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1 publications mentioning dps-mir-1Open access articles that are associated with the species Drosophila pseudoobscura and mention the gene name mir-1. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary. |
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Other miRNAs from this paper: cel-let-7, cel-mir-1, cel-mir-2, cel-mir-43, cel-mir-75, cel-mir-79, cel-mir-80, cel-mir-81, cel-mir-82, cel-mir-86, cel-mir-87, dme-mir-1, dme-mir-2a-1, dme-mir-2a-2, dme-mir-2b-1, dme-mir-2b-2, dme-mir-4, cel-mir-124, cel-mir-233, cel-mir-248, cel-mir-273, dme-mir-184, dme-mir-277, dme-mir-124, dme-mir-79, dme-mir-87, dme-bantam, dme-let-7, dme-mir-2c, cbr-let-7, cbr-mir-1, cbr-mir-43, cbr-mir-75, cbr-mir-79, cbr-mir-80, cbr-mir-81, cbr-mir-82, cbr-mir-86, cbr-mir-87, cbr-mir-124a, cbr-mir-233, cbr-mir-248, cel-mir-356a, dps-bantam, dps-let-7, dps-mir-2a-1, dps-mir-2a-2, dps-mir-2b-1, dps-mir-2b-2, dps-mir-2c, dps-mir-4, dps-mir-79, dps-mir-87, dps-mir-124, dps-mir-184, dps-mir-277, cbr-mir-356, cel-mir-356b, cbr-mir-2, cbr-mir-124b, cbr-mir-124c
Indeed, decreased mRNA levels (in human HeLa cells) were observed for dozens of genes upon transfection of two distinct miRNAs, miR-1 and miR-124; it was also shown that the 3′ untranslated regions (UTRs) of these down-regulated mRNAs have significant complementarity to the 5′ extremity of the transfected miRNAs.
[score:6]
In fact, most of the mRNAs encoding cytosolic sector subunits (A, B, D, E, F, and H) of a C. elegans vacuolar H [+]-ATPase contain a conserved target site for miR-1, suggesting a miRNA -mediated regulation of this proton-pumping complex.
[score:4]
For example, we found that the predicted target set of C. elegans miR-1 (197 genes having a conserved ACAUUCC or CAUUCCA in their 3′UTRs) contains many genes involved in proton transport (p < 10 [−10]) and ATPase activity (p < 10 [−9]).
[score:3]
Similarly, the target sites for miR-2/43 and miR-1 are coconserved in 12 genes (p < 10 [−6]).
[score:3]
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