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2 publications mentioning dvi-mir-309

Open access articles that are associated with the species Drosophila virilis and mention the gene name mir-309. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 27
The expression pattern of Mir-309 in D. virilis showed a peak at 13–20% of development (Fig. 4b), similar to that seen for B. germanica, whereas in T. castaneum, Mir-309 expression increased at 6–11% of development and then remained more or less stable until the end of embryogenesis (Fig. 4b). [score:6]
In B. germanica, an acute expression peak of the Mir-309 cluster miRNAs (which comprises four Mir-309 paralogs) is observed at ED2 (11% of development), which might be involved in maternal mRNA clearance. [score:4]
The expression of Mir-309 followed a CoMod-B pattern, showing an acute peak in ED2 (at 11% of development) (Fig. 4b). [score:3]
In D. melanogaster, maternal mRNA clearing has been associated with the Mir-309 cluster, which includes Mir-9/4/79, Mir-5/6/2944, Mir-3/309 and Mir-279/286, which are mainly expressed between 9 and 12% of embryo development [21]. [score:3]
The libraries were prepared at 1.85%, 0–3.5% and 0–6.67% of development in B. germanica (bge), T. castaneum (tca) and D. virilis (dvi), respectively The present results indicate the embryonic presence of the MIR-309 family of miRNAs in B. germanica, plus 54 novel miRNAs [10, 11]. [score:2]
b Expression of MIR-309 miRNAs compared to that seen in T. castaneum and D. virilis. [score:2]
Four of these belonged to the MIR-309 family (Fig.   1a), which is typical of insects [11] and that in D. melanogaster is involved in the clearance of maternally loaded mRNAs [21]. [score:1]
The present results indicate the embryonic presence of the MIR-309 family of miRNAs in B. germanica, plus 54 novel miRNAs [10, 11]. [score:1]
The identification of B. germanica embryo small RNA sequences unveiled miRNAs not detected in previous studies, such as those of the MIR-309 family and 54 novel miRNAs. [score:1]
As seen for other B. germanica miRNAs [11], most of those reported herein for the first time grouped into genomic clusters, e. g., into the MIR-309 family (Fig. 1b). [score:1]
a Precursor sequences of the MIR-309 miRNAs in B. germanica, T. castaneum, D. melanogaster and D. virilis. [score:1]
Taken together, these data suggest that maternal RNA clearing would involve two successive processes, the first (taking place around ED0-ED1), in which maternal adenylated miRNAs would be degraded, and the second (in ED2), in which maternal mRNAs would be cleared by the activity of Mir-309 and associated scavenger miRNAs. [score:1]
The second wave defined the boundaries of maternal-to-zygotic transition, with maternal mRNAs being cleared, presumably by Mir-309 and associated scavenger miRNAs. [score:1]
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2
[+] score: 6
Downstream analysis suggested that this is at least partly due to the presence of zygotically expressed microRNAs (e. g., from the mir-309∼6 cluster) at relatively high levels in the 0–1 h interval of D. melanogaster, but not in the 0–4 h interval of D. virilis (fig. 3 b). [score:3]
The expression pattern of fast-evolving and lineage-specific microRNAs can also be highly conserved, as exemplified by the mir-309∼6 cluster in Drosophila (Ninova et al. 2014). [score:3]
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