Stem-loop sequence mmu-let-7d

Accession

MI0000405 (change log)

Symbol

MGI:Mirlet7d

Description

Mus musculus let-7d stem-loop

Gene family

MIPF0000002; let-7

Literature search

436 open access papers mention mmu-let-7d
(2204 sentences)

Stem-loop

         uu       a              c      -------uua         
5' aauggg  ccuagga gagguaguagguug auaguu          gggcagag 
   ||||||  ||||||| |||||||||||||| ||||||          ||||||| a
3' uuauuc  ggauucu uuccgucguccagc uaucaa          cccguuuu 
         cg       -              a      uugaggaaca         

Deep sequencing

7452881 reads, 1.96e+04 reads per million, 107 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chr13: 48536012-48536114 [-]
• Overlapping transcripts:

  sense

  OTTMUST00000112524 ; RP24-270A10.4-001; exon 1

  ENSMUST00000181490 ; 6720427I07Rik-001; exon 1

Clustered miRNAs

< 10kb from mmu-let-7d

• mmu-let-7a-1: chr13: 48538179-48538272 [-]
• mmu-let-7f-1: chr13: 48537829-48537917 [-]
• mmu-let-7d: chr13: 48536012-48536114 [-]

Database links

• EntrezGene:Mirnlet7d
• MGI:Mirlet7d
• RNAcentral:URS000075CB5F_10090
• miRBase Tracker:MI0000405

Mature sequence mmu-let-7d-5p

• Accession: MIMAT0000383
• Previous IDs: mmu-let-7d
• Sequence: 16 - agagguaguagguugcauaguu - 37
• Deep sequencing: 7402977 reads, 107 experiments
• Evidence: experimental; cloned [1,3-5], Illumina [6-7]
• Database links:
  • RNAcentral:URS00000A07C1_10090
• Predicted targets:
  • TargetScanVert:mmu-let-7d-5p
  • miRDB:mmu-let-7d-5p
  • microrna.org:mmu-let-7d-5p

Mature sequence mmu-let-7d-3p

• Accession: MIMAT0000384
• Previous IDs: mmu-let-7d*
• Sequence: 70 - cuauacgaccugcugccuuucu - 91
• Deep sequencing: 49885 reads, 106 experiments
• Evidence: experimental; cloned [2,5], Illumina [6-7]
• Database links:
  • RNAcentral:URS000028D142_10090
• Predicted targets:
  • TargetScanVert:mmu-let-7d-3p
  • miRDB:mmu-let-7d-3p
  • microrna.org:mmu-let-7d-3p

References

1. PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
2. PMID:12919684 "Embryonic stem cell-specific MicroRNAs" Houbaviy HB, Murray MF, Sharp PA Dev Cell. 5:351-358(2003).
3. PMID:15538371 "A pancreatic islet-specific microRNA regulates insulin secretion" Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M Nature. 432:226-230(2004).
4. PMID:16766679 "Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes" Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H Genes Dev. 20:1732-1743(2006).
5. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
6. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
7. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).