Stem-loop sequence hsa-mir-296

Accession

MI0000747 (change log)

Symbol

HGNC:MIR296

Description

Homo sapiens miR-296 stem-loop

Gene family

MIPF0000159; mir-296

Literature search

83 open access papers mention hsa-mir-296
(494 sentences)

Stem-loop

     ga      ca       c  c         g   ugc 
5' ag  cccuuc  gagggcc cc cucaauccu uug   c
   ||  ||||||  ||||||| || ||||||||| |||   u
3' uc  gggaag  cucucgg gg ggguuggga gac   a
     uc      uc       a  u         -   uua 

Deep sequencing

8961 reads, 12.3 reads per million, 155 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

This sequence is the predicted human homologue of mouse miR-296 cloned from mouse embryonic stem cells [1,3]. Its expression has also been verified in human ES cells [2].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr20: 58817615-58817694 [-]
• Overlapping transcripts:

  antisense

  OTTHUMT00000079949 ; RP5-1043L13.1-003; intron 1

  OTTHUMT00000079950 ; RP5-1043L13.1-004; intron 1

  OTTHUMT00000079957 ; RP5-1043L13.1-011; intron 1

  OTTHUMT00000079948 ; RP5-1043L13.1-002; intron 3

  OTTHUMT00000079947 ; RP5-1043L13.1-001; intron 3

  OTTHUMT00000079953 ; RP5-1043L13.1-007; intron 7

  ENST00000437035 ; RP5-1043L13.1-003; intron 1

  ENST00000421257 ; RP5-1043L13.1-004; intron 1

  ENST00000427820 ; RP5-1043L13.1-011; intron 1

  ENST00000458422 ; RP5-1043L13.1-002; intron 3

  ENST00000432910 ; RP5-1043L13.1-001; intron 3

  ENST00000431181 ; RP5-1043L13.1-007; intron 7

Clustered miRNAs

< 10kb from hsa-mir-296

• hsa-mir-298: chr20: 58818226-58818313 [-]
• hsa-mir-296: chr20: 58817615-58817694 [-]

Database links

• EntrezGene:MIR296
• HGNC:MIR296
• RNAcentral:URS00006F0310_9606
• miRBase Tracker:MI0000747

Mature sequence hsa-miR-296-5p

• Accession: MIMAT0000690
• Previous IDs: hsa-miR-296
• Sequence: 14 - agggcccccccucaauccugu - 34
• Deep sequencing: 4652 reads, 150 experiments
• Evidence: experimental; cloned [2,4-5]
• Database links:
  • RNAcentral:URS00001C3AC1_9606
• Predicted targets:
  • TargetMiner:hsa-miR-296-5p
  • TargetScanVert:hsa-miR-296-5p
  • miRDB:hsa-miR-296-5p
  • microrna.org:hsa-miR-296-5p

Mature sequence hsa-miR-296-3p

• Accession: MIMAT0004679
• Sequence: 48 - gaggguuggguggaggcucucc - 69
• Deep sequencing: 4308 reads, 118 experiments
• Evidence: experimental; cloned [4]
• Database links:
  • RNAcentral:URS00001F4670_9606
• Predicted targets:
  • TargetMiner:hsa-miR-296-3p
  • TargetScanVert:hsa-miR-296-3p
  • miRDB:hsa-miR-296-3p
  • microrna.org:hsa-miR-296-3p

References

1. PMID:12919684 "Embryonic stem cell-specific MicroRNAs" Houbaviy HB, Murray MF, Sharp PA Dev Cell. 5:351-358(2003).
2. PMID:15183728 "Human embryonic stem cells express a unique set of microRNAs" Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS Dev Biol. 270:488-498(2004).
3. PMID:15634332 "New human and mouse microRNA genes found by homology search" Weber MJ FEBS J. 272:59-73(2005).
4. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
5. PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).