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7 publications mentioning rno-mir-770

Open access articles that are associated with the species Rattus norvegicus and mention the gene name mir-770. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 69
To verify the reliability of the miRNA sequencing results, the most upregulated (miR-500-3p and miR-770-3p) and downregulated (miR-450a-5p and miR-196c-3p) miRNAs in the exosomes derived from old rats in comparison to those from young rats, were selected for further verification using quantitative real-time PCR (qRT-PCR). [score:7]
To understand more thoroughly how miR-500-3p and miR-770-3p may contribute to the aging and CR, we predicted their target genes using TargetScan and analyzed the biological processes, pathways, and protein classes associated with each of the miRNAs using the PANTHER database. [score:5]
The result showed significant downregulation of miR-500-3p and miR-770-3p, which was significantly increased in old rats in comparison to young rats. [score:4]
Among identified miRNAs, miR-500-3p and miR-770-3p, the most highly upregulated miRNAs with aging were significantly decreased by CR. [score:4]
Enrichment analysis for biological processes, pathways, and protein classes of target genes regulated by miR-500-3p and miR-770-3p. [score:4]
ROC curves for classifying the serum exosomal miRNAs from young and old rats were produced using the expression values for (A) miR-500-3p and (B) miR-770-3p. [score:3]
Therefore, miR-500-3p and miR-770-3p may similarly contribute to accelerate the age-related senescence of stem cells and proliferating cells as well as age -associated inflammatory diseases. [score:3]
Particularly, both miR-500-3p and miR-770-3p could mainly target the transcription factors that control the gene transcription and genes involved in the Wnt/chemokines and cytokines-related inflammatory signaling pathways. [score:3]
In addition, we have examined the expression of miR-500-3p and miR-770-3p in serum of young, old, and old-CR rats. [score:3]
In particular, we found that the expression of miR-500-3p and miR-770-3p was significantly increased with aging, whereas these were decreased by CR. [score:3]
Figure 4ROC curves for classifying the serum exosomal miRNAs from young and old rats were produced using the expression values for (A) miR-500-3p and (B) miR-770-3p. [score:3]
Target genes and functional prediction of miR-500-3p and miR-770-3p. [score:3]
Figure 3A showed that the expression of miR-500-3p and miR-770-3p was significantly increased in the old group compared to that in the young group. [score:2]
Finally, using PANTHER analysis, we identified that both miR-500-3p and miR-770-3p might control the gene transcription through regulation of transcription factors and Wnt/chemokines and cytokines-related inflammation signaling pathways during aging. [score:2]
ROC curve analysis of miR-500-3p and miR-770-3p in the serum exosomes of young and old rats. [score:1]
The area under the curve (AUC) for miR-500-3p and miR-770-3p were 0.823 and 0.826, respectively. [score:1]
There are limited previous published reports on miR-500-3p and miR-770-3p which were found in our study. [score:1]
Therefore, exosomal miR-500-3p and miR-770-3p could be potential biomarkers candidates to study aging. [score:1]
Furthermore, we analyzed the role of miR-500-3p and miR-770-3p in aging using PANTHER, a bioinformatics software. [score:1]
This analysis suggests that miR-500-3p and miR-770-3p may be involved in similar biological functions in aging process. [score:1]
Therefore, Figure 3 demonstrates that the qRT-PCR results for miR-500-3p, miR-770-3p, and miR-450a-5p were consistent with those of the RNA sequencing data. [score:1]
We found that among analyzed miRNAs, miR-500-3p and miR-770-3p were modulated by aging and CR. [score:1]
qRT-PCR was used to investigate the expression of (A) miR-500-3p, miR-770-3p, (B) miR-450a-5p, and miR-196c-3p. [score:1]
Therefore, we may need further investigation on miR-500-3p and miR-770-3p expression in human serum exosome to strengthen their potential role as aging biomarkers. [score:1]
miR-500-3p and miR-770-3p, that were significantly changed in both aging and diet, were selected for further analysis. [score:1]
Exosomal miR-500-3p and miR-770-3p as candidates for aging. [score:1]
Therefore, expression of exosomal miR-500-3p and miR-770-3p in aged rat serum might present further possibilities as potential candidates for investigating the aging process. [score:1]
There are no previously published reports on miR-770-3p. [score:1]
The findings from our study provide the notion that miR-500-3p and miR-770-3p in serum exosomes of aging rats might be potential candidates to understand aging and CR. [score:1]
Figure 3qRT-PCR was used to investigate the expression of (A) miR-500-3p, miR-770-3p, (B) miR-450a-5p, and miR-196c-3p. [score:1]
Therefore, it suggests that miR-500-3p and miR-770-3p possess exosome specificity. [score:1]
Therefore, modulation of exosomal miR-500-3p and miR-770-3p by CR may underlie the anti-aging effects. [score:1]
Therefore, further studies are required to clarify the cells or tissues of origin for miR-500-3p and miR-770-3p delivering exosomes and the detailed role of these two miRNAs in the aging process. [score:1]
These data suggests that exosomal miR-500-3p and miR-770-3p could be used to discriminate old rats from young rats. [score:1]
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2
[+] score: 20
Among the 11 significantly dysregulated miRNAs, 4 miRNAs were up-regulated (miR-34c, miR-374, miR-181a, and miR-let-7c-1), and 7 miRNAs were down-regulated (miR-1188, miR-770-5p, miR-127-5p, miR-375, miR-331, miR-873-5p, and miR-328a) (differentially expressed miRNAs were defined by a fold-change >1.5, up or down-regulated; p <0.05). [score:13]
Some of the up-regulated (miR-34c, miR-374, miR-181a, and miR-let-7c-1) and down-regulated (miR-1188, miR-770-5p, miR-127-5p, miR-375, miR-331, miR-873-5p, and miR-328a) miRNAs we detected using miRNA microarray were suggested to be closely connected with memory function. [score:7]
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3
[+] score: 12
miR-770, which was up-regulated in this study, may exert regulatory actions on the activity of Raf1. [score:5]
Levels of miR-144, miR-451, and miR-770 were significantly down-regulated in CCA rats (p < 0.05 vs. [score:4]
Some alteration in miRNA expression following cocaine exposure may persist for a long time, even still being evident after a long-term abstinence from cocaine administration, such as miR-144, miR-451 and miR-770 in this study. [score:3]
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4
[+] score: 8
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-16-1, hsa-mir-17, hsa-mir-21, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-30a, hsa-mir-31, hsa-mir-96, hsa-mir-99a, hsa-mir-16-2, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-182, hsa-mir-183, hsa-mir-211, hsa-mir-217, hsa-mir-218-1, hsa-mir-218-2, hsa-mir-221, hsa-mir-222, hsa-let-7g, hsa-let-7i, hsa-mir-15b, hsa-mir-23b, hsa-mir-30b, hsa-mir-125b-1, hsa-mir-132, hsa-mir-143, hsa-mir-145, hsa-mir-191, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-126, hsa-mir-184, hsa-mir-190a, hsa-mir-195, rno-mir-322-1, rno-let-7d, rno-mir-335, rno-mir-342, rno-mir-135b, hsa-mir-30c-1, hsa-mir-299, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-379, hsa-mir-382, hsa-mir-342, hsa-mir-135b, hsa-mir-335, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-15b, rno-mir-16, rno-mir-17-1, rno-mir-21, rno-mir-23a, rno-mir-23b, rno-mir-24-1, rno-mir-24-2, rno-mir-25, rno-mir-26a, rno-mir-26b, rno-mir-30c-1, rno-mir-30e, rno-mir-30b, rno-mir-30d, rno-mir-30a, rno-mir-30c-2, rno-mir-31a, rno-mir-96, rno-mir-99a, rno-mir-125a, rno-mir-125b-1, rno-mir-125b-2, rno-mir-126a, rno-mir-132, rno-mir-143, rno-mir-145, rno-mir-183, rno-mir-184, rno-mir-190a-1, rno-mir-191a, rno-mir-195, rno-mir-211, rno-mir-217, rno-mir-218a-2, rno-mir-218a-1, rno-mir-221, rno-mir-222, rno-mir-299a, hsa-mir-384, hsa-mir-20b, hsa-mir-409, hsa-mir-412, hsa-mir-489, hsa-mir-494, rno-mir-489, rno-mir-412, rno-mir-543, rno-mir-542-1, rno-mir-379, rno-mir-494, rno-mir-382, rno-mir-409a, rno-mir-20b, hsa-mir-542, hsa-mir-770, hsa-mir-190b, hsa-mir-543, rno-mir-466c, rno-mir-17-2, rno-mir-182, rno-mir-190b, rno-mir-384, rno-mir-673, rno-mir-674, rno-mir-31b, rno-mir-191b, rno-mir-299b, rno-mir-218b, rno-mir-126b, rno-mir-409b, rno-let-7g, rno-mir-190a-2, rno-mir-322-2, rno-mir-542-2, rno-mir-542-3
MiRNAs found to be primarily down-regulated in DHT -treated rats includes rno-miR-770, rno-miR-466c, rno-miR-21, rno-miR-31, rno-miR-182, rno-miR-183, rno-miR-96, rno-miR-132, rno-miR-182, rno-miR-384-3p and rno-miR-184. [score:4]
Thus, it is possible that the down-regulation of miRNAs (rno-miR-770, rno-miR-466c, rno-miR-31, rno-miR-183, rno-miR-96, rno-miR-132, rno-miR-182, rno-miR-384-3p and rno-miR-184) observed in this study could be associated with promoted thecal hyperandrogenesis [37, 38]. [score:4]
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5
[+] score: 7
LncRNA MEG3 also was found to function as a ceRNA of several miRNAs, for instance, miR-125a-5p in immune thrombocytopenic purpura [13], miR-770-5p in Hirschsprung’s disease [22]. [score:3]
PCGEM1 stimulates proliferation of osteoarthritic synoviocytes via targeting miR-770 [8]. [score:3]
The competing endogenous RNA (ceRNA) hypothesis suggested that lncRNAs functioned as a ceRNA of miRNAs to play important roles, for example, PCGEM1 acted as a ceRNA of miR-770 in OA [8]. [score:1]
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6
[+] score: 4
And 17 miRNAs are downregulated as shown in the lower part of this figure, let-7d, miR-665, miR-125b*, let-7b*, miR-124*, miR-770, miR-383, miR-29b-2*, miR-760-3p, miR-324-3p, miR-135b, miR-21, miR-409-5p, let-7f-1*, miR-28, miR-499*,let-7i* (Table 2). [score:4]
[1 to 20 of 1 sentences]
7
[+] score: 3
According to our RNA-seq data, only 10 of 438 currently annotated miRNAs are expressed in the hippocampus of adult rats (Mir155hg, Mir3084d, Mir770, Mir3577, Mir1949, Mir3597-2, Mir568, Mir1843b, Mir3064, and Mir664-2). [score:3]
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