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6 publications mentioning rno-mir-294

Open access articles that are associated with the species Rattus norvegicus and mention the gene name mir-294. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 87
Moreover, miR-344a, miR-294, and miR-133b-3p weakened the upregulation of α-SMA and inhibited the downregulation of E-cadherin in HK2 cells induced by TGF-β1 (Figs. 4e- i and 5e- i). [score:9]
Our data therefore suggested that the downregulation of miR-133b-3p and miR-294 in older rats may be an important cause of suppression of TGF-β1 -induced EMT in aged rats. [score:6]
In addition, miR-133b-3p and miR-294, which were downregulated in BM-MSC-MVs of older rats, remarkably inhibited TGF-β1 -mediated EMT in HK2 cells, suggesting that these may play a role in the fibrosis of aging renal tissues. [score:6]
We also observed that miR-133b-3p and miR-294, which were downregulated in older rats, imparted significant inhibitory effects on TGF-β1 -induced EMT. [score:6]
In secreted BM-MSC-MVs, the expression of miR-344a, miR-133b-3p, miR-294, miR-423-3p, and miR-872-3p was significantly downregulated in older rats than in younger rats (P < 0.05), and the serum level of these miRNAs exhibited the same patterns. [score:6]
Moreover, miR-133b-3p and miR-294, which were downregulated in BM-MSC-MVs and serum of older rats, could remarkably inhibit TGF-β1 -mediated EMT in HK2 cells. [score:6]
miR-344a, miR-133b-3p, miR-294, miR-423-3p, and miR-872-3p in BM-MSC-MVs from aged rats were downregulated, and the expression of miR-294 and miR-872-3p showed a significant decline (P < 0.05) (Fig.   2c). [score:6]
These findings suggest that the downregulated miR-133b-3p and miR-294 in older rats play important roles in causing renal EMT and renal aging. [score:4]
On the other hand, miR-294/302 can indirectly inhibit Tgfbr2 as well as EMT of embryonic stem cells [34]. [score:4]
α-SMA alpha-smooth muscle actin, TGF-β1 transforming growth factor-beta 1 HK2 cells were initially transfected with miR-344a, miR-294, miR-872-3p, miR-133b-3p, and miRNA mimic control and then incubated in a medium containing 8 ng/ml TGF-β1 for 48 h. Compared with non -transfected HK2 cells, the expression level of α-SMA significantly decreased in HK2 cells transfected with miR-344a, miR-294, and miR-133b-3p (P < 0.05), and the expression level of E-cadherin significantly increased in HK2 cells transfected with miR-294 and miR-133b-3p (P < 0.05). [score:4]
Through the regulation of Tgfbr2 and Gsk3-beta, miR-294/302 can inhibit TGF-beta and GSK3 pathways. [score:4]
In the present study, we confirmed that, in older rats, the inhibitory effects of BM-MSC-MVs on TGF-β1 -induced EMT had weakened, and this might be related to the decrease in the levels of miR-133b-3p and miR-294. [score:3]
Lastly, an ABI-Prism 7500 Sequence Detection System (Applied Biosystems, Waltham, MA, USA) and SYBR PrimeScript miRNA RT-PCR Kit (Takara) were used to detect the expression level of specific miRNAs (miR-344a, miR-294, miR-872-3p, miR-133b-3p, and miR-423-3p) and the loading control, miR-191. [score:3]
Guo WT Wang XW Yan YL Li YP Yin X Zhang Q Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7 -induced silencing of self-renewal in embryonic stem cellsCell Death Differ. [score:3]
It also indicated the expression of E-cadherin in HK2 cells treated with TGF-β1 but pre -transfected with miR-872, miR-344, miR-294, miR-133b-3p, and miR-control mimic (e-i). [score:3]
It also indicated the expression of α-SMA in HK2 cells treated with TGF-β1 but pre -transfected with miR-872, miR-344, miR-294, miR-133b-3p, and miR-control mimic (e–i). [score:3]
Among these, miR-133b-3p and miR-294 significantly inhibited TGF-β1 -mediated EMT in HK2 cells (P < 0.05). [score:3]
a, c of E-cadherin and α-SMA expression in HK2 cells under TGF-β1 stimulation co-cultured with Y-MV /O-MV or pre-transfection with miR-872, miR-344, miR-294, miR-133b-3p, and miR-control mimic. [score:3]
However, the target genes, regulatory mechanisms, and signaling pathways of miR-133b-3p and miR-294 currently remain unclear and should be investigated in future studies. [score:2]
In older rats, the level of secreted miR-133b-3p and miR-294 decreased. [score:1]
For the miRNA transfection groups, miR-344a, miR-294, miR-872-3p, miR-133b-3p, and miRNA mimic control (GeneCopoeia Inc. [score:1]
MiR-344a, miR-133b-3p, and miR-294 affected TGF-β1 -mediated EMT in HK2 cells. [score:1]
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2
[+] score: 26
rno-miR-675-5p 4.143757751 Premature senescence of cardiac progenitor cells, G1 arrest, reduced cell proliferation, colony formation, migration and invasion rno-miR-183-3p 3.74730108 Regulates claudin-1 expression rno-miR-299a-5p 3.626723224 Anti-apoptotic role rno-miR-200c-3p 3.593610443 Targets the VEGF-VEGFR2 pathway and angiogenesis rno-miR-665 3.511737089 Negatively targets anti-apoptotic BCL2L1 rno-miR-291a-5p 3.457928187 VSMC migration rno-miR-490-5p 2.373358 Tumour suppressor rno-miR-1 2.505729 Suppresses cell growth rno-miR-133b 2.192279 Inhibits cell proliferation and invasion rno-miR-30c-1-3p 2.70761 Suppresses PXR expression rno-miR-294 2.010496 Promotes proliferation and differentiation rno-miR-127-5p 2.780488 A regulator of MMP-13 and suppresses cell growth rno-miR-503 2.327383 Inhibits cell proliferation and invasion Table 2 Twenty down-regulated miRNAs. [score:26]
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3
[+] score: 5
Similarly, several downregulated microRNAs were associated with genes participating in cell death process, such as yy1 (miR-294) [34], the pro-apoptotic factor bim (miR-144), the pro-apoptotic blcap (miR-294), which stimulates apoptosis independently of p53 and NF-κB [35], and the anti-apoptotic factor Bcl-XL (miR-342) (Figure 7, networks 1, 3 and 4). [score:4]
Specifically, BDNF is related to miR-183, semaphorin 3 to miR-329 and miR-331, Neuritin-1/ nrn1 to miR-331 and miR-342 and Ephrin-B2/ efnb2 to miR-340 and miR-294. [score:1]
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4
[+] score: 5
Members of the miR-290-295 cluster (miR-290, miR-291a, miR-292, miR-291b, miR-293, miR-294 and miR-295-1) were the most abundant among known miRNAs that were upregulated in rat PSCs. [score:4]
Some miRNAs, such as miR-291, miR-294 and miR-295, can enhance reprogramming that is induced by OSK factors [22]. [score:1]
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5
[+] score: 3
Among those differently expressed microRNAs, miR-291a-5p, mir-294, miR-29a, and miR-29b were further detected by qRT-PCR, and the results were consistent with the microRNA array analysis (Fig. 2C). [score:3]
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6
[+] score: 1
173 (miR-186-5p, miR-208a-5p, miR-291a-3p, miR-294-3p, miR-295-3p, miR-302a-3p, miR-302b-3p, miR-302c-3p and miR-302d-3p). [score:1]
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