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5 publications mentioning bmo-mir-124

Open access articles that are associated with the species Bombyx mori and mention the gene name mir-124. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 37
Our results show that miRNAs display a wide variety of expression profiles over the whole life of the silkworm, including continuous expression from embryo to adult (miR-184), up-regulation over the entire life cycle (let-7 and miR-100), down-regulation over the entire life cycle (miR-124), expression associated with embryogenesis (miR-29 and miR-92), up-regulation from early 3 [rd ]instar to pupa (miR-275), and complementary pulses in expression between miR-34b and miR-275. [score:18]
miR-124 was sharply up-regulated to peak levels from the time of its initial expression in the day 6 embryo, followed by down-regulation, despite waning in early 2 [nd ]and early 3 [rd ]instar larvae and early 3 [rd ]molt larvae, and waxing in late 2 [nd ]and late 3 [rd ]instar larvae and late 3 [rd ]molt larvae. [score:9]
miR-124 was typically down-regulated during silkworm development from day 6 embryo to adult moth, and undetectable after the 3 [rd ]instar larva stage (Figure 1A, Additional file 4). [score:5]
At this time-point, 8 miRNAs were initially expressed (including miR-29b, miR-34b, and miR-124). [score:3]
The miR-124 level at the late 1 [st ]instar larval stage was two-fold higher than that during the early 1 [st ]instar larval stage. [score:1]
anti-miR-276-5p, anti-miR-124 and anti-miR-263b displayed signals higher than the threshold of 1,000 at the late 3 [rd ]molt and 4 [th ]molt stages. [score:1]
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[+] score: 13
miR-124 and its antisense transcript showed a high degree of co -expression in the four tissues of fifth-instar day 7 larvae, but expression differences appeared in the larvae at the onset of cocoon spinning, and became greater in the following stages. [score:5]
Similarly, miR-124 is restricted to the central nervous system of the fruit fly [17] and only expressed in the brain of mouse [32]. [score:3]
For example, strong expression signals of miR-124 (No. [score:3]
In total, 63 miRNAs displayed significant alterations in abundance in at least 1 tissue during the developmental transition from larvae to pupae (e. g., bmo-miR-263b and bmo-miR-124). [score:2]
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[+] score: 6
The remaining 39 known miRNAs, including bmo-mir-124 and bmo-mir-1926, were not successfully sequenced, possibly because of low expression levels or stage-/tissue-specific transcription. [score:3]
For example, we could not identify bmo-mir-124 in the present study, but this miRNA was confirmed to be strongly expressed in the embryo and early larval stages of the silkworm [28]. [score:3]
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[+] score: 4
Several of the conserved miRNA, e. g, miR-124, miR-183, miR-193 and miR-210, were expressed at extremely low levels in different stages (Table 3). [score:3]
For instance, miR-124 and miR-183 were found in retina of mouse and Drosophila, respectively [44- 46]. [score:1]
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[+] score: 3
The contrary results were found among bmo-let-7, bmo-miR-1, bmo-miR-100, bmo-miR-124, bmo-miR-137, bmo-miR-14, bmo-miR-252, bmo-miR-275, bmo-miR-305, bmo-miR-307, bmo-miR-34, and bmo-miR-279c, where the literature -based collections showed higher expression levels (Additional file 12: Table S7). [score:3]
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