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7 publications mentioning hsa-mir-1182

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-1182. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 22
miRNA Tissue type Mode of action Reference miR-491-5p Cervical cancerUnknown, inhibits hTERT Zhao et al., 2015 miR-1182 Gastric cancerBinds the ORF of hTERT mRNA, preventing translation Zhang et al., 2015 miR-1207-5p Gastric cancerRepresses hTERT in normal tissues Chen et al., 2014 miR-1266 Gastric cancerRepresses hTERT in normal tissues Chen et al., 2014 miR-138 Anaplastic thyroid carcinoma (ATC)Interaction with 3′UTR of hTERT to reduce protein expression Mitomo et al., 2008 let-7g Pulmonary fibrosisInteraction with 3′UTR of hTERT to reduce expression Singh et al., 2010 miR-133a Jurkat cellsInteraction with 3′UTR of hTERT to reduce expression Hrdličková et al., 2014 miR-342 Jurkat cellsInteraction with the 3′UTR of hTERT to reduce expression Hrdličková et al., 2014 miR-541 Jurkat cellsInteraction with the 3′UTR of hTERT to reduce expression Hrdličková et al., 2014 Non-coding RNAs can also target transcription factors involved in the control of hTERT. [score:17]
miR-1182 attenuates gastric cancer proliferation and metastasis by targeting the open reading frame of hTERT. [score:3]
miR-1182 modulates hTERT protein levels by binding the open reading frame of hTERT mRNA between 2695 and 2719 within different types of gastric cancer cells. [score:1]
Upon examining tissues of patients with gastric cancer, there was an inverse correlation between miR-1182 and hTERT, which shows miR-1182 as a potential treatment of gastric cancer (Zhang et al., 2015). [score:1]
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2
[+] score: 13
Since this is part of the seed sequence, which is important for target recognition, it is likely to affect the miR-1182 regulation of the ZFP14 transcript. [score:4]
Interestingly miR-1182 has a second predicted binding site in the transcript, which strengthens the prediction that it targets ZFP14. [score:3]
Furthermore, since site-selective editing has been shown to be regulated during development with very low levels of editing during embryogenesis, it is likely that the prevention of miR-1182 binding will only occur in the mature animal. [score:3]
Editing of the 3′ UTR in this transcript may prevent processing by miR-1182 and thereby increase stability. [score:1]
We found that this single editing event has the potential to mask a predicted binding site for miR-1182, a primate-specific microRNA (miRNA). [score:1]
The unedited form of ZFP14 has a perfect match at positions 2 to 8 of miR-1182. [score:1]
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3
[+] score: 12
MiR-1182 is other h TERT 3’UTR modulator that is downregulated in bladder cell lines and tumor tissues, and whose overexpression was able to inhibit cell proliferation, colony formation, and invasion [171]. [score:7]
Specifically, miR-1182, miR-1207-5p, miR-1266, miR-532 and miR-3064, which bind within the h TERT 3’UTR, are downregulated and associated with a poor clinical outcome in bladder, gastric and ovarian cancer [169– 171]. [score:4]
Furthermore, miR-1182 induced chemosensitivity to cisplatin in bladder cancer, and thus, might eventually contribute for a better patient’s response to cisplatin -based chemotherapy [171]. [score:1]
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4
[+] score: 6
Recent studies demonstrated that miR-138, miR-133a, miR-342, miR-491-5p, miR-541, miR-1207-5p, miR-1266 and miR-1182 control hTERT expression in leukemic T-cell lymphoblasts, gastric cancer, cervical cancer, thyroid carcinoma and head and neck squamous cell carcinoma [28– 31, 33]. [score:3]
Recent studies reported a role of miR-133a, miR-138, miR-541, miR-491-5p, miR-512-5p, miR-1182, miR-1207-5p and miR-1266 in the control of hTERT expression in various types of cancer cells [27– 33]. [score:3]
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5
[+] score: 3
org/) [20] revealed that all three SNPs are located within potential miRNA target sites: rs17592236 (miR-137), rs4946936 (miR-1182), rs4503258 (miR-1322). [score:3]
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6
[+] score: 3
Zhang D. Xiao Y. F. Zhang J. W. Xie R. Hu C. J. Tang B. Wang S. M. Wu Y. Y. Hao N. B. Yang S. M. miR-1182 attenuates gastric cancer proliferation and metastasis by targeting the open reading frame of hTERTCancer Lett. [score:3]
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7
[+] score: 1
In A33-Exos, we found two known pre-miRNAs (H19 and MIR1182) and five novel pre-miRNAs. [score:1]
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