Stem-loop sequence hsa-mir-7-1

Accession

MI0000263 (change log)

Symbol

HGNC:MIR7-1

Description

Homo sapiens miR-7-1 stem-loop

Gene family

MIPF0000022; mir-7

Literature search

342 open access papers mention hsa-mir-7-1
(2052 sentences)

Stem-loop

   --u    u  -      a  u        a     a       u      --     a 
5'    ugga gu uggccu gu cugugugg agacu gugauuu guuguu  uuuag u
      |||| || |||||| || |||||||| ||||| ||||||| ||||||  |||||  
3'    aucu cg accgga ca gguauacc ucuga cacuaaa caacag  aaauc a
   gac    c  u      -  c        g     -       -      cu     a 

Deep sequencing

1208991 reads, 3.66e+03 reads per million, 162 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. confirm expression in human [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr9: 83969748-83969857 [-]
• Overlapping transcripts:

  intergenic

Database links

• EntrezGene:MIR7-1
• HGNC:MIR7-1
• RNAcentral:URS00002C5007_9606
• Rfam:mir-7
• miRBase Tracker:MI0000263

Mature sequence hsa-miR-7-5p

• Accession: MIMAT0000252
• Previous IDs: hsa-miR-7
• Sequence: 24 - uggaagacuagugauuuuguuguu - 47
• Deep sequencing: 3423555 reads, 162 experiments
• Evidence: experimental; cloned [2-3]
• Database links:
  • RNAcentral:URS0000591950_9606
• Predicted targets:
  • TargetMiner:hsa-miR-7-5p
  • TargetScanVert:hsa-miR-7-5p
  • miRDB:hsa-miR-7-5p
  • microrna.org:hsa-miR-7-5p

Mature sequence hsa-miR-7-1-3p

• Accession: MIMAT0004553
• Previous IDs: hsa-miR-7-1*
• Sequence: 66 - caacaaaucacagucugccaua - 87
• Deep sequencing: 15569 reads, 155 experiments
• Evidence: experimental; cloned [2]
• Database links:
  • RNAcentral:URS000028D811_9606
• Predicted targets:
  • TargetMiner:hsa-miR-7-1-3p
  • TargetScanVert:hsa-miR-7-1-3p
  • miRDB:hsa-miR-7-1-3p
  • microrna.org:hsa-miR-7-1-3p

References

1. PMID:12624257 "Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).
2. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
3. PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).