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17 publications mentioning gga-mir-27b

Open access articles that are associated with the species Gallus gallus and mention the gene name mir-27b. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 28
Starting with 16 known miRNAs validated as differentially expressed between broilers and layers, and eight muscle-related miRNAs (gga-miR-1, gga-miR-206, gga-miR-499, gga-miR-221, gga-miR-222, gga-miR-128, gga-miR-367 and gga-miR-27b), TargetScan (version 5.1) [43] was used to predict putative targets. [score:7]
The CALD1 gene, the putative target of gga-miR-27b, encodes two caldesmon-1 isoforms through alternative splicing: high molecular mass CaD (h-CaD), which is exclusively expressed in smooth muscle, and low molecular mass CaD (l-CaD), which is ubiquitously expressed in all cell types except skeletal muscle. [score:7]
One of the predicted miRNA-target relationships presented in Figure 6B, between miR-27b and the target CYP1B1, has been reported previously [49]. [score:5]
SOX8, the putative target of gga-miR-27b, acts as a specific negative regulator of skeletal muscle differentiation, possibly by interfering with the function of myogenic basic helix-loop-helix proteins [63]. [score:4]
Nr5a2 is the putative target of gga-miR-200b, gga-miR-128 and gga-miR-27b. [score:3]
Of these 13 miRNAs, five (miR-206, miR-1a, miR499, miR-128 and miR-27b) have been reported to have a role during muscle development [30, 50]. [score:2]
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2
[+] score: 13
In our hands, only mir-23, mir-27 and mir-128 showed strong expression in somites (Figure 6B). [score:3]
Sequence alignments show miR predicted targets sites within the 3’UTR of chick Spry2 and chick microRNA sequences of mir-21, mir-23, mir-27, mir-122, and miR-128. [score:3]
Our analysis of Targetscan followed by Northern blots of developing somites showed that mir-23, mir-27 and mir-128 could be part of this negative feedback loop mechanism. [score:3]
The analysis showed that mir-21, mir-23, mir-27, mir-122 and mir-128 can potentially interact with Spry2 through binding to its 3’UTR (Figure 6A). [score:1]
However, further analysis using gain- and loss-of-function of mir-23, mir-27 and mir-128 is required to proof or to exclude an interaction with FGF/Spry2 signalling. [score:1]
RNA was transferred to five membranes (Hybond NX, Amersham Biosciences) then hybridized to [32]P-labeled antisense probes (end -labelled with [γ- [32]P]ATP and T4 kinase) complementary to the mature mirRNA of gga-miR-21, gga-miR-23, gga-miR-27, gga-miR-122 and gga-miR-128 that cover the entire length of the miRNAs. [score:1]
We also propose that mir-23, mir-27 and mir-128 could be part of the negative feedback loop mechanism. [score:1]
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3
[+] score: 13
The DEM miR-27 has an inhibitory role with regard to adipogenesis in mouse and human multipotent adipose-derived stem (hMADS) cells 30, and overexpression of miR-27 specifically inhibited adipocyte formation in mice 31. miR-146b has been related to the differentiation of 3T3-L1 cells 29. [score:7]
Eleven of these (miR-204, miR-19a-3p, miR-19b-3p, miR-30d, miR-26a, miR-122-5p, miR-103-3p, miR-27b-3p, miR-92-3p, miR-142-3p, and miR-17-5p) have been implicated, directly or indirectly, in fat deposition; 9 showed a high fold-change (miR-3535, miR-144-3p, miR-30e-5p, miR-301b-3p, miR-215-5p, miR-200a-3p, miR-133a-3p, miR-133c-3p, and miR-146b-5p). [score:3]
Specifically, the integrated analysis of DEMs and DEGs suggests that nine miRNAs (gga-miR-19a-3p, miR-19b-3p, miR-17-5p, miR-30d, miR-26a, miR-103-3p, miR-27b-3p, miR-142-3p, and miR-92-3p) and three genes (ACSL1, FADS2 and ABCD3) are strong candidate miRNAs and genes involved in regulating the accumulation of AbF in chickens. [score:2]
Changes in four lipid-related DEMs identified by deep sequencing (gga-miR-122-5p, miR-103-3p, miR-27b-3p, and miR-146b-5p) were confirmed by qPCR. [score:1]
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4
[+] score: 12
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-106a, hsa-mir-16-2, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181a-1, hsa-mir-221, hsa-mir-222, hsa-mir-223, hsa-let-7g, hsa-let-7i, hsa-mir-15b, hsa-mir-23b, hsa-mir-27b, hsa-mir-122, hsa-mir-125b-1, hsa-mir-140, hsa-mir-125b-2, hsa-mir-136, hsa-mir-146a, hsa-mir-150, hsa-mir-206, hsa-mir-155, hsa-mir-181b-2, hsa-mir-106b, hsa-mir-302a, hsa-mir-34b, hsa-mir-34c, hsa-mir-302b, hsa-mir-302c, hsa-mir-302d, hsa-mir-367, gga-let-7i, gga-let-7a-3, gga-let-7b, gga-let-7c, gga-mir-125b-2, gga-mir-155, gga-mir-222a, gga-mir-221, gga-mir-92-1, gga-mir-19b, gga-mir-20a, gga-mir-19a, gga-mir-18a, gga-mir-17, gga-mir-16-1, gga-mir-15a, gga-mir-1a-2, gga-mir-206, gga-mir-223, gga-mir-106, gga-mir-302a, gga-mir-181a-1, gga-mir-181b-1, gga-mir-16-2, gga-mir-15b, gga-mir-140, gga-let-7g, gga-let-7d, gga-let-7f, gga-let-7a-1, gga-mir-146a, gga-mir-181b-2, gga-mir-181a-2, gga-mir-1a-1, gga-mir-1b, gga-let-7a-2, gga-mir-34b, gga-mir-34c, gga-let-7j, gga-let-7k, gga-mir-23b, gga-mir-24, gga-mir-122-1, gga-mir-122-2, hsa-mir-429, hsa-mir-449a, hsa-mir-146b, hsa-mir-507, hsa-mir-455, hsa-mir-92b, hsa-mir-449b, gga-mir-146b, gga-mir-302b, gga-mir-302c, gga-mir-302d, gga-mir-455, gga-mir-367, gga-mir-429, gga-mir-449a, hsa-mir-449c, gga-mir-21, gga-mir-1458, gga-mir-1576, gga-mir-1612, gga-mir-1636, gga-mir-449c, gga-mir-1711, gga-mir-1729, gga-mir-1798, gga-mir-122b, gga-mir-1811, gga-mir-146c, gga-mir-15c, gga-mir-449b, gga-mir-222b, gga-mir-92-2, gga-mir-125b-1, gga-mir-449d, gga-let-7l-1, gga-let-7l-2, gga-mir-122b-1, gga-mir-122b-2
Clusters mir-16-1-mir-15a, let-7f-let-7a-1, mir-181a-1-mir-181b-1, let-7j-let-7k, mir-23b-mir-27b-mir-24, and mir-16-2-mir-15b were down-regulated in lungs and mir-181a-1-mir-181b-1 was also down-regulated in tracheae with AIV infection. [score:7]
The miRNAs from five of these clusters (mir-16-1-mir-15a, mir-16-2-mir-15b, let-7f-let-7a-1, let-7j-let-7k and mir-23b-mir-27b-mir-24) identified in both lungs and tracheae were significantly down-regulated in infected lungs compared to non-infected lungs and also had higher expression levels in non-infected lungs than non-infected tracheae. [score:5]
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5
[+] score: 5
In mammals, a number of miRNAs have been demonstrated to target genes involved in adipogenesis and lipid metabolism, such as the regulation on the proliferation of adipose tissue-derived mesenchymal stem cells by miR-21 and miR-196a [4– 6]; the enhancement of adipogenesis by miR-103, miR-224 and the miR-17–92 cluster [7– 9]; the impairment of adipogenesis by the let-7 family, miR-448, miR-15a and miR-27 [10– 13]; the regulation of adipocyte lipid metabolism by miR-27a and miR-143 [13– 15]; and the important role of miR-33 on the repression of sterol transporters reported in numerous studies [16– 24]. [score:5]
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6
[+] score: 5
Another recent study has shown that the two RNAse III endonucleases dicer and drosha inhibit the expression of thrombospondin-1 by controlling the levels of let-7 and miR-27b, thus modulating angiogenesis [23]. [score:5]
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7
[+] score: 5
In ECs, the downregulation of both enzymes decreased the capillary-sprouting and tubule-forming activities induced by regulatory miRNAs, including the let-7 family members and miR-27b [17]. [score:5]
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8
[+] score: 5
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-mir-15a, hsa-mir-18a, hsa-mir-33a, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-107, mmu-mir-27b, mmu-mir-126a, mmu-mir-128-1, mmu-mir-140, mmu-mir-146a, mmu-mir-152, mmu-mir-155, mmu-mir-191, hsa-mir-10a, hsa-mir-211, hsa-mir-218-1, hsa-mir-218-2, mmu-mir-297a-1, mmu-mir-297a-2, hsa-mir-27b, hsa-mir-128-1, hsa-mir-140, hsa-mir-152, hsa-mir-191, hsa-mir-126, hsa-mir-146a, mmu-let-7a-1, mmu-let-7a-2, mmu-mir-15a, mmu-mir-18a, mmu-mir-103-1, mmu-mir-103-2, mmu-mir-342, hsa-mir-155, mmu-mir-107, mmu-mir-10a, mmu-mir-218-1, mmu-mir-218-2, mmu-mir-33, mmu-mir-211, hsa-mir-374a, hsa-mir-342, gga-mir-33-1, gga-let-7a-3, gga-mir-155, gga-mir-18a, gga-mir-15a, gga-mir-218-1, gga-mir-103-2, gga-mir-107, gga-mir-128-1, gga-mir-140, gga-let-7a-1, gga-mir-146a, gga-mir-103-1, gga-mir-218-2, gga-mir-126, gga-let-7a-2, mmu-mir-466a, mmu-mir-467a-1, hsa-mir-499a, hsa-mir-545, hsa-mir-593, hsa-mir-600, hsa-mir-33b, gga-mir-499, gga-mir-211, gga-mir-466, mmu-mir-675, mmu-mir-677, mmu-mir-467b, mmu-mir-297b, mmu-mir-499, mmu-mir-717, hsa-mir-675, mmu-mir-297a-3, mmu-mir-297a-4, mmu-mir-297c, mmu-mir-466b-1, mmu-mir-466b-2, mmu-mir-466b-3, mmu-mir-466c-1, mmu-mir-466e, mmu-mir-466f-1, mmu-mir-466f-2, mmu-mir-466f-3, mmu-mir-466g, mmu-mir-466h, mmu-mir-467c, mmu-mir-467d, mmu-mir-466d, hsa-mir-297, mmu-mir-467e, mmu-mir-466l, mmu-mir-466i, mmu-mir-466f-4, mmu-mir-466k, mmu-mir-467f, mmu-mir-466j, mmu-mir-467g, mmu-mir-467h, hsa-mir-664a, hsa-mir-1306, hsa-mir-1307, gga-mir-1306, hsa-mir-103b-1, hsa-mir-103b-2, gga-mir-10a, mmu-mir-1306, mmu-mir-3064, mmu-mir-466m, mmu-mir-466o, mmu-mir-467a-2, mmu-mir-467a-3, mmu-mir-466c-2, mmu-mir-467a-4, mmu-mir-466b-4, mmu-mir-467a-5, mmu-mir-466b-5, mmu-mir-467a-6, mmu-mir-466b-6, mmu-mir-467a-7, mmu-mir-466b-7, mmu-mir-467a-8, mmu-mir-467a-9, mmu-mir-467a-10, mmu-mir-466p, mmu-mir-466n, mmu-mir-466b-8, hsa-mir-466, hsa-mir-3173, hsa-mir-3618, hsa-mir-3064, hsa-mir-499b, mmu-mir-466q, hsa-mir-664b, gga-mir-3064, mmu-mir-126b, gga-mir-33-2, mmu-mir-3618, mmu-mir-466c-3, gga-mir-191
Out of the 26 miRNA/host gene pairs with coordinated expression, 11 have been found to be coordinately expressed in both, human and mouse [19], [27], [59], [61]– [64], [67]– [69], [71], [73]– [79]: mir-103/ PANK3, mir-107/ PANK1, mir-126/ EGFL7, mir-128-1/ R3HDM1, mir-140/ WWP2, mir-211/ TRPM1, mir-218-1/ SLIT2, mir-218-2/ SLIT3, mir-27b/ C9orf3, mir-33/ SREBF2, and mir-499/ MYH7B. [score:5]
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9
[+] score: 4
Liver PPARA expression is also regulated by miR-21 and miR-27b in humans [42]. [score:4]
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10
[+] score: 3
Other miRNAs from this paper: hsa-mir-27b, hsa-mir-379, hsa-mir-346, hsa-mir-590
Yang W. H. Chang A. C. Wang S. W. Wang S. J. Chang Y. S. Chang T. M. Hsu S. K. Fong Y. C. Tang C. H. Leptin promotes VEGF-C production and induces lymphangiogenesis by suppressing miR-27b in human chondrosarcoma cellsSci. [score:3]
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11
[+] score: 3
Other chicken miRNAs that are expressed at high levels in IAH30 cells include gga-miR-24 (5.5%), gga-miR-27b (4%), gga-miR-19b (3.9%), gga-miR-20a (3.9%), gga-miR-148a (3.7%), gga-miR-23b (3%), and gga-miR-92 (3%). [score:3]
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12
[+] score: 3
Additionally, miR-200a, miR-200b, miR-203, miR-27a, and miR-27b, all of which interact with Wnt signaling components [63], [64], [65], are expressed at 1.5- to 58.9-fold higher levels in duck verses the other species (Table S7). [score:3]
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13
[+] score: 2
gga-miR-221, gga-miR-222, gga-miR148, gga-miR-27b, gga-miR-34a and gga-miR-130a, which are related to differentiation and maturation, could also further influence the function of mature DCs. [score:1]
As shown in Fig. 4, gga-miR-221, gga-miR-125b, gga-miR-211, gga-miR-222a, gga-miR-193b, gga-miR-148a, gga-miR-27b, gga-miR-34a and gga-miR-130a were quantified by qRT-PCR, and these results were consistent with the sequencing analysis. [score:1]
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14
[+] score: 2
Figure 2The muscle specific miRNAs (myo-miR), miR-133a/b, miR-206, miR-486, miR-26a, miR-27b, miR-378, miR-148a and miR-181 were highly enriched in skeletal muscle and play key roles in skeletal muscle metabolism [11]. [score:1]
Figure 2 The muscle specific miRNAs (myo-miR), miR-133a/b, miR-206, miR-486, miR-26a, miR-27b, miR-378, miR-148a and miR-181 were highly enriched in skeletal muscle and play key roles in skeletal muscle metabolism [11]. [score:1]
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15
[+] score: 2
Other miRNAs from this paper: gga-mir-7-1, gga-mir-23b, gga-mir-142, gga-mir-1456, gga-mir-7439
The color of the edge indicates the type of epistatic effect (AA = red; AD = purple; DA = blue; DD = green) Table 3 The SNPs on GGAZ interacted with the SNPs on GGA21, and the Refgenes in the two important regions Chr Position Locus RS# Refgenes Z37,246,32137,440,77037,562,58238,066,34638,424,44838,545,04438,795,33939,120,19839,189,94639,223,66839,256,77039,415,37840,393,05840,411,58540,514,08541,304,56145,300,03045,695,92746,745,968Gga_rs14765324Gga_rs16768474Gga_rs14765605Gga_rs16768723Gga_rs14766107GGaluGA351567Gga_rs16047676Gga_rs16781643Gga_rs14745723Gga_rs16131986Gga_rs14787078Gga_rs16781713Gga_rs14787751Gga_rs16782083Gga_rs16754179Gga_rs16132921Gga_rs14015526GGaluGA352176Gga_rs14016510rs14765324rs16768474rs14765605rs16768723rs14766107rs317567123rs16047676rs16781643rs14745723rs16131986rs14787078rs16781713rs14787751rs16782083rs16754179rs16132921rs14015526rs316100592rs14016510 VPS13A, AGTPBP1, AUH, CAMK4, CDC14B, CDC42SE2, CFC1B, CKS2, CTSL2, DAPK1, FANCC, FBP1, GADD45B, GNAQ, HABP4, HINT1, ISCA1, LOC427470, LOC770548, MIR1456, MIR23B, MIR24-2, MIR27B, MIR7-1, MIR7439, NAA35, NFIL3, NREP, NTRK2, PTCH1, REEP5, RMI1, ROR2, SEMA4D, SLC25A46, SPINZ, STARD4, SYK, TLE4, WDR36, ZCCHC6 2176,02387,719113,769125,790140,660145,617153,135165,390197,067219,311277,332291,087297,203299,152304,979320,390332,352332,687362,742402,941423,299493,436631,537647,587Gga_rs15179992GGaluGA181809Gga_rs15179999Gga_rs10732124Gga_rs15180005Gga_rs15180007GGaluGA181823Gga_rs16176404Gga_rs15180023Gga_rs15180012Gga_rs15180032Gga_rs15180041Gga_rs16176409Gga_rs16176412GGaluGA181852Gga_rs16176425GGaluGA181865GGaluGA181868GGaluGA181877Gga_rs14281175Gga_rs13602346Gga_rs14281291Gga_rs16176824GGaluGA182048rs15179992rs312621287rs15179999rs10732124rs15180005rs15180007rs315641745rs16176404rs15180023rs15180012rs15180032rs15180041rs16176409rs16176412rs314825899rs16176425rs314965954rs313888034rs316891294rs14281175rs13602346rs14281291rs16176824rs312963281 PADI3, PADI1, PADI2, SDHB, MRPS16, PARK7, UTS2, PER3, VAMP3, PHF13, ZBTB48, ICMT, RPL22 Sub-networks 2, 3, 4, 5, 8 and 11 each had several SNPs in the same LD block on one chromosome, which interacted with a single SNP on another chromosome. [score:1]
The color of the edge indicates the type of epistatic effect (AA = red; AD = purple; DA = blue; DD = green) Table 3 The SNPs on GGAZ interacted with the SNPs on GGA21, and the Refgenes in the two important regions Chr Position Locus RS# Refgenes Z37,246,32137,440,77037,562,58238,066,34638,424,44838,545,04438,795,33939,120,19839,189,94639,223,66839,256,77039,415,37840,393,05840,411,58540,514,08541,304,56145,300,03045,695,92746,745,968Gga_rs14765324Gga_rs16768474Gga_rs14765605Gga_rs16768723Gga_rs14766107GGaluGA351567Gga_rs16047676Gga_rs16781643Gga_rs14745723Gga_rs16131986Gga_rs14787078Gga_rs16781713Gga_rs14787751Gga_rs16782083Gga_rs16754179Gga_rs16132921Gga_rs14015526GGaluGA352176Gga_rs14016510rs14765324rs16768474rs14765605rs16768723rs14766107rs317567123rs16047676rs16781643rs14745723rs16131986rs14787078rs16781713rs14787751rs16782083rs16754179rs16132921rs14015526rs316100592rs14016510 VPS13A, AGTPBP1, AUH, CAMK4, CDC14B, CDC42SE2, CFC1B, CKS2, CTSL2, DAPK1, FANCC, FBP1, GADD45B, GNAQ, HABP4, HINT1, ISCA1, LOC427470, LOC770548, MIR1456, MIR23B, MIR24-2, MIR27B, MIR7-1, MIR7439, NAA35, NFIL3, NREP, NTRK2, PTCH1, REEP5, RMI1, ROR2, SEMA4D, SLC25A46, SPINZ, STARD4, SYK, TLE4, WDR36, ZCCHC6 2176,02387,719113,769125,790140,660145,617153,135165,390197,067219,311277,332291,087297,203299,152304,979320,390332,352332,687362,742402,941423,299493,436631,537647,587Gga_rs15179992GGaluGA181809Gga_rs15179999Gga_rs10732124Gga_rs15180005Gga_rs15180007GGaluGA181823Gga_rs16176404Gga_rs15180023Gga_rs15180012Gga_rs15180032Gga_rs15180041Gga_rs16176409Gga_rs16176412GGaluGA181852Gga_rs16176425GGaluGA181865GGaluGA181868GGaluGA181877Gga_rs14281175Gga_rs13602346Gga_rs14281291Gga_rs16176824GGaluGA182048rs15179992rs312621287rs15179999rs10732124rs15180005rs15180007rs315641745rs16176404rs15180023rs15180012rs15180032rs15180041rs16176409rs16176412rs314825899rs16176425rs314965954rs313888034rs316891294rs14281175rs13602346rs14281291rs16176824rs312963281 PADI3, PADI1, PADI2, SDHB, MRPS16, PARK7, UTS2, PER3, VAMP3, PHF13, ZBTB48, ICMT, RPL22 Sub-networks 2, 3, 4, 5, 8 and 11 each had several SNPs in the same LD block on one chromosome, which interacted with a single SNP on another chromosome. [score:1]
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16
[+] score: 2
The regulation roles of miR-125b, miR-221 and miR-27b in porcine Salmonella infection signalling pathway. [score:2]
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17
[+] score: 1
It is also interesting that the miR27 family showed up as one of the most significant gene sets in this particular analysis given the known role of this miRNA in cellular proliferation. [score:1]
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