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19 publications mentioning hsa-mir-1307

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-1307. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 49
Of the 2 downregulated miRNAs, miR-490-5p was significantly downregulated in all 3 samples, and the expression of miR-1307 was down-regulated only in sample 2 (Fig. 3). [score:12]
In order to confirm the results of the microarray analysis, we conducted a northern blot analysis to detect the expression levels of 8 representative differentially expressed miRNAs identified using the microarray, including 4 upregulated miRNAs (miR-196a, miR-193b, miR-383 and miR-143) and 4 downregulated miRNAs (miR-490-5p, miR-1307, miR-125b and miR-590). [score:11]
The miRNAs that exhibited at least a 2-fold change in expression in the hADSCs before and after the induction of chondrogenic differentiation are listed in Table I, and these include 12 upregulated miRNAs (miR-196a, miR-143, miR-383, miR-193b, let-7i, miR-26a, miR-539, miR-199a-3p, miR-337-5p, miR-146a-5p, miR-646, and miR-381) and 8 downregulated miRNAs (miR-490-5p, miR-1307, miR-125b, miR-96-3p, miR-302-3p, miR-23a-3p, miR-590, and miR-510). [score:9]
A northern blot analysis was conducted to confirm that miR-196a and miR-490-5p were indeed differentially expressed in all 3 samples, which is consistent with the microarray results, whereas miR-193b and miR-383 were found to be upregulated in only 2 samples, and miR-1307 was downregulated in only 1 sample. [score:9]
However, only 5 miRNAs [miR-196a, miR-193b, miR-383 (upregulated), miR-490-5p and miR-1307 (downregulated)] produced northern blot analysis signals. [score:7]
The probe sequences were as follows: miR-196a antisense, 5′-CCCAACAACATGAAACTACCTA-3′; miR-193b antisense, 5′-AGCGGGACTTTGAGGGCCAGTT-3′; miR-383 antisense, 5′-AGCCACAATCACCTTCTGATCT-3′; miR-490-5p antisense, 5′-ACCCACCTGGAGATCCATGG-3′; miR-1307 antisense, 5′-AGCCGGTCGAGGTCCGGTCGA-3′; and U6 antisense, 5′-GCCATGCTAATCTTCTCTGTATC-3′. [score:1]
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2
[+] score: 40
c The mean gene expression of RP11-677M14.2 is 86 in paranoid cases, which is highly driven by one outlier with expression 179; the mean gene expression in controls is 160. d The mean expression of AC005009.2 for undifferentiated cases is 23 and 51 in controls a There are 5 individuals in case has non-zero expression on MIR1307 and 11 individuals in controls. [score:11]
Intersecting the list of differentially expressed small and lncRNAs with loci identified in previously reported GWAS studies has highlighted two genes, miRNA (mir1307) and lncRNAs (AC005009.2), that are differentially expressed in SCZ and as such may underlie or contribute to the observed GWAS signals at these loci. [score:5]
The associated locus contains multiple genes; however, we only detected differential expression in our RNA-seq data set from MIR1307 (Table 4). [score:3]
Fig. 1 a There are 5 individuals in case has non-zero expression on MIR1307 and 11 individuals in controls. [score:3]
The expression data raise the possibility that the GWAS association is being driven by MIR1307. [score:3]
Analysis of the GTF file as described in the section resulted in the identification of differential expression of MIR1307 between the SCZ patients and healthy controls. [score:3]
Expression of MIR1307 was approximately threefold higher in controls (p value = 0.0152). [score:3]
Further work will be required to assess the association between the SCZ -associated GWAS variants and MIR1307 expression levels in the brain. [score:3]
AC005009.2 replicated with a significant p value and MIR1307 showed a clear trend toward association, with the same direction of effect, in the DLPFC data. [score:2]
As shown in Table 3, AC005009.2 replicated with a significant p value, and MIR1307 showed a clear trend toward association, with the same direction of effect, in the DLPFC data (Table 3). [score:2]
MIR1307 also maps to a highly significant SCZ GWAS locus (rs11191419, p value = 6.198e−19) in the PGC2 meta-analysis [30]. [score:1]
MIR1307 showed 10-fold higher expression in controls when compared with the undifferentiated subtype in contrast to a two-fold increase when compared with the paranoid subtype. [score:1]
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3
[+] score: 24
Among these AF -associated miRNAs, 22 were up-regulated and 20 were down-regulated (Table  3 and Figure  3B) Table 3 miRNA expression differences between AF-LAA and SR-LAA miRNA SR-LAA signal AF-LAA signal Log 2 (AF-LAA/SR-LAA) P -valueUp-regulated (n = 22*)hsa-miR-3613-3p29430633.381.07E-02hsa-miR-49429618812.675.89E-02hsa-miR-3591-3p53920691.947.14E-02hsa-miR-4485802841.835.03E-02hsa-miR-574-3p4478135161.592.41E-02hsa-miR-466118333431.502.31E-02hsa-miR-44923348341.322.73E-02hsa-let-7d-3p1463441.239.94E-02hsa-miR-4707-5p3878571.152.92E-02hsa-miR-4534791721.126.66E-02hsa-miR-3940-5p3978031.025.71E-02hsa-miR-31781853741.011.97E-02hsa-miR-15b-5p3837230.923.04E-02hsa-miR-21-5p4428190.894.66E-02hsa-miR-3196138324770.841.34E-02hsa-miR-1307-3p821450.835. [score:12]
Among these AF -associated miRNAs, 22 were up-regulated and 20 were down-regulated (Table  3 and Figure  3B) Table 3 miRNA expression differences between AF-LAA and SR-LAA miRNA SR-LAA signal AF-LAA signal Log 2 (AF-LAA/SR-LAA) P -valueUp-regulated (n = 22*)hsa-miR-3613-3p29430633.381.07E-02hsa-miR-49429618812.675.89E-02hsa-miR-3591-3p53920691.947.14E-02hsa-miR-4485802841.835.03E-02hsa-miR-574-3p4478135161.592.41E-02hsa-miR-466118333431.502.31E-02hsa-miR-44923348341.322.73E-02hsa-let-7d-3p1463441.239.94E-02hsa-miR-4707-5p3878571.152.92E-02hsa-miR-4534791721.126.66E-02hsa-miR-3940-5p3978031.025.71E-02hsa-miR-31781853741.011.97E-02hsa-miR-15b-5p3837230.923.04E-02hsa-miR-21-5p4428190.894.66E-02hsa-miR-3196138324770.841.34E-02hsa-miR-1307-3p821450.835. [score:12]
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4
[+] score: 11
severe (p<0.05) cfa-let-7d, cfa-miR-101, cfa-miR-10a, cfa-miR-1296, cfa-miR-1306, cfa-miR-1307, cfa-miR-130a, cfa-miR-136, cfa-miR-17, cfa-miR-181b, cfa-miR-196b, cfa-miR-197, cfa-miR-215, cfa-miR-22, cfa-miR-30d, cfa-miR-33b, cfa-miR-497, cfa-miR-503, cfa-miR-574, cfa-miR-628, cfa-miR-676Comparing the miRNA differential expression analyses between disease states obtained by RT-qPCR and RNAseq, we observed discordances between the two methods. [score:5]
severe (p<0.05) cfa-let-7d, cfa-miR-101, cfa-miR-10a, cfa-miR-1296, cfa-miR-1306, cfa-miR-1307, cfa-miR-130a, cfa-miR-136, cfa-miR-17, cfa-miR-181b, cfa-miR-196b, cfa-miR-197, cfa-miR-215, cfa-miR-22, cfa-miR-30d, cfa-miR-33b, cfa-miR-497, cfa-miR-503, cfa-miR-574, cfa-miR-628, cfa-miR-676 Comparing the miRNA differential expression analyses between disease states obtained by RT-qPCR and RNAseq, we observed discordances between the two methods. [score:5]
severe (p<0.05) cfa-let-7c, cfa-miR-10a, cfa-miR-1307, cfa-miR-132, cfa-miR-136, cfa-miR-181a, cfa-miR-181b, cfa-miR-196b, cfa-miR-20a, cfa-miR-30d, cfa-miR-33b, cfa-miR-34c, cfa-miR-497, cfa-miR-499, cfa-miR-676 Mild vs. [score:1]
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5
[+] score: 10
Within hsa-mir-136, hsa-mir-423, hsa-mir-376b and hsa-mir-1307, their 5p arm miRNAs have higher expression level in the normal tissue; while their 3p arm miRNAs dominated in the tumor tissue. [score:3]
As illustrated in Additional file 2, hsa-mir-1307 encodes mature miRNA at only its 3p arm by miRBase. [score:1]
According to miRBase annotation, hsa-mir-1307 encodes mature miRNA at only its 3p arm. [score:1]
In this study, we used stem-loop RT-PCR to validate the 5p arm miRNA of hsa-mir-1307 as described previously [20]. [score:1]
Figure 2 Detection of 5p arm miRNA of hsa-mir-1307. [score:1]
According to miRBase annotation, hsa-mir-1277, hsa-mir-376a-2, hsa-mir-495, hsa-mir-659, hsa-mir-1303, hsa-mir-1307 and so on encode mature miRNA at only their 3p arms. [score:1]
However, we detected additional mature miRNA at the opposite arm, the 5p arm, of hsa-mir-1307. [score:1]
As shown in Figure 2, we can specifically detect the 5p arm miRNA of hsa-mir-1307 in both normal and tumor tissue. [score:1]
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6
[+] score: 8
SNP ID small RNA ID Type Chr P-value eQTL P-value GWAS GWAS phenotype rs8033963 hsa-miR-184 mature-miRNA 15 1.98E-06 1.01E-02 BMI rs6658641 hsa-miR-197-3p mature-miRNA 1 1.57E-04 4.93E-02 BMI rs2440129 hsa-miR-195-3p mature-miRNA 17 2.44E-05 3.58E-02 BMI rs2053005 SNORD18A snoRNA 15 6.83E-09 4.57E-02 BMI rs16868443 hsa-miR-653 mature-miRNA 7 1.38E-04 3.70E-02 WHR(adjBMI) rs6658641 hsa-miR-197-3p mature-miRNA 1 1.57E-04 7.89E-04 LDL rs2986039 hsa-miR-1307-3p mature-miRNA 10 6.31E-06 1.84E-02 HDL rs6658641 hsa-miR-197-3p mature-miRNA 1 1.57E-04 1.14E-03 TCWhile on the whole, none of the cis-SNPs were genome-wide significant in the GWAS data, they were significantly enriched for nominally significant (p<0.05) SNPs in the BMI GWAS results ([65], binomial p = 0.007), indicating either their pleiotropic effect, or metabolic trait regulation through small RNA expression levels. [score:4]
SNP ID small RNA ID Type Chr P-value eQTL P-value GWAS GWAS phenotype rs8033963 hsa-miR-184 mature-miRNA 15 1.98E-06 1.01E-02 BMI rs6658641 hsa-miR-197-3p mature-miRNA 1 1.57E-04 4.93E-02 BMI rs2440129 hsa-miR-195-3p mature-miRNA 17 2.44E-05 3.58E-02 BMI rs2053005 SNORD18A snoRNA 15 6.83E-09 4.57E-02 BMI rs16868443 hsa-miR-653 mature-miRNA 7 1.38E-04 3.70E-02 WHR(adjBMI) rs6658641 hsa-miR-197-3p mature-miRNA 1 1.57E-04 7.89E-04 LDL rs2986039 hsa-miR-1307-3p mature-miRNA 10 6.31E-06 1.84E-02 HDL rs6658641 hsa-miR-197-3p mature-miRNA 1 1.57E-04 1.14E-03 TC While on the whole, none of the cis-SNPs were genome-wide significant in the GWAS data, they were significantly enriched for nominally significant (p<0.05) SNPs in the BMI GWAS results ([65], binomial p = 0.007), indicating either their pleiotropic effect, or metabolic trait regulation through small RNA expression levels. [score:4]
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7
[+] score: 7
Among them, we found that some miRNA*s such as hsa-miR-766* were significantly up-regulated in the patient group, whilst some miRNA*s such as hsa-miR-1307* were significantly down-regulated in the patient group with fold changes >2.0 and a p-value of <0.001, suggesting miRNA*s could be involved in the progression of ALL. [score:7]
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8
[+] score: 6
miRNA expression analysis by RNAseq, qRT-PCR, and Northern blot revealed that three host miRNAs were significantly up-regulated during infection (miR-1271-5p, miR-532-5p and miR-1307-3p). [score:6]
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9
[+] score: 4
Some of the up-regulated arm specific miRNAs include miR-182-5p, miR-183-5p, miR-21-5p, miR-141-5p, miR-1307-5p, miR-130b-3p, miR-196b-5p, miR-210-3p, miR-21-3p and miR-141-3p. [score:4]
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10
[+] score: 4
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-mir-15a, hsa-mir-18a, hsa-mir-33a, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-107, mmu-mir-27b, mmu-mir-126a, mmu-mir-128-1, mmu-mir-140, mmu-mir-146a, mmu-mir-152, mmu-mir-155, mmu-mir-191, hsa-mir-10a, hsa-mir-211, hsa-mir-218-1, hsa-mir-218-2, mmu-mir-297a-1, mmu-mir-297a-2, hsa-mir-27b, hsa-mir-128-1, hsa-mir-140, hsa-mir-152, hsa-mir-191, hsa-mir-126, hsa-mir-146a, mmu-let-7a-1, mmu-let-7a-2, mmu-mir-15a, mmu-mir-18a, mmu-mir-103-1, mmu-mir-103-2, mmu-mir-342, hsa-mir-155, mmu-mir-107, mmu-mir-10a, mmu-mir-218-1, mmu-mir-218-2, mmu-mir-33, mmu-mir-211, hsa-mir-374a, hsa-mir-342, gga-mir-33-1, gga-let-7a-3, gga-mir-155, gga-mir-18a, gga-mir-15a, gga-mir-218-1, gga-mir-103-2, gga-mir-107, gga-mir-128-1, gga-mir-140, gga-let-7a-1, gga-mir-146a, gga-mir-103-1, gga-mir-218-2, gga-mir-126, gga-let-7a-2, gga-mir-27b, mmu-mir-466a, mmu-mir-467a-1, hsa-mir-499a, hsa-mir-545, hsa-mir-593, hsa-mir-600, hsa-mir-33b, gga-mir-499, gga-mir-211, gga-mir-466, mmu-mir-675, mmu-mir-677, mmu-mir-467b, mmu-mir-297b, mmu-mir-499, mmu-mir-717, hsa-mir-675, mmu-mir-297a-3, mmu-mir-297a-4, mmu-mir-297c, mmu-mir-466b-1, mmu-mir-466b-2, mmu-mir-466b-3, mmu-mir-466c-1, mmu-mir-466e, mmu-mir-466f-1, mmu-mir-466f-2, mmu-mir-466f-3, mmu-mir-466g, mmu-mir-466h, mmu-mir-467c, mmu-mir-467d, mmu-mir-466d, hsa-mir-297, mmu-mir-467e, mmu-mir-466l, mmu-mir-466i, mmu-mir-466f-4, mmu-mir-466k, mmu-mir-467f, mmu-mir-466j, mmu-mir-467g, mmu-mir-467h, hsa-mir-664a, hsa-mir-1306, gga-mir-1306, hsa-mir-103b-1, hsa-mir-103b-2, gga-mir-10a, mmu-mir-1306, mmu-mir-3064, mmu-mir-466m, mmu-mir-466o, mmu-mir-467a-2, mmu-mir-467a-3, mmu-mir-466c-2, mmu-mir-467a-4, mmu-mir-466b-4, mmu-mir-467a-5, mmu-mir-466b-5, mmu-mir-467a-6, mmu-mir-466b-6, mmu-mir-467a-7, mmu-mir-466b-7, mmu-mir-467a-8, mmu-mir-467a-9, mmu-mir-467a-10, mmu-mir-466p, mmu-mir-466n, mmu-mir-466b-8, hsa-mir-466, hsa-mir-3173, hsa-mir-3618, hsa-mir-3064, hsa-mir-499b, mmu-mir-466q, hsa-mir-664b, gga-mir-3064, mmu-mir-126b, gga-mir-33-2, mmu-mir-3618, mmu-mir-466c-3, gga-mir-191
For example, human hsa-mir-1307 gene overlaps with a single host gene USMG5 (up-regulated during skeletal muscle growth 5 homolog (mouse)) gene. [score:4]
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11
[+] score: 4
Other interesting examples are shown in Figure  7. Figure  7a represents the pileup plot for miR-1307-5p. [score:1]
For the three before mentioned miRNAs, the results are presented in Table  1. miR-1307 has with 1-base window values of 31.5% (AD) and 68.1% (control) with a fold change of 0.46. [score:1]
In case of miR-1307-5p, control patients show increased frequency of 1–2 base shifts at the 3p end. [score:1]
Figure 7 a Pileup plot for miR-1307. [score:1]
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12
[+] score: 3
Six of them were overexpressed in CSCs exosomes: hsa-miR-7641, hsa-miR-148a, hsa-miR-1307-3p, hsa-miR-183, hsa-miR-139 and hsa-miR-1307-5p. [score:3]
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13
[+] score: 3
E) Follow up study hsa-miR-1307:rs11191666. [score:1]
A) Abdominal adipose tissue hsa-miR-1255a:rs1822168 (p-value = 1.83E-05 in primary study and p-value = 9.91E-03 in replication study) B) Abdominal adipose tissue hsa-miR-618: rs1716543 (p-value = 5.34E-04 in primary study and p-value = 5.80E-03 in replication study) C) Abdominal adipose tissue hsa-miR-146a*:rs2961920 (p-value = 5.87E-04e in primary study and p-value = 6.45E-06 in replication study) D) Gluteal adipose tissue hsa-miR-1255a:rs1822168 (p-value = 1.56E-05 in primary study and p-value = 1.65E-04 in replication study), E) Gluteal adipose tissue hsa-miR-1307:rs11191666 (p-value = 1.27E-04 in primary study and p-value = 3.55E-04 in replication study), F) Gluteal adipose tissue hsa-miR-330-3p:rs7252175 (p-value = 3.85E-04 in primary study and p-value = 4.04E-02 in replication study). [score:1]
A) Primary study hsa-miR-1255a:rs1822168 B) Primary study hsa-miR-1307:rs11191666. [score:1]
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14
[+] score: 3
Other miRNAs from this paper: hsa-let-7c, hsa-let-7d, hsa-mir-16-1, hsa-mir-21, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-28, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-99a, hsa-mir-101-1, hsa-mir-16-2, mmu-let-7g, mmu-let-7i, mmu-mir-27b, mmu-mir-30a, mmu-mir-99a, mmu-mir-101a, mmu-mir-125b-2, mmu-mir-126a, mmu-mir-128-1, mmu-mir-9-2, mmu-mir-142a, mmu-mir-144, mmu-mir-145a, mmu-mir-151, mmu-mir-152, mmu-mir-185, mmu-mir-186, mmu-mir-24-1, mmu-mir-203, mmu-mir-205, hsa-mir-148a, hsa-mir-34a, hsa-mir-203a, hsa-mir-205, hsa-mir-210, hsa-mir-221, mmu-mir-301a, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-27b, hsa-mir-125b-1, hsa-mir-128-1, hsa-mir-142, hsa-mir-144, hsa-mir-145, hsa-mir-152, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125b-2, hsa-mir-126, hsa-mir-185, hsa-mir-186, mmu-mir-148a, mmu-mir-200a, mmu-let-7c-1, mmu-let-7c-2, mmu-mir-16-1, mmu-mir-16-2, mmu-mir-21a, mmu-mir-24-2, mmu-mir-29a, mmu-mir-31, mmu-mir-34a, mmu-mir-148b, mmu-mir-339, mmu-mir-101b, mmu-mir-28a, mmu-mir-210, mmu-mir-221, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-125b-1, mmu-mir-128-2, hsa-mir-128-2, hsa-mir-200a, hsa-mir-101-2, hsa-mir-301a, hsa-mir-151a, hsa-mir-148b, hsa-mir-339, hsa-mir-335, mmu-mir-335, hsa-mir-449a, mmu-mir-449a, hsa-mir-450a-1, mmu-mir-450a-1, hsa-mir-486-1, hsa-mir-146b, hsa-mir-450a-2, hsa-mir-503, mmu-mir-486a, mmu-mir-542, mmu-mir-450a-2, mmu-mir-503, hsa-mir-542, hsa-mir-151b, mmu-mir-301b, mmu-mir-146b, mmu-mir-708, hsa-mir-708, hsa-mir-301b, hsa-mir-1246, hsa-mir-1277, hsa-mir-2115, mmu-mir-486b, mmu-mir-28c, mmu-mir-101c, mmu-mir-28b, hsa-mir-203b, hsa-mir-5680, hsa-mir-5681a, mmu-mir-145b, mmu-mir-21b, mmu-mir-21c, hsa-mir-486-2, mmu-mir-126b, mmu-mir-142b, mmu-mir-9b-2, mmu-mir-9b-1, mmu-mir-9b-3
Some of these miRNA*s also showed higher expression than their corresponding miRNAs, e. g., miR-1277* and miR-1307*. [score:3]
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15
[+] score: 3
Other miRNAs from this paper: hsa-let-7f-1, hsa-let-7f-2, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-32, mmu-mir-1a-1, mmu-mir-133a-1, mmu-mir-134, mmu-mir-135a-1, mmu-mir-144, mmu-mir-181a-2, mmu-mir-24-1, mmu-mir-200b, mmu-mir-206, hsa-mir-208a, mmu-mir-122, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-181a-1, hsa-mir-214, hsa-mir-200b, mmu-mir-299a, mmu-mir-302a, hsa-mir-1-2, hsa-mir-122, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-135a-1, hsa-mir-135a-2, hsa-mir-144, hsa-mir-134, hsa-mir-206, mmu-mir-200a, mmu-mir-208a, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-24-2, mmu-mir-328, hsa-mir-200c, hsa-mir-1-1, mmu-mir-1a-2, hsa-mir-181b-2, mmu-mir-25, mmu-mir-32, mmu-mir-200c, mmu-mir-181a-1, mmu-mir-214, mmu-mir-135a-2, mmu-mir-181b-1, mmu-mir-181c, hsa-mir-200a, hsa-mir-302a, hsa-mir-299, hsa-mir-361, mmu-mir-361, hsa-mir-302b, hsa-mir-302c, hsa-mir-302d, hsa-mir-367, hsa-mir-377, mmu-mir-377, hsa-mir-328, mmu-mir-133a-2, mmu-mir-133b, hsa-mir-133b, mmu-mir-181b-2, hsa-mir-20b, hsa-mir-429, mmu-mir-429, hsa-mir-483, hsa-mir-486-1, hsa-mir-181d, mmu-mir-483, mmu-mir-486a, mmu-mir-367, mmu-mir-20b, hsa-mir-568, hsa-mir-656, mmu-mir-302b, mmu-mir-302c, mmu-mir-302d, mmu-mir-744, mmu-mir-181d, mmu-mir-568, hsa-mir-892a, hsa-mir-892b, mmu-mir-208b, hsa-mir-744, hsa-mir-208b, mmu-mir-1b, hsa-mir-302e, hsa-mir-302f, eca-mir-208a, eca-mir-208b, eca-mir-200a, eca-mir-200b, eca-mir-302a, eca-mir-302b, eca-mir-302c, eca-mir-302d, eca-mir-367, eca-mir-429, eca-mir-328, eca-mir-214, eca-mir-200c, eca-mir-24-1, eca-mir-1-1, eca-mir-122, eca-mir-133a, eca-mir-144, eca-mir-25, eca-mir-135a, eca-mir-568, eca-mir-133b, eca-mir-206-2, eca-mir-1-2, eca-let-7f, eca-mir-24-2, eca-mir-134, eca-mir-299, eca-mir-377, eca-mir-656, eca-mir-181a, eca-mir-181b, eca-mir-32, eca-mir-486, eca-mir-181a-2, eca-mir-20b, eca-mir-361, mmu-mir-486b, mmu-mir-299b, hsa-mir-892c, hsa-mir-486-2, eca-mir-9021, eca-mir-1307, eca-mir-744, eca-mir-483, eca-mir-1379, eca-mir-7177b, eca-mir-8908j
A total of eight serum-specific miRNAs (eca-miR-1307, eca-miR-1379, eca-miR-7177b, eca-miR-9021, ecaub_novel-miR-1145, ecaub_novel-miR-262, ecaub_novel-miR-79, ecaub_novel-miR-932) were expressed in a tissue-specific manner, although they may derive from other tissues not analysed in the present study and therefore have to be treated with caution. [score:3]
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16
[+] score: 2
This is a total difference of >1800-fold and implies, assuming that miR-197-3p is 100% in RISC, that <0.1% of the miR-1307-5p detected in these 293 cells is actually present in RISC. [score:1]
The most highly RISC -associated endogenous miRNA, miR-197-3p, was found to be ∼59 times more RISC associated than the average miRNA, while the least RISC -associated miRNA, miR-1307-5p, was ∼31-fold less highly RISC associated than the average miRNA (Supplementary Table S1). [score:1]
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Five of these switches were very dramatic, going from > 90% of one arm in one study to > 90% of the opposite arm in the other study (fca-miR-1307, fca-miR-144, fca-miR-197, fca-miR-199 and fca-miR-33a). [score:1]
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The authors validated the effectiveness of a biomarker panel comprising five miRNAs (miR-1246, miR-1307-3p, miR-4634, miR-6861-5p, and miR-6875-5p) for BC diagnosis with 89.7% accuracy. [score:1]
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hsa-miR-10a, hsa-miR-128, hsa-miR-1307, hsa-miR-140-3p, hsa-miR-185, hsa-miR-196a, hsa-miR-25, hsa-miR-320a, hsa-miR-330-3p, hsa-miR-340, hsa-miR-423-5p, hsa-miR-629 and hsa-miR-744 significantly associated with the mitochondria of HEK293. [score:1]
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