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12 publications mentioning gga-mir-22

Open access articles that are associated with the species Gallus gallus and mention the gene name mir-22. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 24
With the highest abundant expression, down-regulated miR-22-3p was predicted to target nine genes (Fig. 5), including ELOVL fatty acid elongase 6 (ELOVL6), long-chain acyl-CoA synthetases (ACSL5) and perilipin 2 (PLIN2), which are the key regulatory factors in lipid metabolism. [score:9]
ELOVL6 and ACSL5 proteins, the target genes of miR-22-3p, are involved in the biosynthesis of unsaturated fatty acids and PPAR signalling pathways, respectively. [score:3]
These results indicate that miR-22-3p may be involved in lipid accumulation by binding to target genes involved in chicken hepatic fatty acid metabolism. [score:3]
The putative target genes of miR-22-3p. [score:3]
Among them, miR-22-3p, as the most highly abundant SDE miRNA, was predicted to target ACSL5, ELOVL6 and PLIN2, all of which are involved in lipid metabolism. [score:3]
MiR-22-3p (−1.33-fold) exhibited the highest expression levels in both libraries, followed by miR-148a-3p (−1.35-fold), whereas miR-146c-5p (−3.69-fold) exhibited the maximum fold-change. [score:3]
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2
[+] score: 14
In vitro target assay for effects of chicken miR-17-3p, miR-22* and miR-1764 on expression of the STAT1 transcript. [score:4]
0076784.g010 Figure 10 In vitro target assay for effects of chicken miR-17-3p, miR-22* and miR-1764 on expression of the STAT1 transcript. [score:4]
In the presence of miR-17-3p, miR-22* and miR-1764 which target the 3′UTR of STAT1, the intensities of GFP signals (21.3±3.4% in control vs. [score:3]
For the dual fluorescence reporter assay, the fusion contained the DsRed gene and either miR-1689* for Sp1; miR-17-3p, miR-22* or miR-1764 for STAT1; miR-1562 for ANGPTL3 and miR-138 for p20K which were designed to be co-expressed under control of the CMV promoter (pcDNA-DsRed-miRNA). [score:2]
6.0±3.1% in miR-17-3p; p<0.01, 4.3±2.1% in miR-22*; p<0.01 and 4.4±2.6% in miR-1764; p<0.01) were decreased, respectively (Figure 10C and 10D). [score:1]
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3
[+] score: 8
Other miRNAs from this paper: hsa-let-7d, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-21, hsa-mir-22, hsa-mir-30a, hsa-mir-32, hsa-mir-33a, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-147a, hsa-mir-34a, hsa-mir-187, hsa-mir-204, hsa-mir-205, hsa-mir-200b, hsa-mir-23b, hsa-mir-30b, hsa-mir-125b-1, hsa-mir-138-2, hsa-mir-142, hsa-mir-144, hsa-mir-125b-2, hsa-mir-138-1, hsa-mir-146a, hsa-mir-190a, hsa-mir-200c, hsa-mir-155, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-30e, hsa-mir-365b, hsa-mir-328, gga-mir-33-1, gga-mir-125b-2, gga-mir-155, gga-mir-17, gga-mir-148a, gga-mir-138-1, gga-mir-187, gga-mir-32, gga-mir-30d, gga-mir-30b, gga-mir-30a, gga-mir-30c-2, gga-mir-190a, gga-mir-204-2, gga-mir-138-2, gga-let-7d, gga-let-7f, gga-mir-146a, gga-mir-205b, gga-mir-200a, gga-mir-200b, gga-mir-34a, gga-mir-30e, gga-mir-30c-1, gga-mir-205a, gga-mir-204-1, gga-mir-23b, gga-mir-142, hsa-mir-449a, hsa-mir-489, hsa-mir-146b, hsa-mir-548a-1, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-33b, hsa-mir-449b, gga-mir-146b, gga-mir-147, gga-mir-489, gga-mir-449a, hsa-mir-449c, gga-mir-21, gga-mir-144, gga-mir-460a, hsa-mir-147b, hsa-mir-190b, gga-mir-460b, gga-mir-1662, gga-mir-1684a, gga-mir-449c, gga-mir-146c, gga-mir-449b, gga-mir-2954, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, gga-mir-365b, gga-mir-33-2, gga-mir-125b-1, gga-mir-190b, gga-mir-449d, gga-mir-205c
And Caruso et al firstly reported miRNAs dysregulation in the progress of PAH by the means of microarray analysis and quantitative polymerase chain reaction, who detected that miR-451and miR-322 up regulated, whereas miR-30, miR-22, and let-7f down regulated in PAH rodent mo dels [27]. [score:4]
Previous research has found that expression of miR-22 performed a significant effect on IRF8 mRNA abundance in development of dendritic cells [50]. [score:4]
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4
[+] score: 8
Among the known miRNAs, miR-10b-5p, gga-miR-148a-3p, gga-miR-22-3p and gga-miR-133a-3p were relatively high expressed in all three stages of chicken skeletal muscle development. [score:4]
These included miRNAs (miR-222a, miR-499-5p, miR-126-5p, miR-10b-5p, miR-22-3p, let-7f-5p, miR-181a-5p and miR-215-5p) (Figure 6) and differentially expressed genes (CPEB3, SUCLA2, MUSTN1, FGFR3 and ABHD3) (Figure 7). [score:3]
The 20 most abundant miRNAs in the three groups were ordered by the average proportion of each miRNA and included miR-148a-3p, miR-22-3p, miR-10b-5p, miR-181a-5p, miR-133a-3p, miR-126-5p, let-7f-5p, miR-10a-5p, miR-30c-5p, miR-146c-5p (Supplementary Table 1). [score:1]
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5
[+] score: 6
miR-22 can regulate the PTEN/AKT pathway and target HDAC6 [66– 68]; miR-206 and miR-1a can suppress hepatic lipogenesis [69]; miR-29b and miR-9 are involved in insulin sensitivity and diabetes [70, 71]; miR-31 and miR-32 participate in differentiation of stem cells into adipocyte and lipid metabolism in oligodendrocytes [72, 73]. [score:6]
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6
[+] score: 5
Other miRNAs which are expressed at high levels in HD11 include gga-miR-142-3p (10.5%), gga-miR-223 (6.9%), gga-miR-19b (4%), gga-miR-20a (3.7%) and gga-miR-22 (3.4%). [score:3]
The miRNAs which showed significant increase upon CD40L-stimulation included gga-miR-21, gga-miR-155, gga-miR-146a, gga-miR-20b, gga-miR-106, gga-miR-222, and gga-miR-22. [score:1]
The miRNAs which showed significant increase upon CD40L-stimulation included gga-miR-21, gga-miR-155, gga-miR-146a, gga-miR-20b, gga-miR-106, gga-miR-222 and gga-miR-22 (Figure 2). [score:1]
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7
[+] score: 5
In addition, the similar phenomenon was also observed in S. mansoni (miR-4, miR-6, miR-9, miR-32, miR-125, miR-3, and miR-5 were expressed in adult worms only, and miR-20, miR-18, miR-22, miR-26, and bantam were expressed in schistosomula only) (Simoes et al., 2011). [score:5]
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8
[+] score: 4
Other miRNAs from this paper: hsa-mir-22, mmu-mir-22, rno-mir-22, ssc-mir-22
However, the role of the syntenic locus in humans has been controversial, and more recent analyses have revealed mir-22 as a regulator of not only HTR2C mRNA expression, but also of other candidate genes for panic disorder [12]. [score:4]
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9
[+] score: 4
In additional, of the top 10 abundantly differentially expressed miRNAs identified in this study, some of them, such as miR-21 [20], miR-30c [14], miR-191 [21], let-7a and miR-22 [22] have also been reported to play important roles in the liver development. [score:4]
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10
[+] score: 3
The top five highly expressed miRNAs were gga-miR-215-5p, gga-miR-10b-5p, gga-miR-21-5p, gga-miR-26-5p, and gga-miR-22-3p, accounting for 40.54, 7.76, 6.78, 6.43, and 6.35% of total known miRNA reads, respectively. [score:3]
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11
[+] score: 3
miRNAs Normalized Reads Total Reads WRRh WRRl XHh XHl gga-miR-133a 3,558,683 3,069,071 1,997,286 2,607,787 11,232,827 gga-miR-133c 3,350,936 2,885,440 1,878,925 2,449,209 10,564,510 gga-miR-133b 3,326,848 2,864,578 1,864,721 2,431,274 10,487,421 gga-let-7a 1,699,621 1,513,865 857,210 1,133,532 5,204,228 gga-miR-22-3p 1,333,233 1,145,421 712,464 988,186 4,179,304 gga-miR-30a-5p 1,213,468 1,148,128 790,893 930,507 4,082,996 gga-miR-26a 1,212,635 1,054,689 691,456 1,006,522 3,965,302 gga-miR-30d 851,887 813,262 583,932 667,002 2,916,083 gga-miR-181a-6p 918,452 836,452 485,661 650,836 2,891,401 gga-miR-10a-5p 943,686 782,180 420,809 663,401 2,810,076 gga-miR-10b 911,725 757,564 398,852 633,567 2,701,708 gga-miR-30e 799,679 730,832 501,718 596,218 2,628,447 gga-let-7j 848,972 756,205 428,182 566,165 2,599,524 gga-let-7f 398,292 363,598 206,995 274,333 1,243,218 gga-miR-148a 288,585 300,432 144,015 180,973 914,005 gga-miR-146c-5p 224,147 207,782 171,443 132,712 736,084 gga-let-7k 211,853 206,518 118,297 155,412 692,080 gga-let-7c 242,661 189,820 111,118 139,257 682,856 gga-miR-199-3p 168,417 152,158 75,346 121,460 517,381 gga-miR-126-5p 139,914 109,805 89,607 86,681 426,007 Differentially expressed miRNAs were identified by DEGseq analysis (fold change > 1.5 or < 0.66; p-value < 0.05; q-value < 0.01), as a result, 200, 279, 257 and 297 miRNAs were detected in four comparisons of WRRh vs. [score:3]
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12
[+] score: 1
Three 3p-derived miRNAs (gga-miR-199-3p, gga-miR-22-3p, and gga-miR-140-3p) had more counts than their corresponding 5p-derived miRNAs. [score:1]
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