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33 publications mentioning hsa-mir-1275

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-1275. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 35
Katsushima et al. [47] recently demonstrated that miR-1275 was downregulated during Glioma stem-like cell differentiation, together with the upregulation of its target, CLDN11, via PRC2-H3K27me3. [score:9]
Very recently, Fawzy et al. [45] showed that IGF1R is a direct target of miR-1275. [score:4]
Fawzy I. O. Hamza M. T. Hosny K. A. Esmat G. El Tayebi H. M. Ab delaziz A. I. miR-1275: A single microRNA that targets the three IGF2-mRNA -binding proteins hindering tumor growth in hepatocellular carcinoma FEBS Lett. [score:3]
In our study, the expression profiles of 3 miRNAs such as miR-181b, miR-1915 and miR-1275 were confirmed by qRT-PCR. [score:3]
Some of the analyzed miRNAs such as miR-1286, miR-1275, miR-665, miR-602 and miR-1248 did not show any corresponding target gene (Table S4). [score:3]
Katsushima K. Shinjo K. Natsume A. Ohka F. Fujii M. Osada H. Sekido Y. Kondo Y. Contribution of microRNA-1275 to claudin11 protein suppression via a polycomb -mediated silencing mechanism in human glioma stem-like cells J. Biol. [score:3]
Due to the limited amount of residual available RNA, only 11 ES samples were tested in duplicate qRT-PCR reactions for the expression of miR-181b, miR-1915 and miR-1275 (Figure 3). [score:3]
MiR-1275 could be postulated to play some critical role in ensuring highly-selective regulation of one or more target genes and perhaps determining heterogeneous cell fate. [score:3]
Consequently, miR-1275 could play a role in ES tumor progression by regulating IGF1R [46]. [score:2]
They suggested that miR-1275 can control hepatocellular carcinoma tumor growth partially through regulating the oncogene IGF2BPs and IGF1R. [score:2]
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2
[+] score: 17
It can be observed for the whole analysed group of 12 miRNAs that their overexpression is associated with increased expression of mRNA transcripts, regulated by the miRNA (except for identified decrease in the transcriptional activity of DIAPH1 with the increased expression of regulating miRNAs: hsa-miR-1275, hsa-miR-143, hsa-miR-1909, and hsa-miR-199a-5p). [score:9]
The incubation of NHDF cell cultures for 2 hours with a biological drug leads to changes in the expression of 12 miRNAs (hsa-miR-1231, hsa-miR-1275, hsa-miR-143, hsa-miR-16, hsa-miR-1909, hsa-miR-196a, hsa-miR-199a-5p, hsa-miR-22, hsa-miR-3162, hsa-miR-34a, hsa-miR-382, and hsa-miR-939), regulating the expression of the analysed transcripts. [score:6]
This situation is observed during the 2-hour incubation of the cells with the drug for three miRNAs: hsa-miR-1275, which posttranscriptionally regulates the activity of following mRNAs: ADA, HRH1, EDN1, DIAPH1, and VAMP2; hsa-miR-34a: EDNRA, VAMP2, and HRH1; hsa-miR-1909: VAMP2 and DIAPH1. [score:2]
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3
[+] score: 17
To confirm the microarray hybridization results, qRT-PCR was performed on 8 up-regulated miRNAs (miR-335, miR-146b-5p, miR-26b, miR-30b, miR-21, miR-378, miR-143 and miR-148a) [10] and 3 down-regulated miRNA (miR-155,miR-221, and miR-1275), chosen on the basis of their levels of expression on the microarray and their biological significance. [score:9]
Of all differentially expressed miRNAs, miR-1275, miR-155 and miR-1268 were down-regulated in mature adipocytes over 10-fold when compared with SVCs and hMSCs-Ad. [score:5]
Among these differentially expressed miRNAs, our group did further research for the adipogenic miRNAs in vivo and in vitro, including miR-148a [5], miR-26b [10], miR-146b [6] and miR-1275. [score:3]
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4
[+] score: 7
Das et al. (2013) analyzed global changes in the miRNA expression profile using microarrays and found that nine miRNA genes (miR-30a, miR-30e, miR-155, miR-1275, miR-3665, miR-3178, miR-4484, miR-4668-5p, and miR-4497) were differentially expressed in THP-1 cells infected with Mtb H37Rv or Mtb H37Ra strains. [score:5]
miR-1275 is associated with liver metastases of cancer (Kahlert et al., 2011) and miR-155 binds a negative regulator associated with TNF-α production (Rajaram et al., 2011). [score:2]
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5
[+] score: 7
Other miRNAs from this paper: hsa-mir-155
Claudin-11 significantly inhibits the growth of glioma stem-like cells [118], and the expression of claudin-11 is regulated by miR-1275, indicating the importance of epigenetic mechanism in the regulation of glioma stem-like cells. [score:7]
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6
[+] score: 7
According to previous reports, rRNA-contained miRNAs such as miR-663, miR-1275, miR-3648, miR-3656, miR-3687, miR-4417, and miR-4516 are associated with tumor suppression, carcinomas, neuronal differentiation, breast cancer, breast cancer/neuronal differentiation, breast cancer, and regulation of signal transducer and activator of transcription 3, respectively [103– 108]. [score:4]
In detail, miR-1268a and miR-1268b were detected from only RNA45S, and miR-1275, miR-3687, and miR-6724 were detected from only rDNA-repeating unit. [score:1]
We conceived an idea of “reversed pattern” of primary structure; for instance, miR-1275 usually exists as 5p sequence in pre-miR-1275 but might exist as 3p sequence in pre-rmiR-1275. [score:1]
Subsequently, seventeen RNA alignments identical to human mature miRNAs, namely, miR-663a, miR-663b-3p, miR-1268a, miR-1268b, miR-1275, miR-3648, miR-3656-3p, miR-3687-3p, miR-4417, miR-4466, miR-4488, miR-4492-3p, miR-4508, miR-4516, miR-4532, miR-6087, and miR-6724, were detected from the human rRNA sequences (Table 1). [score:1]
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7
[+] score: 7
Taken together the hypoxic miRNA profiles of hESCs and hMSCs were largely distinct with only miR-25-3p (upregulated), mir-1275 and miR-23a-5p (both downregulated) overlapping between the two stem cell populations. [score:7]
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8
[+] score: 7
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-19a, hsa-mir-21, hsa-mir-31, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-105-1, hsa-mir-105-2, hsa-mir-199a-1, hsa-mir-34a, hsa-mir-187, hsa-mir-199a-2, hsa-mir-205, hsa-mir-214, hsa-mir-221, hsa-let-7g, hsa-let-7i, hsa-mir-128-1, hsa-mir-141, hsa-mir-144, hsa-mir-145, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-146a, hsa-mir-200c, hsa-mir-128-2, hsa-mir-29c, hsa-mir-376a-1, hsa-mir-378a, hsa-mir-133b, hsa-mir-429, hsa-mir-487a, hsa-mir-515-1, hsa-mir-515-2, hsa-mir-526b, hsa-mir-514a-1, hsa-mir-514a-2, hsa-mir-514a-3, hsa-mir-376a-2, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-656, hsa-mir-542, hsa-mir-378d-2, hsa-mir-548e, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-2114, hsa-mir-548q, hsa-mir-548s, hsa-mir-378b, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, hsa-mir-514b, hsa-mir-378c, hsa-mir-4303, hsa-mir-4309, hsa-mir-4307, hsa-mir-4278, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-378f, hsa-mir-378g, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-378h, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-378i, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-378j, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
Twenty-six among 30 downregulated genes have been reported before such as hsa-miR-31, hsa-miR-1275, hsa-miR-526b, hsa-miR-2114, and hsa-miR-378c; and hsa-miR-4303, hsv2-miR-H13, and hsv2-miR-H10 were first reported with downregulation in gastric cancer. [score:7]
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9
[+] score: 7
Five genes (hsa-miR-494, hsa-miR-1974, hsa-miR-1275, 16S rRNA and GAPDH) were selected for microarray data validation of differential expression in either subcellular compartment. [score:3]
hsa-miR-1275 Chr6: 33967794–33967810 (−) 6p21.31 Intergenic None. [score:1]
We found that genomic locations of the mitomiRs, besides hsa-miR-513a and hsa-miR-1275 were all relevant to mitochondria. [score:1]
While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). [score:1]
Microarray data was independently verified by RT-PCR analysis assessing hsa-miR-494, hsa-miR-1275 and hsa-miR-1974. [score:1]
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10
[+] score: 7
Nineteen of the downregulated miRNAs in chronic patients were found to be associated with carcinogenesis in various organs and tissues, such as miR-1207 [40], miR-3162-5p [41, 42], miR-3196 [43, 44], miR-371b-5p [45], miR-574-5p [46, 47], miR-1225-5p [48], miR-4485 [49], miR-572 [50], miR-4299 [51], miR-3679-5p [52], miR-3940-5p [53], miR-638 [54, 55], miR-1202 [56], miR-5787 [57], miR-1973 [58], miR-4532 [59], miR-1275 [60], miR-4728-5p [61], and miR-1915-3p [62]. [score:4]
miR-1275: a single microRNA that targets the three IGF2-mRNA -binding proteins hindering tumor growth in hepatocellular carcinoma. [score:3]
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11
[+] score: 7
Prior studies using borderline tissue from colorectal liver metastases have validated the liver invasion front-specific down-regulation of miR-19b, miR-194, let-7b and miR-1275, and the tumor invasion front-specific down-regulation of miR-143, miR-145, let-7b and miR-638 [24]. [score:7]
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12
[+] score: 7
Other miRNAs from this paper: hsa-let-7b, hsa-mir-15a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-27a, hsa-mir-28, hsa-mir-30a, hsa-mir-100, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-181a-2, hsa-mir-210, hsa-mir-181a-1, hsa-mir-221, hsa-mir-1-2, hsa-mir-15b, hsa-mir-30b, hsa-mir-122, hsa-mir-132, hsa-mir-141, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-195, hsa-mir-200c, hsa-mir-1-1, hsa-mir-30c-1, hsa-mir-34b, hsa-mir-34c, hsa-mir-30e, hsa-mir-371a, hsa-mir-372, hsa-mir-373, hsa-mir-375, hsa-mir-151a, hsa-mir-429, hsa-mir-449a, hsa-mir-483, hsa-mir-193b, hsa-mir-520e, hsa-mir-520f, hsa-mir-520a, hsa-mir-520b, hsa-mir-520c, hsa-mir-520d, hsa-mir-520g, hsa-mir-520h, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-449b, hsa-mir-151b, hsa-mir-320b-1, hsa-mir-320b-2, hsa-mir-891a, hsa-mir-935, hsa-mir-1233-1, hsa-mir-548e, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-1973, hsa-mir-548q, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, hsa-mir-1233-2, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-371b, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
Among these miRNAs, hsa-miR-429 [36, 51, 52] and hsa-miR-1275 [47, 53], which are up-regulated, and hsa-miR-15b [47, 51, 53], which is down-regulated, are involved in spermatogenesis. [score:7]
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13
[+] score: 6
Another pathway that might involve miR-1275, which has been described to target IMP2 [27] and is downregulated in GBC [28]. [score:6]
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14
[+] score: 6
Five out of the ten most deregulated miRNAs (miRNAs hsa-miR-664, hsa-miR-422a, hsa-miR-584, hsa-miR-1275, and hsa-miR-491-5p) have not yet been associated with any specific functions or human diseases. [score:4]
The ten miRNAs that were most significantly deregulated included hsa-miR-145 (1.46·10 [−7]), hsa-miR-186 (2.89·10 [−7]), hsa-miR-664 (5.25·10 [−5]), hsa-miR-20b (1.48·10 [−4]), hsa-miR-422a (1.48·10 [−4]), hsa-miR-142-3p (1.54·10 [−4]), hsa-miR-584 (1.56·10 [−4]), hsa-miR-223 (1.63·10 [−4]), hsa-miR-1275 (1.16·10 [−4]) and hsa-miR-491-5p (2.83·10 [−4]). [score:2]
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15
[+] score: 6
CNV region position genotypes CNV ID functional relevance expression (mimiRNA/[18] ) conservation mir-1977 chr1:556050-556128 chrM chr1:554403-560267 2,3,4 3.1 not reported/NA primates mir-1324 chr3:75762604-75762699 chr3:75464498-75782745 1,2 1432.2 not reported/NA primates mir-548i-2 chr4:9166887-9167035 chr4:9117494-9354801 1,2 1815.3 not reported/NA primates mir-1275 chr6:34075727-34075806 chr6:34071086-34077139 1,2 2853.12) upregulated in blood cells of MS patients [41] not reported/NA primates mir-1302-2 chr9:20144-20281 chr1, 15,19 chr9:485-38531 2,3 4134_full not reported/NA primates mir-1233 chr15:32461562-32461643 chr15 chr15:32450046-32662643 2,3,4,5 6351.3 1) not reported/NA primates mir-1233 chr15:32607783-32607864 chr15 chr15:32450046-32662643 2,3,4,5 6351.3 1) not reported/NA primates mir-650 chr22:21495270-21495365 chr22:20711019-21578950 0,1,2 8103_full 1) in several tissues (mostly ovary and ovary-derived cancers)/high primatesdupl. [score:6]
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16
[+] score: 4
Interestingly, two of significantly upregulated miRNAs after IR exposures in hESC, such as hsa-mir-1275 and hsa-mir-494, were recently found to localize to mitochondria [65]. [score:4]
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17
[+] score: 4
A class of small ncRNAs, including miR-25 [7], miR-29b [8], miR-93 [9], miR-148a [10], and miR-1275 [11], have been identified as important regulators of adipogenic differentiation by targeting various genes involved in cell self-renewal and differentiation. [score:4]
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18
[+] score: 4
Top 10 up-regulated miRNAs with maximum score and high fold change were: miR-317-5p, miR-373, miR-1268, miR-191*, miR-150, miR-1275, miR-188-5p, miR-1238, miR-134 and miR-296-5p. [score:4]
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19
[+] score: 3
Differential expression between good and poor performers (minimum of two-fold difference) was observed for hsa-miR-505, hsa-miR-34a, hsa-miR-1275, hsa-miR-125a-5p, hsa-miR-449a, hsa-miR-155, hsa-miR-101#, hsa-miR-375, hsa-miR-96, hsa-miR-217 and hsa-miR-125b. [score:3]
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20
[+] score: 3
Among these miRNAs, the functions and target genes for miR-923, miR-1275, and miR-1308 are unknown. [score:3]
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21
[+] score: 3
4. Katsushima K Shinjo K Natsume A Ohka F Fujii M Osada H Contribution of microRNA-1275 to Claudin11 protein suppression via a polycomb -mediated silencing mechanism in human glioma stem-like cellsJ Biol Chem. [score:3]
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22
[+] score: 3
Moreover, many important components of innate immune system, including IRAK1 and MAPK3, are thought to be targeted by IAV -induced miRNAs (e. g., miR-7, miR-132, miR-146a, miR-187 and miR-1275) [64]. [score:3]
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23
[+] score: 3
In the latter group, altered expression levels of miR-421, miR-1275, miR-27b, miR-1201 and miR-122 have been reported. [score:3]
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24
[+] score: 2
Out of these, miR-20b, miR-342-3p (Pool A) and miR-1275, miR-145-3p, miR-151-5p, miR-27b-5p, miR-601 (Pool B) had a maximum of one off-scale/missing C [q] value (Fig. 1). [score:1]
Out of these miRNAs seven were also defined as candidate reference miRNAs (miR-20b, miR-342-3p, miR-1275, miR-145-3p, miR-151-5P, miR-27b-5p, miR-601). [score:1]
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25
[+] score: 2
Three representative miRNAs (miR-4739, miR-1275, and miR-4298) potentially interact with multiple histone mRNAs, all of which form a conspicuously similar potential 3-way junction sxRNA structure. [score:1]
In some cases, the same miRNA was observed to associate with more than one histone mRNA and as depicted in Figures 3D,E, three of the miRNAs (miR-4739, miR-1275, and miR-4298) were predicted to interact with six different histone mRNAs, all of which form a conspicuously similar structure. [score:1]
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26
[+] score: 2
Other miRNAs from this paper: hsa-mir-149
html), at least two (miR-1275 and miR-149) were previously found to be differentially expressed in blood in MS patients compared to controls [52, 53]. [score:2]
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27
[+] score: 2
Other miRNAs from this paper: hsa-mir-17, hsa-mir-18a, hsa-mir-130a, hsa-mir-132, hsa-mir-130b
Moreover, four families of miRNA (miR-18a,b, miR-17,20a,b, miR-130, and miR-1275) were found to be key hubs providing regulatory support to this functionality. [score:2]
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28
[+] score: 1
A more distinct pattern of demarcation in miRNA profiles between these two set of cell types is observed in the region of the heat map depicting miR-1275 to miR-765 (Fig. 3). [score:1]
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29
[+] score: 1
miRNA name Nuclear %Conservation [∗] hsa-miR-768-5pˆ 94.17 n/a hsa-miR-768-3pˆ 93.71 n/a hsa-miR-1299 93.17 No (hsa, ptr, ppy) hsa-miR-297 92.72 Yes hsa-miR-663b 92.17 No (hsa, ptr, ppy, oga, bta) hsa-miR-647 89.19 No (hsa, ppy) hsa-miR-595 88.09 No (hsa, ptr, mml, ppy) hsa-miR-921 83.82 No (hsa, ppy, efu)hsa-miR-593 [∗] 80.62 No (hsa, ptr, mml, ppy) hsa-miR-1183 78.28 No (hsa, ptr, ppy)hsa-miR-664 [∗] 75.44 Yes hsa-miR-1275 73.87 No (hsa, ptr, ppy) hsa-miR-574-5p 71.94 Yes [∗] Species identifiers: hsa, Homo sapiens; ptr, Pan troglodytes; mml, Macaca mulatta; ppy, Pongo pygmaeus; efu, Eptesicus fuscus; Bta, Bos Taurus; oga, Otolemur garnettii. [score:1]
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30
[+] score: 1
miR-1275 induces GSC proliferation via a polycomb mediated silencing mechanism and silencing of Claudin11 protein [96]. [score:1]
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31
[+] score: 1
miRNA △△Ct2 [−] [△△Ct] hsa-miR-1290 −10.05 1063.66 hsa-miR-1275 −9.36 655.36 hsa-miR-1260 −9.25 609.09 hsa-miR-574-3p −4.49 22.48 hsa-miR-454 −4.45 21.93 hsa-miR-148a −4.38 20.85 hsa-miR-539 −4.36 20.57 hsa-miR-223 −4.27 19.29 hsa-miR-142-5p −4.27 19.26 hsa-miR-485-3p −4.21 18.56 hsa-miR-548c-5p −4.13 17.56 hsa-miR-17 −4.12 17.41 hsa-miR-484 −4.10 17.17 hsa-miR-652 −4.09 17.01 hsa-miR-660 −4.07 16.78 hsa-miR-20b −4.06 16. [score:1]
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32
[+] score: 1
Of the four microRNAs signatures, miR-1275 negatively correlated with MtMP-dysfunction genes. [score:1]
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33
[+] score: 1
A miRNA with the same level of nucleolar accumulation as RNU44 has a normalized nucleolus/cell ratio of 1. Some miRNAs, such as miR-1275, have nucleolus/cell ratios that exceed one. [score:1]
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