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2 publications mentioning dme-mir-959

Open access articles that are associated with the species Drosophila melanogaster and mention the gene name mir-959. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 20
Surprisingly, expression pattern analysis did not localize expression of the miR959- 964 to circadian-relevant neurons, despite the fact that elimination of four of six miRNAs (miR959- 962) displayed mild effects on the circadian period (approximately 0.5 h shorter), and overexpression of the cluster in TIM -positive neurons extended the period for more than 1 h [59]. [score:7]
In fact, this cluster is expressed in the peri-cerebral fat body (adult head fat body), an organ involved in metabolism and immunity [60], a finding that is consistent with the predication that most mRNA targets of miR959- 964 are implicated in metabolic and immune functions. [score:5]
Unlike miR- 124 -mediated regulation of the locomotion phase, the miR959- 964 cluster mainly regulates the phase of feeding and immune function [59] (Table  1). [score:3]
The miR959 ~  964 cluster negatively modulates immune response, as the knockdown line exhibited dramatically lowered survival of the pathogen Pseudomonas aeruginosa [59]. [score:2]
The pri-miRNA cluster of miR959- 964 displays an even stronger oscillation than individual mature miRNAs do. [score:1]
The miR959- 964 cluster, which includes six miRNAs, is encoded by two introns proximal to the protein-coding gene, CG31646 [59]. [score:1]
This oscillation is abolished, and levels accumulate in the arrhythmic per [01] mutant, and, oppositely, mature miR959- 964 levels are reduced in the per [01] mutant. [score:1]
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2
[+] score: 12
Additionally, we have revealed in our screen that miR-959 is a general stress response miRNA that is significantly downregulated in the hyperthermic condition regardless of the genomic background. [score:4]
The level of miR-959 is decreased at 33°C in all three genotypes, and is not affected by the mutations. [score:2]
We were particularly interested in Dys signaling miRNA regulation, thus we tested the “Dys Dependent” cluster from Figure  2d: miR-956, miR-252, miR-124, miR-970, miR-283, miR-927, miR-iab-4-5p, miR-962, miR-980, miR-959, and miR-975 (Additional file 1). [score:2]
Potential Dys-regulated miRNAs are miR-956, miR-252, miR-980, miR-124, miR-970, miR-283, miR-927, miR-iab-4-5p, miR-962, miR-959, and miR-975. [score:2]
We also found that miR-959 is a general high temperature stress response miRNA (Figure  3b). [score:1]
Dystrophic miRNAs revealed are miR-956, miR-980, miR-984, miR-975, miR-959, miR-iab-4-5p and miR-1003. [score:1]
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