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6 publications mentioning hsa-mir-1267

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-1267. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 24
a High level of six hsa-miRNAs randomly selected for the validation of expression level by qRT-PCR is consistent with the result from miRNA microarray; b Low level of six hsa-miRNAs randomly selected for the validation of expression level by real-time RT-PCR is consistent with the result from miRNA microarray Fig.  3Validation of 12 hsa-miRNAs using qRT PCR shows hsa-mir-1267, hsa-miR-4309, hsa-miR-554, hsa-miR-1272, hsa-miR-4501, hsa-miR-182-3p were up-regulated and hsa-miR-625-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-197-3p, hsa-miR-4522, hsa-miR-493-5p were down-regulated in each of the peripheral blood samples from narcolepsy patients. [score:11]
Consistent with the results from the microRNA microarray (Fig.   2a, b), hsa-mir-1267, hsa-miR-4309, hsa-miR-554, hsa-miR-1272, hsa-miR-4501, hsa-miR-182-3p were up-regulated and hsa-miR-625-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-197-3p, hsa-miR-4522, hsa-miR-493-5p were down-regulated in each of the peripheral blood samples (Fig.   3). [score:7]
Among these miRNAs with significant change, 12 hsa-miRNAs were validated by qRT PCR which showed that hsa-mir-1267, hsa-miR-4309, hsa-miR-554, hsa-miR-1272, hsa-miR-4501, hsa-miR-182-3p had significantly high expression and hsa-miR-625-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-197-3p, hsa-miR-4522, hsa-miR-493-5p had significantly low expression in each of the peripheral blood samples. [score:5]
In conclusion, we have identified 12 aberrant miRNAs (hsa-mir-1267, hsa-miR-4309, hsa-miR-554, hsa-miR-1272, hsa-miR-4501, hsa-miR-182-3p, hsa-miR-625-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-197-3p, hsa-miR-4522, hsa-miR-493-5p) in plasma from patients with sleep disorder. [score:1]
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2
[+] score: 17
The expression of hsa-miR-103a-3p, hsa-miR-211, hsa-miR-296-5p, hsa-miR-1233 and hsa-miR-1267 in whole saliva and the absence of these miRNAs in parotid saliva suggest that these miRNAs are not specifically expressed and/or secreted from the parotid gland tumor. [score:5]
Of these, 5 miRNAs (hsa-miR-296-5p, hsa-miR-577, hsa-miR-1233, hsa-miR-1267, and hsa-miR-1825) had a significantly higher expression level (lower ΔCt) in whole saliva samples from patients with a parotid gland neoplasm compared to their expression levels in whole saliva from healthy controls. [score:4]
Four of the five tumor-specific miRNAs (hsa-miR-296-5p, hsa-miR-1233, hsa-miR-1267, and hsa-miR-1825) had a significantly higher expression level in whole saliva from patients than in whole saliva from healthy controls (Table 3). [score:3]
miRNA ΔCt control mean(sd) ΔCt neoplasm mean (sd) Wilcoxon 2-sided p-value hsa-miR-103a-3p 14.32 (3.59) 10.00 (4.75) < 0.001 hsa-miR-211 14.91 (3.18) 8.56 (4.37) < 0.001 hsa-miR-296-5p 12.80 (4.15) 6.95 (4.66) < 0.001 hsa-miR-425-5p 9.96 (5.13) 2.54 (4.79) < 0.001 hsa-miR-577 10.19 (1.57) 9.66 (2.85) 0.650 hsa-miR-1233 15.74 (0.70) 9.17 (6.89) < 0.001 hsa-miR-1267 9.78 (5. 03) 4.39 (5.21) < 0.001 hsa-miR-1825 7.47 (7.46) -0.77 (3.95) < 0.001 Samples were collected from patients with a parotid gland neoplasm (n = 46) and controls (n = 14). [score:1]
miRNA ΔCt control mean (sd) ΔCt neoplasm mean (sd) Wilcoxon 2-sided p-value hsa-miR-103a-3p 6.34 (1.71) ND < 0.001 hsa-miR-211 9.45 (1.38) ND < 0.001 hsa-miR-425-5p 11.56 (3.72) ND < 0.001 hsa-miR-296-5p ND 7.41 (3.75) < 0.001 hsa-miR-577 ND 5.96 (3.44) < 0.001 hsa-miR-1233 19.14 (4.98) 8.93 (8.49) 0.002 hsa-miR-1267 ND 3.87 (2.79) < 0.001 hsa-miR-1825 20.94 (2.26) 5.17 (5.38) < 0.001 ND: non-detectable, assigned to samples with a Ct-value of 40 and higher. [score:1]
The full mo del with 7 miRNA markers (hsa-miR-103a-3p, hsa-miR-211, hsa-miR-296-5p, hsa-miR-425-5p, hsa-miR-1233, hsa-miR-1267 and hsa-miR-1825) yielded an AUC of 0.95 (95% CI: 0.88–1.00), a sensitivity of 93% and a specificity of 86%. [score:1]
miRNA ΔCt control mean(sd) ΔCt neoplasm mean (sd) Wilcoxon 2-sided p-value hsa-miR-103a-3p 14.32 (3.59) 10.00 (4.75) < 0.001 hsa-miR-211 14.91 (3.18) 8.56 (4.37) < 0.001 hsa-miR-296-5p 12.80 (4.15) 6.95 (4.66) < 0.001 hsa-miR-425-5p 9.96 (5.13) 2.54 (4.79) < 0.001 hsa-miR-577 10.19 (1.57) 9.66 (2.85) 0.650 hsa-miR-1233 15.74 (0.70) 9.17 (6.89) < 0.001 hsa-miR-1267 9.78 (5. 03) 4.39 (5.21) < 0.001 hsa-miR-1825 7.47 (7.46) -0.77 (3.95) < 0.001 Multivariate logistic regression mo dels with these miRNA biomarkers were constructed for the classification of patient samples into parotid gland neoplasm and healthy categories. [score:1]
The full mo del included 7 miRNAs (hsa-miR-103a-3p, hsa-miR-211, hsa-miR-296-5p, hsa-miR-425-5p, hsa-miR-1233, hsa-miR-1267 and hsa-miR-1825). [score:1]
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3
[+] score: 12
The expression levels of miR-17-5p, miR-593, miR-23a-5p, miR-586, miR-1180, miR-508-5p, miR-511, miR-646, miR-634, miR-149-5p, miR-24-3p, miR-1267, miR-504 and miR-1270 were upregulated. [score:6]
The expression levels of miR-17-5p, miR-593, miR-23a-5p, miR-586, miR-1180, miR-508-5p, miR-511, miR-646, miR-634, miR-149-5p, miR-24-3p, miR-1267, miR-504 and miR-1270 were upregulated (Fig. 2A) (P<0.05). [score:6]
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4
[+] score: 2
Other non-recurrent mutations identified in miRNAs were found in miR-516b1, miR-1267, miR-891a, and miR-632. [score:2]
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5
[+] score: 1
The most significant alignments with human miRNA were obtained with four pre-miRNA (pre-mir-302a, pre-let-7b, pre-mir-1267 and pre-mir-1296; E-value <0.1) and with the two miRNA (mir-365 and mir-31; E-value <0.1) Examples of alignment results show that for some candidates the seed region was perfectly aligned and some others had one or two nucleotide differences (Figure 1). [score:1]
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6
[+] score: 1
48E-051.589 rs12178 ZBTB34 0.456 hsa-miR-1267, hsa-miR-501-5p, hsa-miR-3613-3p, hsa-miR-653 A/C/G/T rs12178 1 9.66E-05 1.277 Eleven putative miRNA-related SNPs link to SCZ-GWAS SNPs with a significance of p < 0.0001. [score:1]
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