Stem-loop sequence mmu-mir-200c

Accession

MI0000694 (change log)

Symbol

MGI:Mir200c

Description

Mus musculus miR-200c stem-loop

Gene family

MIPF0000019; mir-8

Literature search

303 open access papers mention mmu-mir-200c
(2767 sentences)

Stem-loop

     cu    -      a        u   u   gg 
5' cc  cguc uuaccc gcaguguu ggg gcu  u
   ||  |||| |||||| |||||||| ||| |||  u
3' gg  guag aauggg cgucauaa cuc uga  g
     ag    u      c        u   -   gg 

Deep sequencing

326987 reads, 819 reads per million, 102 experiments

Confidence

Annotation confidence: high

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Comments

Mouse mir-200c is predicted [3] based on homology to a cloned miR from human (MI0000650) [1]. Its expression in mouse was later verified independently [2,4]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chr6: 124718322-124718390 [-]
• Overlapping transcripts:

  sense

  OTTMUST00000067268 ; RP24-297C1.9-001; intron 1

  ENSMUST00000143765 ; Gm15884-001; intron 1

  ENSMUST00000083528 ; Mir200c-201; exon 1

Clustered miRNAs

< 10kb from mmu-mir-200c

• mmu-mir-200c: chr6: 124718322-124718390 [-]
• mmu-mir-141: chr6: 124717914-124717985 [-]

Database links

• EntrezGene:Mirn200c
• MGI:Mir200c
• RNAcentral:URS000075B099_10090
• miRBase Tracker:MI0000694

Mature sequence mmu-miR-200c-5p

• Accession: MIMAT0004663
• Previous IDs: mmu-miR-200c*
• Sequence: 5 - cgucuuacccagcaguguuugg - 26
• Deep sequencing: 117 reads, 28 experiments
• Evidence: experimental; cloned [4], Illumina [5-6]
• Database links:
  • RNAcentral:URS0000346F1C_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-200c-5p
  • miRDB:mmu-miR-200c-5p
  • microrna.org:mmu-miR-200c-5p

Mature sequence mmu-miR-200c-3p

• Accession: MIMAT0000657
• Previous IDs: mmu-miR-200c
• Sequence: 45 - uaauacugccggguaaugaugga - 67
• Deep sequencing: 326859 reads, 102 experiments
• Evidence: experimental; cloned [2,4], Illumina [5-6]
• Database links:
  • RNAcentral:URS0000192F9C_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-200c-3p
  • miRDB:mmu-miR-200c-3p
  • microrna.org:mmu-miR-200c-3p

References

1. PMID:14573789 "Reduced accumulation of specific microRNAs in colorectal neoplasia" Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ Mol Cancer Res. 1:882-891(2003).
2. PMID:15538371 "A pancreatic islet-specific microRNA regulates insulin secretion" Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M Nature. 432:226-230(2004).
3. PMID:15634332 "New human and mouse microRNA genes found by homology search" Weber MJ FEBS J. 272:59-73(2005).
4. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
5. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
6. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).