Stem-loop sequence hsa-let-7b

Accession

MI0000063 (change log)

Previous IDs

hsa-let-7bL

Symbol

HGNC:MIRLET7B

Description

Homo sapiens let-7b stem-loop

Gene family

MIPF0000002; let-7

Literature search

1157 open access papers mention hsa-let-7b
(6780 sentences)

Stem-loop

        u                     ucagggcagugaug 
5' cgggg gagguaguagguugugugguu              u
   ||||| |||||||||||||||||||||               
3' guccc uuccgucauccaacauaucaa              u
        -                     uagaaggcuccccg 

Deep sequencing

41519300 reads, 8.34e+04 reads per million, 159 experiments

Confidence

Annotation confidence: high

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Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr22: 46113686-46113768 [+]
• Overlapping transcripts:

  sense

  OTTHUMT00000322280 ; ATXN10-004; intron 1

  OTTHUMT00000318142 ; ATXN10-001; intron 5

  OTTHUMT00000322278 ; ATXN10-002; intron 5

  ENST00000476998 ; ATXN10-004; intron 1

  ENST00000381061 ; ATXN10-201; intron 4

  ENST00000252934 ; ATXN10-001; intron 5

  ENST00000498009 ; ATXN10-002; intron 5

Clustered miRNAs

< 10kb from hsa-let-7b

• hsa-let-7a-3: chr22: 46112749-46112822 [+]
• hsa-mir-4763: chr22: 46113566-46113657 [+]
• hsa-let-7b: chr22: 46113686-46113768 [+]

Database links

• EntrezGene:MIRLET7B
• HGNC:MIRLET7B
• RNAcentral:URS000075A6A4_9606
• Rfam:let-7
• miRBase Tracker:MI0000063

Mature sequence hsa-let-7b-5p

• Accession: MIMAT0000063
• Previous IDs: hsa-let-7b
• Sequence: 6 - ugagguaguagguugugugguu - 27
• Deep sequencing: 41499458 reads, 159 experiments
• Evidence: experimental; cloned [1,3-5], Northern [1]
• Database links:
  • RNAcentral:URS0000324096_9606
• Predicted targets:
  • TargetMiner:hsa-let-7b-5p
  • TargetScanVert:hsa-let-7b-5p
  • miRDB:hsa-let-7b-5p
  • microrna.org:hsa-let-7b-5p

Mature sequence hsa-let-7b-3p

• Accession: MIMAT0004482
• Previous IDs: hsa-let-7b*
• Sequence: 60 - cuauacaaccuacugccuuccc - 81
• Deep sequencing: 19672 reads, 153 experiments
• Evidence: experimental; cloned [4-5]
• Database links:
  • RNAcentral:URS00005918D5_9606
• Predicted targets:
  • TargetMiner:hsa-let-7b-3p
  • TargetScanVert:hsa-let-7b-3p
  • miRDB:hsa-let-7b-3p
  • microrna.org:hsa-let-7b-3p

References

1. PMID:11679670 "Identification of novel genes coding for small expressed RNAs" Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T Science. 294:853-858(2001).
2. PMID:14573789 "Reduced accumulation of specific microRNAs in colorectal neoplasia" Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ Mol Cancer Res. 1:882-891(2003).
3. PMID:15325244 "Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells" Kasashima K, Nakamura Y, Kozu T Biochem Biophys Res Commun. 322:403-410(2004).
4. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
5. PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).