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8 publications mentioning dme-mir-285

Open access articles that are associated with the species Drosophila melanogaster and mention the gene name mir-285. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 12
It is impossible to determine from this analysis whether microRNAs have acquired more targets in one clade or lost targets in the other, but it is striking that both human homologs of the fly microRNAs miR-184 and miR-210 are expressed at low abundance across many human tissues, while the homologs of miR-10, miR-133, miR-125, let-7, and miR-285 are expressed overall at much higher levels [19]. [score:9]
However, certain microRNAs appear to have a significantly higher number of target genes in either humans (miR-10, miR-133, miR-125, let-7, and miR-285) or flies (miR-184 and miR-210). [score:3]
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[+] score: 8
Specifically, Culex pipiens miR-285 and miR-278 were implicated in pyrethroid resistance through the transcriptional regulation of Cyp6n23 and Cyp6ag11 [48, 49], as well as a miRNA cluster involved in regulation of Cyp9j35 and Cyp325bg3 [50] and upregulation of miR-932 that regulates transcript levels of the cuticular gene CpCPR5 [51, 52]. [score:7]
Additionally, miR-285 and miR-278 differentially regulate Cyp6n23 and Cyp6ag11 in pyrethroid resistant compared to susceptible Culex pipiens [48, 49]. [score:1]
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[+] score: 4
Fly miR-285 has no known function and was not identified as a miRNA expressed in the larval CNS (Table S1). [score:3]
Second, of the mammalian miRNAs identified thus far (miRs-29a/b, -132, -134, and -188) only miR-29a/b has a Drosophila family member (miR-285). [score:1]
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[+] score: 3
Note also that over -expression of several miRNAs (e. g., let-7, miR-285, etc. ) [score:3]
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[+] score: 2
Not clustered in other insects Duplication mir-276a/bClustered together in Drosophila lineage >10 kb in D. melanogaster Duplication mir-285 Tandem duplication in vertebrates Duplication mir-285Clustered with mir-3556 and mir-3587 in R. norvegicus New hairpin [a]As annotated in miRBase (http://mirbase. [score:1]
Similarly, mir-285 has been tandemly duplicated in the vertebrate lineage (Table 2). [score:1]
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[+] score: 2
Other miRNAs from this paper: dme-mir-1, dme-mir-11, dme-mir-995, dme-mir-998
While no mutant phenotypes have been reported, a recent investigation of gain-of-function phenotypes showed similar wing defects caused by overexpression of miR-285 and miR-995, although their molecular basis unknown [43]. [score:1]
miR-998 belongs to the miR-29 seed family of miRNAs, which also includes miR-285 and miR-998 in Drosophila [30]. [score:1]
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[+] score: 1
Similarly, “seed paralogs” were found for Drosophila mir-279, mir-285 and mir-286. [score:1]
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[+] score: 1
Two pre-miRNAs only identified mature miRNAs on the star (*) arm (mir-10, mir-285). [score:1]
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