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5 publications mentioning mml-mir-103-2

Open access articles that are associated with the species Macaca mulatta and mention the gene name mir-103-2. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 42
Balderman et al. showed that BMP2 increased Runx2 expression in vascular smooth muscle cells and promoted calcification through down -regulating miR-30b-5p 31. miR-103-3p, identified as a mechanosensitive and bone abundant miRNA, inhibited the differentiation of osteoblasts by directly targeting Runx2 32 and the proliferation of osteoblasts by targeting Cav1.2 33. [score:11]
The results showed that 14 miRNAs (miR-30a-5p, miR-30e-5p, miR-425-5p, miR-142-3p, miR-191a-3p, miR-215, miR-29b-3p, miR-30b-5p, miR-26a-5p, miR-345-5p, miR-361-5p, miR-185-5p, miR-103-3p) were down-regulated but no miRNA was up-regulated among above three altered miRNAs from microarray in OVX serum by normalizing to miR-25-3p (Fig. 3b). [score:7]
The clinical characteristics of the subjects were shown in Table 1. Among the detected miRNAs, miR-30b-5p showed significant down-regulation in both osteopenic and osteoporotic patients, while miR-103-3p and miR-142-3p were markedly down-regulated only in osteoporotic patients (Fig. 4a). [score:5]
And 3 of them (miR-30b-5p, miR-103-3p and 142-3p) were finally confirmed down-regulation in the serum of both OVX rats, postmenopausal osteoporotic patients and bedrest monkeys. [score:4]
As shown in Fig. 4c, miR-30b-5p, miR-103-3p and miR-142-3p were significantly down-regulated after bedrest, while miR-328-3p had no significant change. [score:4]
Three serum miRNA (miR-103-3p, miR-142-3p and miR-328-3p) were markedly down-regulated only in osteoporotic patients and miR-30b-5p decreased in both osteopenic and osteoporotic patients. [score:4]
We presumed the possible reasons as following: Firstly, miR-30b-5p and miR-103-3p were identified as ostemiRs in osteoblasts and osteocytes 30, while postmenopausal osteoporosis was mainly due to the over-activity of osteoclasts 34. [score:1]
miR-30b-5p and miR-103-3p were two osteogenesis-related miRNAs. [score:1]
Secondly, it had been shown that bone loss was partly compensated by increased osteobalstogenesis during estrogen deficiency 35. miR-30b-5p and miR-103-3p may involve in these processes. [score:1]
And the ROC analysis (Fig. 4d) showed considerable diagnostic value: 0.926 for miR-30b-5p (95% CI = 0.67–1.00, p < 0.0001), 0.796 for miR-103-3p (95% CI = 0.52–0.96, p = 0.0133), 0.950 for miR-142-3p (95% CI = 0.68–1.00, p < 0.0001). [score:1]
As shown in Fig. 4b, the AUC of miR-30b-5p was 0.793 (95% CI = 0.625–0.909, p = 0.0001), and 0.800 for miR-103-3p (95% CI = 0.607–0.926, p = 0.0004), 0.789 for miR-142-3p (95% CI = 0.599–0.918, p = 0.0023), and 0.874 for miR-328-3p (95% CI = 0.698–0.967, p < 0.0001). [score:1]
To access the potential diagnostic value of miR-30b-5p for bone loss (osteopenia and osteoporosis), and the value of miR-103-3p, miR-142-3p, miR-328-3p for osteoporosis, ROC analysis was conducted and the associated area under the curve (AUC) was used to confirm the diagnostic value of each miRNA. [score:1]
After adjusting for age, weight and height, miR-30b-5p, miR-103-3p, miR-142-3p and miR-328-3p were significantly positively correlated with H-BMD (total hip BMD) (r = 0.541, p = 0.001; r = 0.355, p = 0.039; r = 0.650, p < 0.001; r = 0.355, p = 0.039 respectively). [score:1]
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[+] score: 4
We excluded those miRNAs from further analysis showing divergent endogenous expression levels as compared to human brain, e. g. hsa-miR-103 and -107 (additional file 2) and the abundantly expressed members of the let-7 family. [score:4]
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[+] score: 4
Additionally, miR-103, miR-21 and miR-378 possessed very high expression level (counts TPM>10000) in despite of origin from parthenogenesis or IVF. [score:3]
Consisting with Laurent and colleagues' reports [14], miR-183–182 cluster, miR-103, miR-21 and miR-378, which were reported to be related to many type carcinomas [33]– [36], were also enriched in both types of rhesus monkey ESCs. [score:1]
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[+] score: 3
A number of miRNAs were stably and highly expressed between species, such as the miR-17 family, miR-21 and miR-103, which suggested conserved functions in ESCs during evolution. [score:3]
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[+] score: 1
Despite the low abundance, most of these miRNA are highly conserved among mammals and some, such as miR-29, miR-103, miR-101, were shown to function in other tissues [20- 23]. [score:1]
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