Stem-loop sequence hsa-mir-105-1

Accession

MI0000111 (change log)

Previous IDs

hsa-mir-105-X.1

Symbol

HGNC:MIR105-1

Description

Homo sapiens miR-105-1 stem-loop

Gene family

MIPF0000074; mir-105

Literature search

35 open access papers mention hsa-mir-105-1
(55 sentences)

Stem-loop

   ugu         u  a          uc        g ug 
5'    gcaucgugg ca augcucagac  cuguggug c  c
      ||||||||| || ||||||||||  |||||||| |  u
3'    uguggcauc gu uacgaguuug  ggcaccac g  c
   auc         -  g          ua        - ua 

Deep sequencing

2750 reads, 15.7 reads per million, 70 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

Mourelatos et al. [1] reported two identical predicted stem loop sequences located on chromosome X, which they named mir-105-X.1 and mir-105-X.2. These sequences have been renamed mir-105-1 (MI0000111) and mir-105-2 (MI0000112) here. mir-105-2 differs slightly from that published in [1] and deposited in EMBL (EMBL:AF480548). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chrX: 152392219-152392299 [-]
• Overlapping transcripts:

  sense

  OTTHUMT00000144474 ; AC151961.1-001; intron 1

  ENST00000456193 ; AC151961.1-001; intron 1

Clustered miRNAs

< 10kb from hsa-mir-105-1

• hsa-mir-105-2: chrX: 152394412-152394492 [-]
• hsa-mir-767: chrX: 152393421-152393529 [-]
• hsa-mir-105-1: chrX: 152392219-152392299 [-]

Database links

• EntrezGene:MIR105-1
• HGNC:MIR105-1
• RNAcentral:URS00004C3DB1_9606
• miRBase Tracker:MI0000111

Mature sequence hsa-miR-105-5p

• Accession: MIMAT0000102
• Previous IDs: hsa-miR-105
• Sequence: 13 - ucaaaugcucagacuccuguggu - 35
• Deep sequencing: 4506 reads, 61 experiments
• Evidence: experimental; cloned [1-2]
• Database links:
  • RNAcentral:URS0000495F5B_9606
• Predicted targets:
  • TargetMiner:hsa-miR-105-5p
  • TargetScanVert:hsa-miR-105-5p
  • miRDB:hsa-miR-105-5p
  • microrna.org:hsa-miR-105-5p

Mature sequence hsa-miR-105-3p

• Accession: MIMAT0004516
• Previous IDs: hsa-miR-105*
• Sequence: 51 - acggauguuugagcaugugcua - 72
• Deep sequencing: 983 reads, 29 experiments
• Evidence: experimental; cloned [2]
• Database links:
  • RNAcentral:URS00002872CB_9606
• Predicted targets:
  • TargetMiner:hsa-miR-105-3p
  • TargetScanVert:hsa-miR-105-3p
  • miRDB:hsa-miR-105-3p
  • microrna.org:hsa-miR-105-3p

References

1. PMID:11914277 "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs" Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G Genes Dev. 16:720-728(2002).
2. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).