Stem-loop sequence mmu-mir-873a

Accession

MI0005550 (change log)

Previous IDs

mmu-mir-873

Symbol

MGI:Mir873a

Description

Mus musculus miR-873 stem-loop

Gene family

MIPF0000390; mir-873

Literature search

7 open access papers mention mmu-mir-873a
(38 sentences)

Stem-loop

   --   u ca   g a         g        a  ga 
5'   gug g  uuu c ggaacuugu agucuccu uu  a
     ||| |  ||| | ||||||||| |||||||| ||  a
3'   cac c  aag g ccuugaaca ucagagga ag  a
   aa   c ac   g c         g        c  au 

Deep sequencing

6404 reads, 6.52 reads per million, 46 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chr4: 36668510-36668586 [-]
• Overlapping transcripts:

  sense

  OTTMUST00000014873 ; Lingo2-001; intron 2

  OTTMUST00000014888 ; Lingo2-005; intron 2

  ENSMUST00000108122 ; Lingo2-001; intron 2

  ENSMUST00000124999 ; Lingo2-005; intron 2

Clustered miRNAs

< 10kb from mmu-mir-873a

• mmu-mir-873b: chr4: 36668510-36668586 [+]
• mmu-mir-873a: chr4: 36668510-36668586 [-]

Database links

• EntrezGene:Mir873
• MGI:Mir873a
• RNAcentral:URS000070559C_10090
• miRBase Tracker:MI0005550

Mature sequence mmu-miR-873a-5p

• Accession: MIMAT0004936
• Previous IDs: mmu-miR-873;mmu-miR-873-5p
• Sequence: 11 - gcaggaacuugugagucuccu - 31
• Deep sequencing: 4701 reads, 41 experiments
• Evidence: experimental; cloned [2], Illumina [3-4]
• Database links:
  • RNAcentral:URS00004996E9_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-873a-5p.1
  • miRDB:mmu-miR-873a-5p
  • microrna.org:mmu-miR-873a-5p

Mature sequence mmu-miR-873a-3p

• Accession: MIMAT0017279
• Previous IDs: mmu-miR-873*;mmu-miR-873-3p
• Sequence: 47 - gagacugacaaguucccggga - 67
• Deep sequencing: 1701 reads, 28 experiments
• Evidence: experimental; Illumina [4]
• Database links:
  • RNAcentral:URS0000159275_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-873a-3p
  • miRDB:mmu-miR-873a-3p

References

1. PMID:16954537 "Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis" Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E Genome Res. 16:1289-1298(2006).
2. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
3. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
4. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).