Stem-loop sequence mmu-mir-154

Accession

MI0000176 (change log)

Symbol

MGI:Mir154

Description

Mus musculus miR-154 stem-loop

Gene family

MIPF0000018; mir-154

Literature search

24 open access papers mention mmu-mir-154
(125 sentences)

Stem-loop

               u      ugcc    - uuu 
5' gaagauagguua ccgugu    uucg c   a
   |||||||||||| ||||||    |||| |   u
3' uuuuuauccagu ggcaca    aagc g   u
               u      uacu    a ugc 

Deep sequencing

31993 reads, 272 reads per million, 74 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chr12: 109738433-109738498 [+]
• Overlapping transcripts:

  sense

  OTTMUST00000113369 ; Mirg-006; intron 1

  OTTMUST00000113370 ; Mirg-002; intron 1

  OTTMUST00000113366 ; Mirg-004; intron 2

  OTTMUST00000113367 ; Mirg-001; intron 2

  OTTMUST00000113368 ; Mirg-005; intron 2

  OTTMUST00000114051 ; Mirg-010; intron 7

  OTTMUST00000114052 ; Mirg-009; intron 8

  OTTMUST00000114049 ; Mirg-011; intron 11

  ENSMUST00000182231 ; Mirg-006; intron 1

  ENSMUST00000181496 ; Mirg-002; intron 1

  ENSMUST00000083514 ; Mir154-201; exon 1

  ENSMUST00000182268 ; Mirg-004; intron 2

  ENSMUST00000181543 ; Mirg-001; intron 2

  ENSMUST00000183116 ; Mirg-005; intron 2

  ENSMUST00000182185 ; Mirg-010; intron 7

  ENSMUST00000182499 ; Mirg-009; intron 8

  ENSMUST00000183144 ; Mirg-011; intron 11

Clustered miRNAs

< 10kb from mmu-mir-154

• mmu-mir-544: chr12: 109729325-109729402 [+]
• mmu-mir-382: chr12: 109733771-109733846 [+]
• mmu-mir-134: chr12: 109734139-109734209 [+]
• mmu-mir-668: chr12: 109734732-109734797 [+]
• mmu-mir-485: chr12: 109734902-109734974 [+]
• mmu-mir-453: chr12: 109735619-109735700 [+]
• mmu-mir-154: chr12: 109738433-109738498 [+]
• mmu-mir-496a: chr12: 109739119-109739197 [+]
• mmu-mir-377: chr12: 109740510-109740577 [+]
• mmu-mir-541: chr12: 109742409-109742498 [+]
• mmu-mir-409: chr12: 109743158-109743236 [+]
• mmu-mir-412: chr12: 109743289-109743368 [+]
• mmu-mir-369: chr12: 109743418-109743496 [+]
• mmu-mir-410: chr12: 109743715-109743795 [+]
• mmu-mir-3072: chr12: 109747878-109747960 [+]

Database links

• EntrezGene:Mir154
• MGI:Mir154
• RNAcentral:URS000075D943_10090
• miRBase Tracker:MI0000176

Mature sequence mmu-miR-154-5p

• Accession: MIMAT0000164
• Previous IDs: mmu-miR-154
• Sequence: 6 - uagguuauccguguugccuucg - 27
• Deep sequencing: 12000 reads, 68 experiments
• Evidence: experimental; cloned [1,3-4], PCR [2], Illumina [5-6]
• Database links:
  • RNAcentral:URS000008931A_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-154-5p
  • miRDB:mmu-miR-154-5p
  • microrna.org:mmu-miR-154-5p

Mature sequence mmu-miR-154-3p

• Accession: MIMAT0004537
• Previous IDs: mmu-miR-154*
• Sequence: 42 - aaucauacacgguugaccuauu - 63
• Deep sequencing: 19993 reads, 68 experiments
• Evidence: experimental; cloned [4], Illumina [5-6]
• Database links:
  • RNAcentral:URS00000C0921_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-154-3p
  • miRDB:mmu-miR-154-3p
  • microrna.org:mmu-miR-154-3p

References

1. PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
2. PMID:15310658 "A large imprinted microRNA gene cluster at the mouse Dlk1-Gtl2 domain" Seitz H, Royo H, Bortolin ML, Lin SP, Ferguson-Smith AC, Cavaille J Genome Res. 14:1741-1748(2004).
3. PMID:15538371 "A pancreatic islet-specific microRNA regulates insulin secretion" Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M Nature. 432:226-230(2004).
4. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
5. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
6. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).