Stem-loop sequence mmu-mir-376c

Accession

MI0003533 (change log)

Symbol

MGI:Mir376c

Description

Mus musculus miR-376c stem-loop

Gene family

MIPF0000091; mir-368

Literature search

24 open access papers mention mmu-mir-376c
(42 sentences)

Stem-loop

   u   gu   u    g     ua     u         --u  u 
5'  uug  auu aaaa gugga  uuccu cuauguuua   gc u
    |||  ||| |||| |||||  ||||| |||||||||   || u
3'  aac  uga uuuu cacuu  aagga gauacaaau   ug u
   a   ug   c    g     ua     -         uag  u 

Deep sequencing

34099 reads, 241 reads per million, 76 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

The mature miR-376c products have been shown to be modified by A to I edits [2].

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chr12: 109722718-109722803 [+]
• Overlapping transcripts:

  intergenic

Clustered miRNAs

< 10kb from mmu-mir-376c

• mmu-mir-758: chr12: 109712810-109712890 [+]
• mmu-mir-329: chr12: 109713481-109713577 [+]
• mmu-mir-494: chr12: 109715318-109715402 [+]
• mmu-mir-679: chr12: 109715577-109715650 [+]
• mmu-mir-1193: chr12: 109715671-109715791 [+]
• mmu-mir-666: chr12: 109717085-109717183 [+]
• mmu-mir-543: chr12: 109717258-109717333 [+]
• mmu-mir-495: chr12: 109718754-109718816 [+]
• mmu-mir-667: chr12: 109720006-109720097 [+]
• mmu-mir-376c: chr12: 109722718-109722803 [+]
• mmu-mir-654: chr12: 109723218-109723301 [+]
• mmu-mir-376b: chr12: 109723458-109723539 [+]
• mmu-mir-376a: chr12: 109723781-109723848 [+]
• mmu-mir-300: chr12: 109724313-109724391 [+]
• mmu-mir-381: chr12: 109726822-109726896 [+]
• mmu-mir-487b: chr12: 109727333-109727414 [+]
• mmu-mir-539: chr12: 109728129-109728202 [+]
• mmu-mir-544: chr12: 109729325-109729402 [+]

Database links

• EntrezGene:Mir376c
• MGI:Mir376c
• RNAcentral:URS000075E4A8_10090
• miRBase Tracker:MI0003533

Mature sequence mmu-miR-376c-5p

• Accession: MIMAT0005295
• Previous IDs: mmu-miR-376c*
• Sequence: 16 - guggauauuccuucuauguuua - 37
• Deep sequencing: 22680 reads, 66 experiments
• Evidence: experimental; cloned [1], Illumina [4-5]
• Database links:
  • RNAcentral:URS0000006BE3_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-376c-5p
  • miRDB:mmu-miR-376c-5p
  • microrna.org:mmu-miR-376c-5p

Mature sequence mmu-miR-376c-3p

• Accession: MIMAT0003183
• Previous IDs: mmu-miR-376c
• Sequence: 53 - aacauagaggaaauuucacgu - 73
• Deep sequencing: 11418 reads, 71 experiments
• Evidence: experimental; cloned [1], Illumina [4-5]
• Database links:
  • RNAcentral:URS00000350B4_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-376c-3p
  • miRDB:mmu-miR-376c-3p
  • microrna.org:mmu-miR-376c-3p

References

1. PMID:16274478 "Identification of clustered microRNAs using an ab initio prediction method" Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M BMC Bioinformatics. 6:267(2005).
2. PMID:17322061 "Redirection of silencing targets by adenosine-to-inosine editing of miRNAs" Kawahara Y, Zinshteyn B, Sethupathy P, Iizasa H, Hatzigeorgiou AG, Nishikura K Science. 315:1137-1140(2007).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
4. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
5. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).