Stem-loop sequence mmu-let-7a-1

Accession

MI0000556 (change log)

Symbol

MGI:Mirlet7a-1

Description

Mus musculus let-7a-1 stem-loop

Gene family

MIPF0000002; let-7

Literature search

484 open access papers mention mmu-let-7a-1
(2969 sentences)

Stem-loop

   u     g     u   gu                uuagggucacac 
5'  ucacu uggga gag  aguagguuguauaguu            c
    ||||| ||||| |||  ||||||||||||||||            c
3'  agugg auccu uuc  ucaucuaacauaucaa            a
   u     a     -   ug                uagagggucacc 

Deep sequencing

124830577 reads, 2.45e+05 reads per million, 109 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chr13: 48538179-48538272 [-]
• Overlapping transcripts:

  sense

  ENSMUST00000083487 ; Mirlet7a-1-201; exon 1

Clustered miRNAs

< 10kb from mmu-let-7a-1

• mmu-let-7a-1: chr13: 48538179-48538272 [-]
• mmu-let-7f-1: chr13: 48537829-48537917 [-]
• mmu-let-7d: chr13: 48536012-48536114 [-]

Database links

• EntrezGene:Mirnlet7a-1
• MGI:Mirlet7a-1
• RNAcentral:URS000075D20D_10090
• miRBase Tracker:MI0000556

Mature sequence mmu-let-7a-5p

• Accession: MIMAT0000521
• Previous IDs: mmu-let-7a
• Sequence: 13 - ugagguaguagguuguauaguu - 34
• Deep sequencing: 249539481 reads, 109 experiments
• Evidence: experimental; cloned [1-4], Illumina [5,7]
• Database links:
  • RNAcentral:URS0000416056_10090
• Predicted targets:
  • TargetScanVert:mmu-let-7a-5p
  • miRDB:mmu-let-7a-5p
  • microrna.org:mmu-let-7a-5p

Mature sequence mmu-let-7a-1-3p

• Accession: MIMAT0004620
• Previous IDs: mmu-let-7a*;mmu-let-7a-1*
• Sequence: 64 - cuauacaaucuacugucuuucc - 85
• Deep sequencing: 10150 reads, 105 experiments
• Evidence: experimental; cloned [4], Illumina [5-6]
• Database links:
  • RNAcentral:URS000022B6DD_10090
• Predicted targets:
  • TargetScanVert:mmu-let-7a-1-3p
  • miRDB:mmu-let-7a-1-3p
  • microrna.org:mmu-let-7a-1-3p

References

1. PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
2. PMID:15538371 "A pancreatic islet-specific microRNA regulates insulin secretion" Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M Nature. 432:226-230(2004).
3. PMID:16766679 "Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes" Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H Genes Dev. 20:1732-1743(2006).
4. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
5. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
6. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).