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10 publications mentioning mmu-mir-674

Open access articles that are associated with the species Mus musculus and mention the gene name mir-674. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 202
Our results showed that the inhibition of miR674 or miR155 significantly up-regulated viral replication at 6 and 24 h, whereas the over -expression of miR674 or miR155 repressed viral replication (Figure 6C and 6D). [score:8]
We found that the NA segment significantly increased the expression of miR-155 and miR-674, whereas the HA segment significantly up-regulated the expression of miR-707, miR-674, and miR-499 (Figure 1A). [score:8]
Furthermore, we found that NA stimulation significantly down-regulated the expression of IRF-3, TRAF-3, and-6. Additionally, the expression of IRF-3 and TRAF-3 were slightly decreased in miR-674 group, compared with blank group. [score:7]
A. The expressions of CD40, CD80/86, and MHCII on BMDCs when miR-155, miR-674, miR-499, and miR-181b1were inhibited (100 μg/ml inhibitor for each miRNA). [score:7]
Figure 4 A. The expressions of CD40, CD80/86, and MHCII on BMDCs when miR-155, miR-674, miR-499, and miR-181b1were inhibited (100 μg/ml inhibitor for each miRNA). [score:7]
B. The expression of CD86 and MHCII on BMDCs when the target genes (Camk1d and Mbnl3) of miR-674 were inhibited (DCs were divided into Isotype, Blank, iCamk1d, Crtl-iCamk1d, iMbnl3, Crtl-iMbnl3, iCamk1d/ miR674, Crtl-iCamk1d/ miR674, iMbnl3/ miR674, and Crtl-iMbnl3/ miR674). [score:7]
The predicted genes target position and mutated position of miR155 and miR674 was listed in Table 7. To determine whether miR-155 and miR-674 could repress the expression of target genes, 293T cells were transfected with miR-155 or miR-674 and pMIR-Report vector, along with pRL-TK to normalize transfection efficiencies. [score:7]
Given that the H9N2 virus and NA segment significantly up-regulated the expression of miR-155 and miR-674 (Figure 1A), we examined the functions of these miRNAs in BMDCs. [score:6]
Additionally, we found that the mRNA expression of Myo1d, Pgm21l, Aldh18a1, Camk1d, and Mbnl3, targeted to miR155 or miR674, were significantly decreased in miR155 and miR674 over -expression groups compared with the pSilencer4.1 control group (Figure 3E). [score:6]
Target genes of miR-155 and miR-674 were predicted using miRanda and Targetscan [36]. [score:5]
FACS revealed that the inhibition of endogenous miR-674 or miR-155 decreased the expression of co-stimulatory molecules (CD80/CD86 and CD40) and MHCII, which was induced by NA. [score:5]
Each 100 nM miRNAs inhibitors (miR155, miR499, miR674 and miR181b1) were transfected into BMDCs for 2h, before NA over -expression plasmid was transfected. [score:5]
Additionally, we found that the mRNA expression of Pgm21l, Aldh18a1, Camk1d, and Mbnl3, targeted to miR674, decreased significantly when treated with NA (Figure 2E). [score:5]
To study the mechanism of action by miR-155 and miR-674, we used Miranda and Targetscan to predict miR-155 and miR674 target genes, considering only the overlap of both algorithms, and further matched the prediction based on our previous microarray data. [score:5]
Effects of miR674 or miR155 inhibition or over -expression on virus replication. [score:5]
To confirm whether miR-155 and miR-674 activated the immune function of DCs by inhibiting their target genes. [score:5]
Finally, we selected Myod1 targeted to miR-155 and Pgm2l1, Entpd6, Aldh18a1, Camk1d, Igf1r, or Mbnl3 targeted to miR-674 for further testing. [score:5]
Detection of viral replication in DCs when miR155 and miR674 were inhibited or over-expressed. [score:5]
Results of miRNA inhibitor treatment and dual luciferase reporter assays for miR155, miR674, and their target genes. [score:4]
Additionally, we identified four cellular miRNAs (miR-155, miR-674, miR-499, and miR-181b1) that were significantly up-regulated by NA. [score:4]
Nevertheless, our data showed that IRF-3 was down-regulated in the NA and miR-674 treated group, indicating a repression of IFN-α production. [score:4]
For cytokines, our data suggested that miR-674 increased the expression of IL-6, IL-12, and TNF-α but had no effect on anti-inflammatory cytokine IL-10. [score:3]
BMDCs were transfect with NA and miR155 or miR674 over expression plasmid for 24h. [score:3]
Our data demonstrated that both NA and miR-155- or miR-674 -treated groups activated p38 pathways, which might be contributed to the regulation of IFN-α by decreasing IRF-3. In summary, our results suggest that cellular miRNAs are important factors in regulating host DC functioning related to defending against viral infection and provide a deeper understanding of the mechanisms underlying the host defence system. [score:3]
We suggest that miR674 mediates the NA -induced immune responses related to DCs by targeting and repressing Mbnl3 gene (Figure 7). [score:3]
Furthermore, the other part of DCs was transfected with miR155 or miR674 after target genes were silenced for 24 h. Finally, this part of BMDCs was stained and examined by FACS. [score:3]
E. Results of the qPCR analysis of select target genes Myo1d, Pgm2l1, Aldh18a1, Camk1d, and Mbnl3) following stimulation by miR155 or miR674. [score:3]
Then, qPCR was conducted to determine the alteration of Pgm21l, Aldh18a1, Camk1d and Mbnl3, targets of miR674 or miR155. [score:3]
The 3′-UTRs of selected target genes (Myo1d, Pgm2l1, Aldh18a1, Entpd6, Camk1d, Igf1r and Mbnl3), harboring the predicted miR155 and miR674 binding sequences, were amplified and cloned into pMIR-Report luciferase vector (Ambion, TX) (Table 3). [score:3]
Our study demonstrated that Myo1d, Camk1d, and Mbnl3 were the target gene of miR-155 and miR-674. [score:3]
The predicted genes target position and mutated position of miR155 and miR674. [score:3]
A. Flow cytometric analysis of the phenotypic alterations in DCs stimulated by miR155, miR499, miR375, miR674, or miR181b1 (i. e. the expressions of CD40, CD80/86, and MHCII on BMDCs stimulated by miRNAs). [score:3]
Figure 3 A. Flow cytometric analysis of the phenotypic alterations in DCs stimulated by miR155, miR499, miR375, miR674, or miR181b1 (i. e. the expressions of CD40, CD80/86, and MHCII on BMDCs stimulated by miRNAs). [score:3]
Our results showed that miR-674 repressed the expression of Pgm2l1, Aldh18a1, Camk1d, and Mbnl3. [score:3]
In this report, we found that the NA segment of H9N2 AIV modulated the immune function of DCs by adjusting miR-155 and miR-674 expression. [score:3]
These results not only indicate that the activation of P38 pathway may involved in the regulation of the DC function when NA or miR-674 stimulation, but also suggested that IRF-3 might be involved in the regulating of NA-stimulated DC immune function. [score:3]
Most genes targeted by miR-674 are involved in immune and inflammatory responses. [score:3]
Furthermore, we found that miR-674 increased the expression of IL6, IL-12, and TNF-α, whereas miR-155 induced IL-6, IL-10, and TNF-α production (Figure 3D). [score:3]
MiR-674 and miR-155 target prediction and validation. [score:3]
Functional experiments demonstrated that miR-674 significantly increased the percentage ratio and MFI of CD40- and CD80 -positive cells in cultured BMDCs and that inhibition of the endogenous miR-674 reversed the effects. [score:3]
Moreover, we found that miR-155 overabundance activated both IkBa and P38 signalling pathways, while miR-674 over -expression group just activated the P38 signal pathway(Supplement 7). [score:3]
miRNA over -expression vectors were constructed and validated, as shown in Supplement 3. FACS results indicated that miR-674 and miR-155 significantly increased the percentage and MFI of CD40 -positive cells (Figure 3A and 3B) compared with the pSilencer group. [score:2]
Primers were listed in Table 1. MiRNAs (miR-155, miR-674, miR-499 and miR-181b1) were amplified and cloned into pSilencer4.1 (Invitrogen), whose primers were listed in Table 2. The 3′-UTRs of Myo1d mRNAs target to miR-155 and the 3′-UTRs of Pgm2l1, Aldh18a1, Entpd6, Camk1d, Igf1r and Mbnl3 mRNAs, harboring the predicted miR-674 binding sequences, were amplified and cloned into pMIR-Report luciferase vector (Ambion, TX) with primers listed in Table 3. The shRNA target to Myo1d, Camk1d and Mbnl3 gene were designed and purchased from Invitrogen. [score:2]
Immune function of miR-674 and miR-155 in regulating mice BMDCs. [score:2]
D. Dual luciferase assay results for miR-674 and its target genes (level significance: P < 0.05 or P < 0.01). [score:2]
This finding is consistent with our hypothesis that NA impacts DC functions by up -regulating miR-155 and miR-674. [score:2]
Previously, we demonstrated that H9N2 AIV activates interferon (IFN) regulatory factor (IRF)-7 and TNF receptor -associated factor (TRAF)-6. Thus, we continued to explore the signalling pathways that may be activated by NA and miR155 or miR674. [score:2]
Furthermore, BMDCs was cultured and collected at 24 h after treatments with miR674 or miR155. [score:1]
Moreover, overabundance of miR-155 and miR-674 promoted lymphocyte proliferation at a ratio of 1:1 and 1:5 respectively (Figure 3C). [score:1]
Thus, miR-674 may be a new immune reinforcing agent that can be used in activating the DC function involved in defending against H9N2 AIV. [score:1]
Effects of NA, miR-674, and miR-155 on signalling pathways. [score:1]
Accumulated IL-12 and enhanced proliferation of lymphocyte cells demonstrated that DCs matured and became activated when stimulated by miR-674. [score:1]
Among them, miR-155 and miR-674 were shown to support the ability of DCs to activate lymphocytes. [score:1]
Previous studies have demonstrated that NA and miR-674 or miR-155 have similar effects on BMDCs. [score:1]
We demonstrated a previously unidentified role for miR674 in the activation of immune responses. [score:1]
Cells were grouped as non-stimulated, pSilencer4.1-stimulated (negative control), miR155- or miR674-stimulated groups and LPS-stimulated (positive control). [score:1]
The current study is the first to focus on the role of miR-674 in evoking the immune activation of BMDCs. [score:1]
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[+] score: 7
These include on the one hand the up-regulated miRNAs: mmu-miR-342-3p, mmu-miR-142-3p, mmu-miR-142-5p, mmu-miR-21, mmu-miR-335-5p, mmu-miR-146a, mmu-miR-146b, mmu-miR-674 and mmu-miR-379; and on the other hand the down-regulated ones after HFD -induced obesity: mmu-miR-122, mmu-miR-133p, mmu-miR-1, mmu-miR-30a, mmu-miR-192 and mmu-miR-203. [score:7]
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[+] score: 6
Profiling of miRNAs expression was also performed in the YAC128 and R6/2 mice, showing that nine miRNAs (miR-22, miR-29c, miR-128, miR-132, miR-138, miR-218, miR-222, miR-344, and miR-674*) are commonly down-regulated in 12-month-old YAC128 mice and 10-week-old R6/2 mice (100). [score:6]
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[+] score: 5
However, the observation of reduced miR-10b-5p, miR-674-3p, miR-3535, and miR-378c expression upon Nrf2 ablation suggests that Nrf2 may be involved in the basal regulation of these miRNAs in the heart. [score:4]
Expression changes were validated for 12 miRNAs using specific primer assays in real-time and revealed a significant decrease in miR-10b-5p, miR-674-3p, miR-3535, and miR-378c while miR-30b-5p, miR-208a-5p, miR-350-3p, and miR-582-5p, and miR-1249-3p levels were increased. [score:1]
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[+] score: 3
Among over-expressed miRNAs, e. g., miR-31, miR-96, and miR-92b, which are known to be involved in cancer progression, eight miRNAs (miR-466b/c/p, miR-674, miR-672, miR-1983, miR-3105, and miR-6539) have not been shown to play a role in breast cancer progression. [score:3]
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[+] score: 3
01 Stress response, cell proliferation miR-542 ↓2.60 NA miR-574 ↑2.09 Inflammation (Tlr9 activation), cell proliferation, apoptosis miR-669j ↑3.12 NA miR-672 ↑2.40 NA miR-674 ↑2.19 NA miR-744 ↑4.35Oncogene (Tgf) suppression miR-873 ↑2.53 ↑3.22 NA miR-1930 ↑3.31 NA miR-1934 ↑2.17 ↑3.27 NA miR-1942 ↑2.49 NA miR-3064 ↑2.50 NA miR-3065 ↑3.20 NA miR-3069 ↑2.98 NA miR-3071 ↑3.51 NA miR-3073 ↓2.78 NA miR-3092 ↑3.48 NA miR-3093 ↑3.28 NA miR-3109 ↓2.07 NAAll reported variations were statistically significant (P < 0.05). [score:3]
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[+] score: 1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-16-1, hsa-mir-17, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-23a, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-27a, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-100, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-16-2, mmu-mir-23b, mmu-mir-27b, mmu-mir-29b-1, mmu-mir-30a, mmu-mir-30b, mmu-mir-127, mmu-mir-128-1, mmu-mir-132, mmu-mir-133a-1, mmu-mir-188, mmu-mir-194-1, mmu-mir-195a, mmu-mir-199a-1, hsa-mir-199a-1, mmu-mir-200b, mmu-mir-205, mmu-mir-206, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-122, mmu-mir-30e, hsa-mir-199a-2, hsa-mir-199b, hsa-mir-205, hsa-mir-211, hsa-mir-212, hsa-mir-214, hsa-mir-217, hsa-mir-200b, hsa-mir-23b, hsa-mir-27b, hsa-mir-30b, hsa-mir-122, hsa-mir-128-1, hsa-mir-132, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-127, hsa-mir-138-1, hsa-mir-188, hsa-mir-194-1, hsa-mir-195, hsa-mir-206, mmu-mir-19b-2, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-mir-200a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-16-1, mmu-mir-16-2, mmu-mir-23a, mmu-mir-26a-1, mmu-mir-26b, mmu-mir-29a, mmu-mir-29c, mmu-mir-27a, mmu-mir-31, mmu-mir-351, hsa-mir-200c, mmu-mir-17, mmu-mir-19a, mmu-mir-100, mmu-mir-200c, mmu-mir-212, mmu-mir-214, mmu-mir-26a-2, mmu-mir-211, mmu-mir-29b-2, mmu-mir-199a-2, mmu-mir-199b, mmu-mir-19b-1, mmu-mir-138-1, mmu-mir-128-2, hsa-mir-128-2, mmu-mir-217, hsa-mir-194-2, mmu-mir-194-2, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-379, mmu-mir-379, mmu-mir-133a-2, mmu-mir-133b, hsa-mir-133b, mmu-mir-412, mmu-mir-431, hsa-mir-431, hsa-mir-451a, mmu-mir-451a, mmu-mir-467a-1, hsa-mir-412, hsa-mir-485, hsa-mir-487a, hsa-mir-491, hsa-mir-503, hsa-mir-504, mmu-mir-485, hsa-mir-487b, mmu-mir-487b, mmu-mir-503, hsa-mir-556, hsa-mir-584, mmu-mir-665, mmu-mir-669a-1, mmu-mir-690, mmu-mir-669a-2, mmu-mir-669a-3, mmu-mir-669c, mmu-mir-696, mmu-mir-491, mmu-mir-504, hsa-mir-665, mmu-mir-467e, mmu-mir-669k, mmu-mir-669f, hsa-mir-664a, mmu-mir-1896, mmu-mir-1894, mmu-mir-1943, mmu-mir-1983, mmu-mir-1839, mmu-mir-3064, mmu-mir-3072, mmu-mir-467a-2, mmu-mir-669a-4, mmu-mir-669a-5, mmu-mir-467a-3, mmu-mir-669a-6, mmu-mir-467a-4, mmu-mir-669a-7, mmu-mir-467a-5, mmu-mir-467a-6, mmu-mir-669a-8, mmu-mir-669a-9, mmu-mir-467a-7, mmu-mir-467a-8, mmu-mir-669a-10, mmu-mir-467a-9, mmu-mir-669a-11, mmu-mir-467a-10, mmu-mir-669a-12, mmu-mir-3473a, hsa-mir-23c, hsa-mir-4436a, hsa-mir-4454, mmu-mir-3473b, hsa-mir-4681, hsa-mir-3064, hsa-mir-4436b-1, hsa-mir-4790, hsa-mir-4804, hsa-mir-548ap, mmu-mir-3473c, mmu-mir-5110, mmu-mir-3473d, mmu-mir-5128, hsa-mir-4436b-2, mmu-mir-195b, mmu-mir-133c, mmu-mir-30f, mmu-mir-3473e, hsa-mir-6825, hsa-mir-6888, mmu-mir-6967-1, mmu-mir-3473f, mmu-mir-3473g, mmu-mir-6967-2, mmu-mir-3473h
WT) Musmusculus mmu-miR-205_st 0.00222063 –12.7246 Musmusculus mmu-miR-200c_st 0.00648219 –5.19281 Musmusculus mmu-miR-152_st 0.00458781 –3.38479 Musmusculus mmu-miR-217_st 0.000331015 –3.0084 Musmusculus mmu-miR-30a-star_st 0.0228718 –2.96337 Musmusculus mmu-miR-491_st 0.000552044 –2.7046 Musmusculus mmu-miR-329_st 0.0117443 –2.6441 Musmusculus mmu-miR-138-1-star_st 0.00500405 –2.41789 Musmusculus mmu-miR-29a_st 0.03658 –2.40317 Musmusculus mmu-miR-128_st 0.00381972 –2.31917 Musmusculus mmu-miR-5100_st 7.60E-05 –2.28855 Musmusculus mmu-miR-412-5p_st 0.0241069 –2.23696 Musmusculus mmu-miR-421_st 0.00638554 –2.0941 Musmusculus mmu-miR-1839-5p_st 0.00541099 –2.05082 Musmusculus mmu-miR-27b_st 0.00384257 –2.02513 Musmusculus mmu-miR-674-star_st 0.0249087 –1. [score:1]
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[+] score: 1
Other miRNAs from this paper: mmu-let-7g, mmu-let-7i, mmu-mir-23b, mmu-mir-29b-1, mmu-mir-30b, mmu-mir-99a, mmu-mir-126a, mmu-mir-132, mmu-mir-141, mmu-mir-181a-2, mmu-mir-185, mmu-mir-193a, mmu-mir-199a-1, mmu-mir-200b, mmu-mir-34c, mmu-let-7d, mmu-mir-196a-1, mmu-mir-196a-2, mmu-mir-200a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-16-1, mmu-mir-16-2, mmu-mir-20a, mmu-mir-22, mmu-mir-23a, mmu-mir-26a-1, mmu-mir-26b, mmu-mir-34a, mmu-mir-200c, mmu-mir-212, mmu-mir-181a-1, mmu-mir-26a-2, mmu-mir-29b-2, mmu-mir-199a-2, mmu-mir-199b, mmu-mir-378a, mmu-mir-451a, mmu-mir-423, mmu-mir-146b, bta-mir-26a-2, bta-let-7f-2, bta-mir-16b, bta-mir-20a, bta-mir-26b, bta-mir-99a, bta-mir-126, bta-mir-181a-2, bta-mir-199a-1, bta-mir-30b, bta-mir-193a, bta-let-7d, bta-mir-132, bta-mir-199b, bta-mir-200a, bta-mir-200c, bta-mir-22, bta-mir-23a, bta-mir-29b-2, bta-mir-423, bta-let-7g, bta-mir-200b, bta-let-7a-1, bta-let-7f-1, bta-let-7i, bta-mir-23b, bta-mir-34c, bta-let-7a-2, bta-let-7a-3, bta-let-7b, bta-let-7c, bta-let-7e, bta-mir-34a, bta-mir-141, bta-mir-146b, bta-mir-16a, bta-mir-185, bta-mir-196a-2, bta-mir-196a-1, bta-mir-199a-2, bta-mir-212, bta-mir-26a-1, bta-mir-29b-1, bta-mir-181a-1, bta-mir-2284i, bta-mir-2284s, bta-mir-2284l, bta-mir-2284j, bta-mir-2284t, bta-mir-2284d, bta-mir-2284n, bta-mir-2284g, bta-mir-2284p, bta-mir-2284u, bta-mir-2284f, bta-mir-2284a, bta-mir-2284k, bta-mir-2284c, bta-mir-2284v, bta-mir-2284q, bta-mir-2284m, bta-mir-2284b, bta-mir-2284r, bta-mir-2284h, bta-mir-2284o, bta-mir-2284e, bta-mir-2284w, bta-mir-2284x, bta-mir-2284y-1, mmu-let-7j, bta-mir-2284y-2, bta-mir-2284y-3, bta-mir-2284y-4, bta-mir-2284y-5, bta-mir-2284y-6, bta-mir-2284y-7, bta-mir-2284z-1, bta-mir-2284aa-1, bta-mir-2284z-3, bta-mir-2284aa-2, bta-mir-2284aa-3, bta-mir-2284z-4, bta-mir-2284z-5, bta-mir-2284z-6, bta-mir-2284z-7, bta-mir-2284aa-4, bta-mir-2285t, bta-mir-2284z-2, mmu-let-7k, mmu-mir-126b, bta-mir-2284ab, bta-mir-2284ac
Sixty miRNA were significantly less loaded (or depleted) in AGO2-RISC (p-value<0.05), including seven that were loaded at less than 10% (miR-674-5p, miR-34c-5p, miR-196a-5p, let-7j-5p, miR-34a-5p, let-7d-5p and miR-185-5p). [score:1]
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[+] score: 1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-20a, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-29a, hsa-mir-30a, hsa-mir-93, hsa-mir-101-1, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-107, hsa-mir-16-2, mmu-let-7g, mmu-let-7i, mmu-mir-15b, mmu-mir-23b, mmu-mir-29b-1, mmu-mir-30a, mmu-mir-30b, mmu-mir-101a, mmu-mir-124-3, mmu-mir-125a, mmu-mir-130a, mmu-mir-9-2, mmu-mir-135a-1, mmu-mir-136, mmu-mir-138-2, mmu-mir-140, mmu-mir-144, mmu-mir-145a, mmu-mir-146a, mmu-mir-149, mmu-mir-152, mmu-mir-10b, mmu-mir-181a-2, mmu-mir-182, mmu-mir-183, mmu-mir-185, mmu-mir-24-1, mmu-mir-191, mmu-mir-193a, mmu-mir-195a, mmu-mir-200b, mmu-mir-204, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-30e, hsa-mir-7-1, hsa-mir-7-2, hsa-mir-7-3, hsa-mir-10a, hsa-mir-10b, hsa-mir-34a, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-182, hsa-mir-183, hsa-mir-204, hsa-mir-181a-1, hsa-mir-221, hsa-mir-222, hsa-mir-200b, mmu-mir-301a, mmu-mir-34c, mmu-mir-34b, mmu-let-7d, mmu-mir-130b, hsa-let-7g, hsa-let-7i, hsa-mir-15b, hsa-mir-23b, hsa-mir-30b, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-130a, hsa-mir-135a-1, hsa-mir-135a-2, hsa-mir-138-2, hsa-mir-140, hsa-mir-144, hsa-mir-145, hsa-mir-152, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-136, hsa-mir-138-1, hsa-mir-146a, hsa-mir-149, hsa-mir-185, hsa-mir-193a, hsa-mir-195, hsa-mir-320a, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-15a, mmu-mir-16-1, mmu-mir-16-2, mmu-mir-20a, mmu-mir-23a, mmu-mir-24-2, mmu-mir-26a-1, mmu-mir-26b, mmu-mir-29a, mmu-mir-29c, mmu-mir-93, mmu-mir-34a, mmu-mir-330, mmu-mir-339, mmu-mir-340, mmu-mir-135b, mmu-mir-101b, hsa-mir-200c, hsa-mir-181b-2, mmu-mir-107, mmu-mir-10a, mmu-mir-17, mmu-mir-200c, mmu-mir-181a-1, mmu-mir-320, mmu-mir-26a-2, mmu-mir-221, mmu-mir-222, mmu-mir-29b-2, mmu-mir-135a-2, mmu-mir-124-1, mmu-mir-124-2, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-138-1, mmu-mir-181b-1, mmu-mir-181c, mmu-mir-7a-1, mmu-mir-7a-2, mmu-mir-7b, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-101-2, hsa-mir-34b, hsa-mir-34c, hsa-mir-301a, hsa-mir-130b, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-361, mmu-mir-361, hsa-mir-376a-1, mmu-mir-376a, hsa-mir-340, hsa-mir-330, hsa-mir-135b, hsa-mir-339, hsa-mir-335, mmu-mir-335, mmu-mir-181b-2, mmu-mir-376b, mmu-mir-434, mmu-mir-467a-1, hsa-mir-376b, hsa-mir-485, hsa-mir-146b, hsa-mir-193b, hsa-mir-181d, mmu-mir-485, mmu-mir-541, hsa-mir-376a-2, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-320b-2, mmu-mir-301b, mmu-mir-146b, mmu-mir-467b, mmu-mir-669c, mmu-mir-708, mmu-mir-676, mmu-mir-181d, mmu-mir-193b, mmu-mir-467c, mmu-mir-467d, hsa-mir-541, hsa-mir-708, hsa-mir-301b, mmu-mir-467e, mmu-mir-467f, mmu-mir-467g, mmu-mir-467h, hsa-mir-320d-1, hsa-mir-320c-2, hsa-mir-320d-2, mmu-mir-467a-2, mmu-mir-467a-3, mmu-mir-467a-4, mmu-mir-467a-5, mmu-mir-467a-6, mmu-mir-467a-7, mmu-mir-467a-8, mmu-mir-467a-9, mmu-mir-467a-10, hsa-mir-320e, hsa-mir-676, mmu-mir-101c, mmu-mir-195b, mmu-mir-145b, mmu-let-7j, mmu-mir-130c, mmu-mir-30f, mmu-let-7k, mmu-mir-9b-2, mmu-mir-124b, mmu-mir-9b-1, mmu-mir-9b-3
88E-0327mmu-miR-451mir-4510.3310.722.79E-046.57E-0366mmu-miR-669c-5pmir-4670.178.847.68E-037.41E-0255mmu-miR-485-3pmir-4850.196.755.52E-036.39E-0265mmu-miR-669nmir-669n0.147.887.46E-037.31E-0260mmu-miR-674-5pmir-6740.178.646.08E-036.45E-0254mmu-miR-676-3pmir-6760.156.634.48E-035.28E-0211mmu-miR-7a-5pmir- [score:1]
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[+] score: 1
There were 2 validated miRNAs in the MGI databases that mapped within Gdac1; Mir674 [1a] (117 mbp) and Mir147 [111a] (122.4 mbp). [score:1]
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