Stem-loop sequence hsa-mir-200c

Accession

MI0000650 (change log)

Symbol

HGNC:MIR200C

Description

Homo sapiens miR-200c stem-loop

Gene family

MIPF0000019; mir-8

Literature search

729 open access papers mention hsa-mir-200c
(4768 sentences)

Stem-loop

     cu    -      a        u   u  ggu 
5' cc  cguc uuaccc gcaguguu ggg gc   u
   ||  |||| |||||| |||||||| ||| ||    
3' gg  guag aauggg cgucauaa cuc ug   g
     ag    u      c        u   -  agg 

Deep sequencing

2055532 reads, 4.88e+03 reads per million, 158 experiments

Confidence

Annotation confidence: high

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Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr12: 6963699-6963766 [+]
• Overlapping transcripts:

  sense

  OTTHUMT00000402982 ; USP5-001; intron 1

  OTTHUMT00000402983 ; USP5-002; intron 1

  OTTHUMT00000402984 ; USP5-003; intron 1

  ENST00000229268 ; USP5-001; intron 1

  ENST00000389231 ; USP5-002; intron 1

  ENST00000542087 ; USP5-003; intron 1

Clustered miRNAs

< 10kb from hsa-mir-200c

• hsa-mir-200c: chr12: 6963699-6963766 [+]
• hsa-mir-141: chr12: 6964097-6964191 [+]

Database links

• EntrezGene:MIR200C
• HGNC:MIR200C
• RNAcentral:URS0000171525_9606
• miRBase Tracker:MI0000650

Mature sequence hsa-miR-200c-5p

• Accession: MIMAT0004657
• Previous IDs: hsa-miR-200c*
• Sequence: 5 - cgucuuacccagcaguguuugg - 26
• Deep sequencing: 2360 reads, 79 experiments
• Evidence: experimental; cloned [3]
• Database links:
  • RNAcentral:URS0000346F1C_9606
• Predicted targets:
  • TargetMiner:hsa-miR-200c-5p
  • TargetScanVert:hsa-miR-200c-5p
  • miRDB:hsa-miR-200c-5p
  • microrna.org:hsa-miR-200c-5p

Mature sequence hsa-miR-200c-3p

• Accession: MIMAT0000617
• Previous IDs: hsa-miR-200c
• Sequence: 44 - uaauacugccggguaaugaugga - 66
• Deep sequencing: 2053151 reads, 158 experiments
• Evidence: experimental; cloned [1-4], Northern [2]
• Database links:
  • RNAcentral:URS0000192F9C_9606
• Predicted targets:
  • TargetMiner:hsa-miR-200c-3p
  • TargetScanVert:hsa-miR-200c-3p
  • miRDB:hsa-miR-200c-3p
  • microrna.org:hsa-miR-200c-3p

References

1. PMID:14573789 "Reduced accumulation of specific microRNAs in colorectal neoplasia" Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ Mol Cancer Res. 1:882-891(2003).
2. PMID:15183728 "Human embryonic stem cells express a unique set of microRNAs" Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS Dev Biol. 270:488-498(2004).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
4. PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).