1 |
[+]
score:
18
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-18a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-21, hsa-mir-23a, hsa-mir-31, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-96, hsa-mir-98, hsa-mir-99a, hsa-mir-106a, mmu-let-7g, mmu-let-7i, mmu-mir-23b, mmu-mir-99a, mmu-mir-127, mmu-mir-128-1, mmu-mir-136, mmu-mir-142a, mmu-mir-145a, mmu-mir-10b, mmu-mir-182, mmu-mir-183, mmu-mir-187, mmu-mir-193a, mmu-mir-195a, mmu-mir-200b, mmu-mir-206, mmu-mir-143, hsa-mir-139, hsa-mir-10b, hsa-mir-182, hsa-mir-183, hsa-mir-187, hsa-mir-210, hsa-mir-216a, hsa-mir-217, hsa-mir-219a-1, hsa-mir-221, hsa-mir-222, hsa-mir-224, hsa-mir-200b, mmu-mir-302a, mmu-let-7d, mmu-mir-106a, hsa-let-7g, hsa-let-7i, hsa-mir-23b, hsa-mir-128-1, hsa-mir-142, hsa-mir-143, hsa-mir-145, hsa-mir-127, hsa-mir-136, hsa-mir-193a, hsa-mir-195, hsa-mir-206, mmu-mir-19b-2, mmu-mir-200a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-18a, mmu-mir-21a, mmu-mir-23a, mmu-mir-31, mmu-mir-92a-2, mmu-mir-96, mmu-mir-98, hsa-mir-200c, mmu-mir-17, mmu-mir-139, mmu-mir-200c, mmu-mir-210, mmu-mir-216a, mmu-mir-219a-1, mmu-mir-221, mmu-mir-222, mmu-mir-224, mmu-mir-19b-1, mmu-mir-92a-1, mmu-mir-128-2, hsa-mir-128-2, mmu-mir-217, hsa-mir-200a, hsa-mir-302a, hsa-mir-219a-2, mmu-mir-219a-2, hsa-mir-363, mmu-mir-363, hsa-mir-302b, hsa-mir-302c, hsa-mir-302d, hsa-mir-371a, hsa-mir-18b, hsa-mir-20b, hsa-mir-452, mmu-mir-452, ssc-mir-106a, ssc-mir-145, ssc-mir-216-1, ssc-mir-217-1, ssc-mir-224, ssc-mir-23a, ssc-mir-183, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-136, ssc-mir-139, ssc-mir-18a, ssc-mir-21, hsa-mir-146b, hsa-mir-493, hsa-mir-495, hsa-mir-497, hsa-mir-505, mmu-mir-20b, hsa-mir-92b, mmu-mir-302b, mmu-mir-302c, mmu-mir-302d, hsa-mir-671, mmu-mir-216b, mmu-mir-671, mmu-mir-497a, mmu-mir-495, mmu-mir-146b, mmu-mir-708, mmu-mir-505, mmu-mir-18b, mmu-mir-493, mmu-mir-92b, hsa-mir-708, hsa-mir-216b, hsa-mir-935, hsa-mir-302e, hsa-mir-302f, ssc-mir-17, ssc-mir-210, ssc-mir-221, mmu-mir-1839, ssc-mir-146b, ssc-mir-206, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-128-2, ssc-mir-143, ssc-mir-10b, ssc-mir-23b, ssc-mir-193a, ssc-mir-99a, ssc-mir-98, ssc-mir-92a-2, ssc-mir-92a-1, ssc-mir-92b, ssc-mir-142, ssc-mir-497, ssc-mir-195, ssc-mir-127, ssc-mir-222, ssc-mir-708, ssc-mir-935, ssc-mir-19b-2, ssc-mir-19b-1, ssc-mir-1839, ssc-mir-505, ssc-mir-363-1, hsa-mir-219b, hsa-mir-371b, ssc-let-7a-2, ssc-mir-18b, ssc-mir-187, ssc-mir-218b, ssc-mir-219a, mmu-mir-195b, mmu-mir-145b, mmu-mir-21b, mmu-let-7j, mmu-mir-21c, ssc-let-7d, ssc-let-7f-2, ssc-mir-20b-1, ssc-mir-20b-2, ssc-mir-31, ssc-mir-182, ssc-mir-216-2, ssc-mir-217-2, ssc-mir-363-2, ssc-mir-452, ssc-mir-493, ssc-mir-671, mmu-let-7k, ssc-mir-7138, mmu-mir-219b, mmu-mir-216c, mmu-mir-142b, mmu-mir-497b, mmu-mir-935, ssc-mir-9843, ssc-mir-371, ssc-mir-219b, ssc-mir-96, ssc-mir-200b
adj ssc-miR-371-5p 11.3640 6.94E-19 7.93E-18 ssc-miR-219b-3p 10.1953 2.42E-32 1.94E-30 ssc-miR-218b 5.3242 5.95E-18 5.95E-17 ssc-miR-92b-3p 3.2034 3.39E-17 3.01E-16 ssc-miR-7138-3p 2.0714 1.31E-02 1.59E-02 ssc-miR-219a 2.0675 1.31E-07 4.37E-07 ssc-miR-99a 1.4504 2.83E-06 8.09E-06 ssc-miR-128 1.1854 1.31E-05 3.49E-05 To validate this differential miRNA expression pattern, we performed quantitative stem-loop RT-PCR to assess the expression of the three[35] selected hpiPSCs- specific miRNAs: ssc-miR-371-5p, ssc-miR-106a and ssc-miR-363, which were found to be more highly expressed in hpiPSCs (Fig 3B).
[score:7]
adj ssc-miR-371-5p 11.3640 6.94E-19 7.93E-18 ssc-miR-219b-3p 10.1953 2.42E-32 1.94E-30 ssc-miR-218b 5.3242 5.95E-18 5.95E-17 ssc-miR-92b-3p 3.2034 3.39E-17 3.01E-16 ssc-miR-7138-3p 2.0714 1.31E-02 1.59E-02 ssc-miR-219a 2.0675 1.31E-07 4.37E-07 ssc-miR-99a 1.4504 2.83E-06 8.09E-06 ssc-miR-128 1.1854 1.31E-05 3.49E-05To validate this differential miRNA expression pattern, we performed quantitative stem-loop RT-PCR to assess the expression of the three[35] selected hpiPSCs- specific miRNAs: ssc-miR-371-5p, ssc-miR-106a and ssc-miR-363, which were found to be more highly expressed in hpiPSCs (Fig 3B).
[score:7]
Cell cycle and Neurotrophin signaling pathway were regulated by ssc-miR-20b, ssc-miR-128, ssc-miR-497, ssc-miR-195 and ssc-miR-371-5p through corresponding putative target genes.
[score:4]
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2 |
[+]
score:
11
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-27a, hsa-mir-29a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-199a-1, hsa-mir-208a, hsa-mir-148a, hsa-mir-10a, hsa-mir-181a-2, hsa-mir-181c, hsa-mir-199a-2, hsa-mir-181a-1, hsa-mir-214, hsa-mir-221, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-23b, hsa-mir-27b, hsa-mir-125b-1, hsa-mir-128-1, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-143, hsa-mir-125b-2, hsa-mir-126, hsa-mir-127, hsa-mir-206, hsa-mir-1-1, hsa-mir-128-2, hsa-mir-29c, hsa-mir-26a-2, hsa-mir-378a, hsa-mir-148b, hsa-mir-133b, hsa-mir-424, ssc-mir-125b-2, ssc-mir-148a, ssc-mir-23a, ssc-mir-24-1, ssc-mir-26a, ssc-mir-29b-1, ssc-mir-181c, ssc-mir-214, ssc-mir-27a, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-103-1, ssc-mir-29c, hsa-mir-486-1, hsa-mir-499a, hsa-mir-503, hsa-mir-411, hsa-mir-378d-2, hsa-mir-208b, hsa-mir-103b-1, hsa-mir-103b-2, ssc-mir-17, ssc-mir-221, ssc-mir-133a-1, ssc-mir-1, ssc-mir-503, ssc-mir-181a-1, ssc-mir-206, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-378-1, ssc-mir-133b, ssc-mir-29a, ssc-mir-199a-2, ssc-mir-128-2, ssc-mir-499, ssc-mir-143, ssc-mir-10a, ssc-mir-486-1, ssc-mir-103-2, ssc-mir-181a-2, ssc-mir-27b, ssc-mir-24-2, ssc-mir-23b, ssc-mir-148b, ssc-mir-208b, ssc-mir-424, ssc-mir-127, ssc-mir-125b-1, hsa-mir-378b, hsa-mir-378c, ssc-mir-411, ssc-mir-133a-2, ssc-mir-126, ssc-mir-199a-1, ssc-mir-378-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-499b, ssc-let-7a-2, ssc-mir-486-2, hsa-mir-378j, ssc-let-7d, ssc-let-7f-2, ssc-mir-29b-2, hsa-mir-486-2, ssc-mir-378b
Notably, in addition to porcine myomiRs (miR-1, -206, -133 a-3p/a-5p/b), three other miRNAs (miR-128, -208b and -378) reported to be related to muscle development in other mammals were also included in up-regulation Cluster 2, suggesting their roles in the regulation of porcine embryonic myogenesis at 35 to 77 dpc.
[score:6]
miR-128 was reported to participate in the regulation of adipogenesis, osteogenesis and myogenesis [36] and herein, together with ssc-miR-411, up regulated at 35 to 77 dpc and fluctuated at 77 dpc to 180 dpn (Figure 5C), might behave in a similar manner as ssc-miR-133b during porcine muscle development.
[score:4]
In addition to the best-studied myomiRs (miR-1, -206 and miR-133 families), 11 other DE muscle-related miRNAs (miR-378 [24], miR-148a [27], miR-26a [28, 29], miR-27a/b [30, 31], miR-23a [32, 33], miR-125b [34], miR-24 [35], miR-128 [36], miR-199a [37] and miR-424 [38]) with high abundance (average RPM >1,000) and another 14 (miR-181a/b/c/d-5p [26], miR-499-5p [11], miR-503 [38], miR-486 [39], miR-214 [40], miR-29a/b/c [41– 43], miR-221/222 [44] and miR-208 [11] with low abundance (average RPM <1,000) were detected in myogenesis of pig.
[score:1]
[1 to 20 of 3 sentences]
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3 |
[+]
score:
7
Other miRNAs from this paper: ssc-mir-125b-2, ssc-mir-145, ssc-mir-15b, ssc-mir-26a, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-15a, ssc-mir-221, ssc-mir-146b, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-29a, ssc-mir-128-2, ssc-mir-27b, ssc-mir-99a, ssc-mir-125a, ssc-mir-142, ssc-mir-19b-2, ssc-mir-19b-1, ssc-mir-125b-1, ssc-mir-155, ssc-mir-146a, ssc-let-7a-2, ssc-let-7d, ssc-let-7f-2
Zhang et al. [17] showed that Salmonella can up-regulate intestinal epithelial miR-128 expression, which in turn decreases levels of epithelial cell-secreted CSF1.
[score:6]
In addition to miR-146 and miR-155, the let-7, miR-15, miR-128 and miR-29a also have roles in Salmonella infection.
[score:1]
[1 to 20 of 2 sentences]
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4 |
[+]
score:
6
Other miRNAs from this paper: hsa-mir-18a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-30a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-30d, hsa-mir-7-1, hsa-mir-7-2, hsa-mir-205, hsa-mir-30b, hsa-mir-128-1, hsa-mir-146a, hsa-mir-193a, hsa-mir-128-2, hsa-mir-365a, hsa-mir-365b, hsa-mir-424, hsa-mir-18b, hsa-mir-450a-1, ssc-mir-24-1, ssc-mir-7-2, ssc-mir-205, ssc-mir-18a, hsa-mir-146b, hsa-mir-193b, hsa-mir-450a-2, hsa-mir-532, hsa-mir-92b, hsa-mir-574, hsa-mir-542, hsa-mir-450b, hsa-mir-744, ssc-mir-30b, ssc-mir-450a, ssc-mir-146b, ssc-mir-30a, ssc-mir-30d, ssc-mir-128-2, ssc-mir-24-2, ssc-mir-193a, ssc-mir-365-2, ssc-mir-365-1, ssc-mir-92a-2, ssc-mir-92a-1, ssc-mir-92b, ssc-mir-424, ssc-mir-542, ssc-mir-450b, ssc-mir-532, ssc-mir-574, ssc-mir-744, ssc-mir-146a, hsa-mir-1343, ssc-mir-18b, ssc-mir-1343, ssc-mir-7-1
Take MAPK signaling pathway for instance, as shown in Fig. S1A, on PID 4, there are 38 DE miRNAs involved in MAPK signaling pathway and most DE miRNAs such as miR-450b-5p, miR-146b, miR-1343, miR-128, and miR-30a-5p were down-regulated while their targets such as MEF2C, NFKB1, TGFBR1, EGFR, JUN, and MAPK1 are key factors in MAPK signaling pathway (see map 04010 in KEGG database).
[score:6]
[1 to 20 of 1 sentences]
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5 |
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score:
2
Other miRNAs from this paper: hsa-mir-15a, hsa-mir-23a, hsa-mir-26a-1, hsa-mir-204, hsa-mir-1-2, hsa-mir-125b-1, hsa-mir-128-1, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-142, hsa-mir-144, hsa-mir-125b-2, hsa-mir-127, hsa-mir-206, hsa-mir-1-1, hsa-mir-128-2, hsa-mir-26a-2, hsa-mir-378a, hsa-mir-381, hsa-mir-331, hsa-mir-133b, hsa-mir-345, ssc-mir-125b-2, ssc-mir-23a, ssc-mir-26a, ssc-mir-204, hsa-mir-486-1, hsa-mir-499a, hsa-mir-378d-2, ssc-mir-15a, ssc-mir-133a-1, ssc-mir-1, ssc-mir-206, ssc-mir-378-1, ssc-mir-133b, ssc-mir-128-2, ssc-mir-499, ssc-mir-486-1, ssc-mir-345-1, ssc-mir-142, ssc-mir-331, ssc-mir-127, ssc-mir-125b-1, hsa-mir-378b, hsa-mir-378c, ssc-mir-133a-2, ssc-mir-381, ssc-mir-378-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-499b, ssc-mir-486-2, hsa-mir-378j, ssc-mir-144, ssc-mir-345-2, hsa-mir-486-2, ssc-mir-378b
Ssc-miR-new-371 and ssc-miR-new-108 were homologous to hsa-miR-381-3p and hsa-miR-128-3p, both of which have been shown to be related to skeletal muscle development [32, 33].
[score:2]
[1 to 20 of 1 sentences]
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6 |
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score:
2
Other miRNAs from this paper: ssc-mir-148a, ssc-mir-181b-2, ssc-mir-23a, ssc-mir-26a, ssc-mir-29b-1, ssc-mir-181c, ssc-mir-214, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-21, ssc-mir-29c, ssc-mir-99b, ssc-mir-199b, ssc-mir-133a-1, ssc-mir-1, ssc-mir-181a-1, ssc-mir-30a, ssc-mir-206, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-378-1, ssc-mir-133b, ssc-mir-29a, ssc-mir-30d, ssc-mir-199a-2, ssc-mir-128-2, ssc-mir-320, ssc-mir-143, ssc-mir-10b, ssc-mir-181a-2, ssc-mir-181b-1, ssc-mir-181d, ssc-mir-100, ssc-mir-196b-1, ssc-mir-542, ssc-mir-127, ssc-mir-369, ssc-mir-155, ssc-mir-133a-2, ssc-mir-126, ssc-mir-199a-1, ssc-mir-378-2, ssc-let-7a-2, ssc-let-7d, ssc-let-7f-2, ssc-mir-29b-2, ssc-mir-196b-2, ssc-mir-378b, ssc-mir-141
Four miRNAs (ssc-miR-29a, ssc-miR-1, ssc-miR-128, ssc-miR-320) showed obviously enhanced expression at D100 compared to E90.
[score:2]
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7 |
[+]
score:
1
LD group, the highest scoring network, based on Fisher’s exact test, had a network score of 73 and was associated with lipid metabolism, and organ morphology; N-acylethanolamine-hydrolyzing acid amidase (NAAA), miR-128, and miR-26a were key components in the network (Fig. 7A).
[score:1]
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8 |
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score:
1
Other miRNAs from this paper: ssc-mir-122, ssc-mir-148a, ssc-mir-181b-2, ssc-mir-28, ssc-mir-95, ssc-mir-181c, ssc-mir-183, ssc-mir-27a, ssc-let-7i, ssc-mir-186, ssc-mir-204, ssc-mir-30b, ssc-mir-146b, ssc-mir-181a-1, ssc-mir-215, ssc-mir-128-2, ssc-mir-143, ssc-mir-181a-2, ssc-mir-181b-1, ssc-mir-181d, ssc-mir-374a, ssc-mir-374b, ssc-mir-424, ssc-mir-195, ssc-mir-744, ssc-mir-22, ssc-mir-376a, ssc-mir-490-1, ssc-mir-376c, ssc-mir-376b, ssc-mir-4332, ssc-mir-218-1, ssc-mir-146a, ssc-mir-126, ssc-mir-218b, ssc-mir-219a, ssc-mir-2320, ssc-mir-144, ssc-mir-150-1, ssc-mir-150-2, ssc-mir-218-2, ssc-mir-490-2, ssc-mir-219b
Among them, six microRNAs (ssc-miR-128, ssc-miR-186, ssc-miR-4332, ssc-miR-218-3p, ssc-miR-2320-5p and ssc-miR-150) were predicted to bind to the 3′UTR of WUH3 PRRSV genome.
[score:1]
[1 to 20 of 1 sentences]
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9 |
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score:
1
Other miRNAs from this paper: ssc-mir-125b-2, ssc-mir-24-1, ssc-mir-140, ssc-mir-205, ssc-mir-214, ssc-let-7f-1, ssc-mir-199b, ssc-mir-133a-1, ssc-mir-206, ssc-mir-199a-2, ssc-mir-128-2, ssc-mir-24-2, ssc-mir-125a, ssc-mir-455, ssc-mir-125b-1, ssc-mir-133a-2, ssc-mir-218-1, ssc-mir-199a-1, ssc-mir-218b, ssc-mir-429, ssc-let-7f-2, ssc-mir-31, ssc-mir-218-2, ssc-mir-141, ssc-mir-200b
Comprehensive consideration of the signal intensity (signal≥500) (Table S6) let to the prediction of 18 key miRNAs, including let-7f, miR-128, miR-200b, and miR-200c (Table 1).
[score:1]
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