Stem-loop sequence hsa-mir-205

Accession

MI0000285 (change log)

Symbol

HGNC:MIR205

Description

Homo sapiens miR-205 stem-loop

Gene family

MIPF0000058; mir-205

Literature search

320 open access papers mention hsa-mir-205
(1803 sentences)

Stem-loop

   aaagaucc    acaa       gcuu      uc           c        ucuca 
5'         ucag    uccaugu    cucuug  cuucauuccac ggagucug     u
           ||||    |||||||    ||||||  ||||||||||| ||||||||     a
3'         aguc    agguacg    gaggac  gaagugaggug cuuuagac     c
   ------ac    ---g       ----      uu           a        caacc 

Deep sequencing

1496079 reads, 6.21e+03 reads per million, 140 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm expression in human [2].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr1: 209432133-209432242 [+]
• Overlapping transcripts:

  intergenic

Database links

• EntrezGene:MIR205
• HGNC:MIR205
• RNAcentral:URS0000016914_9606
• miRBase Tracker:MI0000285

Mature sequence hsa-miR-205-5p

• Accession: MIMAT0000266
• Previous IDs: hsa-miR-205
• Sequence: 34 - uccuucauuccaccggagucug - 55
• Deep sequencing: 1492681 reads, 140 experiments
• Evidence: experimental; cloned [2-3]
• Database links:
  • RNAcentral:URS0000446722_9606
• Predicted targets:
  • TargetMiner:hsa-miR-205-5p
  • TargetScanVert:hsa-miR-205-5p
  • miRDB:hsa-miR-205-5p
  • microrna.org:hsa-miR-205-5p

Mature sequence hsa-miR-205-3p

• Accession: MIMAT0009197
• Previous IDs: hsa-miR-205*
• Sequence: 71 - gauuucaguggagugaaguuc - 91
• Deep sequencing: 3153 reads, 75 experiments
• Evidence: experimental; 454 [4]
• Database links:
  • RNAcentral:URS000038727B_9606
• Predicted targets:
  • TargetMiner:hsa-miR-205-3p
  • TargetScanVert:hsa-miR-205-3p
  • miRDB:hsa-miR-205-3p
  • microrna.org:hsa-miR-205-3p

References

1. PMID:12624257 "Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).
2. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
3. PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).
4. PMID:19144710 "Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas" Zhu JY, Pfuhl T, Motsch N, Barth S, Nicholls J, Grasser F, Meister G J Virol. 83:3333-3341(2009).