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18 publications mentioning hsa-mir-769

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-769. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 30
Five representative differentially expressed miRNAs (hsa-miR-181a, hsa-miR-769-5p, hsa-miR-361-5p, hsa-miR-1304, and hsa-miR-608) were selected to undergo RT-qPCR validation based on highest fold-change as well as putative targets as identified by the TargetScan web tool (Fig. 5a). [score:7]
RT-qPCR indicated that miR-181a, miR-769-5p, and miR-361-5p were all down-regulated in siRNA -transfected A549 and SK-LU1 cells when compared to non -transfected cells, while miR-608 was up-regulated. [score:6]
However, RT-qPCR performed on NP-69 normal cells indicated opposing results in relation to miR-181a, miR-769-5p and miR-1304 expression, with these miRNAs being up-regulated. [score:6]
While hsa-miR-608 was significantly up-regulated in NP-69 cells following transfection with si Bcl-xL, it was found that opposing results were observed in NP-69 cells in regards to the expression of miR-181a, miR-769-5p and miR-1304, in comparison to A549 and SK-LU1 cells (Fig. 5a). [score:6]
Bioinformatic analyses predicted that the five significantly dysregulated miRNAs (hsa-miR-181a, hsa-miR-769-5p, hsa-miR-361-5p, hsa-miR-1304, and hsa-miR-608) were linked to various apoptotic signaling pathways, including the PI3K/AKT, WNT, TGF-β, MAPK/ERK and the intrinsic pathway, and all were implicated as those directly affected by Bcl-xL levels. [score:3]
0081735.g005 Figure 5(A) RT-qPCR of the five miRNAs (hsa-miR-181a, hsa-miR-769-5p, hsa-miR-361-5p, hsa-miR-1304, and hsa-miR-608) validated against microarray results, and presented as normalized fold-change values. [score:1]
All experiments were carried out with three independent biological replicates and presented as mean ± S. D. (A) RT-qPCR of the five miRNAs (hsa-miR-181a, hsa-miR-769-5p, hsa-miR-361-5p, hsa-miR-1304, and hsa-miR-608) validated against microarray results, and presented as normalized fold-change values. [score:1]
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2
[+] score: 30
For hsa-miR-769-3p the microarray -based p-value was 0.00013, in qRT-PCR replicates we observed the same significant up-regulation after 2h EDTA storage (p = 0.004). [score:4]
Besides hsa-miR-769-3p, the expression of hsa-let-7e seems also to be induced due to the 2h storage in EDTA tubes. [score:3]
As mentioned before, other studies found hsa-miR-769-3p expressed in platelets [19]. [score:3]
Fig 3 shows the comparison of the normalized expression of the miR-769-3p for the 6 individuals under the four blood sampling conditions. [score:3]
Hsa-miR-769-3p was previously reported to be highly expressed in platelets [19]. [score:3]
After adjustment for multiple testing only four miRNAs including miR-769-3p remained significant for the comparison between EDTA 2h and PAXgene. [score:1]
We identified specific miRNAs namely miR-769-3p, of which the abundance is strongly altered by the different blood sampling conditions. [score:1]
The most obvious change of abundance of miR-769-3p was found in blood that was transferred in PAXgene [TM] blood RNA tubes 2 h after phlebotomy. [score:1]
For example miRNA-769-3p was found in all six individuals under the 2h EDTA condition but not in any individual under the PAXgene condition. [score:1]
As for the miRNAs that showed an altered abundance under specific conditions, we identified hsa-miR-769-3p that was not detected in any of the six PAXgene blood samples, but in all EDTA 2h samples. [score:1]
Accordingly, hsa-miR-769-3p was also the only miRNA that showed a significantly different abundance between the 4 blood sample conditions by an ANOVA analysis (Benjamini-Hochberg adjusted p-value of 0.003). [score:1]
By performing an analysis of variance (ANOVA) we identified miR-769-3p with an adjusted p-value of 0.003. [score:1]
Box-plots of normalized abundance values of miR-769-3p for the 6 individuals under the four blood sampling conditions. [score:1]
Notable, miR-769-3p was also identified by the above analysis of the binary data. [score:1]
The largest difference was found for miR-769-3p indicated in the lower left corner that was positive in 6 samples under the 2h EDTA condition and not in any sample of the PAXgene condition. [score:1]
Hsa-miR-769-3p was also the only miRNA that showed a significantly different abundance between the 4 blood sample conditions by an ANOVA analysis (adj. [score:1]
In this study only hsa-miR-769-5p but not hsa-miR-769-3p was detected in all analyzed samples. [score:1]
0143321.g003 Fig 3The most obvious change of abundance of miR-769-3p was found in blood that was transferred in PAXgene [TM] blood RNA tubes 2 h after phlebotomy. [score:1]
The most affected miRNA was miR-769-3p that was not detected in any of the six PAXgene blood samples, but in all EDTA 2h samples. [score:1]
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3
[+] score: 8
This resulted in a significant suppression of FAS mRNA, which is a target of miRNA-2320 and miRNA-181a, and decreases of SERPINE mRNA, a target of miRNA-769-3p and miRNA-128, respectively [77]. [score:7]
Chen et al. [77] recently demonstrated that the addition of porcine milk exosomes to IPEC-J2 intestinal cells raised intracellular levels of milk-specific miRNA-7134, miRNA-1343, miRNA-2320, miRNA-181a, miRNA-769-3p, and miRNA-128. [score:1]
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4
[+] score: 8
Though miR-29b has been shown to target PTEN transcripts [60], a basis for the differential expression of the two microRNAs, miR-29b and miR-769-3p, between the PTEN mutant and wild-type lines (figure 4) is not evident in published literature. [score:5]
Using empirical Bayes moderated t-statistics and Benjamini-Hochberg correction for FDR <5%, microRNAs miR-29b and miR-769-3p were found to be the only two microRNAs that were differentially expressed between the 47 mutant PTEN and 12 wild-type PTEN lines (P<0.01 for both microRNAs). [score:3]
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5
[+] score: 7
Statistical significance enrichment analysis identified nine miRNAs as frequently targeted at detected spliced transcripts: hsa-miR-769-3p (predicted to target four transcripts), hsa-miR-378 (with six targets) as well as hsa-mir-320, hsa-miR-92b-5p, hsa-miR-16, hsa-miR-150, hsa-miR-671, hsa-miR-20a, and hsa-miR-18b (The full list and adjusted p-values are given under Table S10). [score:7]
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6
[+] score: 7
For example, a kidney developing gene, Homeobox A11 (HOXA11), was regulated by three miRNAs in KIRC and suppressed expression was observed during progression (3-fold, miR-769-3p (Stage I); 2.9-fold, miR-484 (Stage II); 2.1-fold, miR-30d-5p (Stage III); 2.2-fold, none (Stage IV)) (Fig.   4A). [score:6]
Similar observation was made on Kinesin Family Member 1 C (KIF1C) gene: five miRNAs interacted with KIF1C in three stages of KIRC (1.8-fold, miR-484 and miR-769-3p (Stage I); 1.9-fold, miR-1260b, let-7b-5p, miR-149-5p, miR-769-3p and miR-484 (Stage II); 2.0-fold, miR-769-3p (Stage III); 2.2-fold, none (Stage IV)) (Fig.   4B). [score:1]
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7
[+] score: 6
Five miRNAs were upregulated (miR-130b, miR-182, miR10b, miR320a, and miR769) ranging from a 2.9 to 30-fold induction in the NanoString miRNA assay, whereas six miRNAs were downregulated (miR122, miR451a, miR200a, miR139, miR148a, and miR375) ranging from −2.2 to −6 fold (Table  6). [score:6]
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8
[+] score: 5
Conversely, miR-192-5p, miR-30a-5p, miR-381-3p, miR-769-5p and let7i-5p were significantly up-regulated, both at 16 and 36 hrs of H [2]O [2] treatment (Fig. 4A and supplementary Fig. S7 in linear scale). [score:4]
On the other side, in the qPCR-array study [19] miR-192-5p was induced by H [2]O [2] treatment, but not further pursued, miR-16-5p was not modulated, while probes for miR769-5p were not present in the array. [score:1]
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9
[+] score: 4
14 hsa-miR-127-5p 1708.96 hsa-miR-139-5p 1096.97 hsa-miR-146b-5p 1662.59 hsa-miR-23b-3p 1281.21 hsa-miR-193b-3p 1275.18 hsa-miR-320b 1148.60 hsa-miR-146a-5p 1135.37 hsa-miR-210 1055.20 hsa-miR-708-3p 1027.45 hsa-miR-769-5p 1004.10 hsa-miR-378d 1000.99 To determine if adjacent fascia exhibits a disease-like molecular phenotype, we compared the adjacent fascia biopsies with patient matched diseased Dupuytren’s fascia. [score:4]
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10
[+] score: 4
P38 MAPKs (MAPK11, MAPK13, and MAPK14) were found to be regulated by miR-769-5p, miR-146b-5p, let-7g, miR-30b, miR-31, miR-361-3p, and miR-362-3p (Figure 7), which were all down expressed in H1N1 critically ill patients. [score:4]
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11
[+] score: 4
Increased expression of miR-494, miR-769-3p and miR-490-3p was associated with ≥70% coronary stenosis. [score:3]
As seen in Table 4, anti-hypertensive therapy, smoking and miR-769-3p were significantly associated with the coronary status. [score:1]
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12
[+] score: 3
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-mir-16-1, hsa-mir-17, hsa-mir-18a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-29a, hsa-mir-31, hsa-mir-99a, hsa-mir-100, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-106a, hsa-mir-16-2, hsa-mir-192, hsa-mir-199a-1, hsa-mir-208a, hsa-mir-30c-2, hsa-mir-147a, hsa-mir-10a, hsa-mir-34a, hsa-mir-181b-1, hsa-mir-199a-2, hsa-mir-203a, hsa-mir-204, hsa-mir-217, hsa-mir-219a-1, hsa-mir-221, hsa-mir-222, hsa-mir-223, hsa-mir-200b, hsa-mir-27b, hsa-mir-30b, hsa-mir-122, hsa-mir-125b-1, hsa-mir-132, hsa-mir-140, hsa-mir-142, hsa-mir-143, hsa-mir-145, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-126, hsa-mir-146a, hsa-mir-150, hsa-mir-185, hsa-mir-193a, hsa-mir-195, hsa-mir-200c, hsa-mir-155, hsa-mir-181b-2, hsa-mir-30c-1, hsa-mir-219a-2, hsa-mir-296, hsa-mir-130b, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-302d, hsa-mir-374a, hsa-mir-375, hsa-mir-378a, hsa-mir-330, hsa-mir-328, hsa-mir-342, hsa-mir-325, hsa-mir-424, hsa-mir-429, hsa-mir-450a-1, hsa-mir-486-1, hsa-mir-146b, hsa-mir-497, hsa-mir-520e, hsa-mir-520f, hsa-mir-520a, hsa-mir-520b, hsa-mir-520c, hsa-mir-520d, hsa-mir-520g, hsa-mir-520h, hsa-mir-450a-2, hsa-mir-503, hsa-mir-608, hsa-mir-625, hsa-mir-629, hsa-mir-663a, hsa-mir-1271, hsa-mir-378d-2, hsa-mir-675, hsa-mir-147b, hsa-mir-374b, hsa-mir-663b, hsa-mir-378b, hsa-mir-378c, hsa-mir-374c, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-4661, hsa-mir-219b, hsa-mir-203b, hsa-mir-378j, hsa-mir-486-2
Among these, miR-328, miR-330-3p, miR-221, and miR-125a-5p had their expressions reduced, while miR-192, miR-486-5p, miR-19b, miR-106a, miR-130b, miR-18a, and miR-769-5p displayed increased levels after the intervention. [score:3]
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13
[+] score: 3
34 hsa-miR-335 −0.35hsa-miR-345 [44], [53], [71] 1.16 hsa-miR-363 0.99 hsa-miR-371-5p 0.55 hsa-miR-421 0.50 hsa-miR-483-5p 1.33 hsa-miR-494 0.87 hsa-miR-505* −0.40 hsa-miR-513a-5p 1.06 hsa-miR-513b 1.19 hsa-miR-513c 1.22 hsa-miR-551b −0.40 hsa-miR-574-5p 0.97hsa-miR-630 [68], [73] 0.96 hsa-miR-769-5p −0.34 hsa-miR-801 0.66 hsa-miR-873 −0.64 hsa-miR-877* 0.72 hsa-miR-923 0.89 hsa-miR-940 0.49 hsa-miR-95 −0.44 hsa-miR-99a −0.64Irradiated and non-irradiated PBL of the same donors were incubated in static gravity (1 g) for 4 and 24 h, and miRNA expression profile was analyzed at the end of each incubation time. [score:3]
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14
[+] score: 2
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-30a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-100, hsa-mir-101-1, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-34a, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-30b, hsa-mir-144, hsa-mir-153-1, hsa-mir-153-2, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-1-1, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-101-2, hsa-mir-34b, hsa-mir-34c, hsa-mir-30e, hsa-mir-92b, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-548e, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-548q, bma-let-7, bma-lin-4, bma-mir-2a, bma-mir-2b-1, bma-mir-2b-2, bma-mir-2c, bma-mir-9, bma-mir-34, bma-mir-71, bma-mir-72, bma-mir-92, bma-mir-100a, bma-mir-100b, bma-mir-100c, bma-mir-100d, bma-mir-153, bma-mir-228, bma-mir-279, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, bma-mir-2i, bma-mir-2g, bma-mir-2e, hsa-mir-548ba, bma-mir-252, bma-mir-2d, bma-mir-84-1, bma-mir-84-2, bma-mir-2f, bma-mir-2h-1, bma-mir-2h-2, hsa-mir-548bb, hsa-mir-548bc
Other miRNA families, such as miR-228, miR-8 and miR-769 had only one member detected in this study. [score:1]
The ten most abundant miRNA families are shown in Table 1. In comparison to B. xylophilus, miR-100, miR-1, miR-71 and let-7 were the most frequently sequenced miRNA in both species, while miR-279, miR-9, miR-101, miR-2 and miR-769 exhibited high abundance in D. immitis only. [score:1]
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15
[+] score: 1
Furthermore, the abundance of 3 miRNAs (miR-27a-5p, miR-769-5p and miR-30c-1-5p) significantly decreased in response to AraC treatment of infected cells at 6 hpi (Fig 2c). [score:1]
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16
[+] score: 1
MiR-186, miR-769, miR-95, miR-202 and let-7 g were also relevant to cancer pathways, but did not serve other functions. [score:1]
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17
[+] score: 1
MRESS SNPs FST Gene miR CNM SNPs FST Gene miR rs3822506 0.8743 TCERG1 miR-590 rs7665492 0.8942 ENAM miR-3916 rs1217382 0.8469 BCL2L15 miR-17 rs1043809 0.8900 EPN2 miR-3616-3p rs3087542 0.8428 EMCN miR-197 rs2470102 0.8859 MYEF2 miR-1180 rs3742988 0.8385 CDAN1 miR-378 rs7290134 0.8695 TNFRSF13C miR-1205 rs1071738 0.8298 PALLD miR-182 rs8057598 0.8596 NOL3 miR-769-3p rs1969589 0.8545 RGMA miR-593* rs1246014 0.8476 COPS7B miR-1273d rs12449157 0.8399 GFOD2 miR-125a-3p rs16990309 0.8398 SLC23A2 miR-760 rs3742988 0.8385 CDAN1 miR-326 rs2292549 0.8361 GPBAR1 miR-936 rs1995939 0.8338 STARD9 miR-3943 rs3199486 0.8321 STARD9 miR-2278 rs873258 0.8312 TSPAN14 miR-873MRESS and CNM SNPs showing highest levels of population sub-division among HapMap phase 3 data- All SNPs falling 2 SDs from the mean F [ST ]of 3'UTR SNPs. [score:1]
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18
[+] score: 1
Other miRNAs from this paper: hsa-mir-188, hsa-mir-155
For three of the genes of interest, we identified experimentally validated miRNAs relevant in the context of breast cancer: for ERBB2, miR-155 [36], for LAPTM4B, miR-188 [37], and for NDRG1, miR-769 [38]. [score:1]
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