sort by

5 publications mentioning hsa-mir-1258

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-1258. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 15
Moreover, western blot analysis indicates that miR-1258 inhibits phosphorylation and expression of heparanase-related proteins AKT, EGFR, MMP-9, and COX-2, resulting in decrease of breast cancer brain metastasis [95]. [score:5]
It has been recently reported that heparanase expression and activity in brain metastatic breast cancer cell (MDA-MB-231) can be inhibited by the microRNA miR-1258 [91]. [score:5]
Thus, invasive ductal carcinoma and malignant cells showed attenuated expression of miR-1258. [score:3]
Heparanase and miRNA-1258 in Breast Cancer. [score:1]
According to this idea, it was shown that miR-1258 and heparanase levels are inversely correlated in breast carcinoma [95]. [score:1]
[1 to 20 of 5 sentences]
2
[+] score: 14
Notably, the up-regulated miR-1258 was demonstrated to target heparanase that has been speculated to be involved in astrogliosis [26, 27], thus contributing to the pathology of ischemic stroke progression by encouraging the movement of reactive astrocytes to the infarct lesion. [score:6]
We found 13 miRNAs (miR-1258, -125a-5p, -1260, -1273, -149, -220b, -302e, -34b, -490-3p, -506, -659, -920, -934) that showed similar expression in all ischemic stroke samples, target genes that are involved in proliferation, hemostasis, inflammation and oxidative stress processes (Supplementary Data Table 2). [score:5]
Twenty-one (21) miRNAs (hsa-miR-1258, -125a-5p, -1260, -1273, -149, -220b, -23a*, -25*, -26b*, -29b-1*, -302e, -34b, -483-5p, -488, -490-3p, -498, -506, -659, -890, -920, -934) were observed to have similar expression level in all ischemic stroke samples (BB, DB, E, LB, LC, LX, BE, LM; Table 1). [score:3]
[1 to 20 of 3 sentences]
3
[+] score: 14
Studies have shown that hsa-miR-1258 inhibits the expression and activity of HSPE in BMBC cells, and stable expression of hsa-miR-1258 in BMBC cells inhibits HSPE -induced cell invasion in vitro and brain metastasis in an experimental mo del 36. [score:9]
Another example is the tumor suppressor- hsa-miR-1258, which was hypermethylated on the 3′ CGI shore and was under-expressed in breast cancer samples in the present study (Figure 6E). [score:5]
[1 to 20 of 2 sentences]
4
[+] score: 12
Further data confirmed that ectopic expression of miR-1258 impaired RTA synthesis and enhanced Nef -mediated inhibition of KSHV replication [39]. [score:5]
Indeed, at least five of the 99 miRNAs upregulated by Nef (miR-557, miR-766, miR-1227, miR-1258, and miR-1301) had putative binding sites in the 3’ UTR of viral lytic reactivation activator, Rta [39]. [score:4]
Yan Q. Ma X. Shen C. Cao X. Feng N. Qin D. Zeng Y. Zhu J. Gao S. J. Lu C. Inhibition of Kaposi’s sarcoma -associated herpesvirus lytic replication by HIV-1 Nef and cellular microRNA hsa-miR-1258 J. Virol. [score:3]
[1 to 20 of 3 sentences]
5
[+] score: 9
For example, hsa-miR-1258 was confirmed to target RTA 3′UTR downregulating this reactivation factor, resulting in the reduction of KSHV reactivation [194]. [score:6]
Yan Q. Ma X. Shen C. Cao X. Feng N. Qin D. Zeng Y. Zhu J. Gao S. -J. Lu C. Inhibition of Kaposi’s sarcoma -associated herpesvirus lytic replication by HIV-1 Nef and cellular microRNA hsa-miR-1258 J. Virol. [score:3]
[1 to 20 of 2 sentences]