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2 publications mentioning rno-mir-3573Open access articles that are associated with the species Rattus norvegicus and mention the gene name mir-3573. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary. |
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Other miRNAs from this paper: rno-mir-326, rno-mir-330, rno-mir-344a-1, rno-mir-345, rno-mir-347, rno-mir-20a, rno-mir-17-1, rno-mir-19b-1, rno-mir-19b-2, rno-mir-19a, rno-mir-21, rno-mir-22, rno-mir-29b-2, rno-mir-29a, rno-mir-29b-1, rno-mir-30b, rno-mir-34b, rno-mir-34c, rno-mir-34a, rno-mir-99a, rno-mir-103-2, rno-mir-103-1, rno-mir-125a, rno-mir-142, rno-mir-146a, rno-mir-223, rno-mir-290, rno-mir-542-1, rno-mir-382, rno-mir-20b, rno-mir-466b-1, rno-mir-466b-2, rno-mir-743b, rno-mir-874, rno-mir-17-2, rno-mir-568, rno-mir-3548, rno-mir-3596d, rno-mir-344a-2, rno-mir-3580, rno-mir-155, rno-mir-29b-3, rno-mir-466b-3, rno-mir-466b-4, rno-mir-542-2, rno-mir-542-3
miRNA expression profiling of lung tissues demonstrated differential expression of seven miRNAs, with downregulation of miR-344a-3p (−2.36-fold change) and upregulation of miR-103 (4.04-fold change), miR-22 (2.72-fold change), miR-30b-5p (1.51-fold change), miR-347 (1.95-fold change), miR-382 (2.82-fold change), and miR-3573-3p (3.32-fold change) (Figures 3A,B).
[score:11]
[1 to 20 of 1 sentences]
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Other miRNAs from this paper: rno-mir-323, rno-mir-324, rno-let-7d, rno-mir-328a, rno-mir-129-2, rno-mir-7a-1, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-7a-2, rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-21, rno-mir-26b, rno-mir-27b, rno-mir-31a, rno-mir-129-1, rno-mir-133a, rno-mir-186, rno-mir-204, rno-mir-206, rno-mir-221, rno-mir-320, rno-mir-433, rno-mir-383, rno-mir-361, rno-mir-133b, rno-mir-409a, rno-mir-503-1, rno-mir-505, rno-mir-880, rno-mir-202, rno-mir-449c, rno-mir-133c, rno-let-7g, rno-mir-503-2
We then used a screening system based on the luciferase reporter plasmid carrying the full-length 3′UTR of the FSHb mRNA and found that 18 miRNAs, specifically miR-433-3p, miR-323-3p, miR-328a-3p, miR-3573-3p, miR-204-5p, miR-206-5p, miR-31a-5p, miR-7a-5p, miR-880-3p, miR-186-5p, miR-503-5p, miR-383-5p, miR-324-5p, miR-505-5p, miR-27b-3p, miR-221-5p, miR-320-3p and miR-21-3p, could suppress the expression of the reporter by more than 30% (Figure 1).
[score:5]
Interestingly, we identified 12 other miRNAs (miR-323-3p, miR-328a-3p, miR-3573-3p, miR-204-5p, miR-206-5p, miR-31a-5p, miR-7a-5p, miR-880-3p, miR-186-5p, miR-503-5p, miR-383-5p and miR-320-3p) that might also regulate FSHb expression, and then affected FSH secretion, but their specific effects need to be verified through further experiments.
[score:4]
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