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1 publications mentioning dps-mir-2a-1

Open access articles that are associated with the species Drosophila pseudoobscura and mention the gene name mir-2a-1. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 24
These genes are not yet known to be miRNA targets, and therefore constitute strong candidates for experimental verification of regulation by members of the miR-2 family. [score:4]
Consistent with previous observations [17], target sites for miR-2a/2b/2c/6/13a/13b (UGUGAUA, K box) and miR-277 (AGCUUUA, Brd box) are significantly coconserved within fly 3′UTRs (p < 10 [−17]). [score:3]
Indeed, the target set for miR-2a/b/c contains the Brd genes m2, m4, and mα and the E(spl) genes m3, m5, mδ, and E(spl). [score:3]
In another case, also in worms, the target sites for two coconserved and distinct miRNAs (or miRNA sets) miR-2/miR-43 (CUGUGAU) and miR-80/miR-81/miR-82 (UGAUCUC), were found to overlap more often than expected by chance (p < 10 [−5]) (note that we limited the extent of the overlap to 4 nt in our coconservation analysis). [score:3]
Indeed, our predicted target set for miR-2a/2b/2c (259 genes having a conserved CUGUGAU or UGUGAUA in their 3′UTRs) contains the reaper and sickle genes (but not grim), as well as several other genes known to be involved in apoptosis: CG10345, CG11593, tartan, croquemort, and Ice. [score:3]
For example, Figure 5B shows that some worm miRNAs potentially regulate hundreds of genes (e. g., miR-2/ miR-43), while others may regulate fewer than ten genes (e. g., miR-273). [score:3]
Similarly, the target sites for miR-2/43 and miR-1 are coconserved in 12 genes (p < 10 [−6]). [score:3]
As another example, recent in vitro and in vivo experiments suggest that members of the fly miR-2 family (miR-2a/2b/2c) regulate the proapoptotic genes reaper, grim, and sickle in D. melanogaster [9]. [score:2]
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