Stem-loop sequence hsa-mir-181b-2

AccessionMI0000683 (change log)
Symbol HGNC:MIR181B2
DescriptionHomo sapiens miR-181b-2 stem-loop
Gene family MIPF0000007; mir-181
Literature search

362 open access papers mention hsa-mir-181b-2
(1567 sentences)

   cuga   -     cucaa         cu           u  gu 
5'     ugg cugca     cauucauug  gucgguggguu ga  c
       ||| |||||     |||||||||  ||||||||||| ||  u
3'     acc ggcgu     guaaguaac  uagucacucaa cu  g
   acaa   a     caaac         --           -  aa 
Get sequence
Deep sequencing
700041 reads, 894 reads per million, 157 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Its expression was later verified in human BC-1 cells [3]. There are two predicted hairpin precursor sequences in the human genome; mir-181b-1 (MI0000270) is found on chromosome 1 [1], and mir-181b-2 (MI0000683) on chromosome 9 [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context
Coordinates (GRCh38; GCA_000001405.15) Overlapping transcripts
chr9: 124693710-124693798 [+]
OTTHUMT00000053903 ; C9orf148-001; intron 1
OTTHUMT00000106443 ; TTLL11-003; intron 5
OTTHUMT00000053906 ; TTLL11-001; intron 6
ENST00000411790 ; TTLL11-IT1-001; intron 1
ENST00000474723 ; TTLL11-003; intron 5
ENST00000373778 ; TTLL11-001; intron 6
ENST00000321582 ; TTLL11-201; intron 6
Clustered miRNAs
< 10kb from hsa-mir-181b-2
hsa-mir-181a-2chr9: 124692442-124692551 [+]
hsa-mir-181b-2chr9: 124693710-124693798 [+]
Database links

Mature sequence hsa-miR-181b-5p

Accession MIMAT0000257
Previous IDshsa-miR-181b

16 - 


 - 38

Get sequence
Deep sequencing1387103 reads, 157 experiments
Evidence experimental; cloned [3-5]
Database links
Predicted targets

Mature sequence hsa-miR-181b-2-3p

Accession MIMAT0031893

54 - 


 - 73

Get sequence
Deep sequencing1909 reads, 114 experiments
Evidence not experimental
Database links
Predicted targets


PMID:12624257 "Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).
PMID:15800047 "Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells" Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR Proc Natl Acad Sci U S A. 102:5570-5575(2005).
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).