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5 publications mentioning eca-mir-133b

Open access articles that are associated with the species Equus caballus and mention the gene name mir-133b. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 32
Special attention deserves miR-206 together with described above miR-1 and miR-133 which regulate expression of one of its potential target genes cx43 involved not only in muscle development but also in muscle regeneration where its upregulation was observed [35]. [score:10]
Moreover, some of the identified miRNAs showed the opposite trend of expression change to this mentioned above (miR-1↓, miR-133↓, miR-206↓), promoting cell differentiation and proliferation in case of miRNA upregulation and downregulation, respectively. [score:9]
Similar observations were done for miR-133, in which upregulation was described as proliferation-inducing while its downregulation was responsible for differentiation progression [26]. [score:7]
A group of miRNAs, highly enriched in skeletal and/or cardiac muscles (myomiRs), has recently been identified and includes miR-1, miR-133a, miR-133b, miR-206, miR-208, miR-208b, miR-486, and miR-499 [14] which regulate skeletal muscle development. [score:3]
Several potential target genes for identified miRNAs were classified as follow: hypertrophy: tpm3 (miR-1, miR-206), tpm1 (miR-142-5p), sgcd (miR-142-5p), cacnb1 (miR-208b), itgav (miR-142-5p), itga2 (miR-30c, miR-128); muscle regeneration-related processes and pathways: cx43 (miR-206), klf4 (miR-30 c), and vegfc (miR-128, miR-133). [score:3]
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[+] score: 13
Other miRNAs from this paper: eca-mir-454, eca-mir-204b-2, eca-mir-486, eca-mir-374b
Although our down-regulated miRNAs, miR-133b and miR-454, are certainly not pregnancy specific, their down-regulation during pregnancy allows for an increase in the translation of numerous mRNAs, including X-linked RNA binding motif protein (RBMX) which is implicated in regulation of gene transcription and alternative splicing, as well as repairing double-stranded DNA breaks [28, 29] and DEAD (Asp-Glu-Ala-Asp) box helicase 6 (DDX6) which maintains adult progenitor cell function [30]. [score:10]
Top twenty pathways predicted for miRNAs differentially regulated during pregnancy (miR-133b, miR-204b, miR-454, miR-486-5p). [score:2]
Looking at miR-133b, large fold-changes between pregnancy and diestrus were consistently noted, ranging from a 45 X decrease during the post-partum period to a 164 X decrease at 9 m gestation. [score:1]
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[+] score: 5
Consistent with the known role of miRNAs in the control of bone remo deling (for review see [8]) and their involvement in key regulation pathways of bone formation and remo deling such as BMP-signaling pathway (mir-133, mir-135) [51] and Wnt-signaling pathway (mir-29a) [52], miRNA predicted targets were found to be involved in the regulation of several signaling pathways (FGF, TGFb, IGF1). [score:5]
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[+] score: 2
In view of this result, the relationship between blood cell levels and plasma/serum levels of miR-133 also warrant further examination. [score:1]
In contrast, however, we found some significant, positive correlations between miR-133 levels and changes in plasma creatine kinase and aspartate transaminase levels (which reportedly reflect cell damage in human athletes after a marathon race 19). [score:1]
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[+] score: 1
Muscle-specific miRNAs such as miR-1, miR-133, and miR-206 have a central role in myogenesis (22). [score:1]
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