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33 publications mentioning bta-mir-148a

Open access articles that are associated with the species Bos taurus and mention the gene name mir-148a. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 208
Note that EGFR expression in PCa cells is negatively regulated by MIG6 [337], which is a direct target of miRNA-148a [278]. [score:7]
Whereas veterinary medicine unintentionally further increases the burden of miRNA-148a for the human milk consumer, lipidologists are concerned about high expression of miRNA-148a in the context of dyslipidemia and cardiovascular disease and recommend miRNA-148a inhibition as a promising therapeutic approach [406]. [score:7]
Furthermore, miRNA-148a directly downregulates the expression DNMT3B [121]. [score:7]
miRNA-29 via targeting DNMT3B and miRNA-148a via targeting DNMT1 may decrease FTO promoter methylation associated with higher FTO expression resulting in decreased m [6]A levels in mRNAs. [score:7]
Rho -associated coiled-coil containing protein kinase 1 (ROCK1), a known inhibitor of myogenesis, has been identified as a direct target of miRNA-148a (Table 2) [261]. [score:6]
Milk miRNA-148a -mediated suppression of DNMT1 may thus impair the binding of MeCP2 and thus HDAC recruitment resulting in histone hyperacetylation thereby promoting the expression of developmental genes such as the NR4A subfamily of orphan nuclear receptors (Figure 2). [score:6]
Downregulation of miRNA-148a expression plays a critical role in CRC carcinogenesis and progression [339, 340, 341]. [score:6]
Milk-derived DNMT -targeting exosomal miRNAs (miRNA-148a, miRNA-152, miRNA-21, miRNA-29s) may play a pivotal epigenetic role in reducing CpG methylation of critical gene regulatory sites of FTO resulting in increased FTO expression required for increased postnatal mRNA transcription (Figure 2) [135]. [score:6]
Remember that miRNA-148a directly targets the pivotal genes regulating triglyceride synthesis (FAS), cholesterol homeostasis (LDLR), cholesterol efflux (ABCA1), and β-oxidation (CTPA1) [106]. [score:5]
The expression of DNMT1 is inversely related to the expression miRNA-148a and miRNA-152 [119, 120]. [score:5]
ACL -mediated suppression of DNMT1 occurs at least in part by promoting expression of miRNA-148a, which represses DNMT1 [244]. [score:5]
In the pathogenesis of PCa, miRNA-148a is apparently a critically ‘oncomiR’ such as miRNA-21 [342, 343, 344, 345], which is one of the earliest identified cancer-promoting ‘oncomiRs’, targeting numerous tumor suppressor genes associated with proliferation, apoptosis and invasion [346, 347, 348]. [score:5]
Pan W. Zhu S. Yuan M. Cui H. Wang L. Luo X. Li J. Zhou H. Tang Y. Shen N. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in Lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1 J. Immunol. [score:5]
Key miRNAs that are abundantly expressed in lactating bovine MECs that promote lactation performance, lipid and protein synthesis include the DNMT -targeting miRNA-148/152- and the miRNA-29 family [116, 117, 122]. [score:5]
Based on our translational insights, we have identified a fundamental epigenetic signaling motive of milk that involves the transfer of DNMT -targeting miRNAs, such as milk’s most abundant miRNA-148a, to the milk recipient. [score:5]
Continued consumption of cow’s milk and persistent uptake of bovine exosomal miRNA-148a, which is identical with human miRNA-148a, may represent an epigenetic mechanism suppressing DNMT1, which via SNCA demethylation may increase the expression of α-synuclein, a key aggregating protein in PD (Table 5). [score:5]
Milk-derived exosomal miRNAs that target DNMT1 (miRNA-148a, miRNA-21) and DNMT3B (miRNA-148a, miRNA-29b) have been suggested to play a fundamental epigenetic role for milk -induced FoxP3 expression and Treg stabilization [130, 193, 194]. [score:5]
Importantly, it has recently been demonstrated that miRNA-148a via targeting DNMT1 increased FABP4 promoter hyomethylation thereby enhancing FABP4 expression [243, 307]. [score:5]
miRNA-148a via targeting DNMT1 and subsequent promoter hypomethylation enhances adipogenic gene expression including insulin (INS), insulin-like growth factor-1 (IGF1), caveolin-1 (CAV1), leptin (LEP), PPAR-γ2 (PPARG2), fatty acid -binding protein 4 (FABP4), and lipoprotein lipase (LPL) [170, 174, 175, 179, 243]. [score:5]
Murata T. Takayama K. Katayama S. Urano T. Horie-Inoue K. Ikeda K. Takahashi S. Kawazu C. Hasegawa A. Ouchi Y. miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression Prostate Cancer Prostatic Dis. [score:5]
Milk exosomal DNMT -targeting miRNAs (miRNA-148a, miRNA-21 and miRNA-29s) may thus enhance insulin secretion required for mTORC1 -driven translation and anabolism (Figure 2). [score:5]
The DNMT1 -targeting miRNA-148a plays a critical role for the regulation of neurological development in the brain of the zebrafish [391]. [score:5]
Kim J. Zhang Y. Skalski M. Hayes J. Kefas B. Schiff D. Purow B. Parsons S. Lawler S. Abounader R. microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastoma Cancer Res. [score:4]
Notably, overexpression of miRNA-148a and miRNA-17-5p promoted triacylglycerol synthesis while knockdown of miRNA-148a and miRNA-17-5p impaired triacylglycerol synthesis in goat MECs [108]. [score:4]
Importantly, DNMT1 is a direct target of miRNA-148a [118]. [score:4]
Furthermore, miRNA-148a directly targets the mRNAs of ABCA1, LDLR and CPT1A, thus attenuates cholesterol efflux, hepatic LDL uptake, and mitochondrial fatty acid β-oxidation [106]. [score:4]
It is important to mention that MIG6 has been identified as a direct target of miRNA-148a (Table 2) [278]. [score:4]
Importantly, miRNA-148a targets the largest number of known PCa drivers [334]. [score:3]
Intriguingly, in bovine MEC cultures, the expression of miRNA-148a was stimulated by treatment with dexamethasone, insulin, and prolactin (DIP) [117]. [score:3]
Goedeke L. Rotllan N. Canfrán-Duque A. Aranda J. F. Ramírez C. M. Araldi E. Lin C. S. Anderson N. N. Wagschal A. de Cabo R. MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels Nat. [score:3]
Blocking the function of miRNA-148a with a 2′-O-methylated antisense oligonucleotide inhibitor repressed C2C12 myoblast differentiation [260]. [score:3]
Overexpression of miRNA-148a significantly promoted myogenic differentiation of both C2C12 myoblast and primary muscle cells. [score:3]
Exosomal transfer of DNMT1 -targeting miRNA-148a via cow’s milk consumption may decrease APOE and FTO methylation. [score:3]
Additionally, milk miRNA-148a -mediated FTO promoter demethylation may further enhance RNA transcription of the key adipogenic transcription factors RUNX1T1, PPARγ, CEBPα, and PGC1α via erasing m [6]A marks on their target mRNAs. [score:3]
The generation of DNMT -targeting miRNAs (miRNA-152, miRNA-148a, miRNA-29, miRNA-21) is thus a fundamental epigenetic mechanism increasing lactation-specific gene transcription thereby enhancing lactation performance as well as milk yield in domestic animals. [score:3]
In comparison to nonlactating mammary glands of the Chinese swamp buffalo, the expression of miRNA-148a among other lactation-related miRNAs significantly increased during lactation [107]. [score:3]
The medium-to-cell expression ratio of miRNA-148a was significantly elevated in these DIP -treated bovine MECs, suggesting extracellular secretion of miRNA-148a into the culture medium after hormonal stimulation of lactation [117]. [score:3]
Intriguingly, the expression of miRNA-148a was significantly elevated by DIP treatment in bovine MEC culture medium [117]. [score:3]
Zhang J. Ying Z. Z. Tang Z. L. Long L. Q. Li K. MicroRNA-148a promotes myogenic differentiation by targeting the ROCK1 gene J. Biol. [score:2]
Chen Z. Luo J. Sun S. Cao D. Shi H. Loor J. J. miR-148a and miR-17-5p synergistically regulate milk TAG synthesis via PPARGC1A and PPARA in goat mammary epithelial cells RNA Biol. [score:2]
Hu C. W. Tseng C. W. Chien C. W. Huang H. C. Ku W. C. Lee S. J. Chen Y. J. Juan H. F. Quantitative proteomics reveals diverse roles of miR-148a from gastric cancer progression to neurological development J. Proteome Res. [score:2]
In goat MECs, miRNA-148a and miRNA-17-5p have been shown to synergistically increase milk triacylglycerol synthesis via regulation of PPARGC1A and PPARA. [score:2]
In this regards, milk-miRNA-148a and miRNA-29b -mediated DNMT suppression resulting in DNA demethylation features just the opposite epigenetic signaling compared to metformin -induced DNA methylation. [score:2]
Xu Q. Jiang Y. Yin Y. Li Q. He J. Jing Y. Qi Y. T. Xu Q. Li W. Lu B. A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1 J. Mol. [score:2]
Intruigingly, a recent study provided evidence that genome-wide miRNA binding site variation between extinct wild aurochs and modern cattle identifies candidate miRNA-regulated domestication genes including MIR148a [111]. [score:2]
Taken together, miRNA-148a, the most abundant miRNA of milk, is epigenetically involved in the differentiation of Tregs, adipogenesis, myogenesis and osteogenesis. [score:1]
miRNA-148a, miRNA-148b, and miRNA-152 are three members of the miRNA-148/152 family that share substantial homology in their seed sequence. [score:1]
It should be noticed that in contrast to fermented milk, nonfermented milk contains higher amounts of bioactive miRNAs including miRNA-148a, the most abundant miRNA of cow’s milk [63]. [score:1]
It has been reported that miRNA-148a-3p levels increased after homogenization and thus pressure -induced dispersion of MFGs [130]. [score:1]
Intriguingly, recent evidence links miRNA-148a to the promotion of LNCaP prostate cell growth [334]. [score:1]
Notably, miRNA-148a is highly expressed in human and bovine milk fat [49, 130] and has been measured in substantial amounts in bovine skim milk and human milk exosomes [43]. [score:1]
Milk-derived miRNA-148a and miRNA-21 are critically involved in adipogenesis. [score:1]
Muroya et al. [117] reported that elevated miRNA-148a levels in DIP -treated bovine MECs are associated with their increase in milk during the bovine lactation period. [score:1]
It is of critical importance to appreciate that the nucleotide seeding sequences of miRNA-148a-3p, miRNA-21-5p, and miRNA-29b-1-3p of Homo sapiens and Bos taurus are identical (mirbase. [score:1]
The addition of cow milk as an exogenous source of miRNA-148a to LNCaP prostate cancer cells in vitro stimulated PCa cell growth producing an average increase in growth rate of over 30% [335]. [score:1]
Taken together, cow’s milk transfers obesogenic and orexigenic miRNAs, predominantly miRNA-148a and miRNA-21, that maintain an epigenetic status that is intimately involved in the pathogenesis of diabesity. [score:1]
miRNA-148a-3p is by far the most abundant miRNA detected in human milk, bovine colostrum and bovine mature milk, porcine colostrum and porcine mature milk [37, 40, 41, 43, 130]. [score:1]
Thus, milk-derived miRNA-148a loaded exosomes may substitute miRNA-148a deficiency in colorectal adenoma cells thereby preventing their further progression to CRC. [score:1]
miRNA-148a is not only involved in adipogenesis but also enhances myogenic differentiation. [score:1]
Exosomal milk-derived miRNA-148a and miRNA-21 may thus provide oncogenic signals inducing an epigenetic landscape for tumorigenesis maintained by the consumption of cow’s milk in the majority of cancers except CRC. [score:1]
It is thus conceivable that milk-derived exosomal miRNA-148a and miRNA-29 support the epigenetic program of myogenesis. [score:1]
It is possible that MFGs of nonpasteurized cow’s milk release miRNA-148a carried in crescent exosomes [52]. [score:1]
One of the five most abundant exosomal miRNAs isolated from bone marrow derived mesenchymal stem cells, which is involved in osteogenic differentiation, is miRNA-148a [270]. [score:1]
In this regard, milk-derived exosomal miRNA-148a may promote epidermal proliferation as well as proliferation of other EGFR -dependent cells (Table 4) [279]. [score:1]
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2
[+] score: 66
Intriguingly, among the miRNAs tested, the elevated miR-148a expression and the reduced miR-339a expression in the BMEC culture media were consistent with the expression ratio of the medium to the cells, indicating that both the biogenesis and the secretion of those miRNAs were changed cooperatively. [score:7]
In addition, the medium/cell ratio of miR-148a expression was up-regulated with induction of lactogenic differentiation in BMECs in this study. [score:6]
In addition, it is especially unique that the miR-148a expression in the medium was up-regulated in the DIP -treated BMECs compared to that in the untreated cells (P = 0.013). [score:5]
The miR-148a that is secreted by BMECs into milk may thus affect its target gene expression in the recipient cells of the secreted miRNA, such as that in muscles and bones [43]. [score:5]
We also observed that the expression level of miR-148a in the culture medium of DIP -treated BMEC was higher than that in the untreated cell culture medium in the present study, although its expression in the cells did not change with DIP treatment. [score:5]
In a cell culture medium, miR-339a expression was lower and miR-148a expression was higher in the DIP -treated culture than in the untreated culture. [score:5]
The medium-to-cell expression ratios of miR-103 (P = 0.025), miR-148a (P < 0.001), and miR-223 (P = 0.013) were elevated in the DIP -treated BMECs, suggesting that the lactogenic differentiation -induced secretion of these three miRNAs in BMECs. [score:3]
A total of 630 bovine genes are predicted as the targets of miR-148a. [score:3]
Intriguingly, miR-148a is unique in that its elevated expression in milk and MGT during lactation has been consistently reported [2, 3, 7]. [score:3]
In addition, miR-148a is associated with osteogenic differentiation [37] and angiogenesis in breast cancer by targeting not only v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ERBB3) [38] but also DNA methyltransferase-1 (DNMT1), insulin-like growth factor-1 receptor (IGF-1R), and insulin receptor substrate-1 (IRS-1) [39]. [score:3]
As well as miR-148a, miR-103 and miR-223 expression in BMEC culture media was also elevated by DIP-treatment, suggesting secretion of miR-103 and miR-223 in BMEC was also enhanced by lactogenic hormones. [score:3]
It was reported that miR-148a promotes myogenic differentiation by targeting the Rho -associated coiled-coil containing protein kinase 1 (ROCK1) gene [36]. [score:3]
Intriguingly, the miR-148a expression in cell culture medium was elevated by DIP treatment of BMEC culture (P = 0.018). [score:3]
These results suggest that the increase in miR-148a expression in milk during lactation may be due to the elevated secretion of miR-148a by differentiated mammary epithelial cells. [score:3]
Bioinformatic analysis of miR-148a resulted in the extraction of GO terms associated with the regulation of transcription, angiogenesis, and the phosphate metabolic process. [score:2]
The ratios of miR-25, miR-103, miR-148a, and miR-223 were elevated (P = 0.062, = 0.025, < 0.001, and = 0.014, respectively) but those of miR-107, miR-182, and miR-339a were reduced in the DIP -treated BMECs (P = 0.057, = 0.022, and = 0.020, respectively) in comparison to those in the untreated cells (Fig.   4c). [score:1]
The elevated miR-148a level during BMEC differentiation may be associated with its increase in milk during the lactation period of cows, though secretion of milk proteins is not determined in the present study. [score:1]
The genes related to these events in potential recipient cells of miR-148a may also be affected by the miR-148a in milk. [score:1]
Of those, miR-7b, miR-21-5p, miR-23-3p, miR-26a, miR-30a, miR-103, miR-107, miR-148a, miR-200c, and miR-320a were among the top 30 most abundant miRNAs in the milk. [score:1]
The elevated miR-148a level in DIP -treated BMECs may be associated with its increase in milk during the lactation period of cows. [score:1]
The role of miR-148a secreted in milk remains unknown, however. [score:1]
In particular, the content of miR-148a in bovine milk is elevated during 5 months of lactation [2, 3], whereas those of let-7a, miR-25, miR-30d, miR-182, miR-191, miR-200c, and miR-375 are reduced within the first month of lactation [2]. [score:1]
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3
[+] score: 60
Thus, milk orchestrates both pro-survival and anti-apoptotic signaling, a most favorable constellation for the growing infant but a disastrous promoter of diseases in patients associated with disrupted p53 homeostasis such as acne vulgaris and prostate cancer Milk miRNA-148a -mediated DNMT1 suppression may thus modify chromatin structure, unwinding chromatin to allow access to the DNA sequence and subsequent transcription, important regulatory events for the growing mammal. [score:6]
Thus, milk orchestrates both pro-survival and anti-apoptotic signaling, a most favorable constellation for the growing infant but a disastrous promoter of diseases in patients associated with disrupted p53 homeostasis such as acne vulgaris and prostate cancer Milk miRNA-148a -mediated DNMT1 suppression may thus modify chromatin structure, unwinding chromatin to allow access to the DNA sequence and subsequent transcription, important regulatory events for the growing mammal. [score:6]
The expression of DNMT1 is thus inversely related to the expression miRNA-148a and its family homolog miRNA-152 [57, 58]. [score:5]
The increased cellular expression of miRNA-148a was associated with a significant decrease in the expression of DNMT1 [13]. [score:5]
Importantly, DNMT1 is a direct target of miRNA-148a [56]. [score:4]
miRNA-148a homology of DNMT1 -targeting miRNA-148a is regarded as an ancestral epigenetic regulator in various mammalian species [13]. [score:4]
Importantly, it has recently been shown that the expression of miRNA-148a of normal colon cells (CRL1831) and K562 leukemia cells increased after incubation with milk exosomes and the fat layer isolated from human milk [13]. [score:3]
In fact, recent co -expression and network and pathway analyses identified bovine miRNA-148a as a major determinant enhancing milk yield [62]. [score:3]
Genetic and epigenetic selection of dairy cows intended to increase lactation performance and milk yield further enhances the expression of lactation-promoting miRNAs such as miRNA-148a [50, 59]. [score:3]
Thus, reduced DNMT1 expression via continued uptake of milk-derived DNMT1-tageting miRNA-148a may promote EMT and the CSC phenotype facilitating PCa progression [158]. [score:3]
Furthermore, miRNA-148a is highly expressed in human and bovine milk fat [13, 50, 51] and has been detected in substantial amounts in bovine skim milk and human milk exosomes [13, 25, 34]. [score:3]
Lactogenic hormones such as prolactin induce cellular and extracellular miRNA-148a expression in bovine MECs [59]. [score:3]
These data correspond to the findings of Do et al. [53] who confirmed that miRNA-148a belongs to the most abundantly expressed miRNA of bovine milk since it accounts for more than 10% of the read counts in each stage of dairy cow lactation. [score:3]
Golan-Gerstl et al. [13] recently demonstrated that miRNA-148a-3p represents the top one miRNA of pasteurized skim milk (16.09% of all miRNAs) and the top two miRNA of pasteurized milk fat (7.16%), respectively. [score:1]
miRNA-148a is by far the most abundant miRNA detected in human milk, bovine colostrum and mature cow’s milk, porcine colostrum and mature porcine milk [25, 34, 38, 39, 49– 51]. [score:1]
Notably, the vast majority of cow milk-derived miRNA-148a has been shown to survive pasteurization, homogenization, and the attacks of digestive enzymes in comparison to untreated cow’s milk [13, 26, 50]. [score:1]
Notably, there was no significant difference in the levels of miRNA-148a, miRNA-21 and miRNA-25 between in vitro digested exosomes and their respective undigested controls [26]. [score:1]
The absence of miRNA-148a and related DNMT1 signaling may explain why miRNA -deficient milk protein powder did not affect prostate tumor progression in two mouse mo dels of benign and neoplastic lesions [159], whereas commercial milk including bioactive miRNAs added to PCa cells in culture significantly promoted cell proliferation [131]. [score:1]
miRNA-148a, miRNA-148b, and miRNA-152 are three members of the miRNA-148/152 family, which shares substantial homology in their seed sequences [54]. [score:1]
Furthermore, miRNA-148a has been shown to induce milk triacylglycerol synthesis in goat MECs [60]. [score:1]
It is of critical importance to mention that the mature and seed sequences of human and bovine miRNA-148a are identical (Table 1). [score:1]
It is possible that milk fat globules (MFGs) of cow’s milk release miRNA-148a carried in crescent exosomes of MFGs [52], especially after the process of homogenization [50]. [score:1]
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4
[+] score: 36
Highly up-regulated miRNAs were bta-miR-15b, bta-miR-17-3p, bta-miR-16b, bta-miR-148a, bta-miR-26b, bta-miR-101, bta-miR-29b, bta-miR-27b and bta-miR-215 (≥10 magnitude of Fold Regulation) whereas bta-miR-148b, bta-miR-199a-3p, bta-miR-122, bta-miR-200b and bta-miR-10a (≤−10 magnitude of Fold Regulation) were highly down-regulated in cows with metritis compared to control cows (Table 2). [score:8]
The E. coli infection may have down-regulated the genes necessary for the uterine involution through up-regulation of bta-miR-148a. [score:7]
Serum levels of miR-16, miR-17, miR-20a, miR-20b, miR-26a, and miR-26b were up-regulated in an experimental sepsis condition induced by cecal ligation and puncture in mice 34, whereas over -expression of miR-21, miR-29b and miR-148a occurred in systemic lupus erythematosus 35 36. [score:6]
Differential expression of these miRNAs’ would have been an outcome of immune -mediated inflammatory responses in systemic lupus erythematosus, and in the present study, up-regulation of bta-miR-148a may be the result of uterine inflammatory processes in response to post-partum microbial infections. [score:6]
In the present study, upregulation of bta-miR-148a may have been due to E. coli infection associated with metritis. [score:4]
In addition, some of the predicted target genes for the bta-miR-148 are involved in apoptosis and matrix degradation. [score:3]
Bta-miR-184, miR-24-3p, miR-148, miR-486 and let-7a-5p were unique to E. coli, whereas bta-miR-2339, miR-499, miR-23a and miR-99b were specific to S. aureus in an in-vitro study with bovine mammary epithelial cells 32. [score:1]
Interestingly, in the current study, serum bta-miR-148b level was lower, in contrast to the higher serum level of bta-miR-148a in cows with metritis, although they belong to the same miRNA gene family. [score:1]
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5
[+] score: 32
Enrichment of transcription factors for target genes of miRNAs in the GREEN module identified significantly enriched transcription factors, such as EHMT2, ZNF350, HHEX, MITF, CCND1, TP53, SP1, RYBP, TAL1, and members of SMAD family, including SMAD 2, 3, and 7. Interestingly, miR-148a regulates HHEX, while HHEX regulates several genes, including VEGEA (targeted by miR-186), NRP1 (targeted by miR-148a), or MYH10 (targeted by miR-141 and miR-200a) in the GREEN module (Figure 2). [score:11]
Some miRNA members of the GREEN module are known to have potential roles in various aspects related to milk yield, including mammary gland development, such as miR-200a [27, 28], immune response and epigenetic upregulation, such as miR-148a [29, 30, 31], or nutrient response, such as miR-141 [18]. [score:5]
Recently, Melnik et al. [30] reviewed the epigenetic regulatory roles of miR-148a in lactation, and suggested that bovine miR-148a could be a critical factor for human health, since it is a component of milk fat globule and milk exosomes and highly expressed in milk, as well as having an identical seed region with human miR-148a. [score:4]
The transcription factor HHEX was targeted by miR-148a. [score:3]
In fact, three miRNAs (miR-148a, miR-186 and miR-200a) that displayed the highest positive correlations with milk yield (r = 0.52–0.54) (Table 2) are among the most abundantly expressed miRNAs in mammary gland tissues or milk [18, 19, 32, 33], suggesting important roles for these miRNAs during lactation [34]. [score:3]
For instance, both miR-148a and miR-200a are known to be involved in the regulation of cell proliferation and death [28, 35, 36, 37], crucial processes for the regulation of milk yield. [score:3]
Guo S. -L. Peng Z. Yang X. Fan K. -J. Ye H. Li Z. -H. Wang Y. Xu X. -L. Li J. Wang Y. -L. MiR-148a promoted cell proliferation by targeting p27 in gastric cancer cellsInt. [score:2]
Moreover, Cai et al. [59] reported that promoter binding of STAT3 is required for transactivation of miR-148a (and other members of miR-17/92 cluster) in human macrophage cells following Toxoplasma infection. [score:1]
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6
[+] score: 30
According to the results of TargetScan analysis, totally 2743 bovine genes were predicted as the targets of c-miRNAs significantly down-regulated by grazing (miR-19b, miR-148a, miR-150, miR-221, miR-223 miR-320a, miR-361, and miR-486). [score:8]
In previous studies, miR-148a expression was up-regulated during mouse adipogenesis [41] and shown to promote myogenesis of C2C12 myoblasts [42]. [score:6]
Thus, the lower level of circulating miR-148a in the grazing cattle might affect expression of target genes in their skeletal muscle or adipose tissue. [score:5]
The pattern of changes in the miR-221 expression level was closely similar to that of miR-148a in the present study. [score:3]
Of these c-miRNAs, circulation levels of miR-19b, miR-148a, miR-150, miR-221, miR-223, miR-320a, miR-361, and miR-486 were significantly down-regulated in the grazing cattle compared to housed cattle, whereas the miR-451 level was higher in the grazing than in the housed cattle. [score:3]
The microRNA-148/152 family: multi-faceted players. [score:1]
Exercise-related miRNAs: miR-148a, miR-221. [score:1]
In the present study, miR-148a showed a temporarily higher circulation level at 1 mo in the housed cattle than in the grazing cattle. [score:1]
The circulating level of miR-148a decreased from baseline levels after 12 weeks of endurance training [43]. [score:1]
The results of qRT-PCR normalized with the let-7g level showed that the levels of miR-19b, miR-148a, miR-150, miR-221, and miR-361, and miR-486 in the grazing cattle were lower than those in the housed cattle at 1 mo of grazing (P = 0.013, 0.014, 0.093, 0.011, 0.041, and 0.023, respectively) (Fig 6A). [score:1]
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7
[+] score: 17
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-22, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-27a, hsa-mir-29a, hsa-mir-30a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-98, hsa-mir-99a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-106a, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-10a, hsa-mir-10b, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-182, hsa-mir-181a-1, hsa-mir-221, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-15b, hsa-mir-27b, hsa-mir-30b, hsa-mir-130a, hsa-mir-152, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-185, hsa-mir-193a, hsa-mir-320a, hsa-mir-200c, hsa-mir-1-1, hsa-mir-181b-2, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-99b, hsa-mir-130b, hsa-mir-30e, hsa-mir-363, hsa-mir-374a, hsa-mir-375, hsa-mir-378a, hsa-mir-148b, hsa-mir-331, hsa-mir-339, hsa-mir-423, hsa-mir-20b, hsa-mir-491, hsa-mir-193b, hsa-mir-181d, hsa-mir-92b, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-320b-2, hsa-mir-378d-2, bta-mir-29a, bta-let-7f-2, bta-mir-18a, bta-mir-20a, bta-mir-221, bta-mir-27a, bta-mir-30d, bta-mir-320a-2, bta-mir-99a, bta-mir-181a-2, bta-mir-27b, bta-mir-30b, bta-mir-106a, bta-mir-10a, bta-mir-15b, bta-mir-181b-2, bta-mir-193a, bta-mir-20b, bta-mir-30e, bta-mir-92a-2, bta-mir-98, bta-let-7d, bta-mir-148b, bta-mir-17, bta-mir-181c, bta-mir-191, bta-mir-200c, bta-mir-22, bta-mir-29b-2, bta-mir-29c, bta-mir-423, bta-let-7g, bta-mir-10b, bta-mir-24-2, bta-mir-30a, bta-let-7a-1, bta-let-7f-1, bta-mir-30c, bta-let-7i, bta-mir-25, bta-mir-363, bta-let-7a-2, bta-let-7a-3, bta-let-7b, bta-let-7c, bta-let-7e, bta-mir-15a, bta-mir-19a, bta-mir-19b, bta-mir-331, bta-mir-374a, bta-mir-99b, hsa-mir-374b, hsa-mir-320d-1, hsa-mir-320c-2, hsa-mir-320d-2, bta-mir-1-2, bta-mir-1-1, bta-mir-130a, bta-mir-130b, bta-mir-152, bta-mir-181d, bta-mir-182, bta-mir-185, bta-mir-24-1, bta-mir-193b, bta-mir-29d, bta-mir-30f, bta-mir-339a, bta-mir-374b, bta-mir-375, bta-mir-378-1, bta-mir-491, bta-mir-92a-1, bta-mir-92b, bta-mir-9-1, bta-mir-9-2, bta-mir-29e, bta-mir-29b-1, bta-mir-181a-1, bta-mir-181b-1, bta-mir-320b, bta-mir-339b, bta-mir-19b-2, bta-mir-320a-1, bta-mir-193a-2, bta-mir-378-2, hsa-mir-378b, hsa-mir-320e, hsa-mir-378c, bta-mir-148c, hsa-mir-374c, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-378j, bta-mir-378b, bta-mir-378c, bta-mir-378d, bta-mir-374c, bta-mir-148d
In this study, three members of this family (miR-148a, miR-148b and miR-152, Figure 12H) showed modest expression levels, suggesting that miR-148 may be a stably expressed miRNA in exosomes of most mammals including pigs. [score:5]
MiR-148a has been reported to be a tumor metastasis suppressor in gastric cancer [59], and ectopic expression of miR-148a was shown to induce apoptosis and silence Bcl-2 in colorectal cancer cells [60]. [score:5]
Furthermore, miR-148a, a potential biomarker for quality control in bovine milk [57] and human milk [28], which was found to be highly expressed throughout the lactation period of Yorkshire sows [29], was only detected at a moderate level in Landrace pigs in our study. [score:3]
By bioinformatics analysis, miR-148a was determined to be possibly related to immunity and gastrointestinal health, but the underlying regulatory mechanism remains unclear. [score:2]
In our study, 8 miRNA families (let-7, mir-1, mir-17, mir-181, mir-148, mir-30, mir-92 and mir-99) were found with at least 3 members among all exosome miRNAs. [score:1]
MiR-148a was reported to be an important biomarker for milk exosome miRNAs [28, 57]. [score:1]
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8
[+] score: 16
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-mir-21, hsa-mir-26a-1, hsa-mir-27a, hsa-mir-28, hsa-mir-30a, hsa-mir-96, hsa-mir-98, hsa-mir-99a, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-196a-1, hsa-mir-199a-1, hsa-mir-148a, hsa-mir-30d, hsa-mir-34a, hsa-mir-196a-2, hsa-mir-199a-2, hsa-mir-23b, hsa-mir-27b, hsa-mir-125b-1, hsa-mir-143, hsa-mir-145, hsa-mir-152, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-194-1, hsa-mir-194-2, hsa-mir-200a, hsa-mir-99b, hsa-mir-26a-2, hsa-mir-378a, hsa-mir-342, hsa-mir-148b, hsa-mir-338, hsa-mir-335, hsa-mir-196b, hsa-mir-484, hsa-mir-486-1, hsa-mir-1271, hsa-mir-378d-2, bta-mir-26a-2, bta-mir-103-1, bta-mir-21, bta-mir-27a, bta-mir-30d, bta-mir-484, bta-mir-99a, bta-mir-125a, bta-mir-125b-1, bta-mir-145, bta-mir-199a-1, bta-mir-27b, bta-mir-98, bta-mir-148b, bta-mir-200a, bta-mir-30a, bta-let-7a-1, bta-mir-342, bta-mir-23b, bta-let-7a-2, bta-let-7a-3, bta-mir-103-2, bta-mir-125b-2, bta-mir-34a, bta-mir-99b, hsa-mir-885, hsa-mir-103b-1, hsa-mir-103b-2, bta-mir-143, bta-mir-152, bta-mir-16a, bta-mir-194-2, bta-mir-196a-2, bta-mir-196a-1, bta-mir-196b, bta-mir-199a-2, bta-mir-26a-1, bta-mir-28, bta-mir-335, bta-mir-338, bta-mir-378-1, bta-mir-486, bta-mir-885, bta-mir-96, bta-mir-1271, bta-mir-2299, bta-mir-199c, bta-mir-1388, bta-mir-194-1, bta-mir-378-2, hsa-mir-378b, bta-mir-3431, hsa-mir-378c, hsa-mir-4286, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, bta-mir-4286-1, bta-mir-4286-2, hsa-mir-378j, bta-mir-378b, bta-mir-378c, hsa-mir-486-2, bta-mir-378d, bta-mir-194b, bta-mir-194b-2
For example, miR-148a and miR-143 are highly expressed in both bovine and goat mammary glands during lactation [49]; miR-148a and miR-26a have been shown to demonstrate consistent expression patterns in bovine milk throughout the lactation period [50] and miR-21-5p increased in expression remarkably at fresh period compared with dry period [23]. [score:6]
Six (bta-miR-148a, miR-26a, miR-21-5p, miR-27b, le-7f and let-7a-5p), four (bta-miR-30a-5p, miR-26a, miR-21-5p and let-7a-5p) and five (bta-miR-148a, miR-26a, let-7a-5p, miR-143 and miR-21-5p) of the highly expressed miRNAs in our study are also among the top 10 highly expressed miRNAs detected respectively in bovine mammary epithelial cells (MAC-T) [43] and lactating glands [24, 48]. [score:5]
Furthermore, miR-148a can repress WNT (Wingless/INT-1) signaling and thus promote adipogenesis [53] while miR-27b can repress human adipocyte differentiation by directly targeting PPARγ [54]. [score:4]
Accumulating evidence support the notion that miR-148a can promote cell proliferation and differentiation [51, 52]. [score:1]
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[+] score: 14
When cows consumed CS diet, the expression of duodenal miR-148a, was positively correlated with feed (R = 0.84) and N efficiency (R = 0.85), where as the expression of ruminal miR-99b, two hepatic miRNAs including miR-502b, −874, and mammary gland let-7b was negatively correlated with feed (R ranged from −0.81 ~ −0.89, P < 0.05) and N efficiency (R ranged from −0.82 ~ −0.99, P < 0.05) (Table S7) Moreover, the expression of some miRNAs was correlated with the same trait in different tissues, under certain diet (Table S7). [score:7]
When cows consumed CS diet, the expression of duodenal miR-148a, was positively correlated with feed (R = 0.84) and N efficiency (R = 0.85), where as the expression of ruminal miR-99b, two hepatic miRNAs including miR-502b, −874, and mammary gland let-7b was negatively correlated with feed (R ranged from −0.81 ~ −0.89, P < 0.05) and N efficiency (R ranged from −0.82 ~ −0.99, P < 0.05) (Table S7)Moreover, the expression of some miRNAs was correlated with the same trait in different tissues, under certain diet (Table S7). [score:7]
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[+] score: 13
Other miRNAs from this paper: bta-mir-148b, bta-mir-152, bta-mir-148c, bta-mir-148d
In addition, Liu et al. also showed that miR-148/152 can inhibit TLR-triggered MHC-II expression, which may act as a fine-tuner in the regulation of immune responses (14). [score:6]
Considering that miRNA is a highly conserved regulatory molecule in many different species, it is possible that the bovine MHC-I heavy chain is regulated by miR-148/152. [score:3]
There is some evidence to suggest that miR-148/152 specifically mediates HLA-G expression and other immune responses (14, 15). [score:3]
Several studies have demonstrated that miR-148/152 is associated with the immune process (15, 29, 30). [score:1]
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11
[+] score: 13
Those miRNAs responsible for the separation of the two milk fractions in the PCA were highly expressed miRNAs, such as miR-148a or miR-21-5p, however also less abundant but instead highly differently expressed miRNAs between MC and SM (Table 1). [score:5]
Immune cell related miRNAs, such as miR-146a, miR-155, miR-221 or miR-15b, as well as highly expressed milk specific miRNAs like miR-148a, miR-221-5p, miR-30a-5p, miR-200a, miR-99a-5p, miR-7f demonstrated a significant correlation while approximately half of the highest expressed miRNAs (let-7a-5p, miR-26a, miR-200c, let-7f, miR-92a) were not significantly correlated between both milk fractions. [score:5]
Similar to the findings of Alsaweed et al. 2015, in human breast milk miR-148a and miR-30a were highly abundant in both milk fractions, and were higher expressed in SM than in MC [43]. [score:3]
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[+] score: 12
For instance, miR-148a and miR-152 down-regulate human leukocyte antigen-G (HLA-G) expression, contributing to a healthy pregnancy [21]. [score:6]
In our results, the antigen processing and presentation and allograft rejection pathways were targeted by miRNAs including bta-miR-148a, bta-miR-148b, bta-miR-152, bta-miR-375, bta-miR-3431, novel_3, bta-miR-224, bta-miR-199a-5p, bta-miR-504, bta-miR-200b, bta-miR-200c, and bta-miR-429. [score:3]
A study demonstrated that HLA-G, an immunomodulatory molecule, is mainly expressed by extravillous cytotrophoblasts and controlled by miR-148a and miR-152 in humans [21]. [score:3]
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13
[+] score: 11
The predicted targets of miR-148a cluster primarily to molecular functions involved with transcription (Figure S2). [score:3]
We postulate that, through repression of the many transcription factors known or predicted to be targets of this miRNA, miR-148a contributes to the low level of general transcriptional activity [4] in the maturing oocyte. [score:3]
miR-148a was the most abundant miRNA with stable expression throughout the stages examined (Figure S1). [score:3]
Importantly, a study in Xenopus oocytes has demonstrated that Drosha processes pri-xtr-miR-148a more efficiently than other miRNAs [41] which may represent an additional factor contributing to the high level of this miRNA. [score:1]
The mean number of miR-148a reads in our pools of GV, MII and PZ was 904,472, miR-10a had a mean read number of 415,282 and miR-21 had a mean of 172,010 reads in our three sequenced stages (Tables S2 and S3). [score:1]
[1 to 20 of 5 sentences]
14
[+] score: 11
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-21, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-99a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-16-2, hsa-mir-192, hsa-mir-148a, hsa-mir-10b, hsa-mir-181a-2, hsa-mir-181a-1, hsa-mir-215, hsa-mir-223, hsa-mir-224, hsa-mir-200b, hsa-mir-15b, hsa-mir-27b, hsa-mir-125b-1, hsa-mir-141, hsa-mir-143, hsa-mir-152, hsa-mir-125b-2, hsa-mir-126, hsa-mir-146a, hsa-mir-184, hsa-mir-200c, hsa-mir-155, hsa-mir-29c, hsa-mir-200a, hsa-mir-99b, hsa-mir-296, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-378a, hsa-mir-342, hsa-mir-148b, hsa-mir-451a, ssc-mir-125b-2, ssc-mir-148a, ssc-mir-15b, ssc-mir-184, ssc-mir-224, ssc-mir-23a, ssc-mir-24-1, ssc-mir-26a, ssc-mir-29b-1, ssc-let-7f-1, ssc-mir-103-1, ssc-mir-21, ssc-mir-29c, hsa-mir-486-1, hsa-mir-499a, hsa-mir-671, hsa-mir-378d-2, bta-mir-26a-2, bta-mir-29a, bta-let-7f-2, bta-mir-103-1, bta-mir-16b, bta-mir-21, bta-mir-499, bta-mir-99a, bta-mir-125b-1, bta-mir-126, bta-mir-181a-2, bta-mir-27b, bta-mir-31, bta-mir-15b, bta-mir-215, bta-mir-30e, bta-mir-148b, bta-mir-192, bta-mir-200a, bta-mir-200c, bta-mir-23a, bta-mir-29b-2, bta-mir-29c, bta-mir-10b, bta-mir-24-2, bta-mir-30a, bta-mir-200b, bta-let-7a-1, bta-mir-342, bta-let-7f-1, bta-let-7a-2, bta-let-7a-3, bta-mir-103-2, bta-mir-125b-2, bta-mir-15a, bta-mir-99b, hsa-mir-664a, ssc-mir-99b, hsa-mir-103b-1, hsa-mir-103b-2, ssc-mir-15a, ssc-mir-16-2, ssc-mir-16-1, bta-mir-141, bta-mir-143, bta-mir-146a, bta-mir-152, bta-mir-155, bta-mir-16a, bta-mir-184, bta-mir-24-1, bta-mir-223, bta-mir-224, bta-mir-26a-1, bta-mir-296, bta-mir-29d, bta-mir-378-1, bta-mir-451, bta-mir-486, bta-mir-671, bta-mir-29e, bta-mir-29b-1, bta-mir-181a-1, ssc-mir-181a-1, ssc-mir-215, ssc-mir-30a, bta-mir-2318, bta-mir-2339, bta-mir-2430, bta-mir-664a, bta-mir-378-2, ssc-let-7a-1, ssc-mir-378-1, ssc-mir-29a, ssc-mir-30e, ssc-mir-499, ssc-mir-143, ssc-mir-10b, ssc-mir-486-1, ssc-mir-152, ssc-mir-103-2, ssc-mir-181a-2, ssc-mir-27b, ssc-mir-24-2, ssc-mir-99a, ssc-mir-148b, ssc-mir-664, ssc-mir-192, ssc-mir-342, ssc-mir-125b-1, oar-mir-21, oar-mir-29a, oar-mir-125b, oar-mir-181a-1, hsa-mir-378b, hsa-mir-378c, ssc-mir-296, ssc-mir-155, ssc-mir-146a, bta-mir-148c, ssc-mir-126, ssc-mir-378-2, ssc-mir-451, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-451b, hsa-mir-499b, ssc-let-7a-2, ssc-mir-486-2, hsa-mir-664b, hsa-mir-378j, ssc-let-7f-2, ssc-mir-29b-2, ssc-mir-31, ssc-mir-671, bta-mir-378b, bta-mir-378c, hsa-mir-486-2, oar-let-7a, oar-let-7f, oar-mir-103, oar-mir-10b, oar-mir-143, oar-mir-148a, oar-mir-152, oar-mir-16b, oar-mir-181a-2, oar-mir-200a, oar-mir-200b, oar-mir-200c, oar-mir-23a, oar-mir-26a, oar-mir-29b-1, oar-mir-30a, oar-mir-99a, bta-mir-664b, chi-let-7a, chi-let-7f, chi-mir-103, chi-mir-10b, chi-mir-125b, chi-mir-126, chi-mir-141, chi-mir-143, chi-mir-146a, chi-mir-148a, chi-mir-148b, chi-mir-155, chi-mir-15a, chi-mir-15b, chi-mir-16a, chi-mir-16b, chi-mir-184, chi-mir-192, chi-mir-200a, chi-mir-200b, chi-mir-200c, chi-mir-215, chi-mir-21, chi-mir-223, chi-mir-224, chi-mir-2318, chi-mir-23a, chi-mir-24, chi-mir-26a, chi-mir-27b, chi-mir-296, chi-mir-29a, chi-mir-29b, chi-mir-29c, chi-mir-30a, chi-mir-30e, chi-mir-342, chi-mir-378, chi-mir-451, chi-mir-499, chi-mir-671, chi-mir-99a, chi-mir-99b, bta-mir-378d, ssc-mir-378b, oar-mir-29b-2, ssc-mir-141, ssc-mir-200b, ssc-mir-223, bta-mir-148d
Ye et al. (2012) examined miRNA expression in the duodenum of E. coli F18-sensitive and -resistant weaned piglets and identified 12 candidate miRNA (ssc-miR-143, ssc-let-7f, ssc-miR-30e, ssc-miR-148a, ssc-miR-148b, ssc-miR-181a, ssc-miR-192, ssc-miR-27b, ssc-miR-15b, ssc-miR-21, ssc-miR-215, and ssc-miR-152) disease markers. [score:5]
Additionally, a number of miRNAs including miR-148a, miR-26a, miR-21-5p, miR-27b, miR-143, bta-miR-30a-5p, let-7a-5p, let-7f, miR-10b, and miR-99a-5p are highly expressed in bovine mammary gland/mammary epithelial cells (Li et al., 2012a, 2014a; Jin et al., 2014a; Le Guillou et al., 2014) suggesting roles in the lactation process and mammary gland functions. [score:3]
Similarly, Jin et al. (2014a) demonstrated a differential expression of nine miRNAs (bta-miR-184, miR-24-3p, miR-148, miR-486, and let-7a-5p, miR-2339, miR-499, miR-23a, and miR-99b) upon challenge of MACT-cells (bovine mammary epithelia cell line) with heat inactivated E. coli and S. aureus bacteria. [score:3]
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15
[+] score: 10
Other miRNAs from this paper: bta-mir-26a-2, bta-mir-101-2, bta-mir-30d, bta-mir-126, bta-mir-181a-2, bta-mir-27b, bta-mir-30b, bta-mir-142, bta-mir-30e, bta-mir-148b, bta-mir-186, bta-mir-191, bta-mir-22, bta-mir-30a, bta-mir-150, bta-mir-30c, bta-mir-101-1, bta-mir-141, bta-mir-146a, bta-mir-223, bta-mir-26a-1, bta-mir-30f, bta-mir-181a-1, bta-mir-2284i, bta-mir-2285a, bta-mir-2284s, bta-mir-2285d, bta-mir-2284l, bta-mir-2284j, bta-mir-2284t, bta-mir-2285b-1, bta-mir-2284d, bta-mir-2284n, bta-mir-2284g, bta-mir-2284p, bta-mir-2284u, bta-mir-2284f, bta-mir-2284a, bta-mir-2284k, bta-mir-2284c, bta-mir-2284v, bta-mir-2285c, bta-mir-2284q, bta-mir-2284m, bta-mir-2284b, bta-mir-2284r, bta-mir-2284h, bta-mir-2284o, bta-mir-2284e, bta-mir-1388, bta-mir-2898, bta-mir-2904-1, bta-mir-2904-2, bta-mir-2904-3, bta-mir-2284w, bta-mir-2284x, bta-mir-148c, bta-mir-2284y-1, bta-mir-2285e-1, bta-mir-2285e-2, bta-mir-2285f-1, bta-mir-2285f-2, bta-mir-2285g-1, bta-mir-2285h, bta-mir-2285i, bta-mir-2285j-1, bta-mir-2285j-2, bta-mir-2285k-1, bta-mir-2285l, bta-mir-2285o-1, bta-mir-2285o-2, bta-mir-2285n-1, bta-mir-2285n-2, bta-mir-2285p, bta-mir-2285m-1, bta-mir-2285m-2, bta-mir-2284y-2, bta-mir-2285n-3, bta-mir-2285n-4, bta-mir-2284y-3, bta-mir-2285o-3, bta-mir-2285o-4, bta-mir-2285m-3, bta-mir-2284y-4, bta-mir-2284y-5, bta-mir-2284y-6, bta-mir-2285m-4, bta-mir-2285o-5, bta-mir-2285m-5, bta-mir-2285n-5, bta-mir-2285n-6, bta-mir-2284y-7, bta-mir-2285n-7, bta-mir-2284z-1, bta-mir-2284aa-1, bta-mir-2285k-2, bta-mir-2284z-3, bta-mir-2284aa-2, bta-mir-2284aa-3, bta-mir-2285k-3, bta-mir-2285k-4, bta-mir-2284z-4, bta-mir-2285k-5, bta-mir-2284z-5, bta-mir-2284z-6, bta-mir-2284z-7, bta-mir-2284aa-4, bta-mir-2285q, bta-mir-2285r, bta-mir-2285s, bta-mir-2285t, bta-mir-2285b-2, bta-mir-2285v, bta-mir-2284z-2, bta-mir-2285g-2, bta-mir-2285g-3, bta-mir-2285af-1, bta-mir-2285af-2, bta-mir-2285y, bta-mir-2285w, bta-mir-2285x, bta-mir-2285z, bta-mir-2285u, bta-mir-2285aa, bta-mir-2285ab, bta-mir-2284ab, bta-mir-2285ac, bta-mir-2285ad, bta-mir-2284ac, bta-mir-2285ae, bta-mir-1842, bta-mir-2285ag, bta-mir-2285ah, bta-mir-2285ai, bta-mir-2285aj, bta-mir-2285ak, bta-mir-2285al, bta-mir-2285am, bta-mir-2285ar, bta-mir-2285as-1, bta-mir-2285as-2, bta-mir-2285as-3, bta-mir-2285at-1, bta-mir-2285at-2, bta-mir-2285at-3, bta-mir-2285at-4, bta-mir-2285au, bta-mir-2285av, bta-mir-2285aw, bta-mir-2285ax-1, bta-mir-2285ax-2, bta-mir-2285ax-3, bta-mir-2285ay, bta-mir-2285az, bta-mir-2285an, bta-mir-2285ao-1, bta-mir-2285ao-2, bta-mir-2285ap, bta-mir-2285ao-3, bta-mir-2285aq-1, bta-mir-2285aq-2, bta-mir-2285ba-1, bta-mir-2285ba-2, bta-mir-2285bb, bta-mir-2285bc, bta-mir-2285bd, bta-mir-2285be, bta-mir-2285bf-1, bta-mir-2285bf-2, bta-mir-2285bf-3, bta-mir-2285bg, bta-mir-2285bh, bta-mir-2285bi-1, bta-mir-2285bi-2, bta-mir-2285bj-1, bta-mir-2285bj-2, bta-mir-2285bk, bta-mir-2285bl, bta-mir-2285bm, bta-mir-2285bn, bta-mir-2285bo, bta-mir-2285bp, bta-mir-2285bq, bta-mir-2285br, bta-mir-2285bs, bta-mir-2285bt, bta-mir-2285bu-1, bta-mir-2285bu-2, bta-mir-2285bv, bta-mir-2285bw, bta-mir-2285bx, bta-mir-2285by, bta-mir-2285bz, bta-mir-2285ca, bta-mir-2285cb, bta-mir-2285cc, bta-mir-2285cd, bta-mir-2285ce, bta-mir-2285cf, bta-mir-2285cg, bta-mir-148d, bta-mir-2285ch, bta-mir-2285ci, bta-mir-2285cj, bta-mir-2285ck, bta-mir-2285cl, bta-mir-2285cm, bta-mir-2285cn, bta-mir-2285co, bta-mir-2285cp, bta-mir-2285cq, bta-mir-2285cr-1, bta-mir-2285cr-2, bta-mir-2285cs, bta-mir-2285ct, bta-mir-2285cu, bta-mir-2285cv-1, bta-mir-2285cv-2, bta-mir-2285cw-1, bta-mir-2285cw-2, bta-mir-2285cx, bta-mir-2285cy, bta-mir-2285cz, bta-mir-2285da, bta-mir-2285db, bta-mir-2285dc, bta-mir-2285dd, bta-mir-2285de, bta-mir-2285df, bta-mir-2285dg, bta-mir-2285dh, bta-mir-2285di, bta-mir-2285dj, bta-mir-2285dk, bta-mir-2285dl-1, bta-mir-2285dl-2, bta-mir-2285dm
Also wi dely studied for possible involvement in tumor progression, miR-148-3p has been shown to directly target the TGIF2 gene in ovarian cancer [48], the drug metabolizing PXR gene in human cancer metastasis [49], and CAND1 expression in human prostate cancer to promote prostate cell growth [50]. [score:6]
Previous miRNA expression studies using bovine mammary tissue [42, 43] or milk [26] also found miR-148a and -181a as significantly elevated during lactation, respectively. [score:3]
However, miR-148a-3p, which accounted for ~18.6 % of the total miRNA associated sequence reads, has previously been suggested as a nutritional biomarker corresponding to the protein content of various bovine-derived milk products [26]. [score:1]
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16
[+] score: 10
Identification of putative messenger RNA targets for miR-21, miR-23, miR-148a and miR-182 using gene ontology analysis suggested that these miRNAs may play important roles in regulation of cell development, morphogenesis, differentiation and apoptosis (data not shown). [score:5]
qRT-PCR was performed to quantify expression of miR-93, miR-103, miR-26a, miR-191, miR-23b, Let-7a and U6 for bovine samples and miR-21, miR-26a, miR-93, miR-103, miR-148a, miR-182 and miR-191 for porcine oocytes. [score:3]
miR-21 miR-26a miR-93 miR-103 miR-148 miR-182 miR-191 coeff. [score:1]
In porcine samples, the miRNAs identified as fluctuating least in bovine samples, namely miR-26a, miR-93, miR-103 and miR-191 were examined together with miR-21, miR-148a, and miR-182. [score:1]
[1 to 20 of 4 sentences]
17
[+] score: 9
Specific knockdown of miR-148 in pancreatic β-cells or in isolated primary islets down-regulates insulin mRNA levels [37]. [score:5]
Specifically, miR-26a (cell proliferation) was the most abundantly expressed, followed by miR-148 (may control insulin content) and miR-21 (cell proliferation). [score:3]
Mammary gland does not synthesize insulin, therefore miR-148 is not included in the “lipid metabolism” cluster. [score:1]
[1 to 20 of 3 sentences]
18
[+] score: 8
For example, miR-29, miR-181 and miR-148a can promote myoblast differentiation by inhibiting the expression of downstream target genes Akt3, Hox-A1 and ROCK1 at protein levels [10– 12]. [score:7]
MiR-148a, miR-206 and miR-214 have been shown to be similar to miR-322/424 and miR-503 [12, 33, 34]. [score:1]
[1 to 20 of 2 sentences]
19
[+] score: 7
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-21, hsa-mir-22, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-26b, hsa-mir-27a, hsa-mir-31, hsa-mir-33a, hsa-mir-99a, hsa-mir-100, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-199a-1, hsa-mir-148a, hsa-mir-147a, hsa-mir-34a, hsa-mir-182, hsa-mir-199a-2, hsa-mir-212, hsa-mir-221, hsa-mir-224, hsa-let-7g, hsa-let-7i, hsa-mir-27b, hsa-mir-30b, hsa-mir-125b-1, hsa-mir-130a, hsa-mir-132, hsa-mir-142, hsa-mir-145, hsa-mir-152, hsa-mir-153-1, hsa-mir-153-2, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-127, hsa-mir-134, hsa-mir-200c, hsa-mir-106b, hsa-mir-361, hsa-mir-148b, hsa-mir-20b, hsa-mir-410, hsa-mir-202, hsa-mir-503, hsa-mir-33b, hsa-mir-643, hsa-mir-659, bta-let-7f-2, bta-mir-103-1, bta-mir-21, bta-mir-221, bta-mir-26b, bta-mir-27a, bta-mir-99a, bta-mir-125a, bta-mir-125b-1, bta-mir-145, bta-mir-199a-1, bta-mir-27b, bta-mir-30b, bta-mir-31, bta-mir-127, bta-mir-142, bta-mir-20b, bta-let-7d, bta-mir-132, bta-mir-148b, bta-mir-200c, bta-mir-22, bta-mir-23a, bta-mir-29b-2, bta-mir-361, bta-let-7g, bta-mir-24-2, bta-let-7a-1, bta-let-7f-1, bta-let-7i, bta-mir-25, bta-let-7a-2, bta-let-7a-3, bta-let-7b, bta-let-7c, bta-let-7e, bta-mir-103-2, bta-mir-125b-2, bta-mir-34a, hsa-mir-708, hsa-mir-147b, hsa-mir-877, hsa-mir-940, hsa-mir-548j, hsa-mir-302e, hsa-mir-103b-1, hsa-mir-103b-2, bta-mir-100, bta-mir-106b, bta-mir-130a, bta-mir-134, bta-mir-147, bta-mir-152, bta-mir-153-1, bta-mir-153-2, bta-mir-182, bta-mir-24-1, bta-mir-199a-2, bta-mir-202, bta-mir-212, bta-mir-224, bta-mir-33a, bta-mir-33b, bta-mir-410, bta-mir-708, bta-mir-877, bta-mir-940, bta-mir-29b-1, bta-mir-148c, bta-mir-503, bta-mir-148d
The miR-148*, a minor form of miR-148, was also significantly up-regulated in follicular fluid of hyperstimulated heifers. [score:4]
Although, the role of this miRNA in follicular development is unclear, miR-148/152 family was found to be important for growth and development of normal tissue [42]. [score:3]
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20
[+] score: 7
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-16-1, hsa-mir-21, hsa-mir-22, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-27a, hsa-mir-31, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-16-2, hsa-mir-192, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-181a-2, hsa-mir-205, hsa-mir-181a-1, hsa-mir-214, hsa-mir-219a-1, hsa-mir-221, hsa-mir-222, hsa-mir-223, hsa-let-7g, hsa-let-7i, hsa-mir-27b, hsa-mir-30b, hsa-mir-125b-1, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125b-2, hsa-mir-146a, hsa-mir-184, hsa-mir-186, hsa-mir-193a, hsa-mir-194-1, hsa-mir-155, hsa-mir-194-2, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-219a-2, hsa-mir-99b, hsa-mir-26a-2, hsa-mir-365a, hsa-mir-365b, hsa-mir-374a, hsa-mir-148b, hsa-mir-423, hsa-mir-486-1, hsa-mir-499a, hsa-mir-532, hsa-mir-590, bta-mir-26a-2, bta-let-7f-2, bta-mir-103-1, bta-mir-16b, bta-mir-21, bta-mir-221, bta-mir-222, bta-mir-27a, bta-mir-499, bta-mir-125b-1, bta-mir-181a-2, bta-mir-205, bta-mir-27b, bta-mir-30b, bta-mir-31, bta-mir-193a, bta-let-7d, bta-mir-148b, bta-mir-186, bta-mir-191, bta-mir-192, bta-mir-200a, bta-mir-214, bta-mir-22, bta-mir-23a, bta-mir-29c, bta-mir-423, bta-let-7g, bta-mir-24-2, bta-let-7a-1, bta-mir-532, bta-let-7f-1, bta-mir-30c, bta-let-7i, bta-let-7a-2, bta-let-7a-3, bta-let-7b, bta-let-7c, bta-let-7e, bta-mir-103-2, bta-mir-125b-2, bta-mir-365-1, bta-mir-374a, bta-mir-99b, hsa-mir-374b, hsa-mir-664a, hsa-mir-103b-1, hsa-mir-103b-2, hsa-mir-1915, bta-mir-146a, bta-mir-155, bta-mir-16a, bta-mir-184, bta-mir-24-1, bta-mir-194-2, bta-mir-219-1, bta-mir-223, bta-mir-26a-1, bta-mir-365-2, bta-mir-374b, bta-mir-486, bta-mir-763, bta-mir-9-1, bta-mir-9-2, bta-mir-181a-1, bta-mir-2284i, bta-mir-2284s, bta-mir-2284l, bta-mir-2284j, bta-mir-2284t, bta-mir-2284d, bta-mir-2284n, bta-mir-2284g, bta-mir-2339, bta-mir-2284p, bta-mir-2284u, bta-mir-2284f, bta-mir-2284a, bta-mir-2284k, bta-mir-2284c, bta-mir-2284v, bta-mir-2284q, bta-mir-2284m, bta-mir-2284b, bta-mir-2284r, bta-mir-2284h, bta-mir-2284o, bta-mir-664a, bta-mir-2284e, bta-mir-1388, bta-mir-194-1, bta-mir-193a-2, bta-mir-2284w, bta-mir-2284x, bta-mir-148c, hsa-mir-374c, hsa-mir-219b, hsa-mir-499b, hsa-mir-664b, bta-mir-2284y-1, bta-mir-2284y-2, bta-mir-2284y-3, bta-mir-2284y-4, bta-mir-2284y-5, bta-mir-2284y-6, bta-mir-2284y-7, bta-mir-2284z-1, bta-mir-2284aa-1, bta-mir-2284z-3, bta-mir-2284aa-2, bta-mir-2284aa-3, bta-mir-2284z-4, bta-mir-2284z-5, bta-mir-2284z-6, bta-mir-2284z-7, bta-mir-2284aa-4, bta-mir-2284z-2, hsa-mir-486-2, hsa-mir-6516, bta-mir-2284ab, bta-mir-664b, bta-mir-6516, bta-mir-219-2, bta-mir-2284ac, bta-mir-219b, bta-mir-374c, bta-mir-148d
Five differentially expressed miRNAs (bta-miR-184, miR-24-3p, miR-148, miR-486 and let-7a-5p) were unique to E. coli while four (bta-miR-2339, miR-499, miR-23a and miR-99b) were unique to S. aureus. [score:3]
Furthermore, the differential expression pattern of five miRNAs (bta-miR184, miR-24-3p, miR-148, miR-486 and bta-let-7a-5p) were unique to E. coli while four (bta-miR-2339, miR-499, miR-23a and miR-99b) were unique to S. aureus. [score:3]
Interestingly, our study shows that a different set of five miRNAs (miR-184, miR-24-3p, miR-148, miR-486 and let-7a-5p) were unique to E. coli bacteria while another set of four (miR-2339, miR-499, miR-23a and miR-99b) were unique to S. aureus bacteria. [score:1]
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[+] score: 6
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-21, hsa-mir-22, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-26a-1, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-99a, mmu-let-7g, mmu-let-7i, mmu-mir-27b, mmu-mir-99a, mmu-mir-140, mmu-mir-10b, mmu-mir-181a-2, mmu-mir-24-1, mmu-mir-191, hsa-mir-192, hsa-mir-148a, hsa-mir-30d, mmu-mir-122, hsa-mir-10b, hsa-mir-181a-2, hsa-mir-181a-1, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-27b, hsa-mir-122, hsa-mir-140, hsa-mir-191, hsa-mir-320a, mmu-mir-30d, mmu-mir-148a, mmu-mir-192, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-21a, mmu-mir-22, mmu-mir-24-2, mmu-mir-26a-1, mmu-mir-92a-2, mmu-mir-25, mmu-mir-181a-1, mmu-mir-26a-2, mmu-mir-92a-1, hsa-mir-26a-2, hsa-mir-423, hsa-mir-451a, mmu-mir-451a, hsa-mir-486-1, mmu-mir-486a, mmu-mir-423, bta-mir-26a-2, bta-let-7f-2, bta-mir-21, bta-mir-30d, bta-mir-320a-2, bta-mir-99a, bta-mir-181a-2, bta-mir-27b, bta-mir-140, bta-mir-92a-2, bta-let-7d, bta-mir-191, bta-mir-192, bta-mir-22, bta-mir-423, bta-let-7g, bta-mir-10b, bta-mir-24-2, bta-let-7a-1, bta-let-7f-1, bta-mir-122, bta-let-7i, bta-mir-25, bta-let-7a-2, bta-let-7a-3, bta-let-7b, bta-let-7c, bta-let-7e, hsa-mir-1246, bta-mir-24-1, bta-mir-26a-1, bta-mir-451, bta-mir-486, bta-mir-92a-1, bta-mir-181a-1, bta-mir-320a-1, mmu-mir-486b, hsa-mir-451b, bta-mir-1246, mmu-mir-21b, mmu-let-7j, mmu-mir-21c, mmu-mir-451b, mmu-let-7k, hsa-mir-486-2
Several microRNAs had similar expression when comparing results from the present study with those of There were nine microRNAs (bta-miR-10b, bta-miR-423-3p, bta-miR-99a-5p, bta-miR-181a, bta-miR-423-5p, bta-miR-148a, bta-miR-26a, bta-miR-192, and bta-miR-486), that were upregulated in earlier stages of life in both studies. [score:6]
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[+] score: 6
It has been reported that simultaneous inhibition of miR-148a and miR-152 could significantly protect MCF-7 cells from 4-OHT induced cell viability reduction and inhibit cell apoptosis [39]. [score:5]
The mature sequence of miR-152, a member of the miR-148/152 family (miR-148a, miR-148b, and miR-152), is relatively conservative [15]. [score:1]
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23
[+] score: 5
qPCR results of the two top expressed miRNAs (bta-miR-148, miR-21-5p) were consistent with results of miRNA-sequencing, demonstrating the highest level of expression in the corresponding milk fraction and in mammary gland tissue. [score:5]
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[+] score: 3
In a related study, Xu et al. found that a novel miR-148a/152-DNMT1 regulatory circuit might exist in breast cancer [20]. [score:2]
MiR-152 is one of the three members of the miR-148/152 family, which contain miR-148a, miR-148b and miR-152. [score:1]
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[+] score: 3
In these two libraries, bta-let-7f, bta-miR-122, bta-miR-148a, bta-miR-192, bta-miR-21-5p, bta-miR-26a/c, and bta-miR-30a-5p were the dominantly expressed miRNAs (Table  S2). [score:3]
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26
[+] score: 3
MiR-148a and miR-26a were the most abundantly expressed miRNAs since they accounted for more than 10% of the read counts in each stage of lactation. [score:3]
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27
[+] score: 2
Other miRNAs from this paper: ssc-mir-122, ssc-mir-135-1, ssc-mir-135-2, ssc-mir-148a, ssc-mir-19a, ssc-mir-20a, ssc-mir-224, ssc-mir-24-1, ssc-mir-323, ssc-mir-140, ssc-mir-183, ssc-mir-214, ssc-mir-27a, ssc-mir-325, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-103-1, ssc-mir-107, ssc-mir-136, ssc-mir-153, ssc-mir-18a, ssc-mir-186, ssc-mir-196a-2, ssc-mir-204, ssc-mir-21, bta-mir-18b, bta-let-7f-2, bta-mir-101-2, bta-mir-103-1, bta-mir-18a, bta-mir-20a, bta-mir-21, bta-mir-221, bta-mir-27a, bta-mir-27b, bta-mir-107, bta-mir-140, bta-mir-20b, bta-mir-215, bta-let-7d, bta-mir-17, bta-mir-186, bta-mir-199b, bta-mir-210, bta-mir-214, bta-mir-450a-2, bta-let-7g, bta-mir-24-2, bta-let-7a-1, bta-let-7f-1, bta-mir-122, bta-let-7i, bta-let-7a-2, bta-let-7a-3, bta-let-7b, bta-let-7c, bta-let-7e, bta-mir-103-2, bta-mir-15a, bta-mir-19a, bta-mir-204, ssc-mir-15a, ssc-mir-17, ssc-mir-199b, ssc-mir-210, ssc-mir-221, bta-mir-101-1, bta-mir-133a-2, bta-mir-133a-1, bta-mir-135a-2, bta-mir-135a-1, bta-mir-135b, bta-mir-136, bta-mir-146b, bta-mir-153-1, bta-mir-153-2, bta-mir-183, bta-mir-24-1, bta-mir-196a-2, bta-mir-196a-1, bta-mir-196b, bta-mir-224, bta-mir-323, ssc-mir-101-1, ssc-mir-101-2, ssc-mir-133a-1, ssc-mir-450a, ssc-mir-146b, ssc-mir-215, bta-mir-1343, bta-mir-2320, bta-mir-2326, bta-mir-2366, bta-mir-2411, bta-mir-2483, bta-mir-450a-1, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-103-2, ssc-mir-27b, ssc-mir-24-2, ssc-mir-196b-1, ssc-mir-450b, ssc-mir-450c, ssc-mir-133a-2, ssc-let-7a-2, ssc-mir-18b, ssc-mir-1343, ssc-mir-2320, bta-mir-450b, ssc-let-7d, ssc-let-7f-2, ssc-mir-20b-1, ssc-mir-20b-2, ssc-mir-196a-1, ssc-mir-196b-2, ssc-mir-2366-1, ssc-mir-2366-2, ssc-mir-2411, ssc-mir-2483
Obviously, high-abundant miRNAs (let-7c, let-7f, miR-148a, miR-21 and miR-24) had higher edited probability in backfat tissue. [score:1]
However, the total reads of two conserved miRNAs (ssc-miR-148a and ssc-let-7c) were striking, almost 1.7 million and 1.6 million, respectively (Table S2). [score:1]
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[+] score: 2
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-21, hsa-mir-23a, hsa-mir-30a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-196a-1, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-196a-2, hsa-mir-210, hsa-mir-181a-1, hsa-mir-218-1, hsa-let-7g, hsa-let-7i, hsa-mir-23b, hsa-mir-30b, hsa-mir-128-1, hsa-mir-145, hsa-mir-191, hsa-mir-181b-2, hsa-mir-128-2, hsa-mir-30c-1, hsa-mir-99b, hsa-mir-296, hsa-mir-30e, hsa-mir-361, hsa-mir-337, hsa-mir-148b, hsa-mir-196b, hsa-mir-425, hsa-mir-20b, hsa-mir-486-1, hsa-mir-488, hsa-mir-181d, hsa-mir-498, hsa-mir-519c, hsa-mir-520a, hsa-mir-526b, hsa-mir-520d, hsa-mir-506, hsa-mir-92b, hsa-mir-608, hsa-mir-617, hsa-mir-625, hsa-mir-641, hsa-mir-1264, hsa-mir-1271, bta-let-7f-2, bta-mir-103-1, bta-mir-21, bta-mir-30d, bta-mir-128-1, bta-mir-145, bta-mir-181a-2, bta-mir-30b, bta-mir-181b-2, bta-mir-20b, bta-mir-30e, bta-mir-92a-2, bta-let-7d, bta-mir-148b, bta-mir-181c, bta-mir-191, bta-mir-210, bta-mir-23a, bta-mir-361, bta-mir-425, bta-let-7g, bta-mir-30a, bta-let-7a-1, bta-let-7f-1, bta-mir-30c, bta-let-7i, bta-mir-23b, bta-let-7a-2, bta-let-7a-3, bta-let-7b, bta-let-7c, bta-let-7e, bta-mir-103-2, bta-mir-99b, hsa-mir-890, hsa-mir-888, hsa-mir-889, hsa-mir-938, hsa-mir-1184-1, hsa-mir-1203, hsa-mir-1204, hsa-mir-1265, hsa-mir-103b-1, hsa-mir-103b-2, bta-mir-128-2, bta-mir-181d, bta-mir-196a-2, bta-mir-196a-1, bta-mir-196b, bta-mir-218-1, bta-mir-296, bta-mir-30f, bta-mir-486, bta-mir-488, bta-mir-92a-1, bta-mir-92b, bta-mir-1271, bta-mir-181a-1, bta-mir-181b-1, bta-mir-148c, hsa-mir-1184-2, hsa-mir-1184-3, hsa-mir-486-2, bta-mir-1264, bta-mir-148d
Other report [29] also showed that bovine mammary epithelial cells challenged with Staphylococcus aureus (S. aureus) or Escherichia coli (E. coli) resulted in dysregulation of 17 miRNAs of which five miRNAs including miR-148, miR-486 and let-7a-5p were unique to E. coli while four miRNAs including miR-23a and miR-99b were unique to S. aureus. [score:2]
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[+] score: 2
Top-ranked milk miRNA (ref 9) miRNA% milk miRNAs FC (T0 to T3) let-7b 39.1% -111 let-7a/c 37.0% 5 let-7f 2.8% 14 miR-30a 1.9% -39 miR-21 1.7% 23 miR-99a 1.7% -33 let-7d 1.4% ND (T3) miR-148a 1.2% 32 miR-92a 1.1% 8 miR-30d 1.0% -1144 Total reads in the RNA-seq datasets for plasma at T0, T3, T6, and T9 are shown, along with the number and percentage of reads mapped using miRge, Chimira, or Bowtie. [score:1]
Top-ranked milk miRNA (ref 9) miRNA% milk miRNAs FC (T0 to T3) let-7b 39.1% -111 let-7a/c 37.0% 5 let-7f 2.8% 14 miR-30a 1.9% -39 miR-21 1.7% 23 miR-99a 1.7% -33 let-7d 1.4% ND (T3) miR-148a 1.2% 32 miR-92a 1.1% 8 miR-30d 1.0% -1144 We attempted to replicate and expand on the report of Baier et al., that milk intake increases presence of bovine miRNAs in human plasma and PBMCs. [score:1]
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MiR-122 was the most abundant miRNA in the FBS, followed by miR-1246, miR-423-5p, miR-148a-3p, and let-7 family (Fig. 1f). [score:1]
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Other miRNAs from this paper: hsa-let-7c, hsa-let-7d, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-17, hsa-mir-20a, hsa-mir-21, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-99a, hsa-mir-148a, hsa-mir-7-1, hsa-mir-7-2, hsa-mir-7-3, hsa-mir-181a-2, hsa-mir-181a-1, hsa-mir-125b-1, hsa-mir-143, hsa-mir-125b-2, hsa-mir-126, hsa-mir-146a, hsa-mir-155, hsa-mir-106b, hsa-mir-99b, hsa-mir-26a-2, hsa-mir-378a, hsa-mir-151a, hsa-mir-450a-1, hsa-mir-452, hsa-mir-450a-2, hsa-mir-92b, hsa-mir-151b, hsa-mir-378d-2, bta-mir-26a-2, bta-let-7f-2, bta-mir-151, bta-mir-16b, bta-mir-20a, bta-mir-21, bta-mir-26b, bta-mir-99a, bta-mir-125b-1, bta-mir-126, bta-mir-181a-2, bta-mir-92a-2, bta-let-7d, bta-mir-17, bta-mir-450a-2, bta-mir-7-3, bta-let-7f-1, bta-let-7c, bta-mir-125b-2, bta-mir-15a, bta-mir-99b, hsa-mir-450b, bta-mir-106b, bta-mir-143, bta-mir-146a, bta-mir-155, bta-mir-16a, bta-mir-26a-1, bta-mir-378-1, bta-mir-452, bta-mir-92a-1, bta-mir-92b, bta-mir-7-2, bta-mir-7-1, bta-mir-181a-1, bta-mir-2284i, bta-mir-2285a, bta-mir-2284s, bta-mir-2285d, bta-mir-2284l, bta-mir-2284j, bta-mir-2284t, bta-mir-2285b-1, bta-mir-2284d, bta-mir-2284n, bta-mir-2284g, bta-mir-2284p, bta-mir-2284u, bta-mir-2284f, bta-mir-2284a, bta-mir-2284k, bta-mir-2284c, bta-mir-2284v, bta-mir-2285c, bta-mir-2284q, bta-mir-2284m, bta-mir-2284b, bta-mir-2284r, bta-mir-2284h, bta-mir-2284o, bta-mir-2284e, bta-mir-450a-1, bta-mir-378-2, hsa-mir-378b, bta-mir-2284w, bta-mir-2284x, hsa-mir-378c, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, bta-mir-450b, bta-mir-2284y-1, bta-mir-2285e-1, bta-mir-2285e-2, bta-mir-2285f-1, bta-mir-2285f-2, bta-mir-2285g-1, bta-mir-2285h, bta-mir-2285i, bta-mir-2285j-1, bta-mir-2285j-2, bta-mir-2285k-1, bta-mir-2285l, hsa-mir-378j, bta-mir-2285o-1, bta-mir-2285o-2, bta-mir-2285n-1, bta-mir-2285n-2, bta-mir-2285p, bta-mir-2285m-1, bta-mir-2285m-2, bta-mir-2284y-2, bta-mir-378b, bta-mir-2285n-3, bta-mir-2285n-4, bta-mir-2284y-3, bta-mir-2285o-3, bta-mir-2285o-4, bta-mir-2285m-3, bta-mir-378c, bta-mir-2284y-4, bta-mir-2284y-5, bta-mir-2284y-6, bta-mir-2285m-4, bta-mir-2285o-5, bta-mir-2285m-5, bta-mir-2285n-5, bta-mir-2285n-6, bta-mir-2284y-7, bta-mir-2285n-7, bta-mir-2284z-1, bta-mir-2284aa-1, bta-mir-2285k-2, bta-mir-2284z-3, bta-mir-2284aa-2, bta-mir-2284aa-3, bta-mir-2285k-3, bta-mir-2285k-4, bta-mir-2284z-4, bta-mir-2285k-5, bta-mir-2284z-5, bta-mir-2284z-6, bta-mir-2284z-7, bta-mir-2284aa-4, bta-mir-2285q, bta-mir-2285r, bta-mir-2285s, bta-mir-2285t, bta-mir-2285b-2, bta-mir-2285v, bta-mir-2284z-2, bta-mir-2285g-2, bta-mir-2285g-3, bta-mir-2285af-1, bta-mir-2285af-2, bta-mir-2285y, bta-mir-2285w, bta-mir-2285x, bta-mir-2285z, bta-mir-2285u, bta-mir-2285aa, bta-mir-2285ab, bta-mir-2284ab, bta-mir-2285ac, bta-mir-2285ad, bta-mir-2284ac, bta-mir-2285ae, bta-mir-378d, bta-mir-2285ag, bta-mir-2285ah, bta-mir-2285ai, bta-mir-2285aj, bta-mir-2285ak, bta-mir-2285al, bta-mir-2285am, bta-mir-2285ar, bta-mir-2285as-1, bta-mir-2285as-2, bta-mir-2285as-3, bta-mir-2285at-1, bta-mir-2285at-2, bta-mir-2285at-3, bta-mir-2285at-4, bta-mir-2285au, bta-mir-2285av, bta-mir-2285aw, bta-mir-2285ax-1, bta-mir-2285ax-2, bta-mir-2285ax-3, bta-mir-2285ay, bta-mir-2285az, bta-mir-2285an, bta-mir-2285ao-1, bta-mir-2285ao-2, bta-mir-2285ap, bta-mir-2285ao-3, bta-mir-2285aq-1, bta-mir-2285aq-2, bta-mir-2285ba-1, bta-mir-2285ba-2, bta-mir-2285bb, bta-mir-2285bc, bta-mir-2285bd, bta-mir-2285be, bta-mir-2285bf-1, bta-mir-2285bf-2, bta-mir-2285bf-3, bta-mir-2285bg, bta-mir-2285bh, bta-mir-2285bi-1, bta-mir-2285bi-2, bta-mir-2285bj-1, bta-mir-2285bj-2, bta-mir-2285bk, bta-mir-2285bl, bta-mir-2285bm, bta-mir-2285bn, bta-mir-2285bo, bta-mir-2285bp, bta-mir-2285bq, bta-mir-2285br, bta-mir-2285bs, bta-mir-2285bt, bta-mir-2285bu-1, bta-mir-2285bu-2, bta-mir-2285bv, bta-mir-2285bw, bta-mir-2285bx, bta-mir-2285by, bta-mir-2285bz, bta-mir-2285ca, bta-mir-2285cb, bta-mir-2285cc, bta-mir-2285cd, bta-mir-2285ce, bta-mir-2285cf, bta-mir-2285cg, bta-mir-2285ch, bta-mir-2285ci, bta-mir-2285cj, bta-mir-2285ck, bta-mir-2285cl, bta-mir-2285cm, bta-mir-2285cn, bta-mir-2285co, bta-mir-2285cp, bta-mir-2285cq, bta-mir-2285cr-1, bta-mir-2285cr-2, bta-mir-2285cs, bta-mir-2285ct, bta-mir-2285cu, bta-mir-2285cv-1, bta-mir-2285cv-2, bta-mir-2285cw-1, bta-mir-2285cw-2, bta-mir-2285cx, bta-mir-2285cy, bta-mir-2285cz, bta-mir-2285da, bta-mir-2285db, bta-mir-2285dc, bta-mir-2285dd, bta-mir-2285de, bta-mir-2285df, bta-mir-2285dg, bta-mir-2285dh, bta-mir-2285di, bta-mir-2285dj, bta-mir-2285dk, bta-mir-2285dl-1, bta-mir-2285dl-2, bta-mir-2285dm
7 mir-155 14,390 2,101.7 let-7c 14,020 2,047.7 mir-143 12,204 1,782.4 mir-181a-2//mir-181a-1 11,882 1,735.4 mir-146a 10,952 1,599.6 mir-15a 9,938 1,451.5 mir-99b 9,755 1,424.8 mir-148a 9,502 1,387.8 mir-125b-1//mir-125b-2 9,395 1,372.2 mir-106b 9,284 1,356.0 mir-26b 9,146 1,335.8 mir-16b 8,750 1,278.0 let-7d 8,273 1,208.3 mir-16a 8,007 1,169.5 mir-92//mir-92a 7,427 1,084.7 mir-7//mir-7-2//mir-7-1 6,852 1,000.8 Fig. 2IsomiRs and detection of star sequences. [score:1]
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However, in our study, several previously reported miRNAs 19, 22– 24, such as bta-miR-100, miR-1388-3p, miR-141, miR-148a, miR-181c, miR-181d, miR-199a-3p, miR-199b, miR-200b, miR-221, miR-32, miR-362-3p, miR-375, miR-20b, miR-215 and miR-9-5p, were also detected. [score:1]
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In total, 22 miRNAs (bta-miR-21-5p, -miR-143, -miR-10b, -let-7i, -miR-202, -miR-148a, -let-7f, -miR-3600, -miR-99a55p, -let-7a-5p, -miR-27b, -miT-100, -let7g, -miR-26a, -miR-378, -miR-30d, -miR-125b, -450a, -miR-30e-5p, -let-7b, -miR-199a-3p, and -miR-26c) contributed to the top twenty most abundantly sequenced miRNAs in the bovine CL. [score:1]
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