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6 publications mentioning dme-mir-278

Open access articles that are associated with the species Drosophila melanogaster and mention the gene name mir-278. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 13
This miRNA -based regulation was miR-980-specific, since overexpression of other miRNAs that are not predicted to target Rbfox1 (miR-966 and miR-278) did not result in the downregulation of the luciferase reporter containing Rbfox1 3′UTR (Fig.   1b, Supplementary Table  2). [score:9]
We used plasmids expressing miR-980, miR-966 and miR-278 miRNAs. [score:3]
Bioinformatic predictions did not detect putative binding sites for miR-966 and miR-278 miRNAs in either P1 or P2 regions. [score:1]
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2
[+] score: 13
Other miRNAs from this paper: dme-mir-14
miR-278 down-regulates dilps expressed in the IPCs while miR-14 positively regulates dilp3 and dilp5 expression. [score:9]
miRNA-278 knockout flies had elevated transcript levels of dilps2, 3, 5 and also had higher circulating levels of trehalose indicating a condition akin to insulin resistance (Teleman et al., 2006). [score:2]
Drosophila lacking microRNA miR-278 are defective in energy homeostasis. [score:1]
Another miRNA found in the fat body, miR-278 acts to improve insulin sensitivity. [score:1]
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3
[+] score: 8
Specifically, Culex pipiens miR-285 and miR-278 were implicated in pyrethroid resistance through the transcriptional regulation of Cyp6n23 and Cyp6ag11 [48, 49], as well as a miRNA cluster involved in regulation of Cyp9j35 and Cyp325bg3 [50] and upregulation of miR-932 that regulates transcript levels of the cuticular gene CpCPR5 [51, 52]. [score:7]
Additionally, miR-285 and miR-278 differentially regulate Cyp6n23 and Cyp6ag11 in pyrethroid resistant compared to susceptible Culex pipiens [48, 49]. [score:1]
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4
[+] score: 7
Expression of THADA in the fat body using two fat body drivers, adh-GAL4 and mir278-GAL4 (see Figure S3B for expression patterns), partially rescued THADA [KO] obesity (Figures 1E and 1F), as did expression of THADA in all neurons (Figure 1H), indicating that defects in both the fat body and the nervous system contribute to the fat phenotype. [score:7]
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5
[+] score: 5
The final wave, represented by CoMod-C, is expressed in late embryos and post-embryonic development and involves bantam, Mir-1, Mir-8, Mir-278, Mir- 281, Mir-252 and Mir-31. [score:4]
In D. melanogaster larvae, Mir-8 has been related to the regulation of growth factors in body fat [29] and with body size [30], whereas Mir-278 and Mir-277 influence energy homeostasis [31, 32]. [score:1]
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6
[+] score: 5
Promoter regions assayed were those of 4E-BP (a direct FOXO target), mir-278 and sty (two negative controls) and two regions of the first intron of pudgy, P1 and P2, as indicated in Panel D. (G) Insulin signaling represses pudgy expression in fat body and muscle. [score:5]
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