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10 publications mentioning cel-mir-228

Open access articles that are associated with the species Caenorhabditis elegans and mention the gene name mir-228. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 64
The daf-16 target gene dao-4 is predicted to be upregulated in response to suppression of miR-1820 and miR-228 by HSF-1. HSF-1 has previously been linked to having a non-stress role in controlling metabolism, where caloric restriction, metabolic factors, and insulin-like signaling factors have been linked to HSF-1 and the HSR [8, 42– 45]. [score:8]
miR-228 is another miRNA downregulated by HSF-1 independently of HS, however this miRNA is also downregulated by HSF-1 during HS. [score:7]
Thus, HSF-1 may normally suppress miR-228 and miR-48 expression during HS to promote longevity and stress resistance, and to control developmental timing events during stress conditions. [score:6]
We next determined the top biological processes upregulated in response to suppression of miR-48 and miR-228 by HSF-1 during HS (S7B Fig). [score:6]
We next determined the biological processes upregulated in response to suppression of miR-1820 and miR-228 by HSF-1 independently of HS (S8B Fig). [score:6]
miR-228 is thus likely an important HSF-1 target that may be regulated by HSF-1 to regulate longevity in both a stress -dependent and -independent fashion. [score:5]
Through this method of data analysis, we have determined that miR-239b, miR-1820, and miR-228 are normally downregulated by HSF-1 independently of HS. [score:4]
miR-228 is upregulated during aging, and a deletion of miR-228 increases longevity and stress resistance. [score:4]
Overall, we have determined that HSF-1 normally suppresses miR-239b, miR-1820, and miR-228, which may regulate longevity and metabolic processes independently of HS. [score:4]
Normally downregulated by hsf-1 upon heat shock miR-228 -0.13 miR-228 appears to be conserved in C. briggsae. [score:4]
Through this method of data analysis, we found that miR-48 and miR-228 are normally downregulated by HSF-1 upon HS. [score:4]
miR-228 is upregulated in aging worms, and a miR-228 deletion has been shown to increase longevity and heat stress resistance [15, 31]. [score:4]
miR-228 -0.11 miR-228 appears to be conserved in C. briggsae. [score:1]
miR-228 belongs to the miR-124 family of microRNAs along with human miR-124a-1, miR-124a-2, miR-124-a-3, m iR-183, and Drosophila miR-268. [score:1]
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2
[+] score: 11
Members of the let-7 miRNA family, as well as miR-228-5p, miR-66-5p, miR-70-3p and miR-59-3p were found to be highly expressed, but did not significantly change their expression upon starvation. [score:5]
Another highly expressed miRNA is miR-228-5p (Fig 5). [score:3]
Under dietary restriction conditions, multiple miRNAs changed their expression level, including miR-71 and miR-228, among others [23, 24]. [score:3]
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3
[+] score: 3
When comparing these results, we found that the motif GANNNNGA is especially abundant in the 1000 bp upstream sequences of miRNAs mir-1, mir-124 and mir-228 in both worms. [score:1]
To determine whether the motif GANNNGA is conserved in the upstream sequences of mir-1, mir-124 and mir-228 orthologs in other species, we located all its occurrences from 1000 bp upstream sequences of all miRNAs that, according to miRBase [17], belong to mir-1 or mir-124 family in human and mouse genomes. [score:1]
Mir-228 is not found from these two genomes, and generally it is included in the mir-124 family [18]. [score:1]
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4
[+] score: 3
Of the highly expressed miRNAs common to both parasites, five (lin-4, mir-45, mir-50, mir-71, mir-228) are shared with C. elegans, where all except mir-50 are also abundant (using the same read number criteria) [42]. [score:3]
[1 to 20 of 1 sentences]
5
[+] score: 3
The following forward primers were designed to confirm the sequencing results of miRNAs that showed differential expression patterns: tsp-miR-100 5′-AAC CCG TAG ATC CGA ACT TGT GT-3′; tsp-let-7 5′-TGA GGT AGT AGG TTG TAT AGT T-3′; tsp-miR-228 5′-AAT GGC ACT GGA TGA ATT CAC GG-3′; tsp-miR-1 5′-TGG AAT GTA AAG AAG TAT GTA G-3′; tsp-miR-31 5′-AGG CAA GAT GTT GGC ATA GCT GA-3′; tsp-novel-108 5′-CTT GGC ACT GTA AGA ATT CAC AGA-3′; tsp-novel-83 5′-TTG AGC AAT TTT GAT CGT AGC-3′; tsp-novel-46 5′-TGG ACG GCG AAT TAG TGG AAG-3′; tsp-novel-86 5′-TGA GAT CAC CGT GAA AGC CTT T-3′; tsp-novel-21 5′-TCA CCG GGT AAT AAT TCA CAG C-3′. [score:2]
Five conserved miRNAs (tsp-miR-228, tsp-miR-100, tsp-let-7, tsp-miR-1 and tsp-miR-31) and five novel miRNAs (tsp-novel-108, tsp-novel-83, tsp-novel-46, tsp-novel-86 and tsp-novel-21) with relatively higher TPM values identified by sequencing were validated by qRT-PCR and Northern blot. [score:1]
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6
[+] score: 3
Among the dysregulated miRNAs, the further bioinformatics analysis demonstrated that lin-4, mir-228, mir-249, mir-47, mir-355, mir-45, mir-2210, mir-57, mir-1018, mir-360, mir-64, mir-2209, mit-793, mir-1830, mir-2210, mir-83, mir-789, and mir-806 might be involved in the control of MWCNTs toxicity through affecting the functions of identified dysregulated genes in exposed nematodes (Table S6). [score:3]
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7
[+] score: 3
Other miRNAs from this paper: cel-mir-1, cel-mir-71, cel-mir-72, cel-mir-74, cel-mir-248, cel-mir-255
Based on these criteria, we identified six potential miRNAs (mir-71, mir-72, mir-74, mir-228, mir-248, mir-255) predicted to target unc-2, unc-43, tir-1, nsy-1, and sek-1 (Figure S1A). [score:3]
[1 to 20 of 1 sentences]
8
[+] score: 2
Other miRNAs from this paper: cel-mir-1, cel-mir-71, dme-mir-1, dme-mir-210
miR-71 and miR-228 are induced by the calorie restriction and the regulation of these microRNA depends on SKN-1 [114]. [score:2]
[1 to 20 of 1 sentences]
9
[+] score: 1
In some instances loss of specific miRNAs (lin-4, miR-71, miR-238, miR-246 or miR-228) has resulted in shortened lifespan, whereas in others (miR-80 or miR-239a/b) lifespan extension has been observed [18– 23]. [score:1]
[1 to 20 of 1 sentences]
10
[+] score: 1
Levels of miRNAs cel-miR-241, cel-miR-53, cel-miR-57 and cel-miR-228 were decreased in day 8 in WT compare to day 1 levels, but failed to so in eat-2(ad1116) (Cluster E). [score:1]
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