[+] score: 7
For example, gga-miR-18, gga-miR-193a, gga-miR-193b, gga-miR-30b, gga-miR-146a, gga-miR-24, gga-miR-92, gga-miR-7b, gga-miR-7-1, and gga-miR-7-2 are up-regulated after avian influenza virus infection in previous studies whereas in our results these miRNAs are down-regulated on PID 4 33. [score:7]
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6
[+] score: 7
Three of the up-regulated miRNAs (ssc-miR-7, ssc-miR-221-5p, and ssc-miR-451) likewise overlapped with miRNAs we have previously found to be up-regulated in necrotic lung tissue compared to visually unaffected lung tissue of pigs experimentally infected with the Gram -negative bacterium Actinobacillus pleuropneumoniae [49], suggesting a potential common function of these during both viral and Gram -negative bacterial pulmonary infection in pigs. [score:6]
These include ssc-miR-7 [56], ssc-miR-15a [26], ssc-miR-18a [26, 56], ssc-miR-21 [55, 56], mmu-miR-34b-3p [26], ssc-miR-34c [26], ssc-miR-92b-3p [26], ssc-miR-193a-3p [55], hsa-miR-449a [26], and ssc-miR-671-3p [26]. [score:1]
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7
[+] score: 7
The known cardiac-expressed miRNAs (i. e., miR-24-2-5p, miR-542-5, miR-27b-5p, miR-7, and miR-30c-3p; see Table 1) were prominent among the miRNAs that showed a significant downregulated expression (~2-fold decrease) in the paced group compared with controls. [score:7]
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8
[+] score: 6
To verify that this high expression of miR-21 was not due to technical artefacts of deep sequencing, the expression of miR-21 was examined using qPCR in independent samples (DCs challenged with PRV in the same conditions and collected at 4 and 12 hours PI) and compared to the levels of expression of six known miRNAs (miR-339-3p, miR-184, miR-7, miR-370, miR-708*, miR-29b-1*) and U6 small nuclear RNA. [score:6]
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9
[+] score: 5
Therefore, miRNAs up-regulated in F50 cerebellum (e. g. miR-135a, miR-135b and miR-7, see Figure 2) and F100 cerebellum (e. g. miR-216a and miR-216) make promising candidates for developmental switches in the cerebellum. [score:5]
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10
[+] score: 4
A case study supporting the buffering role of miRNAs showed that miR-7 can stabilize the developmental process against temperature perturbation in Drosophila by buffering the expression of yan and ato [11]. [score:4]
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11
[+] score: 3
HPGA-related miRNAs are wi dely reported, and several studies have shown that the miR-7 family is highly expressed in the hypothalamus and pituitary [15], [16]. [score:3]
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12
[+] score: 1
For example, Hamrick et al., (2010) reported that miR-7, miR-468, miR-542, and miR-698 levels in mouse muscle tissue substantially increased with age, whereas miR-124a, miR-181a, miR-221, miR-382, miR-434, and miR-455 levels substantially decreased with age. [score:1]
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