Stem-loop sequence mmu-mir-503

Accession

MI0003538 (change log)

Symbol

MGI:Mir503

Description

Mus musculus miR-503 stem-loop

Gene family

MIPF0000183; mir-503

Literature search

49 open access papers mention mmu-mir-503
(459 sentences)

Stem-loop

        ua    c            g   u a  gu 
5' ugccc  gcag gggaacaguacu cag g gu  u
   |||||  |||| |||||||||||| ||| | ||  u
3' auggg  cguc ccuuuguuauga guc c cg  g
        uc    a            g   - -  ug 

Deep sequencing

204874 reads, 1.34e+03 reads per million, 105 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5].

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chrX: 53053984-53054054 [-]
• Overlapping transcripts:

  intergenic

Clustered miRNAs

< 10kb from mmu-mir-503

• mmu-mir-322: chrX: 53054255-53054349 [-]
• mmu-mir-503: chrX: 53053984-53054054 [-]
• mmu-mir-351: chrX: 53053255-53053353 [-]
• mmu-mir-542: chrX: 53049403-53049487 [-]
• mmu-mir-450a-2: chrX: 53048299-53048367 [-]
• mmu-mir-450a-1: chrX: 53048154-53048244 [-]
• mmu-mir-450b: chrX: 53047997-53048078 [-]

Database links

• EntrezGene:Mir503
• MGI:Mir503
• RNAcentral:URS00006ED333_10090
• miRBase Tracker:MI0003538

Mature sequence mmu-miR-503-5p

• Accession: MIMAT0003188
• Previous IDs: mmu-miR-503
• Sequence: 6 - uagcagcgggaacaguacugcag - 28
• Deep sequencing: 190444 reads, 103 experiments
• Evidence: experimental; cloned [1,4-5], MPSS [2], miRAP-cloned [3], Illumina [6-7]
• Database links:
  • RNAcentral:URS000041F764_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-503-5p
  • miRDB:mmu-miR-503-5p
  • microrna.org:mmu-miR-503-5p

Mature sequence mmu-miR-503-3p

• Accession: MIMAT0004790
• Previous IDs: mmu-miR-503*
• Sequence: 47 - gaguauuguuuccacugccugg - 68
• Deep sequencing: 14341 reads, 99 experiments
• Evidence: experimental; cloned [5], Illumina [6-7]
• Database links:
  • RNAcentral:URS0000011312_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-503-3p
  • miRDB:mmu-miR-503-3p
  • microrna.org:mmu-miR-503-3p

References

1. PMID:16274478 "Identification of clustered microRNAs using an ab initio prediction method" Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M BMC Bioinformatics. 6:267(2005).
2. PMID:16582102 "The expression profile of microRNAs in mouse embryos" Mineno J, Okamoto S, Ando T, Sato M, Chono H, Izu H, Takayama M, Asada K, Mirochnitchenko O, Inouye M, Kato I Nucleic Acids Res. 34:1765-1771(2006).
3. PMID:16973894 "Mouse microRNA profiles determined with a new and sensitive cloning method" Takada S, Berezikov E, Yamashita Y, Lagos-Quintana M, Kloosterman WP, Enomoto M, Hatanaka H, Fujiwara S, Watanabe H, Soda M, Choi YL, Plasterk RH, Cuppen E, Mano H Nucleic Acids Res. 34:e115(2006).
4. PMID:16766679 "Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes" Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H Genes Dev. 20:1732-1743(2006).
5. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
6. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
7. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).