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9 publications mentioning mmu-mir-344c

Open access articles that are associated with the species Mus musculus and mention the gene name mir-344c. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

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[+] score: 280
miR-344 was found downregulated in the brain of Huntington disease mouse mo dels [20] while it was upregulated in the lungs of the rat mo del for acute respiratory distress syndrome [21]. [score:9]
Predicted Target Genes of miR-344b and miR-344c To identify the genes targeted by miR-344b and miR-344c, we employed four online bioinformatics databases, namely, miRanda, miRDB, TargetScanMouse, and DIANA micro-T CDS. [score:7]
Our subsequent attempt to validate Olig2 and Otx2 as downstream targets of miR-344b and miR-344c unexpectedly did not concur with our earlier predictions, as chimeric Olig2 and Otx2 were not suppressed by their respective miRNAs in the luciferase suppression assay. [score:6]
While miR-344b and miR-344c predicted downstream targets were Olig2 and Otx2, respectively, these target genes were not validated via luciferase suppression assay. [score:6]
miR-344b was lowly expressed in adult mouse testes while skeletal muscles have the lowest expression of miR-344c. [score:5]
In addition, miR-344b and miR-344c were expressed throughout the brain all sections, suggesting a wide regulatory role for these miRNAs during brain development, such as neuronal proliferation, migration, and differentiation. [score:5]
Spatiotemporal Expression Profiling of miR-344b and miR-344c during Mouse Brain DevelopmentTo investigate the expression profiles of miR-344b and miR-344c during mouse brain development, we performed in situ hybridization on the sagittal plane of mice at E11.5, E13.5, E15.5, E17.5, P1, and P86 (n = 2). [score:5]
Besides being expressed in adult (P86) cerebral cortex, miR-344c was also expressed in the adult olfactory bulb (Figure 4(a)). [score:5]
Four data mining tools, miRanda (August 2010 Release), miRDB (version 4.0, January 2012), TargetScan Mouse (Release 6.2, June 2012), and DIANA micro-T CDS (version 5.0), were used to identify the candidate target genes of miR-344b and miR-344c. [score:5]
In Silico AnalysisFour data mining tools, miRanda (August 2010 Release), miRDB (version 4.0, January 2012), TargetScan Mouse (Release 6.2, June 2012), and DIANA micro-T CDS (version 5.0), were used to identify the candidate target genes of miR-344b and miR-344c. [score:5]
Subsequent study showed miR-344 inhibited cell differentiation by targeting the Wnt/ β-catenin signalling pathway [19]. [score:5]
Stem-Loop RT-qPCR Expression Analysis of miR-344b and miR-344c To quantify the expression of miR-344b and miR-344c (Figure 5), we performed stem-loop RT-qPCR in embryonic mouse whole brain and multiple organs of adult mice. [score:5]
To identify the genes targeted by miR-344b and miR-344c, we employed four online bioinformatics databases, namely, miRanda, miRDB, TargetScanMouse, and DIANA micro-T CDS. [score:5]
Both expressions of miR-344b and miR-344c were found coexpressed with DAPI (Figures 9(g), 9(j), 10(g), and 10(j)) as opposed to Tuj1 staining where green fluorescence was only found at the periphery of the cell (Figures 9(h), 9(k), 10(h), and 10(k)). [score:5]
In this study, we demonstrated comprehensive spatiotemporal expression of miR-344b and miR-344c throughout mouse brain development via in situ hybridization. [score:4]
Studies revealed that miR-344 is expressed during mouse brain development at E15.5 [10, 15] and in the adult mouse brain [16]. [score:4]
In contrast to miR-344b, miR-344c was globally expressed throughout brain development from E11.5 to P1 and decreased in adulthood (Figures 1(g)– 1(l)). [score:4]
Recently, miR-344-3p was reported to be expressed in neural-specific regions during mouse embryonic development [10]. [score:4]
In this study, we profiled the expression of miR-344b and miR-344c in mouse brain development via in situ hybridization at both embryonic and postnatal stages. [score:4]
Spatiotemporal Expression Profiling of miR-344b and miR-344c during Mouse Brain Development. [score:4]
Both miR-344b and miR-344c were localized to the nucleus, suggesting that these mRNAs were not direct targets of these mature miRNAs. [score:4]
We further compared the expression of miR-344c in multiple adult organs and found significant differences in its expression among them (P < 0.0001; Figure 5(d)). [score:4]
To quantify the expression of miR-344b and miR-344c (Figure 5), we performed stem-loop RT-qPCR in embryonic mouse whole brain and multiple organs of adult mice. [score:3]
Furthermore, a previous study by Ling et al. [15] showed two mature isoforms of miR-344-3p (miR-344b and miR-344c) were expressed in the whole developing mouse brain (E15.5) via Northern blot. [score:3]
Immunofluorescence staining confirmed that miR-344b and miR-344c were expressed in the nucleus of the neurons. [score:3]
A high throughput microarray study revealed that miR-344 was one of the 29 miRNAs identified which inhibits adipogenesis via Wnt signally pathway [18]. [score:3]
Similar to miR-344b, the normalized luciferase bioluminescence level was not affected by overexpression of miR-344c (Figure 7(d)). [score:3]
In the adult stage (P86), miR-344c was not expressed in the brain with exception of the olfactory bulb and granular cell layer of the cerebellum (Figure 1(r)). [score:3]
The expression profiles for miR-344b and miR-344c were generally similar with slight differences at select brain regions or time points. [score:3]
The adult mouse brain had the highest miR-344c expression, followed by the pancreas, skin, kidney, liver, large intestine, stomach, lung, adipose tissue, thymus, heart, small intestine, ovary and fallopian tubes, spleen, testes, and skeletal muscle. [score:3]
Bioinformatics analysis was employed to predict the potential downstream target genes of miR-344b and miR-344c. [score:3]
In contrast to miR-344c, expression of miR-344b was reduced at E17.5 and P1. [score:3]
Using whole brain samples (n = 5), a significant difference was observed in miR-344c expression at E11.5, E13.5, E15.5, E17.5, or P1, or in adult brain samples (P < 0.0001; Figure 5(c)). [score:3]
Higher magnification on these neuronal cells showed that miR-344b and miR-344c expressions were unevenly distributed in the nucleus, with an average of 5 foci per nucleus. [score:3]
The same experiment was performed for miR-344c and its chimeric target gene, Otx2. [score:3]
Colocalization Study of miR-344b and miR-344c Bioinformatics study had predicted Olig2 and Otx2 were target genes of miR-344b and miR-344c, respectively. [score:3]
Our study predicted Olig2 and Otx2 as the most probable targets of miR-344b and miR-344c, respectively. [score:3]
miR-344c was significantly increased from E11.5 to E13.5 and continued to express until the adult stage (Figure 5(c)). [score:3]
Our findings concur with previous studies that showed miR-344-3p was expressed in embryonic and adult mouse brain [10]. [score:3]
As the predicted target of miR-344c, Otx2 has been shown to be localized in the nuclei of cells of the olfactory bulb [43]. [score:3]
Stem-Loop RT-qPCR Expression Analysis of miR-344b and miR-344c. [score:3]
As miR-344c was expressed in the olfactory bulb, a brain region for odour recognition, miR-344c may be involved in transmission, integration, and processing of olfactory signals. [score:3]
The expression of miR-344b and miR-344c may be wi dely diffused in the brain and it was not earlier detected via in situ hybridization, which was performed on a specific plane or section of the brain. [score:3]
At E17.5, miR-344c continued to be expressed in the cortical plate and intermediate zone but not the marginal zone (Figure 3(j)). [score:3]
The Venn diagram summarized the number of genes targeted by miR-344b (Figure 6(a)) and miR-344c (Figure 6(b)) using the different databases. [score:3]
In the cerebellum (Figure 4(c)), miR-344c was lowly expressed in the granular cell layer (Figure 4(d)). [score:3]
Bioinformatics study had predicted Olig2 and Otx2 were target genes of miR-344b and miR-344c, respectively. [score:3]
In conclusion, our study shows that miR-344b and miR-344c are spatiotemporally expressed in the developing mouse brain. [score:3]
Comparison of multiple adult mouse organs showed the adult pancreas highly expressed both miR-344b and miR-344c. [score:3]
Interestingly, miR-344-3p was also found to be primarily expressed in the olfactory bulb and cerebellar cortex of the adult mouse brain [10]. [score:3]
Both miR-344b and miR-344c had significantly increased from E11.5 to E13.5 and their expression remained in a steady state until adulthood. [score:3]
Although evidence had shown that miR-344, particularly miR-344b and miR-344c, was expressed in the developing mouse brain, the function of these miRNAs had yet to be ascertained. [score:3]
At E11.5, miR-344c was expressed in both the ventricular zone and preplate of the developing cerebral cortex (Figure 3(a)). [score:3]
miR-344c was expressed throughout the developing midbrain from E11.5 to P1 (Figures 3(b), 3(e), 3(h), 3(k), and 3(n)) but not in the adult stage at P86. [score:3]
A closer look into the expression profiles revealed that both the miR-344b and miR-344c were localized in the nuclei of neuronal cells, suggesting that they may function in nuclei rather than cytosol in a noncanonical manner. [score:3]
Our analysis provides further insight into miR-344b and miR-344c at other time points (E11.5, E13.5), as well as their expression in multiple adult mouse organs. [score:3]
On the other hand, miR-344c showed strong expression throughout the brain from E11.5 to P1 (Figures 1(m)– 1(r)). [score:3]
In the developing cerebellum, miR-344c was expressed in the cerebellar neuroepithelium at E11.5 (Figure 3(c)), E13.5 (Figure 3(f)), and E15.5 (Figure 3(i)). [score:3]
At P1, miR-344c was expressed in layers I, II, and III of the cerebral cortex (Figure 3(m)). [score:3]
At E17.5 and P1, miR-344c was expressed in the molecular, Purkinje, and granular cell layers of the developing cerebellum (Figures 3(l) and 3(o)). [score:3]
Moreover, miR-344 had been implicated in Huntington disease and acute respiratory distress syndrome animal mo dels. [score:3]
Predicted Target Genes of miR-344b and miR-344c. [score:3]
At higher magnifications, miR-344c was found globally expressed across the developing mouse brain. [score:3]
We chose Olig2 and Otx2 genes as potential targets of miR-344b and miR-344c, respectively, for further validation. [score:3]
Stem-loop RT-qPCR was carried out to determine the overexpression of miR-344b and miR-344c (Figure 7(b)). [score:3]
Besides the brain, other studies have shown that miR-344 is expressed in the pancreas [39], lungs [21], and adipose tissue [18, 19], which concur with our findings in the current study. [score:3]
In the adult mouse brain (P86), only miR-344c was expressed and found localized to the olfactory bulb and subgranular zone of the cerebellum. [score:3]
To investigate the expression profiles of miR-344b and miR-344c during mouse brain development, we performed in situ hybridization on the sagittal plane of mice at E11.5, E13.5, E15.5, E17.5, P1, and P86 (n = 2). [score:2]
In contrast, miRNA array analysis suggested that miR-344 was expressed specifically in the brain when compared to liver and heart tissues of the adult mouse [16]. [score:2]
Supplementary materials contain two tables which described the list of commonly predicted target genes of miR-344b and miR-344c (Supplemental Table 1 and 2 respectively), one figure which showed the specificity of the stem-loop RT-qPCR assay (Supplemental Figure 1), and two figures which showed negative control staining (miR-scramble) for miR-344b and miR-344c (Supplemental figure 2 and 3 respectively). [score:2]
It was also found that the expression of miR-344c in thymus, heart, small intestine, ovary and fallopian tubes, spleen, testes, and skeletal muscle was significantly lower compared to the brain (Figure 5(d)). [score:2]
The roles of spatiotemporally expressed miR-344b and miR-344c in brain development, however, are yet to be determined and warrant further characterization. [score:2]
We conducted a luciferase assay to determine whether Olig2 and Otx2 were targeted by miR-344b and miR-344c, respectively. [score:2]
Therefore, we sought to determine the localization of miR-344b and miR-344c in the cells of the developing brain. [score:1]
First strand cDNA contained a target site for universal reverse primer (5′-GTAGGATGCC GCTCTCAGG-3′) and Universal ProbeLibrary (UPL) probe #21 (Roche Diagnostics), which were used together with specific forward primers for miR-344b (5′-GGACCATTTA GCCAAAGCCT-3′) and miR-344c (5′-GCGTGATCTA GTCAAAGCCT-3′), respectively. [score:1]
A study by Royo et al. showed that miR-344 was one of the imprinted small RNA genes at the Prader-Willi locus of the transgenic mouse mo del. [score:1]
Subsequent stem-loop RT-qPCR analysis of miR-344b and miR-344c was performed to validate our in situ hybridization findings. [score:1]
Transfection of plasmids with miR-344b, miR-344c, Olig2, and Otx2, purchased from GeneCopoeia ™, USA, was performed using Lipofectamine3000 (Invitrogen) as per the manufacturer's protocol. [score:1]
Colocalization Study of miR-344b and miR-344c. [score:1]
In addition to the whole mouse brain, we also performed similar analyses on miR-344b and miR-344c in various organs of the adult mouse. [score:1]
In the cerebellum, miR-344c was found in the subgranular zone, which gives excitatory outputs to Purkinje cells. [score:1]
Therefore, miR-344 is a nonconserved miRNA and it is specific to rodents. [score:1]
Besides the developing brain, miR-344 had been implicated in mouse adipocyte differentiation [17, 18]. [score:1]
miR-344 is a novel miRNA that was first reported in 2004 as one of the many miRNAs found in rat cortical neurons [9]. [score:1]
As for miR-344c, 539 genes were predicted by miRanda, while 29 genes were predicted by miRDB. [score:1]
qPCR results for miR-344b and miR-344c were normalized against the U6 small nuclear RNA used as endogenous controls. [score:1]
It was used as a preliminary study to understand the functional role of miR-344b and miR-344c. [score:1]
However, miR-344 was not detected in homologous human Prader-Willi domain at 15q11q13 or any nonrodent genomes [11]. [score:1]
However, more studies are required to validate the potential role and mechanisms of miR-344b and miR-344c in the cell nucleus. [score:1]
org/10.1155/2016/1951250) predicted in the study warrant a more extensive validation in order to elucidate with the potential functional role of miR-344b and miR-344c. [score:1]
Merged images of three different channels confirmed the locality of miR-344b and miR-344c in the nucleus of a neuronal cell (Figures 9(i), 9(l), 10(i), and 10(l)). [score:1]
The same analysis was performed on miR-344c using embryonic mouse whole brain and multiple adult mouse organs. [score:1]
miR-344 family had nine known isoforms, miR-344a to miR-344i. [score:1]
miR-344 is located on mouse chromosome 7, which contains 19 mature sequences [10]. [score:1]
Closer observations of ISH brain sections revealed that both miR-344b and miR-344c were localized to the nuclei instead of the cytoplasm of the cell (Figures 8(a) and 8(b)). [score:1]
After 2 h of prehybridization, custom-made miR-344b, miR-344c, or miR-scrambled locked nucleic acid probes (Exiqon) were added to the hybridization buffer to a final concentration of 0.020 pmol/ µL. [score:1]
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[+] score: 26
As shown in Figure 4, miR-181d and miR-872 were down-regulated with a 0.5-fold change in the infarct region of the MCAO mice, while miR-106b and miR-344 were up-regulated with two fold changes in the infarct region of the MCAO mice. [score:7]
Another study found that miR-344 was commonly down-regulated in Huntington’s disease mo dels [22]. [score:6]
Additionally, one study found that miR-344 inhibited the adipocyte differentiation via targeting GSK3β, and subsequently activating the Wnt/β-catenin signaling pathway [21]. [score:5]
Chen H. Wang S. Chen L. Chen Y. Wu M. Zhang Y. Yu K. Huang Z. Qin L. Mo D. MicroRNA-344 inhibits 3T3-L1 cell differentiation via targeting GSK3β of Wnt/β-catenin signaling pathway FEBS Lett. [score:4]
Four differentially expressed miRNAs (miR-181d, miR-872, miR106b, and miR-344) were validated using the miRCURY LNA™ Universal RT microRNA PCR (Exiqon A/S, DK-2950 Vedbaek, Denmark). [score:3]
To further confirm the accuracy of the miRNA microarray results, the miR-181d, miR-872, miR-106b, and miR-344 of 30 miRNAs were verified by qRT-PCR. [score:1]
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Profiling of miRNAs expression was also performed in the YAC128 and R6/2 mice, showing that nine miRNAs (miR-22, miR-29c, miR-128, miR-132, miR-138, miR-218, miR-222, miR-344, and miR-674*) are commonly down-regulated in 12-month-old YAC128 mice and 10-week-old R6/2 mice (100). [score:6]
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They suggested miR-22 and miR-125 as possible master regulators, and miR-344-5p/484 and miR-488 as possible master coregulators that may influence the genes involved in one-carbon metabolism. [score:3]
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Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-26b, hsa-mir-29a, hsa-mir-30a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-106a, mmu-let-7g, mmu-let-7i, mmu-mir-15b, mmu-mir-29b-1, mmu-mir-30a, mmu-mir-30b, mmu-mir-125a, mmu-mir-125b-2, mmu-mir-130a, mmu-mir-138-2, mmu-mir-181a-2, mmu-mir-182, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-30e, hsa-mir-10a, hsa-mir-34a, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-182, hsa-mir-181a-1, mmu-mir-297a-1, mmu-mir-297a-2, mmu-mir-301a, mmu-mir-34c, mmu-mir-34b, mmu-let-7d, mmu-mir-106a, mmu-mir-106b, hsa-let-7g, hsa-let-7i, hsa-mir-15b, hsa-mir-30b, hsa-mir-125b-1, hsa-mir-130a, hsa-mir-138-2, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-138-1, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-15a, mmu-mir-26b, mmu-mir-29a, mmu-mir-29c, mmu-mir-34a, rno-mir-301a, rno-let-7d, rno-mir-344a-1, mmu-mir-344-1, rno-mir-346, mmu-mir-346, rno-mir-352, hsa-mir-181b-2, mmu-mir-10a, mmu-mir-181a-1, mmu-mir-29b-2, mmu-mir-138-1, mmu-mir-181b-1, mmu-mir-181c, mmu-mir-125b-1, hsa-mir-106b, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-34b, hsa-mir-34c, hsa-mir-301a, hsa-mir-30e, hsa-mir-362, mmu-mir-362, hsa-mir-369, hsa-mir-374a, mmu-mir-181b-2, hsa-mir-346, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-10a, rno-mir-15b, rno-mir-26b, rno-mir-29b-2, rno-mir-29a, rno-mir-29b-1, rno-mir-29c-1, rno-mir-30c-1, rno-mir-30e, rno-mir-30b, rno-mir-30d, rno-mir-30a, rno-mir-30c-2, rno-mir-34b, rno-mir-34c, rno-mir-34a, rno-mir-106b, rno-mir-125a, rno-mir-125b-1, rno-mir-125b-2, rno-mir-130a, rno-mir-138-2, rno-mir-138-1, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-181a-1, hsa-mir-449a, mmu-mir-449a, rno-mir-449a, mmu-mir-463, mmu-mir-466a, hsa-mir-483, hsa-mir-493, hsa-mir-181d, hsa-mir-499a, hsa-mir-504, mmu-mir-483, rno-mir-483, mmu-mir-369, rno-mir-493, rno-mir-369, rno-mir-374, hsa-mir-579, hsa-mir-582, hsa-mir-615, hsa-mir-652, hsa-mir-449b, rno-mir-499, hsa-mir-767, hsa-mir-449c, hsa-mir-762, mmu-mir-301b, mmu-mir-374b, mmu-mir-762, mmu-mir-344d-3, mmu-mir-344d-1, mmu-mir-673, mmu-mir-344d-2, mmu-mir-449c, mmu-mir-692-1, mmu-mir-692-2, mmu-mir-669b, mmu-mir-499, mmu-mir-652, mmu-mir-615, mmu-mir-804, mmu-mir-181d, mmu-mir-879, mmu-mir-297a-3, mmu-mir-297a-4, mmu-mir-344-2, mmu-mir-466b-1, mmu-mir-466b-2, mmu-mir-466b-3, mmu-mir-466c-1, mmu-mir-466e, mmu-mir-466f-1, mmu-mir-466f-2, mmu-mir-466f-3, mmu-mir-466g, mmu-mir-466h, mmu-mir-493, mmu-mir-504, mmu-mir-466d, mmu-mir-449b, hsa-mir-374b, hsa-mir-301b, rno-mir-466b-1, rno-mir-466b-2, rno-mir-466c, rno-mir-879, mmu-mir-582, rno-mir-181d, rno-mir-182, rno-mir-301b, rno-mir-463, rno-mir-673, rno-mir-652, mmu-mir-466l, mmu-mir-669k, mmu-mir-466i, mmu-mir-669i, mmu-mir-669h, mmu-mir-466f-4, mmu-mir-466k, mmu-mir-466j, mmu-mir-1193, mmu-mir-767, rno-mir-362, rno-mir-504, rno-mir-582, rno-mir-615, mmu-mir-3080, mmu-mir-466m, mmu-mir-466o, mmu-mir-466c-2, mmu-mir-466b-4, mmu-mir-466b-5, mmu-mir-466b-6, mmu-mir-466b-7, mmu-mir-466p, mmu-mir-466n, mmu-mir-344e, mmu-mir-344b, mmu-mir-344g, mmu-mir-344f, mmu-mir-374c, mmu-mir-466b-8, hsa-mir-466, hsa-mir-1193, rno-mir-449c, rno-mir-344b-2, rno-mir-466d, rno-mir-344a-2, rno-mir-1193, rno-mir-344b-1, hsa-mir-374c, hsa-mir-499b, mmu-mir-466q, mmu-mir-344h-1, mmu-mir-344h-2, mmu-mir-344i, rno-mir-344i, rno-mir-344g, mmu-let-7j, mmu-mir-30f, mmu-let-7k, mmu-mir-692-3, rno-let-7g, rno-mir-15a, rno-mir-762, mmu-mir-466c-3, rno-mir-29c-2, rno-mir-29b-3, rno-mir-344b-3, rno-mir-466b-3, rno-mir-466b-4
1Proliferation, Invasion, Tumor suppression [63– 66] miR-344 ↓2.0 ↓3.2 NA miR-346 ↓2.4Proliferation [67, 68] miR-362 ↓2.3Proliferation, Invasion, Apoptosis [69– 76] miR-369 ↓2.8 ↓2.6 ↓2.1Aerobic glycolysis [77] miR-374 ↑3.0 ↓2.2 NA miR-449 ↑2.7 ↑2.4Proliferation [78– 81] miR-463 ↓2.7 NAmiR-466 [°] ↑2.4 ↑2.1 ↓3.5 NA miR-483 ↓3.2Apoptosis [82] miR-493 ↑2.1 ↓2.2Proliferation [83– 85] miR-499a ↓5.0 ↑2.3Proliferation [86] miR-504 ↓2.6 ↑2.0Proliferation, Apoptosis [87, 88] miR-579 ↑2.8 NAmiR-582 [^] ↑2.4Proliferation [89] miR-615 ↓2.1Proliferation, Invasion [90, 91] miR-652 ↑2.4Proliferation, EMT [92, 93] miR-669b ↓2.1 NA miR-669h ↓3.6 ↑2.3 NA miR-669i ↓2.3 NA miR-669k ↓7.2 ↓5. [score:3]
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Specifically, miR-19a-3p, miR-344-3p, miR-34b-3p and miR-497-5p were all detected only in samples from RML infected mice (Figure S7A). [score:1]
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For example, the members of miR-344 family were all produced from shRNAs (Table S4). [score:1]
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S7 7. Nrf2 -dependent effect of 5 mg / kg PQ Nrf2(+/+) PQ5—Nrf2(–/–) PQ5 miR-135a, miR-376c, miR-31, miR-let-7i*, miR-669b*, miR-344, miR-15b, miR-700*, miR-3099, miR-377, miR-338-5p, miR-382, miR-219-3p and miR-310a S8 8. Nrf2 -dependent effect of 10 mg / kg PQ Nrf2(+/+) PQ10—Nrf2(–/–) PQ10 miR-495*, miR-154*, miR-let-7b, miR-1983, miR-103 and miR-26a S9 The miR-380-3p / Sp3 mRNA pathway is worth to mention here. [score:1]
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Three miRNAs in FCx (miR-128, miR-129-5p, and miR-344) and one miRNA in HP (miR-7a) map to two chromosomal loci (Table S1). [score:1]
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