Stem-loop sequence mmu-mir-377

Accession

MI0000794 (change log)

Symbol

MGI:Mir377

Description

Mus musculus miR-377 stem-loop

Gene family

MIPF0000018; mir-154

Literature search

22 open access papers mention mmu-mir-377
(112 sentences)

Stem-loop

   u              c   -    a    - uuu 
5'  gagcagagguugcc uug guga uucg c   a
    |||||||||||||| ||| |||| |||| |   u
3'  uuuguuuucaacgg aac cacu aagu g   u
   g              a   a    -    u uag 

Deep sequencing

31993 reads, 293 reads per million, 73 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chr12: 109740510-109740577 [+]
• Overlapping transcripts:

  sense

  OTTMUST00000113366 ; Mirg-004; intron 2

  OTTMUST00000113367 ; Mirg-001; intron 2

  OTTMUST00000113370 ; Mirg-002; exon 2

  OTTMUST00000113368 ; Mirg-005; intron 3

  OTTMUST00000114051 ; Mirg-010; intron 7

  OTTMUST00000114052 ; Mirg-009; intron 9

  OTTMUST00000114049 ; Mirg-011; intron 11

  ENSMUST00000182268 ; Mirg-004; intron 2

  ENSMUST00000181543 ; Mirg-001; intron 2

  ENSMUST00000181496 ; Mirg-002; exon 2

  ENSMUST00000183116 ; Mirg-005; intron 3

  ENSMUST00000182185 ; Mirg-010; intron 7

  ENSMUST00000182499 ; Mirg-009; intron 9

  ENSMUST00000183144 ; Mirg-011; intron 11

Clustered miRNAs

< 10kb from mmu-mir-377

• mmu-mir-382: chr12: 109733771-109733846 [+]
• mmu-mir-134: chr12: 109734139-109734209 [+]
• mmu-mir-668: chr12: 109734732-109734797 [+]
• mmu-mir-485: chr12: 109734902-109734974 [+]
• mmu-mir-453: chr12: 109735619-109735700 [+]
• mmu-mir-154: chr12: 109738433-109738498 [+]
• mmu-mir-496a: chr12: 109739119-109739197 [+]
• mmu-mir-377: chr12: 109740510-109740577 [+]
• mmu-mir-541: chr12: 109742409-109742498 [+]
• mmu-mir-409: chr12: 109743158-109743236 [+]
• mmu-mir-412: chr12: 109743289-109743368 [+]
• mmu-mir-369: chr12: 109743418-109743496 [+]
• mmu-mir-410: chr12: 109743715-109743795 [+]
• mmu-mir-3072: chr12: 109747878-109747960 [+]

Database links

• EntrezGene:Mirn377
• MGI:Mir377
• RNAcentral:URS000075E879_10090
• miRBase Tracker:MI0000794

Mature sequence mmu-miR-377-5p

• Accession: MIMAT0017079
• Previous IDs: mmu-miR-377*
• Sequence: 6 - agagguugcccuuggugaauuc - 27
• Deep sequencing: 1730 reads, 54 experiments
• Evidence: experimental; Illumina [5]
• Database links:
  • RNAcentral:URS000036BEF1_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-377-5p
  • miRDB:mmu-miR-377-5p

Mature sequence mmu-miR-377-3p

• Accession: MIMAT0000741
• Previous IDs: mmu-miR-377
• Sequence: 44 - aucacacaaaggcaacuuuugu - 65
• Deep sequencing: 30263 reads, 71 experiments
• Evidence: experimental; cloned [1-3], Illumina [4-5]
• Database links:
  • RNAcentral:URS000007F792_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-377-3p
  • miRDB:mmu-miR-377-3p
  • microrna.org:mmu-miR-377-3p

References

1. PMID:15538371 "A pancreatic islet-specific microRNA regulates insulin secretion" Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M Nature. 432:226-230(2004).
2. PMID:16274478 "Identification of clustered microRNAs using an ab initio prediction method" Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M BMC Bioinformatics. 6:267(2005).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
4. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
5. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).